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Volumn 4, Issue 6, 2012, Pages 775-783

Biodistribution studies with tumor-targeting bispecific antibodies reveal selective accumulation at the tumor site

Author keywords

Antibody; Biodistribution; Bispecific; Syngeneic; Tumor

Indexed keywords

BISPECIFIC ANTIBODY; CD3 ANTIGEN; FIBRONECTIN; HELXEDB ANTIBODY; IODINE 125; LYSOZYME; MCD3EXEDB ANTIBODY; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

EID: 84869798378     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.22271     Document Type: Article
Times cited : (29)

References (49)
  • 1
    • 0021832361 scopus 로고
    • Hybrid antibodies can target sites for attack by T cells
    • PMID:2859527
    • Staerz UD, Kanagawa O, Bevan MJ. Hybrid antibodies can target sites for attack by T cells. Nature 1985; 314:628-31; PMID:2859527; http://dx.doi.org/10. 1038/314628a0
    • (1985) Nature , vol.314 , pp. 628-631
    • Staerz, U.D.1    Kanagawa, O.2    Bevan, M.J.3
  • 2
    • 0021997079 scopus 로고
    • Specific targeting of cytotoxic T cells by anti-T3 linked to anti-target cell antibody
    • PMID:3160953
    • Perez P, Hoffman RW, Shaw S, Bluestone JA, Segal DM. Specific targeting of cytotoxic T cells by anti-T3 linked to anti-target cell antibody. Nature 1985; 316:354-6; PMID:3160953; http://dx.doi.org/10.1038/316354a0
    • (1985) Nature , vol.316 , pp. 354-356
    • Perez, P.1    Hoffman, R.W.2    Shaw, S.3    Bluestone, J.A.4    Segal, D.M.5
  • 3
    • 84858996878 scopus 로고    scopus 로고
    • Generation of single-chain bispecific green fluorescent protein fusion antibodies for imaging of antibody-induced T cell synapses
    • PMID:22274538
    • Stamova S, Feldmann A, Cartellieri M, Arndt C, Koristka S, Apel F, et al. Generation of single-chain bispecific green fluorescent protein fusion antibodies for imaging of antibody-induced T cell synapses. Anal Biochem 2012; 423:261-8; PMID:22274538; http://dx.doi.org/10.1016/j.ab.2011.12.042
    • (2012) Anal Biochem , vol.423 , pp. 261-268
    • Stamova, S.1    Feldmann, A.2    Cartellieri, M.3    Arndt, C.4    Koristka, S.5    Apel, F.6
  • 4
    • 28944434529 scopus 로고    scopus 로고
    • Induction of regular cytolytic T cell synapses by bispecific single-chain antibody constructs on MHC class I-negative tumor cells
    • PMID:16360021
    • Offner S, Hofmeister R, Romaniuk A, Kufer P, Baeuerle PA. Induction of regular cytolytic T cell synapses by bispecific single-chain antibody constructs on MHC class I-negative tumor cells. Mol Immunol 2006; 43:763-71; PMID:16360021; http://dx.doi.org/10.1016/j.molimm.2005.03.007
    • (2006) Mol Immunol , vol.43 , pp. 763-771
    • Offner, S.1    Hofmeister, R.2    Romaniuk, A.3    Kufer, P.4    Baeuerle, P.A.5
  • 5
    • 17644385543 scopus 로고    scopus 로고
    • Serial killing of tumor cells by cytotoxic T cells redirected with a CD19-/ CD3-bispecific single-chain antibody construct
    • PMID:15688411
    • Hoffmann P, Hofmeister R, Brischwein K, Brandl C, Crommer S, Bargou R, et al. Serial killing of tumor cells by cytotoxic T cells redirected with a CD19-/ CD3-bispecific single-chain antibody construct. Int J Cancer 2005; 115:98-104; PMID:15688411; http://dx.doi.org/10.1002/ijc.20908
    • (2005) Int J Cancer , vol.115 , pp. 98-104
    • Hoffmann, P.1    Hofmeister, R.2    Brischwein, K.3    Brandl, C.4    Crommer, S.5    Bargou, R.6
  • 6
    • 20144387546 scopus 로고    scopus 로고
    • Eradication of tumors from a human colon cancer cell line and from ovarian cancer metastases in immunodeficient mice by a single-chain Ep-CAM-/CD3-bispecific antibody construct
    • PMID:15805290
    • Schlereth B, Fichtner I, Lorenczewski G, Kleindienst P, Brischwein K, da Silva A, et al. Eradication of tumors from a human colon cancer cell line and from ovarian cancer metastases in immunodeficient mice by a single-chain Ep-CAM-/CD3-bispecific antibody construct. Cancer Res 2005; 65:2882-9; PMID:15805290; http://dx.doi.org/10.1158/0008-5472.CAN-04-2637
    • (2005) Cancer Res , vol.65 , pp. 2882-2889
    • Schlereth, B.1    Fichtner, I.2    Lorenczewski, G.3    Kleindienst, P.4    Brischwein, K.5    Da Silva, A.6
  • 7
    • 0025746633 scopus 로고
    • Bispecific anti-idiotype/anti-CD3 antibody therapy of murine B cell lymphoma
    • PMID:1834746
    • Weiner GJ, Hillstrom JR. Bispecific anti-idiotype/anti-CD3 antibody therapy of murine B cell lymphoma. J Immunol 1991; 147:4035-44; PMID:1834746
    • (1991) J Immunol , vol.147 , pp. 4035-4044
    • Weiner, G.J.1    Hillstrom, J.R.2
  • 8
    • 0025910046 scopus 로고
    • Treatment of murine B cell lymphoma with bispecific monoclonal antibodies (anti-idiotype x anti-CD3)
    • PMID:1830596
    • Demanet C, Brissinck J, Van Mechelen M, Leo O, Thielemans K. Treatment of murine B cell lymphoma with bispecific monoclonal antibodies (anti-idiotype x anti-CD3). J Immunol 1991; 147:1091-7; PMID:1830596
    • (1991) J Immunol , vol.147 , pp. 1091-1097
    • Demanet, C.1    Brissinck, J.2    Van Mechelen, M.3    Leo, O.4    Thielemans, K.5
  • 9
    • 0028263914 scopus 로고
    • Role of T-cell subsets in the bispecific antibody (anti-idiotype x anti-CD3) treatment of the BCL1 lymphoma
    • PMID:8187084
    • Demanet C, Brissinck J, Leo O, Moser M, Thielemans K. Role of T-cell subsets in the bispecific antibody (anti-idiotype x anti-CD3) treatment of the BCL1 lymphoma. Cancer Res 1994; 54:2973-8; PMID:8187084
    • (1994) Cancer Res , vol.54 , pp. 2973-2978
    • Demanet, C.1    Brissinck, J.2    Leo, O.3    Moser, M.4    Thielemans, K.5
  • 10
    • 49649120397 scopus 로고    scopus 로고
    • Tumor regression in cancer patients by very low doses of a T cell-engaging antibody
    • PMID:18703743
    • Bargou R, Leo E, Zugmaier G, Klinger M, Goebeler M, Knop S, et al. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science 2008; 321:974-7; PMID:18703743; http://dx.doi.org/10.1126/science. 1158545
    • (2008) Science , vol.321 , pp. 974-977
    • Bargou, R.1    Leo, E.2    Zugmaier, G.3    Klinger, M.4    Goebeler, M.5    Knop, S.6
  • 11
    • 79959312575 scopus 로고    scopus 로고
    • Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival
    • PMID:21576633
    • Topp MS, Kufer P, Gökbuget N, Goebeler M, Klinger M, Neumann S, et al. Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival. J Clin Oncol 2011; 29:2493-8; PMID:21576633; http://dx.doi.org/10.1200/JCO.2010.32.7270
    • (2011) J Clin Oncol , vol.29 , pp. 2493-2498
    • Topp, M.S.1    Kufer, P.2    Gökbuget, N.3    Goebeler, M.4    Klinger, M.5    Neumann, S.6
  • 12
    • 0020518331 scopus 로고
    • Hybrid hybridomas and their use in immunohistochemistry
    • PMID:6137772
    • Milstein C, Cuello AC. Hybrid hybridomas and their use in immunohistochemistry. Nature 1983; 305:537-40; PMID:6137772; http://dx.doi.org/10.1038/305537a0
    • (1983) Nature , vol.305 , pp. 537-540
    • Milstein, C.1    Cuello, A.C.2
  • 13
    • 0027197493 scopus 로고
    • "Diabodies": Small bivalent and bispecific antibody fragments
    • PMID:8341653
    • Holliger P, Prospero T, Winter G. "Diabodies": small bivalent and bispecific antibody fragments. Proc Natl Acad Sci USA 1993; 90:6444-8; PMID:8341653; http://dx.doi.org/10.1073/pnas.90.14.6444
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6444-6448
    • Holliger, P.1    Prospero, T.2    Winter, G.3
  • 15
    • 0036837633 scopus 로고    scopus 로고
    • Selective targeting of tumoral vasculature: Comparison of different formats of an antibody (L19) to the ED-B domain of fibronectin
    • PMID:12353237
    • Borsi L, Balza E, Bestagno M, Castellani P, Carnemolla B, Biro A, et al. Selective targeting of tumoral vasculature: comparison of different formats of an antibody (L19) to the ED-B domain of fibronectin. Int J Cancer 2002; 102:75-85; PMID:12353237; http://dx.doi.org/10.1002/ijc.10662
    • (2002) Int J Cancer , vol.102 , pp. 75-85
    • Borsi, L.1    Balza, E.2    Bestagno, M.3    Castellani, P.4    Carnemolla, B.5    Biro, A.6
  • 16
    • 0033555628 scopus 로고    scopus 로고
    • Increased binding affinity and valence of recombinant antibody fragments lead to improved targeting of tumoral angiogenesis
    • PMID:9927045
    • Viti F, Tarli L, Giovannoni L, Zardi L, Neri D. Increased binding affinity and valence of recombinant antibody fragments lead to improved targeting of tumoral angiogenesis. Cancer Res 1999; 59:347-52; PMID:9927045
    • (1999) Cancer Res , vol.59 , pp. 347-352
    • Viti, F.1    Tarli, L.2    Giovannoni, L.3    Zardi, L.4    Neri, D.5
  • 17
    • 0033569478 scopus 로고    scopus 로고
    • Bispecific tandem diabody for tumor therapy with improved antigen binding and pharmacokinetics
    • PMID:10512714
    • Kipriyanov SM, Moldenhauer G, Schuhmacher J, Cochlovius B, Von der Lieth CW, Matys ER, et al. Bispecific tandem diabody for tumor therapy with improved antigen binding and pharmacokinetics. J Mol Biol 1999; 293:41-56; PMID:10512714; http://dx.doi.org/10.1006/jmbi.1999.3156
    • (1999) J Mol Biol , vol.293 , pp. 41-56
    • Kipriyanov, S.M.1    Moldenhauer, G.2    Schuhmacher, J.3    Cochlovius, B.4    Von Der Lieth, C.W.5    Matys, E.R.6
  • 18
    • 70350059390 scopus 로고    scopus 로고
    • Generation of bispecific and tandem diabodies
    • PMID:19554296
    • Kipriyanov SM. Generation of bispecific and tandem diabodies. Methods Mol Biol 2009; 562:177-93; PMID:19554296; http://dx.doi.org/10.1007/978-1-60327- 302-2-14
    • (2009) Methods Mol Biol , vol.562 , pp. 177-193
    • Kipriyanov, S.M.1
  • 19
    • 77956344338 scopus 로고    scopus 로고
    • Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3) as a targeted cancer immunotherapy
    • PMID:20347527
    • Seimetz D, Lindhofer H, Bokemeyer C. Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3) as a targeted cancer immunotherapy. Cancer Treat Rev 2010; 36:458-67; PMID:20347527; http://dx.doi.org/10.1016/j. ctrv.2010.03.001
    • (2010) Cancer Treat Rev , vol.36 , pp. 458-467
    • Seimetz, D.1    Lindhofer, H.2    Bokemeyer, C.3
  • 20
    • 84869794027 scopus 로고    scopus 로고
    • Dosage regimen for administering a CD19xCD3 bispecific antibody
    • Patent Nr.WO2011051307A1. In: WIPO/OMPI, ed.
    • Nagorsen D, Kufer P, Zugmaier G, Baeuerle P. Dosage regimen for administering a CD19xCD3 bispecific antibody (Patent Nr.WO2011051307A1). In: WIPO/OMPI, ed., 2011
    • (2011)
    • Nagorsen, D.1    Kufer, P.2    Zugmaier, G.3    Baeuerle, P.4
  • 21
    • 0034662632 scopus 로고    scopus 로고
    • Cure of Burkitt's lymphoma in severe combined immunodeficiency mice by T cells, tetravalent CD3 x CD19 tandem diabody, and CD28 costimulation
    • PMID:10969772
    • Cochlovius B, Kipriyanov SM, Stassar MJ, Schuhmacher J, Benner A, Moldenhauer G, et al. Cure of Burkitt's lymphoma in severe combined immunodeficiency mice by T cells, tetravalent CD3 x CD19 tandem diabody, and CD28 costimulation. Cancer Res 2000; 60:4336-41; PMID:10969772
    • (2000) Cancer Res , vol.60 , pp. 4336-4341
    • Cochlovius, B.1    Kipriyanov, S.M.2    Stassar, M.J.3    Schuhmacher, J.4    Benner, A.5    Moldenhauer, G.6
  • 22
    • 0027406812 scopus 로고
    • Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes
    • PMID:8430336
    • Shinkai Y, Koyasu S, Nakayama K, Murphy KM, Loh DY, Reinherz EL, et al. Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science 1993; 259:822-5; PMID:8430336; http://dx.doi.org/10.1126/ science.8430336
    • (1993) Science , vol.259 , pp. 822-825
    • Shinkai, Y.1    Koyasu, S.2    Nakayama, K.3    Murphy, K.M.4    Loh, D.Y.5    Reinherz, E.L.6
  • 23
    • 70350018276 scopus 로고    scopus 로고
    • Biodistribution of a bispecific single-chain diabody and its half-life extended derivatives
    • PMID:19628871
    • Stork R, Campigna E, Robert B, Müller D, Kontermann RE. Biodistribution of a bispecific single-chain diabody and its half-life extended derivatives. J Biol Chem 2009; 284:25612-9; PMID:19628871; http://dx.doi.org/10. 1074/jbc.M109.027078
    • (2009) J Biol Chem , vol.284 , pp. 25612-25619
    • Stork, R.1    Campigna, E.2    Robert, B.3    Müller, D.4    Kontermann, R.E.5
  • 24
    • 0028116528 scopus 로고
    • The fibronectin isoform containing the ED-B oncofetal domain: A marker of angiogenesis
    • PMID:7525495
    • Castellani P, Viale G, Dorcaratto A, Nicolo G, Kaczmarek J, Querze G, et al. The fibronectin isoform containing the ED-B oncofetal domain: a marker of angiogenesis. Int J Cancer 1994; 59:612-8; PMID:7525495; http://dx.doi.org/10. 1002/ ijc.2910590507
    • (1994) Int J Cancer , vol.59 , pp. 612-618
    • Castellani, P.1    Viale, G.2    Dorcaratto, A.3    Nicolo, G.4    Kaczmarek, J.5    Querze, G.6
  • 25
    • 0032555478 scopus 로고    scopus 로고
    • Design and use of a phage display library. Human antibodies with subnanomolar affinity against a marker of angiogenesis eluted from a two-dimensional gel
    • PMID:9705314
    • Pini A, Viti F, Santucci A, Carnemolla B, Zardi L, Neri P, et al. Design and use of a phage display library. Human antibodies with subnanomolar affinity against a marker of angiogenesis eluted from a two-dimensional gel. J Biol Chem 1998; 273:21769-76; PMID:9705314; http://dx.doi.org/10.1074/ jbc.273.34.21769
    • (1998) J Biol Chem , vol.273 , pp. 21769-21776
    • Pini, A.1    Viti, F.2    Santucci, A.3    Carnemolla, B.4    Zardi, L.5    Neri, P.6
  • 26
    • 0023392493 scopus 로고
    • Transformed human cells produce a new fibronectin isoform by preferential alternative splicing of a previously unobserved exon
    • PMID:2822387
    • Zardi L, Carnemolla B, Siri A, Petersen TE, Paolella G, Sebastio G, et al. Transformed human cells produce a new fibronectin isoform by preferential alternative splicing of a previously unobserved exon. EMBO J 1987; 6:2337-42; PMID:2822387
    • (1987) EMBO J , vol.6 , pp. 2337-2342
    • Zardi, L.1    Carnemolla, B.2    Siri, A.3    Petersen, T.E.4    Paolella, G.5    Sebastio, G.6
  • 27
    • 0033560794 scopus 로고    scopus 로고
    • NMR structure of the human oncofoetal fibronectin ED-B domain, a specific marker for angiogenesis
    • PMID:10196121
    • Fattorusso R, Pellecchia M, Viti F, Neri P, Neri D, Wüthrich K. NMR structure of the human oncofoetal fibronectin ED-B domain, a specific marker for angiogenesis. Structure 1999; 7:381-90; PMID:10196121; http://dx.doi.org/10. 1016/S0969-2126(99)80051-3
    • (1999) Structure , vol.7 , pp. 381-390
    • Fattorusso, R.1    Pellecchia, M.2    Viti, F.3    Neri, P.4    Neri, D.5    Wüthrich, K.6
  • 28
    • 0037314650 scopus 로고    scopus 로고
    • Immunoscintigraphic detection of the ED-B domain of fibronectin, a marker of angiogenesis, in patients with cancer
    • PMID:12576420
    • Santimaria M, Moscatelli G, Viale GL, Giovannoni L, Neri G, Viti F, et al. Immunoscintigraphic detection of the ED-B domain of fibronectin, a marker of angiogenesis, in patients with cancer. Clin Cancer Res 2003; 9:571-9; PMID:12576420
    • (2003) Clin Cancer Res , vol.9 , pp. 571-579
    • Santimaria, M.1    Moscatelli, G.2    Viale, G.L.3    Giovannoni, L.4    Neri, G.5    Viti, F.6
  • 29
    • 63849261384 scopus 로고    scopus 로고
    • Expression of the oncofetal ED-B-containing fibronectin isoform in hematologic tumors enables ED-B-targeted 131I-L19SIP radioimmunotherapy in Hodgkin lymphoma patients
    • PMID:19131554
    • Sauer S, Erba PA, Petrini M, Menrad A, Giovannoni L, Grana C, et al. Expression of the oncofetal ED-B-containing fibronectin isoform in hematologic tumors enables ED-B-targeted 131I-L19SIP radioimmunotherapy in Hodgkin lymphoma patients. Blood 2009; 113:2265-74; PMID:19131554; http://dx.doi.org/10.1182/ blood-2008-06-160416
    • (2009) Blood , vol.113 , pp. 2265-2274
    • Sauer, S.1    Erba, P.A.2    Petrini, M.3    Menrad, A.4    Giovannoni, L.5    Grana, C.6
  • 30
    • 84861894823 scopus 로고    scopus 로고
    • Radioimmunotherapy with radretumab in patients with relapsed hematologic malignancies
    • PMID:22577235
    • Erba PA, Sollini M, Orciuolo E, Traino C, Petrini M, Paganelli G, et al. Radioimmunotherapy with radretumab in patients with relapsed hematologic malignancies. J Nucl Med 2012; 53:922-7; PMID:22577235; http://dx.doi.org/10. 2967/jnumed.111.101006
    • (2012) J Nucl Med , vol.53 , pp. 922-927
    • Erba, P.A.1    Sollini, M.2    Orciuolo, E.3    Traino, C.4    Petrini, M.5    Paganelli, G.6
  • 31
    • 84861610591 scopus 로고    scopus 로고
    • Immunocytokines: A novel class of potent armed antibodies
    • PMID:22289353
    • Pasche N, Neri D. Immunocytokines: a novel class of potent armed antibodies. Drug Discov Today 2012; 17:583-90; PMID:22289353; http://dx.doi.org/10.1016/j.drudis.2012.01.007
    • (2012) Drug Discov Today , vol.17 , pp. 583-590
    • Pasche, N.1    Neri, D.2
  • 32
    • 20344367537 scopus 로고    scopus 로고
    • Tumour vascular targeting
    • PMID:15928674
    • Neri D, Bicknell R. Tumour vascular targeting. Nat Rev Cancer 2005; 5:436-46; PMID:15928674; http://dx.doi.org/10.1038/nrc1627
    • (2005) Nat Rev Cancer , vol.5 , pp. 436-446
    • Neri, D.1    Bicknell, R.2
  • 33
    • 22044456976 scopus 로고    scopus 로고
    • Engineered vascular-targeting antibody-interferon-gamma fusion protein for cancer therapy
    • PMID:15800913
    • Ebbinghaus C, Ronca R, Kaspar M, Grabulovski D, Berndt A, Kosmehl H, et al. Engineered vascular-targeting antibody-interferon-gamma fusion protein for cancer therapy. Int J Cancer 2005; 116:304-13; PMID:15800913; http://dx.doi.org/10.1002/ ijc.20952
    • (2005) Int J Cancer , vol.116 , pp. 304-313
    • Ebbinghaus, C.1    Ronca, R.2    Kaspar, M.3    Grabulovski, D.4    Berndt, A.5    Kosmehl, H.6
  • 34
    • 0036891467 scopus 로고    scopus 로고
    • An antibody-calmodulin fusion protein reveals a functional dependence between macromolecular isoelectric point and tumor targeting performance
    • PMID:12459375
    • Melkko S, Halin C, Borsi L, Zardi L, Neri D. An antibody-calmodulin fusion protein reveals a functional dependence between macromolecular isoelectric point and tumor targeting performance. Int J Radiat Oncol Biol Phys 2002; 54:1485-90; PMID:12459375; http://dx.doi.org/10.1016/S0360-3016(02)03927-5
    • (2002) Int J Radiat Oncol Biol Phys , vol.54 , pp. 1485-1490
    • Melkko, S.1    Halin, C.2    Borsi, L.3    Zardi, L.4    Neri, D.5
  • 35
    • 0036074754 scopus 로고    scopus 로고
    • Quantitation of the tumor-targeting properties of antibody fragments conjugated to cell-permeating HIV-1 TAT peptides
    • PMID:12121127
    • Niesner U, Halin C, Lozzi L, Günthert M, Neri P, Wunderli-Allenspach H, et al. Quantitation of the tumor-targeting properties of antibody fragments conjugated to cell-permeating HIV-1 TAT peptides. Bioconjug Chem 2002; 13:729-36; PMID:12121127; http://dx.doi.org/10.1021/bc025517+
    • (2002) Bioconjug Chem , vol.13 , pp. 729-736
    • Niesner, U.1    Halin, C.2    Lozzi, L.3    Günthert, M.4    Neri, P.5    Wunderli-Allenspach, H.6
  • 36
    • 0037058313 scopus 로고    scopus 로고
    • Tumor-targeting properties of antibody-vascular endothelial growth factor fusion proteins
    • PMID:12385005
    • Halin C, Niesner U, Villani ME, Zardi L, Neri D. Tumor-targeting properties of antibody-vascular endothelial growth factor fusion proteins. Int J Cancer 2002; 102:109-16; PMID:12385005; http://dx.doi.org/10.1002/ijc.10674
    • (2002) Int J Cancer , vol.102 , pp. 109-116
    • Halin, C.1    Niesner, U.2    Villani, M.E.3    Zardi, L.4    Neri, D.5
  • 37
    • 0037731516 scopus 로고    scopus 로고
    • Synergistic therapeutic effects of a tumor targeting antibody fragment, fused to interleukin 12 and to tumor necrosis factor alpha
    • PMID:12810649
    • Halin C, Gafner V, Villani ME, Borsi L, Berndt A, Kosmehl H, et al. Synergistic therapeutic effects of a tumor targeting antibody fragment, fused to interleukin 12 and to tumor necrosis factor alpha. Cancer Res 2003; 63:3202-10; PMID:12810649
    • (2003) Cancer Res , vol.63 , pp. 3202-3210
    • Halin, C.1    Gafner, V.2    Villani, M.E.3    Borsi, L.4    Berndt, A.5    Kosmehl, H.6
  • 38
    • 33748866249 scopus 로고    scopus 로고
    • An engineered antibody-interleukin-12 fusion protein with enhanced tumor vascular targeting properties
    • PMID:16823838
    • Gafner V, Trachsel E, Neri D. An engineered antibody-interleukin-12 fusion protein with enhanced tumor vascular targeting properties. Int J Cancer 2006; 119:2205-12; PMID:16823838; http://dx.doi.org/10.1002/ijc.22101
    • (2006) Int J Cancer , vol.119 , pp. 2205-2212
    • Gafner, V.1    Trachsel, E.2    Neri, D.3
  • 39
    • 0001637710 scopus 로고
    • Identification of a monoclonal antibody specific for a murine T3 polypeptide
    • PMID:2950524
    • Leo O, Foo M, Sachs DH, Samelson LE, Bluestone JA. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc Natl Acad Sci USA 1987; 84:1374-8; PMID:2950524; http://dx.doi.org/10.1073/pnas.84.5.1374
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 1374-1378
    • Leo, O.1    Foo, M.2    Sachs, D.H.3    Samelson, L.E.4    Bluestone, J.A.5
  • 40
    • 0029102761 scopus 로고
    • An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity
    • PMID:7636216
    • Alegre ML, Tso JY, Sattar HA, Smith J, Desalle F, Cole M, et al. An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity. J Immunol 1995; 155:1544-55; PMID:7636216
    • (1995) J Immunol , vol.155 , pp. 1544-1555
    • Alegre, M.L.1    Tso, J.Y.2    Sattar, H.A.3    Smith, J.4    Desalle, F.5    Cole, M.6
  • 41
    • 39149130004 scopus 로고    scopus 로고
    • Therapeutic window of MuS110, a single-chain antibody construct bispecific for murine EpCAM and murine CD3
    • PMID:18172306
    • Amann M, Brischwein K, Lutterbuese P, Parr L, Petersen L, Lorenczewski G, et al. Therapeutic window of MuS110, a single-chain antibody construct bispecific for murine EpCAM and murine CD3. Cancer Res 2008; 68:143-51; PMID:18172306; http://dx.doi. org/10.1158/0008-5472.CAN-07-2182
    • (2008) Cancer Res , vol.68 , pp. 143-151
    • Amann, M.1    Brischwein, K.2    Lutterbuese, P.3    Parr, L.4    Petersen, L.5    Lorenczewski, G.6
  • 42
    • 28744455481 scopus 로고    scopus 로고
    • Potent inhibition of local and disseminated tumor growth in immunocompetent mouse models by a bispecific antibody construct specific for Murine CD3
    • PMID:16187083
    • Schlereth B, Kleindienst P, Fichtner I, Lorenczewski G, Brischwein K, Lippold S, et al. Potent inhibition of local and disseminated tumor growth in immunocompetent mouse models by a bispecific antibody construct specific for Murine CD3. Cancer Immunol Immunother 2006; 55:785-96; PMID:16187083; http://dx.doi.org/10.1007/s00262-005-0082-x
    • (2006) Cancer Immunol Immunother , vol.55 , pp. 785-796
    • Schlereth, B.1    Kleindienst, P.2    Fichtner, I.3    Lorenczewski, G.4    Brischwein, K.5    Lippold, S.6
  • 43
    • 79151478660 scopus 로고    scopus 로고
    • Comparative in vivo analysis of the atherosclerotic plaque targeting properties of eight human monoclonal antibodies
    • PMID:21167484
    • Fiechter M, Frey K, Fugmann T, Kaufmann PA, Neri D. Comparative in vivo analysis of the atherosclerotic plaque targeting properties of eight human monoclonal antibodies. Atherosclerosis 2011; 214:325-30; PMID:21167484; http://dx.doi.org/10.1016/j.atherosclerosis.2010.11.027
    • (2011) Atherosclerosis , vol.214 , pp. 325-330
    • Fiechter, M.1    Frey, K.2    Fugmann, T.3    Kaufmann, P.A.4    Neri, D.5
  • 44
    • 20644469912 scopus 로고    scopus 로고
    • Design, construction, and characterization of a large synthetic human antibody phage display library
    • PMID:15880779
    • Silacci M, Brack S, Schirru G, Mårlind J, Ettorre A, Merlo A, et al. Design, construction, and characterization of a large synthetic human antibody phage display library. Proteomics 2005; 5:2340-50; PMID:15880779; http://dx.doi.org/10.1002/ pmic.200401273
    • (2005) Proteomics , vol.5 , pp. 2340-2350
    • Silacci, M.1    Brack, S.2    Schirru, G.3    Mårlind, J.4    Ettorre, A.5    Merlo, A.6
  • 45
    • 0034730312 scopus 로고    scopus 로고
    • Heterodimeric CD3epsilongamma extracellular domain fragments: Production, purification and structural analysis
    • PMID:10993731
    • Kim KS, Sun ZY, Wagner G, Reinherz EL. Heterodimeric CD3epsilongamma extracellular domain fragments: production, purification and structural analysis. J Mol Biol 2000; 302:899-916; PMID:10993731; http://dx.doi.org/10. 1006/jmbi.2000.4098
    • (2000) J Mol Biol , vol.302 , pp. 899-916
    • Kim, K.S.1    Sun, Z.Y.2    Wagner, G.3    Reinherz, E.L.4
  • 46
    • 0033168617 scopus 로고    scopus 로고
    • A high-affinity human antibody that targets tumoral blood vessels
    • PMID:10381513
    • Tarli L, Balza E, Viti F, Borsi L, Castellani P, Berndorff D, et al. A high-affinity human antibody that targets tumoral blood vessels. Blood 1999; 94:192-8; PMID:10381513
    • (1999) Blood , vol.94 , pp. 192-198
    • Tarli, L.1    Balza, E.2    Viti, F.3    Borsi, L.4    Castellani, P.5    Berndorff, D.6
  • 47
    • 0035096320 scopus 로고    scopus 로고
    • Selective targeting of tumour neovasculature by a radiohalogenated human antibody fragment specific for the ED-B domain of fibronectin
    • PMID:11357506
    • Demartis S, Tarli L, Borsi L, Zardi L, Neri D. Selective targeting of tumour neovasculature by a radiohalogenated human antibody fragment specific for the ED-B domain of fibronectin. Eur J Nucl Med 2001; 28:534-9; PMID:11357506; http://dx.doi.org/10.1007/s002590100480
    • (2001) Eur J Nucl Med , vol.28 , pp. 534-539
    • Demartis, S.1    Tarli, L.2    Borsi, L.3    Zardi, L.4    Neri, D.5
  • 48
    • 10744221996 scopus 로고    scopus 로고
    • Selective targeted delivery of TNFalpha to tumor blood vessels
    • PMID:12933583
    • Borsi L, Balza E, Carnemolla B, Sassi F, Castellani P, Berndt A, et al. Selective targeted delivery of TNFalpha to tumor blood vessels. Blood 2003; 102:4384-92; PMID:12933583; http://dx.doi.org/10.1182/blood-2003-04-1039
    • (2003) Blood , vol.102 , pp. 4384-4392
    • Borsi, L.1    Balza, E.2    Carnemolla, B.3    Sassi, F.4    Castellani, P.5    Berndt, A.6
  • 49
    • 0036856493 scopus 로고    scopus 로고
    • Optimizing anti-CD3 affinity for effective T cell targeting against tumor cells
    • PMID:12385030
    • Bortoletto N, Scotet E, Myamoto Y, D'Oro U, Lanzavecchia A. Optimizing anti-CD3 affinity for effective T cell targeting against tumor cells. Eur J Immunol 2002; 32:3102-7; PMID:12385030; http://dx.doi. org/10.1002/1521- 4141(200211)32:11〈3102::AIDIMMU3102〉3.0.CO;2-C
    • (2002) Eur J Immunol , vol.32 , pp. 3102-3107
    • Bortoletto, N.1    Scotet, E.2    Myamoto, Y.3    D'Oro, U.4    Lanzavecchia, A.5


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