Post-translational proteolytic events influence LRP-1 functions

Bio-Medical Materials and Engineering

Volumn 20, Issue 3-4, 2010, Pages 203-207

  Selvais, Charlotte ^a   Dedieu, Stéphane ^b   Hornebeck, William ^b   Emonard, Hervé ^b  

^a DE DUVE INSTITUTE   (Belgium)

^b UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

Author keywords

Endocytosis; low density lipoprotein receptor related protein; regulation; shedding; signaling

Indexed keywords

BIOLOGICAL FUNCTIONS; ENDOCYTOSIS; LOW DENSITY LIPOPROTEINS; MEMBRANE RECEPTORS; PROTEOLYTIC PROCESS; REGULATION; SHEDDING; SIGNALING FUNCTIONS;

MOLECULAR BIOLOGY; PROTEINS;

SIGNALING;

LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN;

ANIMAL; BIOLOGICAL MODEL; ENDOCYTOSIS; HUMAN; METABOLISM; PHYSIOLOGY; PROTEIN PROCESSING; REVIEW;

ANIMALS; ENDOCYTOSIS; HUMANS; LDL-RECEPTOR RELATED PROTEIN 1; MODELS, BIOLOGICAL; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 78649523266     PISSN: 09592989     EISSN: None     Source Type: Journal    
DOI: 10.3233/BME-2010-0633     Document Type: Conference Paper

References (19)

1. J. Herz D.K. Strickland LRP: a multifunctional scavenger and signaling receptor J. Clin. Invest. 108(2001), 779-784.
2. H. Emonard, G. Bellon, P. de Diesbach, M. Mettlen, W. Hornebeck and P.J. Courtoy, Regulation of matrix metallopro-teinase (MMP) activity by the low-density lipoprotein receptor-related protein (LRP). A new function for an "old friend", Biochimie 87 (2005), 369-376.
3. A.P. Lillis, L.B. Van Duyn, J.E. Murphy-Ullrich and D.K. Strickland, LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies, Physiol. Rev. 88 (2008), 887-918.
4. H. Kutt, J. Herz and K.K. Stanley, Structure of the low-density lipoprotein receptor-related protein (LRP) promoter, Biochim. Biophys. Acta 1009 (1989), 229-236.
5. D.V. Rozanov, E. Hahn-Dantona, D.K. Strickland and A.Y. Strongin, The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells, J. Biol. Chem. 279 (2004), 4260-4268.
6. K.A. Quinn, P.G. Grimsley, Y.P. Dai, M. Tapner, C.N. Chesterman and D.A. Owensby, Soluble low density lipoprotein receptor-related protein (LRP) circulates in human plasma, J. Biol. Chem. 272 (1997), 23946-23951.
7. K.A. Quinn, V.J. Pye, Y.P. Dai, C.N. Chesterman and D.A. Owensby, Characterization of the soluble form of the low density lipoprotein receptor-related protein (LRP), Exp. Cell Res. 251 (1999), 433-441.
8. C.A. von Arnim, A. Kinoshita, I.D. Peltan, M.M. Tangredi, L. Herl, B.M. Lee, R. Spoelgen, T.T. Hshieh, S. Ranganathan, F.D. Battey, L.X. Liu, B.J. Bacskai, S. Sever, M.C. Irizarry, D.K. Strickland and B.T. Hyman, The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate, J. Biol. Chem. 280 (2005), 17777-17785.
9. R. Polavarapu, M.C. Gongora, H. Yi, S. Ranganthan, D.A. Lawrence, D. Strickland and M. Yepes, Tissue-type plasmino-gen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit, Blood 109 (2007), 3270-3278.
10. Q. Liu, J. Zhang, H. Tran, M.M. Verbeek, K. Reiss, S. Estus and G. Bu, LRP1 shedding in human brain: roles of ADAM10 and ADAM17, Mol. Neurodegener. 4 (2009), 17.
11. A. Gaultier, S. Arandjelovic, X. Li, J. Janes, N. Dragojlovic, G.P. Zhou, J. Dolkas, R.R. Myers, S.L. Gonias and W.M. Campana, A shed form of LDL receptor-related protein-1 regulates peripheral nerve injury and neuropathic pain in rodents, J. Clin. Invest. 118 (2008), 161-172.
12. C. Selvais, H.P. Gaide Chevronnay, P. Lemoine, S. Dedieu, P. Henriet, P.J. Courtoy, E. Marbaix and H. Emonard, Metalloproteinase-dependent shedding of LRP-1 ectodomain decreases endocytic clearance of endometrial matrix metalloproteinases-2 and-9 at menstruation, Endocrinology 150 (2009), 3792-3799.
13. H. Steiner, R. Fluhrer and C. Haass, Intramembrane proteolysis by gamma-secretase, J. Biol. Chem. 283 (2008), 29627-29631.
14. P. May, Y.K. Reddy and J. Herz, Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain, J. Biol. Chem. 277 (2002), 18736-18743.
15. A. Kinoshita, T. Shah, M.M. Tangredi, D.K. Strickland and B.T. Hyman, The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65, J. Biol. Chem. 278 (2003), 41182-41188.
16. R. Polavarapu, J. An, C. Zhang and M. Yepes, Regulated intramembrane proteolysis of the low-density lipoprotein receptor-related protein mediates ischemic cell death, Am. J. Pathol. 172 (2008), 1355-1362.
17. K. Zurhove, C. Nakajima, J. Herz, H.H. Bock and P. May, Gamma-secretase limits the inflammatory response through the processing of LRP1, Sci. Signal. 1 (2008), ra15.
18. S. Dedieu, B. Langlois, J. Devy, B. Sid, C. Schneider, P. Henriet, H. Sartelet, G. Bellon, H. Emonard and L. Martiny, LRP-1 silencing prevents malignant cell invasion despite increased pericellular proteolytic activities, Mol. Cell. Biol. 28 (2008), 2980-2995.
19. B. Langlois, G. Perrot, C. Schneider, P. Henriet, H. Emonard, L. Martiny and S. Dedieu, LRP-1 promotes cancer cell invasion by supporting ERK and inhibiting JNK signaling pathways, PLoS One 5(7) (2010), e11584.