Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity

BMC Cell Biology

Volumn 2, Issue , 2001, Pages

  Turenne, Gaetan A ^a   Price, Brendan D ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; DNA; GLYCOGEN SYNTHASE KINASE 3ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; PROTEIN KINASE; PROTEIN P53; SERINE;

APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CELL DIFFERENTIATION; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVATION; ENZYME INHIBITION; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

EID: 2342549202     PISSN: 14712121     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2121-2-12     Document Type: Article

References (50)

1. Canman CE, Lim D-S: The role of ATM in DNA damage responses to cancer Oncogene 1998, 17:3301-3308
2. Lowe SW: Activation of p53 by Oncogenes Endocr Relat 1999, 6:45-48
3. Lundberg AS, Hahn WC, Gupta P, Weinberg RA: Genes involved in senescence and immortalization Curr Opin Cell Biol. 2000, 12:705-709
4. Vousden KH: p53:death star Cell 2000, 103:691-694
5. Vogelstein B, Lane D, Levine AJ: Surfing the p53 network Nature 2001, 108:307-310
6. Haupt Y, Maya R, Kazaz A, Oren M: Mdm2 promotes the rapid degradation of p53 Nature 1997, 387:296-299
7. Kubbutat MCG, Jones SN, Vousden KH: Regulation of p53 stability by mdm2 Nature 1997, 387:299-303
8. Pomerantz J, Schreiber-Agus N, Liegeosis NJ, Silverman A, Alland L, Chin L, Potes J, Chen K, Orlow I, Lee H-W, Cordon-Cardo C, De-Pinho RA: The Ink4a tumor suppressor gene product p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53 Cell 1998, 92:713-723
9. Meyn MS: Ataxia Telangiectasia, cancer and the pathobiology of the ATM gene Clin Genet 1999, 55:289-304
10. Banin S, Moyal L, Shieh S-Y, Taya Y, Anderson CW, Chessa L, Smorodinsky NI, Prives C, Reiss Y, Shiloh Y, Ziv Y: Enhanced phosphorylation of p53 byATM in response to DNA damage Science 1998, 281:1674-1678
11. Canman CE, Lim D-S, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD: Activation of the ATM kinase by ionizing radiation and phosphorylation of p53 Science 1998, 281:1677-1682
12. Matsuoka S, Huang M, Elledge SJ: Linkage of ATM to cell cycle regulation by the chk2 protein kinase Science 1998, 282:1893-1897
13. Shieh S-Y, Ahn J, Tamai K, Taya Y, Prives C: The human homologs of checkpoint kinases Chk1 and Cds1 (chk2) phosphorylate p53 at multiple DNA damage-inducible sites Genes Dev 2000, 14:289-300
14. Chebab NH, Malikzay A, Appel M, Halozonetis TD: Chk2/hCds1 functions as a DNA damage checkpoint in G1 by stabilizing p53 Genes Dev 2000, 14:278-288
15. Shieh S-Y, Taya Y, Prives C: DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization EMBO J. 1999, 18:1815-1823
16. Sakaguchi K, Herrera JE, Saito S, Miki T, Bustin M, Vassilev A, Anderson CW, Appella E: DNA damage activates p53 through a phosphorylation-acetylation cascade Genes Dev. 1998, 12:2831-2841
17. Siliciano JD, Canman CE, Taya Y, Sakaguchi K, Appella E, Kastan MB: DNA damage induces phosphorylation of the amino-terminus of p53 Genes Dev. 1997, 11:3471-3481
18. Shieh S-Y, Ikeda M, Taya Y, Prives C: DNA-damage induced phosphorylation of p53 alleviates inhibition by mdm2 Cell 1997, 91:325-334
19. Gu W, Roeder RG: Activation of p53-sequence-specific DNA binding by acetylation of the p53 C-terminal domain Cell 1997, 90:595-606
20. Steegenga WT, van der Eb AJ, Jochemsen AG: How phosphorylation regulates the activity of p53 J.Mol. Biol. 1996, 263:103-113
21. Oda K, Arakawa H, Tanaka T, Matsuda K, Tanikawa C, Mori T, Nishimori H, Tamai K, Tokino T, Nakamura Y, Taya Y: p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53 Cell 2000, 102:849-862
22. Higashimto H, Saito S, Tong XH, Hong A, Sakaguchi K, Appella E, Anderson CW: Human p53 is phosphorylated on serines 6 and 9 in response to DNA damage-inducing agents J Biol Chem 2000, 275:23199-23203
23. Franke TF, Kaplan DR, Cantley LC: PI3K: Downstream Aktion blocks apoptosis Cell 1997, 88:435-437
24. Kirn L, Kimmel AR: GSK3, a master switch regulating cell-fate specification and tumorigenesis Curr Opin Gen Dev 2000, 10:508-514
25. Kennedy SG, Wagner AJ, Conzen SD, Jordan J, Bellacosa A, Tsichlis PN, Hay N: The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal Genes Dev 1997, 11:701-713
26. Neal JW, Clipstone NA: Glycogen Synthase kinase-3 inhibits the DNA binding activity of NFATc J Biol Chem 2000, 276:3666-3673
27. Xavier LJ, Mercier PA, McLoughlin CM, Ali A, Woodgett JR, Ovsenek N: Glycogen Synthase Kinase 3β negatively regulates both DNA-Binding and transcriptional activities of Heat Shock factor-1 J Biol Chem 2000, 275:29147-29152
28. Eldar-Finkelman H, Argast GM, Foord B, EH Fischer, EG Krebbs: Expression and characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity in intact cells Proc Natl Acad 1996, 93:1028-10233
29. Cross DAE, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B Nature 1995, 378:785-789
30. Meek DW, Simon S, Kikkawa U, W Eckhart: The p53 tumor suppresser protein is phosphorylated at serine 389 by casein kinase II EMBO J 1994, 9:3253-3260
31. Miller DM, Campbell DG, Caudwell FB, Meek DW: Phosphorylation of the tumor suppressor p53 by mitogen activated kinases J Biol Chem 1994, 269:9253-9260
32. Lees-Miller SP, Sakaguchi K, Ullrich SJ, Appella E, Anderson CW: Human DNA activated protein kinase phosphorylates serines 15 and 37 in the amino terminal transactivation domain of human p53 Mol Cell Biol 1992, 12:5041-5049
33. Youmell M, Park SJ, Basu S, Price BD: Regulation of the p53 protein by protein kinase Cα and protein kinase CE Biochem Biophys Res Comm 1998, 245:514-518
34. Adler V, Pincus MR, Minamoto T, Fuchs SY, Bluth MJ, Brandt-Rauf T, Friedman FK, Robison RC, Chen JM, Wang XW, Harris CC, Ronai Z: Conformation-dependent phosphorylation of p53 Proc Natl Acad Sci 1997, 94:1686-1691
35. Fuchs SY, Adler V, Buschman T, Yin Z, Wu X, Jones SN, Ronai Z: JNK targets p53 ubiquitination and degradation in nonstressed cells Genes Dev 1998, 12:2658-2663
36. Woodgett JR: Molecular cloning and expression of glycogen synthase kinase-3/Factor A EMBO J 1990, 9:2431-2438
37. Hoeflich KP, Luo J, Ruble EA, Tsao M-S, Jin U, JR Woodgett: Requirement for glycogen synthase kinase-3β in cell survival and NF-κ B activation Nature 2000, 406:86-90
38. Unger T, Sionov RV, Moallen E, Yee CL, Howley PM, Oren M, Haupt Y: Mutations in serines 15 and 20 of human p53 impair its apoptotic activity Oncogene 1999, 18:3205-3212
39. Ashcroft M, Kubbutata HG, Vousden KH: Regulation of p53 function and stability by phosphorylation Mol. Cell Biol. 1999, 19:1751-1758
40. Blattner C, Tobiasch E, Litfen M, Rahmsdorf HJ, Herrlich P: DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation Oncogene 1999, 18:1723-1732
41. Featherstone C, Jackson SP: DNA-dependent protein kinase gets a break: its role in repairing DNA and maintaining genomic integrity Br J Cancer 1999, 80 Suppl(1):14-19
42. Woo RA, McLure KG, Lees-Miller SP, Rancourt DE, Lee PW: DNA-dependent protein kinase acts upstream of p53 in response to DNA damage Nature 1998, 394:700-704
43. Jimenez GS, Bryntesson F, Torres-Arzayus MI, Priestly A, Beche M, Sakaguchi K, Appella E, Jeggo PA, Taccioli GE, Wahl GM, Hubank F: DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage Nature 1999, 400:81-83
44. Tibbetts RS, Brumbaugh KM, Williams JM, Sarkaria JN, Cliby WA, Shieh S-Y, Taya Y, Prives C, Abraham RT: A role for ATR in the DNA damage-induced phosphorylation of p53 Genes Dev 1999, 13:152-157
45. Jayaraman L, Tamai K, Taya Y, Prives C, ZQ Pan: p53 is phosporylated by CDK7-cyclin H in a p36mat1 dependent manner Mol Cell Biol 1997, 17:7220-7229
46. Sanchez-Prieto R, Rojas JM, Taya Y, Gutkind JS: A role for p38 mitogen-activated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents Cancer Research 2000, 60:2464-2472
47. Datta SR, Brunet A, Greenberg ME: Cellular survival: a play in three akts Genes Dev 1999, 13:2905-2927
48. Mazzoni IE, Said FA, Aloyz R, Miller FD, Kaplan D: Ras regulates sympathetic neuron survival by suppressing the p53-mediated cell death pathway J Neuro 1999, 19:9716-9727
49. Sabbatini P, McCormick F: Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis J Biol Chem 1999, 274:24263-24269
50. Yamaguchi A, Tamatani M, Matsuzuki H, Namikawa K, Kiyama H, Vitek MP, Mitsuda N, Tohyama M: Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53 J Biol Chem 2001, 276:5256-5264