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Volumn 16, Issue 4, 2014, Pages 686-696

Apolipoprotein E Isoform-Specific Effects on Lipoprotein Receptor Processing

Author keywords

Apolipoprotein E; Beta amyloid; Blood brain barrier; Lipoprotein receptor

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); APOLIPOPROTEIN E; APOLIPOPROTEIN E4; ISOPROTEIN; LDLR PROTEIN, HUMAN; LOW DENSITY LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; LRP1 PROTEIN, HUMAN; PEPTIDE FRAGMENT;

EID: 84923319414     PISSN: 15351084     EISSN: 15591174     Source Type: Journal    
DOI: 10.1007/s12017-014-8318-6     Document Type: Article
Times cited : (42)

References (70)
  • 1
    • 84855767006 scopus 로고    scopus 로고
    • Association of ApoE and LRP mRNA levels with dementia and AD neuropathology
    • PID: 21676498
    • Akram, A., Schmeidler, J., Katsel, P., Hof, P. R., & Haroutunian, V. (2012). Association of ApoE and LRP mRNA levels with dementia and AD neuropathology. Neurobiology of Aging,33(3), e1–e14.
    • (2012) Neurobiology of Aging , vol.33 , Issue.3 , pp. e1-e14
    • Akram, A.1    Schmeidler, J.2    Katsel, P.3    Hof, P.R.4    Haroutunian, V.5
  • 2
    • 0037099306 scopus 로고    scopus 로고
    • LRP and senile plaques in Alzheimer’s disease: Colocalization with apolipoprotein E and with activated astrocytes
    • COI: 1:CAS:528:DC%2BD38XltFSitbs%3D, PID: 12117549
    • Arelin, K., Kinoshita, A., Whelan, C. M., Irizarry, M. C., Rebeck, G. W., Strickland, D. K., et al. (2002). LRP and senile plaques in Alzheimer’s disease: Colocalization with apolipoprotein E and with activated astrocytes. Molecular Brain Research,104(1), 38–46.
    • (2002) Molecular Brain Research , vol.104 , Issue.1 , pp. 38-46
    • Arelin, K.1    Kinoshita, A.2    Whelan, C.M.3    Irizarry, M.C.4    Rebeck, G.W.5    Strickland, D.K.6
  • 3
    • 75149142375 scopus 로고    scopus 로고
    • The molecular biology of senile plaques and neurofibrillary tangles in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3cXitlWlsLY%3D, PID: 20054780
    • Armstrong, R. A. (2009). The molecular biology of senile plaques and neurofibrillary tangles in Alzheimer’s disease. Folia Neuropathologica,47(4), 289–299.
    • (2009) Folia Neuropathologica , vol.47 , Issue.4 , pp. 289-299
    • Armstrong, R.A.1
  • 4
    • 78651497015 scopus 로고    scopus 로고
    • Characterization and use of human brain microvascular endothelial cells to examine beta-amyloid exchange in the blood–brain barrier
    • COI: 1:CAS:528:DC%2BC3cXhsV2gu7vE, PID: 20954006
    • Bachmeier, C., Mullan, M., & Paris, D. (2010). Characterization and use of human brain microvascular endothelial cells to examine beta-amyloid exchange in the blood–brain barrier. Cytotechnology,62(6), 519–529.
    • (2010) Cytotechnology , vol.62 , Issue.6 , pp. 519-529
    • Bachmeier, C.1    Mullan, M.2    Paris, D.3
  • 6
    • 66149181776 scopus 로고    scopus 로고
    • Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice
    • COI: 1:CAS:528:DC%2BD1MXmvVGisrs%3D, PID: 19474305
    • Bales, K. R., Liu, F., Wu, S., Lin, S., Koger, D., DeLong, C., et al. (2009). Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice. Journal of Neuroscience,29(21), 6771–6779.
    • (2009) Journal of Neuroscience , vol.29 , Issue.21 , pp. 6771-6779
    • Bales, K.R.1    Liu, F.2    Wu, S.3    Lin, S.4    Koger, D.5    DeLong, C.6
  • 7
    • 84859980871 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Abeta uptake and degradation by astrocytes
    • COI: 1:CAS:528:DC%2BC38XlvVGltr0%3D, PID: 22383525
    • Basak, J. M., Verghese, P. B., Yoon, H., Kim, J., & Holtzman, D. M. (2012). Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Abeta uptake and degradation by astrocytes. Journal of Biological Chemistry,287(17), 13959–13971.
    • (2012) Journal of Biological Chemistry , vol.287 , Issue.17 , pp. 13959-13971
    • Basak, J.M.1    Verghese, P.B.2    Yoon, H.3    Kim, J.4    Holtzman, D.M.5
  • 8
    • 0842308984 scopus 로고    scopus 로고
    • Soluble LDL-R are formed by cell surface cleavage in response to phorbol esters
    • COI: 1:CAS:528:DC%2BD2cXhtlWgsLY%3D, PID: 14728679
    • Begg, M. J., Sturrock, E. D., & van der Westhuyzen, D. R. (2004). Soluble LDL-R are formed by cell surface cleavage in response to phorbol esters. European Journal of Biochemistry,271(3), 524–533.
    • (2004) European Journal of Biochemistry , vol.271 , Issue.3 , pp. 524-533
    • Begg, M.J.1    Sturrock, E.D.2    van der Westhuyzen, D.R.3
  • 9
    • 47849090167 scopus 로고    scopus 로고
    • Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels
    • COI: 1:CAS:528:DC%2BD1cXkvV2rtrw%3D, PID: 18430993
    • Bekris, L. M., Millard, S. P., Galloway, N. M., Vuletic, S., Albers, J. J., Li, G., et al. (2008). Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels. Journal of Alzheimer’s Disease,13(3), 255–266.
    • (2008) Journal of Alzheimer’s Disease , vol.13 , Issue.3 , pp. 255-266
    • Bekris, L.M.1    Millard, S.P.2    Galloway, N.M.3    Vuletic, S.4    Albers, J.J.5    Li, G.6
  • 10
    • 34247506244 scopus 로고    scopus 로고
    • Transport pathways for clearance of human Alzheimer’s amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system
    • COI: 1:CAS:528:DC%2BD2sXlvVSktro%3D, PID: 17077814
    • Bell, R. D., Sagare, A. P., Friedman, A. E., Bedi, G. S., Holtzman, D. M., Deane, R., et al. (2007). Transport pathways for clearance of human Alzheimer’s amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. Journal of Cerebral Blood Flow and Metabolism,27(5), 909–918.
    • (2007) Journal of Cerebral Blood Flow and Metabolism , vol.27 , Issue.5 , pp. 909-918
    • Bell, R.D.1    Sagare, A.P.2    Friedman, A.E.3    Bedi, G.S.4    Holtzman, D.M.5    Deane, R.6
  • 11
    • 27944463991 scopus 로고    scopus 로고
    • Immunotherapy for Alzheimer’s disease and other dementias
    • COI: 1:CAS:528:DC%2BD28XitF2jtw%3D%3D, PID: 16280685
    • Boche, D., Nicoll, J. A., & Weller, R. O. (2005). Immunotherapy for Alzheimer’s disease and other dementias. Current Opinion in Neurology,18(6), 720–725.
    • (2005) Current Opinion in Neurology , vol.18 , Issue.6 , pp. 720-725
    • Boche, D.1    Nicoll, J.A.2    Weller, R.O.3
  • 12
    • 0036545673 scopus 로고    scopus 로고
    • APOE polymorphism and clinical duration determine regional neuropathology in Swedish APP(670, 671) mutation carriers: Implications for late-onset Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD38Xmt1Gmtbs%3D, PID: 12169205
    • Bogdanovic, N., Corder, E., Lannfelt, L., & Winblad, B. (2002). APOE polymorphism and clinical duration determine regional neuropathology in Swedish APP(670, 671) mutation carriers: Implications for late-onset Alzheimer’s disease. Journal of Cellular and Molecular Medicine,6(2), 199–214.
    • (2002) Journal of Cellular and Molecular Medicine , vol.6 , Issue.2 , pp. 199-214
    • Bogdanovic, N.1    Corder, E.2    Lannfelt, L.3    Winblad, B.4
  • 13
    • 67349270965 scopus 로고    scopus 로고
    • Apolipoprotein E and its receptors in Alzheimer’s disease: Pathways, pathogenesis and therapy
    • COI: 1:CAS:528:DC%2BD1MXjvV2ks7g%3D, PID: 19339974
    • Bu, G. (2009). Apolipoprotein E and its receptors in Alzheimer’s disease: Pathways, pathogenesis and therapy. Nature Reviews Neuroscience,10(5), 333–344.
    • (2009) Nature Reviews Neuroscience , vol.10 , Issue.5 , pp. 333-344
    • Bu, G.1
  • 14
    • 0028298886 scopus 로고
    • Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons
    • COI: 1:CAS:528:DyaK2cXksl2itb4%3D, PID: 7518435
    • Bu, G., Maksymovitch, E. A., Nerbonne, J. M., & Schwartz, A. L. (1994). Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons. Journal of Biological Chemistry,269(28), 18521–18528.
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.28 , pp. 18521-18528
    • Bu, G.1    Maksymovitch, E.A.2    Nerbonne, J.M.3    Schwartz, A.L.4
  • 15
    • 0033564771 scopus 로고    scopus 로고
    • Expression of human apolipoprotein E3 or E4 in the brains of Apoe−/− mice: Isoform-specific effects on neurodegeneration
    • COI: 1:CAS:528:DyaK1MXjvVCrsrc%3D, PID: 10366621
    • Buttini, M., Orth, M., Bellosta, S., Akeefe, H., Pitas, R. E., Wyss-Coray, T., et al. (1999). Expression of human apolipoprotein E3 or E4 in the brains of Apoe−/− mice: Isoform-specific effects on neurodegeneration. Journal of Neuroscience,19(12), 4867–4880.
    • (1999) Journal of Neuroscience , vol.19 , Issue.12 , pp. 4867-4880
    • Buttini, M.1    Orth, M.2    Bellosta, S.3    Akeefe, H.4    Pitas, R.E.5    Wyss-Coray, T.6
  • 16
    • 84866539065 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Abeta clearance in a mouse model of beta-amyloidosis
    • COI: 1:CAS:528:DC%2BC38XhsVyjtLjF, PID: 22927427
    • Castellano, J. M., Deane, R., Gottesdiener, A. J., Verghese, P. B., Stewart, F. R., West, T., et al. (2012). Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Abeta clearance in a mouse model of beta-amyloidosis. Proc Natl Acad Sci USA,109(38), 15502–15507.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.38 , pp. 15502-15507
    • Castellano, J.M.1    Deane, R.2    Gottesdiener, A.J.3    Verghese, P.B.4    Stewart, F.R.5    West, T.6
  • 18
    • 77951776829 scopus 로고    scopus 로고
    • Alzheimer’s disease: Strategies for disease modification
    • COI: 1:CAS:528:DC%2BC3cXlsVWjsrw%3D, PID: 20431570
    • Citron, M. (2010). Alzheimer’s disease: Strategies for disease modification. Nature Reviews Drug Discovery,9(5), 387–398.
    • (2010) Nature Reviews Drug Discovery , vol.9 , Issue.5 , pp. 387-398
    • Citron, M.1
  • 19
    • 20444415354 scopus 로고    scopus 로고
    • Mouse syngenic in vitro blood–brain barrier model: A new tool to examine inflammatory events in cerebral endothelium
    • COI: 1:CAS:528:DC%2BD2MXktlWiu74%3D, PID: 15908914
    • Coisne, C., Dehouck, L., Faveeuw, C., Delplace, Y., Miller, F., Landry, C., et al. (2005). Mouse syngenic in vitro blood–brain barrier model: A new tool to examine inflammatory events in cerebral endothelium. Laboratory Investigation,85(6), 734–746.
    • (2005) Laboratory Investigation , vol.85 , Issue.6 , pp. 734-746
    • Coisne, C.1    Dehouck, L.2    Faveeuw, C.3    Delplace, Y.4    Miller, F.5    Landry, C.6
  • 20
    • 65649105035 scopus 로고    scopus 로고
    • Clearance of amyloid–beta peptide across the blood–brain barrier: Implication for therapies in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD1MXktlanur8%3D
    • Deane, R., Bell, R. D., Sagare, A., & Zlokovic, B. V. (2009). Clearance of amyloid–beta peptide across the blood–brain barrier: Implication for therapies in Alzheimer’s disease. CNS and Neurological Disorders: Drug Targets,8(1), 16–30.
    • (2009) CNS and Neurological Disorders: Drug Targets , vol.8 , Issue.1 , pp. 16-30
    • Deane, R.1    Bell, R.D.2    Sagare, A.3    Zlokovic, B.V.4
  • 21
    • 57449084208 scopus 로고    scopus 로고
    • apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain
    • COI: 1:CAS:528:DC%2BD1cXhsVKgu7vM, PID: 19033669
    • Deane, R., Sagare, A., Hamm, K., Parisi, M., Lane, S., Finn, M. B., et al. (2008). apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. The Journal of Clinical Investigation,118(12), 4002–4013.
    • (2008) The Journal of Clinical Investigation , vol.118 , Issue.12 , pp. 4002-4013
    • Deane, R.1    Sagare, A.2    Hamm, K.3    Parisi, M.4    Lane, S.5    Finn, M.B.6
  • 22
    • 9144224765 scopus 로고    scopus 로고
    • ApoE and clusterin cooperatively suppress Abeta levels and deposition: Evidence that ApoE regulates extracellular Abeta metabolism in vivo
    • COI: 1:CAS:528:DC%2BD2cXhtVahsLg%3D, PID: 14741101
    • DeMattos, R. B., Cirrito, J. R., Parsadanian, M., May, P. C., O’Dell, M. A., Taylor, J. W., et al. (2004). ApoE and clusterin cooperatively suppress Abeta levels and deposition: Evidence that ApoE regulates extracellular Abeta metabolism in vivo. Neuron,41(2), 193–202.
    • (2004) Neuron , vol.41 , Issue.2 , pp. 193-202
    • DeMattos, R.B.1    Cirrito, J.R.2    Parsadanian, M.3    May, P.C.4    O’Dell, M.A.5    Taylor, J.W.6
  • 23
    • 0037111263 scopus 로고    scopus 로고
    • Apolipoprotein E alters the processing of the beta-amyloid precursor protein in APP(V717F) transgenic mice
    • COI: 1:CAS:528:DC%2BD38Xotl2itL8%3D, PID: 12419536
    • Dodart, J. C., Bales, K. R., Johnstone, E. M., Little, S. P., & Paul, S. M. (2002). Apolipoprotein E alters the processing of the beta-amyloid precursor protein in APP(V717F) transgenic mice. Brain Research,955(1–2), 191–199.
    • (2002) Brain Research , vol.955 , Issue.1-2 , pp. 191-199
    • Dodart, J.C.1    Bales, K.R.2    Johnstone, E.M.3    Little, S.P.4    Paul, S.M.5
  • 24
    • 84863005570 scopus 로고    scopus 로고
    • Lipopolysaccharide impairs amyloid beta efflux from brain: Altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood–brain barrier
    • COI: 1:CAS:528:DC%2BC38Xhsl2jt7zJ, PID: 22747709
    • Erickson, M. A., Hartvigson, P. E., Morofuji, Y., Owen, J. B., Butterfield, D. A., & Banks, W. A. (2012). Lipopolysaccharide impairs amyloid beta efflux from brain: Altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood–brain barrier. Journal of Neuroinflammation,9, 150–164.
    • (2012) Journal of Neuroinflammation , vol.9 , pp. 150-164
    • Erickson, M.A.1    Hartvigson, P.E.2    Morofuji, Y.3    Owen, J.B.4    Butterfield, D.A.5    Banks, W.A.6
  • 26
    • 80051818777 scopus 로고    scopus 로고
    • An ABCA1-independent pathway for recycling a poorly lipidated 8.1 nm apolipoprotein E particle from glia
    • COI: 1:CAS:528:DC%2BC3MXhtVKqt73K, PID: 21705806
    • Fan, J., Stukas, S., Wong, C., Chan, J., May, S., DeValle, N., et al. (2011). An ABCA1-independent pathway for recycling a poorly lipidated 8.1 nm apolipoprotein E particle from glia. Journal of Lipid Research,52(9), 1605–1616.
    • (2011) Journal of Lipid Research , vol.52 , Issue.9 , pp. 1605-1616
    • Fan, J.1    Stukas, S.2    Wong, C.3    Chan, J.4    May, S.5    DeValle, N.6
  • 27
    • 0042821761 scopus 로고    scopus 로고
    • Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice
    • COI: 1:CAS:528:DC%2BD3sXmvFGhurk%3D, PID: 12944519
    • Fryer, J. D., Taylor, J. W., DeMattos, R. B., Bales, K. R., Paul, S. M., Parsadanian, M., et al. (2003). Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice. Journal of Neuroscience,23(21), 7889–7896.
    • (2003) Journal of Neuroscience , vol.23 , Issue.21 , pp. 7889-7896
    • Fryer, J.D.1    Taylor, J.W.2    DeMattos, R.B.3    Bales, K.R.4    Paul, S.M.5    Parsadanian, M.6
  • 28
    • 84876779428 scopus 로고    scopus 로고
    • The role of amyloid beta in the pathogenesis of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3sXpt1Citrs%3D, PID: 23526599
    • Gilbert, B. J. (2013). The role of amyloid beta in the pathogenesis of Alzheimer’s disease. Journal of Clinical Pathology,66(5), 362–366.
    • (2013) Journal of Clinical Pathology , vol.66 , Issue.5 , pp. 362-366
    • Gilbert, B.J.1
  • 29
    • 77957866595 scopus 로고    scopus 로고
    • Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages
    • COI: 1:CAS:528:DC%2BC3cXht1KitrrO, PID: 20610799
    • Gorovoy, M., Gaultier, A., Campana, W. M., Firestein, G. S., & Gonias, S. L. (2010). Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages. Journal of Leukocyte Biology,88(4), 769–778.
    • (2010) Journal of Leukocyte Biology , vol.88 , Issue.4 , pp. 769-778
    • Gorovoy, M.1    Gaultier, A.2    Campana, W.M.3    Firestein, G.S.4    Gonias, S.L.5
  • 30
    • 0031673996 scopus 로고    scopus 로고
    • Soluble low-density lipoprotein receptor-related protein
    • COI: 1:CAS:528:DyaK1MXitVOh, PID: 14987551
    • Grimsley, P. G., Quinn, K. A., & Owensby, D. A. (1998). Soluble low-density lipoprotein receptor-related protein. Trends in Cardiovascular Medicine,8(8), 363–368.
    • (1998) Trends in Cardiovascular Medicine , vol.8 , Issue.8 , pp. 363-368
    • Grimsley, P.G.1    Quinn, K.A.2    Owensby, D.A.3
  • 31
    • 33847240080 scopus 로고    scopus 로고
    • Apolipoprotein E-containing lipoproteins protect neurons from apoptosis via a signaling pathway involving low-density lipoprotein receptor-related protein-1
    • COI: 1:CAS:528:DC%2BD2sXivV2jtbg%3D, PID: 17314289
    • Hayashi, H., Campenot, R. B., Vance, D. E., & Vance, J. E. (2007). Apolipoprotein E-containing lipoproteins protect neurons from apoptosis via a signaling pathway involving low-density lipoprotein receptor-related protein-1. Journal of Neuroscience,27(8), 1933–1941.
    • (2007) Journal of Neuroscience , vol.27 , Issue.8 , pp. 1933-1941
    • Hayashi, H.1    Campenot, R.B.2    Vance, D.E.3    Vance, J.E.4
  • 32
    • 20444409468 scopus 로고    scopus 로고
    • Regulation of ApoE receptor proteolysis by ligand binding
    • COI: 1:CAS:528:DC%2BD2MXltFarsLk%3D, PID: 15950758
    • Hoe, H. S., & Rebeck, G. W. (2005). Regulation of ApoE receptor proteolysis by ligand binding. Molecular Brain Research,137(1–2), 31–39.
    • (2005) Molecular Brain Research , vol.137 , Issue.1-2 , pp. 31-39
    • Hoe, H.S.1    Rebeck, G.W.2
  • 33
    • 4243215848 scopus 로고    scopus 로고
    • Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD3cXitVahtrs%3D, PID: 10694577
    • Holtzman, D. M., Bales, K. R., Tenkova, T., Fagan, A. M., Parsadanian, M., Sartorius, L. J., et al. (2000). Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer’s disease. Proc Natl Acad Sci USA,97(6), 2892–2897.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.6 , pp. 2892-2897
    • Holtzman, D.M.1    Bales, K.R.2    Tenkova, T.3    Fagan, A.M.4    Parsadanian, M.5    Sartorius, L.J.6
  • 34
    • 77249165764 scopus 로고    scopus 로고
    • Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer’s disease
    • PID: 20205790
    • Kajiwara, Y., Franciosi, S., Takahashi, N., Krug, L., Schmeidler, J., Taddei, K., et al. (2010). Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer’s disease. Molecular Neurodegeneration,5(1), 1–11.
    • (2010) Molecular Neurodegeneration , vol.5 , Issue.1 , pp. 1-11
    • Kajiwara, Y.1    Franciosi, S.2    Takahashi, N.3    Krug, L.4    Schmeidler, J.5    Taddei, K.6
  • 35
    • 84889041948 scopus 로고    scopus 로고
    • Neuronal clearance of amyloid-beta by endocytic receptor LRP1
    • COI: 1:CAS:528:DC%2BC3sXhvFSqu7fN, PID: 24305823
    • Kanekiyo, T., Cirrito, J. R., Liu, C. C., Shinohara, M., Li, J., Schuler, D. R., et al. (2013). Neuronal clearance of amyloid-beta by endocytic receptor LRP1. Journal of Neuroscience,33(49), 19276–19283.
    • (2013) Journal of Neuroscience , vol.33 , Issue.49 , pp. 19276-19283
    • Kanekiyo, T.1    Cirrito, J.R.2    Liu, C.C.3    Shinohara, M.4    Li, J.5    Schuler, D.R.6
  • 36
    • 84869037441 scopus 로고    scopus 로고
    • LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer’s amyloid-beta
    • COI: 1:CAS:528:DC%2BC38XhslagurrF, PID: 23152628
    • Kanekiyo, T., Liu, C. C., Shinohara, M., Li, J., & Bu, G. (2012). LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer’s amyloid-beta. Journal of Neuroscience,32(46), 16458–16465.
    • (2012) Journal of Neuroscience , vol.32 , Issue.46 , pp. 16458-16465
    • Kanekiyo, T.1    Liu, C.C.2    Shinohara, M.3    Li, J.4    Bu, G.5
  • 37
    • 84858339480 scopus 로고    scopus 로고
    • Apolipoprotein E genotype-specific short-term cognitive benefits of treatment with the antihypertensive nilvadipine in Alzheimer’s patients—An open-label trial
    • PID: 21560164
    • Kennelly, S., Abdullah, L., Kenny, R. A., Mathura, V., Luis, C. A., Mouzon, B., et al. (2012). Apolipoprotein E genotype-specific short-term cognitive benefits of treatment with the antihypertensive nilvadipine in Alzheimer’s patients—An open-label trial. International Journal of Geriatric Psychiatry,27(4), 415–422.
    • (2012) International Journal of Geriatric Psychiatry , vol.27 , Issue.4 , pp. 415-422
    • Kennelly, S.1    Abdullah, L.2    Kenny, R.A.3    Mathura, V.4    Luis, C.A.5    Mouzon, B.6
  • 38
    • 68249134074 scopus 로고    scopus 로고
    • The role of apolipoprotein E in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD1MXhtFyhsb%2FK, PID: 19679070
    • Kim, J., Basak, J. M., & Holtzman, D. M. (2009). The role of apolipoprotein E in Alzheimer’s disease. Neuron,63(3), 287–303.
    • (2009) Neuron , vol.63 , Issue.3 , pp. 287-303
    • Kim, J.1    Basak, J.M.2    Holtzman, D.M.3
  • 39
    • 3142781310 scopus 로고    scopus 로고
    • Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides
    • COI: 1:CAS:528:DC%2BD2cXlt1Gjsbw%3D, PID: 15195085
    • Koistinaho, M., Lin, S., Wu, X., Esterman, M., Koger, D., Hanson, J., et al. (2004). Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides. Nature Medicine,10(7), 719–726.
    • (2004) Nature Medicine , vol.10 , Issue.7 , pp. 719-726
    • Koistinaho, M.1    Lin, S.2    Wu, X.3    Esterman, M.4    Koger, D.5    Hanson, J.6
  • 40
    • 77956955758 scopus 로고    scopus 로고
    • The role of microglia in amyloid clearance from the AD brain
    • COI: 1:CAS:528:DC%2BC3cXpvVSrsL4%3D, PID: 20552234
    • Lee, C. Y., & Landreth, G. E. (2010). The role of microglia in amyloid clearance from the AD brain. Journal of Neural Transmission,117(8), 949–960.
    • (2010) Journal of Neural Transmission , vol.117 , Issue.8 , pp. 949-960
    • Lee, C.Y.1    Landreth, G.E.2
  • 42
    • 34249293987 scopus 로고    scopus 로고
    • Abeta42 neurotoxicity in primary co-cultures: Effect of apoE isoform and Abeta conformation
    • COI: 1:CAS:528:DC%2BD2sXmtVahsrk%3D, PID: 16837105
    • Manelli, A. M., Bulfinch, L. C., Sullivan, P. M., & LaDu, M. J. (2007). Abeta42 neurotoxicity in primary co-cultures: Effect of apoE isoform and Abeta conformation. Neurobiology of Aging,28(8), 1139–1147.
    • (2007) Neurobiology of Aging , vol.28 , Issue.8 , pp. 1139-1147
    • Manelli, A.M.1    Bulfinch, L.C.2    Sullivan, P.M.3    LaDu, M.J.4
  • 43
    • 0030779128 scopus 로고    scopus 로고
    • Isoform-specific effects of apolipoproteins E2, E3, and E4 on cerebral capillary sequestration and blood–brain barrier transport of circulating Alzheimer’s amyloid beta
    • COI: 1:CAS:528:DyaK2sXmvVKksbc%3D, PID: 9349544
    • Martel, C. L., Mackic, J. B., Matsubara, E., Governale, S., Miguel, C., Miao, W., et al. (1997). Isoform-specific effects of apolipoproteins E2, E3, and E4 on cerebral capillary sequestration and blood–brain barrier transport of circulating Alzheimer’s amyloid beta. Journal of Neurochemistry,69(5), 1995–2004.
    • (1997) Journal of Neurochemistry , vol.69 , Issue.5 , pp. 1995-2004
    • Martel, C.L.1    Mackic, J.B.2    Matsubara, E.3    Governale, S.4    Miguel, C.5    Miao, W.6
  • 44
    • 78650678688 scopus 로고    scopus 로고
    • Decreased clearance of CNS beta-amyloid in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3cXhsF2jtbrF, PID: 21148344
    • Mawuenyega, K. G., Sigurdson, W., Ovod, V., Munsell, L., Kasten, T., Morris, J. C., et al. (2010). Decreased clearance of CNS beta-amyloid in Alzheimer’s disease. Science,330(6012), 1774.
    • (2010) Science , vol.330 , Issue.6012 , pp. 1774
    • Mawuenyega, K.G.1    Sigurdson, W.2    Ovod, V.3    Munsell, L.4    Kasten, T.5    Morris, J.C.6
  • 45
    • 79954988524 scopus 로고    scopus 로고
    • Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells
    • COI: 1:CAS:528:DC%2BC3MXls1Ohur4%3D, PID: 21395585
    • Mitchell, R. W., On, N. H., Del Bigio, M. R., Miller, D. W., & Hatch, G. M. (2011). Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells. Journal of Neurochemistry,117(4), 735–746.
    • (2011) Journal of Neurochemistry , vol.117 , Issue.4 , pp. 735-746
    • Mitchell, R.W.1    On, N.H.2    Del Bigio, M.R.3    Miller, D.W.4    Hatch, G.M.5
  • 46
    • 79952860789 scopus 로고    scopus 로고
    • Selective antihypertensive dihydropyridines lower Abeta accumulation by targeting both the production and the clearance of Abeta across the blood–brain barrier
    • COI: 1:CAS:528:DC%2BC3MXjvFWgt7Y%3D, PID: 21170472
    • Paris, D., Bachmeier, C., Patel, N., Quadros, A., Volmar, C. H., Laporte, V., et al. (2011). Selective antihypertensive dihydropyridines lower Abeta accumulation by targeting both the production and the clearance of Abeta across the blood–brain barrier. Molecular Medicine,17(3–4), 149–162.
    • (2011) Molecular Medicine , vol.17 , Issue.3-4 , pp. 149-162
    • Paris, D.1    Bachmeier, C.2    Patel, N.3    Quadros, A.4    Volmar, C.H.5    Laporte, V.6
  • 47
    • 0026536066 scopus 로고
    • Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells
    • COI: 1:CAS:528:DyaK38XktVGms7o%3D, PID: 1584779
    • Piedrahita, J. A., Zhang, S. H., Hagaman, J. R., Oliver, P. M., & Maeda, N. (1992). Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc Natl Acad Sci USA,89(10), 4471–4475.
    • (1992) Proc Natl Acad Sci USA , vol.89 , Issue.10 , pp. 4471-4475
    • Piedrahita, J.A.1    Zhang, S.H.2    Hagaman, J.R.3    Oliver, P.M.4    Maeda, N.5
  • 48
    • 0035020834 scopus 로고    scopus 로고
    • Elevation of LDL receptor-related protein levels via ligand interactions in Alzheimer disease and in vitro
    • COI: 1:CAS:528:DC%2BD3MXktlersr4%3D, PID: 11379818
    • Qiu, Z., Strickland, D. K., Hyman, B. T., & Rebeck, G. W. (2001). Elevation of LDL receptor-related protein levels via ligand interactions in Alzheimer disease and in vitro. Journal of Neuropathology and Experimental Neurology,60(5), 430–440.
    • (2001) Journal of Neuropathology and Experimental Neurology , vol.60 , Issue.5 , pp. 430-440
    • Qiu, Z.1    Strickland, D.K.2    Hyman, B.T.3    Rebeck, G.W.4
  • 49
    • 0030863621 scopus 로고    scopus 로고
    • Soluble low density lipoprotein receptor-related protein (LRP) circulates in human plasma
    • COI: 1:CAS:528:DyaK2sXmtlOit70%3D, PID: 9295345
    • Quinn, K. A., Grimsley, P. G., Dai, Y. P., Tapner, M., Chesterman, C. N., & Owensby, D. A. (1997). Soluble low density lipoprotein receptor-related protein (LRP) circulates in human plasma. Journal of Biological Chemistry,272(38), 23946–23951.
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.38 , pp. 23946-23951
    • Quinn, K.A.1    Grimsley, P.G.2    Dai, Y.P.3    Tapner, M.4    Chesterman, C.N.5    Owensby, D.A.6
  • 51
    • 84859755505 scopus 로고    scopus 로고
    • Alzheimer’s disease and the amyloid cascade hypothesis: A critical review
    • Reitz, C. (2012). Alzheimer’s disease and the amyloid cascade hypothesis: A critical review. International Journal of Alzheimers Disease,2012, 1–11.
    • (2012) International Journal of Alzheimers Disease , vol.2012 , pp. 1-11
    • Reitz, C.1
  • 52
    • 33745266146 scopus 로고    scopus 로고
    • Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD28Xnt1agu7k%3D, PID: 16446752
    • Risner, M. E., Saunders, A. M., Altman, J. F., Ormandy, G. C., Craft, S., Foley, I. M., et al. (2006). Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer’s disease. Pharmacogenomics Journal,6(4), 246–254.
    • (2006) Pharmacogenomics Journal , vol.6 , Issue.4 , pp. 246-254
    • Risner, M.E.1    Saunders, A.M.2    Altman, J.F.3    Ormandy, G.C.4    Craft, S.5    Foley, I.M.6
  • 53
    • 84865410560 scopus 로고    scopus 로고
    • LRP1 expression in cerebral cortex, choroid plexus and meningeal blood vessels: Relationship to cerebral amyloid angiopathy and APOE status
    • COI: 1:CAS:528:DC%2BC38Xht1Sktb3P, PID: 22967844
    • Ruzali, W. A., Kehoe, P. G., & Love, S. (2012). LRP1 expression in cerebral cortex, choroid plexus and meningeal blood vessels: Relationship to cerebral amyloid angiopathy and APOE status. Neuroscience Letters,525(2), 123–128.
    • (2012) Neuroscience Letters , vol.525 , Issue.2 , pp. 123-128
    • Ruzali, W.A.1    Kehoe, P.G.2    Love, S.3
  • 54
    • 73349091534 scopus 로고    scopus 로고
    • A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease
    • COI: 1:CAS:528:DC%2BD1MXhsFait7rN, PID: 19923550
    • Salloway, S., Sperling, R., Gilman, S., Fox, N. C., Blennow, K., Raskind, M., et al. (2009). A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. Neurology,73(24), 2061–2070.
    • (2009) Neurology , vol.73 , Issue.24 , pp. 2061-2070
    • Salloway, S.1    Sperling, R.2    Gilman, S.3    Fox, N.C.4    Blennow, K.5    Raskind, M.6
  • 55
    • 0027365822 scopus 로고
    • Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease
    • COI: 1:CAS:528:DyaK2cXmtFel, PID: 8415756
    • Schmechel, D. E., Saunders, A. M., Strittmatter, W. J., Crain, B. J., Hulette, C. M., Joo, S. H., et al. (1993). Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc Natl Acad Sci USA,90(20), 9649–9653.
    • (1993) Proc Natl Acad Sci USA , vol.90 , Issue.20 , pp. 9649-9653
    • Schmechel, D.E.1    Saunders, A.M.2    Strittmatter, W.J.3    Crain, B.J.4    Hulette, C.M.5    Joo, S.H.6
  • 57
    • 84860860029 scopus 로고    scopus 로고
    • Apolipoprotein E3 (ApoE3) but not ApoE4 protects against synaptic loss through increased expression of protein kinase C epsilon
    • COI: 1:CAS:528:DC%2BC38XmsVegtro%3D, PID: 22427674
    • Sen, A., Alkon, D. L., & Nelson, T. J. (2012). Apolipoprotein E3 (ApoE3) but not ApoE4 protects against synaptic loss through increased expression of protein kinase C epsilon. Journal of Biological Chemistry,287(19), 15947–15958.
    • (2012) Journal of Biological Chemistry , vol.287 , Issue.19 , pp. 15947-15958
    • Sen, A.1    Alkon, D.L.2    Nelson, T.J.3
  • 59
    • 0034521392 scopus 로고    scopus 로고
    • Clearance of Alzheimer’s amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood–brain barrier
    • COI: 1:CAS:528:DC%2BD3cXovFagtbs%3D, PID: 11120756
    • Shibata, M., Yamada, S., Kumar, S. R., Calero, M., Bading, J., Frangione, B., et al. (2000). Clearance of Alzheimer’s amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood–brain barrier. The Journal of Clinical Investigation,106(12), 1489–1499.
    • (2000) The Journal of Clinical Investigation , vol.106 , Issue.12 , pp. 1489-1499
    • Shibata, M.1    Yamada, S.2    Kumar, S.R.3    Calero, M.4    Bading, J.5    Frangione, B.6
  • 60
    • 84876672025 scopus 로고    scopus 로고
    • Brain regional correlation of amyloid-beta with synapses and apolipoprotein E in non-demented individuals: Potential mechanisms underlying regional vulnerability to amyloid-beta accumulation
    • COI: 1:CAS:528:DC%2BC3sXltFCmsrw%3D, PID: 23371365
    • Shinohara, M., Petersen, R. C., Dickson, D. W., & Bu, G. (2013). Brain regional correlation of amyloid-beta with synapses and apolipoprotein E in non-demented individuals: Potential mechanisms underlying regional vulnerability to amyloid-beta accumulation. Acta Neuropathologica,125(4), 535–547.
    • (2013) Acta Neuropathologica , vol.125 , Issue.4 , pp. 535-547
    • Shinohara, M.1    Petersen, R.C.2    Dickson, D.W.3    Bu, G.4
  • 61
    • 0030741533 scopus 로고    scopus 로고
    • Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis
    • COI: 1:CAS:528:DyaK2sXkslKnsLo%3D, PID: 9218423
    • Sullivan, P. M., Mezdour, H., Aratani, Y., Knouff, C., Najib, J., Reddick, R. L., et al. (1997). Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis. Journal of Biological Chemistry,272(29), 17972–17980.
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.29 , pp. 17972-17980
    • Sullivan, P.M.1    Mezdour, H.2    Aratani, Y.3    Knouff, C.4    Najib, J.5    Reddick, R.L.6
  • 62
    • 0025295847 scopus 로고
    • Capillary depletion method for quantification of blood–brain barrier transport of circulating peptides and plasma proteins
    • COI: 1:CAS:528:DyaK3cXksFGgt7Y%3D, PID: 2338547
    • Triguero, D., Buciak, J., & Pardridge, W. M. (1990). Capillary depletion method for quantification of blood–brain barrier transport of circulating peptides and plasma proteins. Journal of Neurochemistry,54(6), 1882–1888.
    • (1990) Journal of Neurochemistry , vol.54 , Issue.6 , pp. 1882-1888
    • Triguero, D.1    Buciak, J.2    Pardridge, W.M.3
  • 64
    • 84877326649 scopus 로고    scopus 로고
    • ApoE influences amyloid-beta (Abeta) clearance despite minimal apoE/Abeta association in physiological conditions
    • COI: 1:CAS:528:DC%2BC3sXptFejurg%3D, PID: 23620513
    • Verghese, P. B., Castellano, J. M., Garai, K., Wang, Y., Jiang, H., Shah, A., et al. (2013). ApoE influences amyloid-beta (Abeta) clearance despite minimal apoE/Abeta association in physiological conditions. Proc Natl Acad Sci USA,110(19), E1807–E1816.
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.19 , pp. E1807-E1816
    • Verghese, P.B.1    Castellano, J.M.2    Garai, K.3    Wang, Y.4    Jiang, H.5    Shah, A.6
  • 66
    • 38349026548 scopus 로고    scopus 로고
    • Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells
    • COI: 1:CAS:528:DC%2BD1cXntlarsQ%3D%3D, PID: 18055545
    • Wilhelmus, M. M., Otte-Holler, I., van Triel, J. J., Veerhuis, R., Maat-Schieman, M. L., Bu, G., et al. (2007). Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells. American Journal of Pathology,171(6), 1989–1999.
    • (2007) American Journal of Pathology , vol.171 , Issue.6 , pp. 1989-1999
    • Wilhelmus, M.M.1    Otte-Holler, I.2    van Triel, J.J.3    Veerhuis, R.4    Maat-Schieman, M.L.5    Bu, G.6
  • 68
    • 0032917743 scopus 로고    scopus 로고
    • Apolipoprotein E in cerebrospinal fluid: Relation to phenotype and plasma apolipoprotein E concentrations
    • COI: 1:CAS:528:DyaK1MXisVWhtL8%3D, PID: 10102909
    • Yamauchi, K., Tozuka, M., Nakabayashi, T., Sugano, M., Hidaka, H., Kondo, Y., et al. (1999). Apolipoprotein E in cerebrospinal fluid: Relation to phenotype and plasma apolipoprotein E concentrations. Clinical Chemistry,45(4), 497–504.
    • (1999) Clinical Chemistry , vol.45 , Issue.4 , pp. 497-504
    • Yamauchi, K.1    Tozuka, M.2    Nakabayashi, T.3    Sugano, M.4    Hidaka, H.5    Kondo, Y.6
  • 69
    • 0033941425 scopus 로고    scopus 로고
    • Apolipoprotein E–low density lipoprotein receptor interaction. Influences of basic residue and amphipathic α–helix organization in the ligand
    • COI: 1:CAS:528:DC%2BD3cXltF2qtrk%3D, PID: 10884290
    • Zaiou, M., Arnold, K. S., Newhouse, Y. M., Innerarity, T. L., Weisgraber, K. H., Segall, M. L., et al. (2000). Apolipoprotein E–low density lipoprotein receptor interaction. Influences of basic residue and amphipathic α–helix organization in the ligand. Journal of Lipid Research,41(7), 1087–1095.
    • (2000) Journal of Lipid Research , vol.41 , Issue.7 , pp. 1087-1095
    • Zaiou, M.1    Arnold, K.S.2    Newhouse, Y.M.3    Innerarity, T.L.4    Weisgraber, K.H.5    Segall, M.L.6
  • 70
    • 70249137220 scopus 로고    scopus 로고
    • Understanding the basis for the association of apoE4 with Alzheimer’s disease: Opening the door for therapeutic approaches
    • COI: 1:CAS:528:DC%2BD1MXhtFChtrvO, PID: 19874264
    • Zhong, N., & Weisgraber, K. H. (2009). Understanding the basis for the association of apoE4 with Alzheimer’s disease: Opening the door for therapeutic approaches. Current Alzheimer Research,6(5), 415–418.
    • (2009) Current Alzheimer Research , vol.6 , Issue.5 , pp. 415-418
    • Zhong, N.1    Weisgraber, K.H.2


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