Factors determining antibody distribution in tumors

Trends in Pharmacological Sciences

Volumn 29, Issue 2, 2008, Pages 57-61

  Thurber, Greg M ^a   Schmidt, Michael M ^a   Wittrup, K Dane ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CETUXIMAB; DOXORUBICIN; RITUXIMAB; TRASTUZUMAB;

ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY COMPLEX; ARTICLE; DRUG CLEARANCE; DRUG MECHANISM; DRUG METABOLISM; DRUG PENETRATION; EXTRAVASATION; HUMAN; NEOPLASM; PRIORITY JOURNAL;

ANTIBODIES; ANTINEOPLASTIC AGENTS; DRUG DESIGN; HUMANS; MODELS, BIOLOGICAL; NEOPLASMS; PERMEABILITY; TISSUE DISTRIBUTION;

EID: 38749139878     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2007.11.004     Document Type: Article

References (29)

1. Adams G.P., and Weiner L.M. Monoclonal antibody therapy of cancer. Nat. Biotechnol. 23 (2005) 1147-1157
2. Wu A.M., and Senter P.D. Arming antibodies: prospects and challenges for immunoconjugates. Nat. Biotechnol. 23 (2005) 1137-1146
3. Adams G.P., et al. High affinity restricts the localization and tumor penetration of single-chain Fv antibody molecules. Cancer Res. 61 (2001) 4750-4755
4. Dennis M.S., et al. Imaging tumors with an albumin-binding Fab, a novel tumor-targeting agent. Cancer Res. 67 (2007) 254-261
5. Saga T., et al. Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 8999-9003
6. Minchinton A.I., and Tannock I.F. Drug penetration in solid tumours. Nat. Rev. Cancer 6 (2006) 583-592
7. Luo F.R., et al. Correlation of pharmacokinetics with the antitumor activity of cetuximab in nude mice bearing the GEO human colon carcinoma xenograft. Cancer Chemother. Pharmacol. 56 (2005) 455-464
8. Jain R.K. Transport of molecules, particles, and cells in solid tumors. Annu. Rev. Biomed. Eng. 1 (1999) 241-263
9. 2, and Fab in tumors. Cancer Res. 49 (1989) 5656-5663
10. Swartz M.A., and Skobe M. Lymphatic function, lymphangiogenesis, and cancer metastasis. Microsc. Res. Tech. 55 (2001) 92-99
11. Jain R.K., and Baxter L. Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure. Cancer Res. 48 (1988) 7022-7032
12. Yuan F., et al. Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. Cancer Res. 55 (1995) 3752-3756
13. Dreher M.R., et al. Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers. J. Natl. Cancer Inst. 98 (2006) 335-344
14. Graff C.P., and Wittrup K.D. Theoretical analysis of antibody targeting of tumor spheroids: importance of dosage for penetration, and affinity for retention. Cancer Res. 63 (2003) 1288-1296
15. Berk D.A., et al. Direct in vivo measurement of targeted binding in a human tumor xenograft. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 1785-1790
16. Brown E.B., et al. Measurement of macromolecular diffusion coefficients in human tumors. Microvasc. Res. 67 (2004) 231-236
17. Thurber G.M., et al. Theoretic criteria for antibody penetration into solid tumors and micrometastases. J. Nucl. Med. 48 (2007) 995-999
18. Baish J.W., et al. Role of tumor vascular architecture in nutrient and drug delivery: an invasion percolation-based network model. Microvasc. Res. 51 (1996) 327-346
19. Kyriakos R.J., et al. The fate of antibodies bound to the surface of tumor cells in vitro. Cancer Res. 52 (1992) 835-842
20. Austin C.D., et al. Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics trastuzumab and geldanamycin. Mol. Biol. Cell 15 (2004) 5268-5282
21. Lammerts van Bueren J.J., et al. Effect of target dynamics on pharmacokinetics of a novel therapeutic antibody against the epidermal growth factor receptor: implications for the mechanisms of action. Cancer Res. 66 (2006) 7630-7638
22. Wiley H.S. Trafficking of the ErbB receptors and its influence on signaling. Exp. Cell Res. 284 (2003) 78-88
23. Michel R.B., et al. Antibody localization to B-cell lymphoma xenografts in immunodeficient mice: importance of using residualizing radiolabels. Clin. Cancer Res. 8 (2002) 2632-2639
24. Deen W. Analysis of Transport Phenomena (1998), Oxford University Press
25. Blumenthal R.D., et al. The effect of antibody protein dose on the uniformity of tumor distribution of radioantibodies - an autoradiographic study. Cancer Immunol. Immunother. 33 (1991) 351-358
26. Ong G.L., and Mattes M.J. Penetration and binding of antibodies in experimental human solid tumors grown in mice. Cancer Res. 49 (1989) 4264-4273
27. Thurber, G.M. et al. Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance. Adv. Drug Deliv. Rev. (in press)
28. Baxter L.T., and Jain R.K. Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism. Microvasc. Res. 41 (1991) 5-23
29. Nielsen U.B., et al. Targeting of bivalent anti-ErbB2 diabody antibody fragments to tumor cells is independent of the intrinsic antibody affinity. Cancer Res. 60 (2000) 6434-6440