Protein Engineering for Improved Pharmacologic Characteristics of Established Monoclonal Antibody-Based Therapeutics

Clinical Pharmacokinetics

Volumn 53, Issue 10, 2014, Pages 863-864

  Meibohm, Bernd ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY CONJUGATE; BETA1A INTERFERON; BISPECIFIC ANTIBODY; DACLIZUMAB; FC RECEPTOR; HUMAN MONOCLONAL ANTIBODY; HYBRID PROTEIN; INTERFERON BETA SERINE; MONOCLONAL ANTIBODY; NANOBODY; NATALIZUMAB; POLYPEPTIDE; RECOMBINANT ANTIBODY;

AMINO TERMINAL SEQUENCE; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTIBODY STRUCTURE; DRUG CLEARANCE; DRUG MANUFACTURE; EDITORIAL; GRAFT REJECTION; HEAVY CHAIN; HUMAN; IMMUNOGENICITY; KIDNEY GRAFT; PHARMACEUTICAL CARE; PROPHYLAXIS; PROTEIN ENGINEERING; PROTEIN GLYCOSYLATION; PROTEIN STRUCTURE; GENETICS;

ANTIBODIES, MONOCLONAL; HUMANS; PROTEIN ENGINEERING;

EID: 84918795323     PISSN: 03125963     EISSN: 11791926     Source Type: Journal    
DOI: 10.1007/s40262-014-0186-6     Document Type: Editorial

References (7)

1. Dirks NL, Meibohm B. Population pharmacokinetics of therapeutic monoclonal antibodies. Clin Pharmacokinet. 2010;49(10):633–59.
2. Kontermann RE. Dual targeting strategies with bispecific antibodies. MAbs. 2012;4(2):182–97.
3. Wu AM, Senter PD. Arming antibodies: prospects and challenges for immunoconjugates. Nat Biotechnol. 2005;23(9):1137–46.
4. Feagan BG, Choquette D, Ghosh S, Gladman DD, Ho V, Meibohm B, et al. The challenge of indication extrapolation for infliximab biosimilars. Biologicals. 2014;42(4):177–83.
5. Othman AA, Tran JQ, Tang MT, Dutta S. Population pharmacokinetics of daclizumab high-yield process in healthy volunteers: integrated analysis of intravenous and subcutaneous, single- and multiple-dose administration. Clin Pharmacokinet. 2014. doi:10.1007/s40262-014-0159-9.
6. Yamane-Ohnuki N, Satoh M. Production of therapeutic antibodies with controlled fucosylation. MAbs. 2009;1(3):230–6.
7. Hartman TE, Sauer PW, Burky JE, Wesson MC, Huang PY, Robinson TJ, et al., inventors. DAC HYP compositions and methods. US patent US 2012/0301429 A1. 29 Nov 2012.