The sigma-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands

Biochemical Journal

Volumn 466, Issue , 2015, Pages 263-271

  Mishra, Ashish K ^a   Mavlyutov, Timur ^b   Singh, Deo R ^a,c   Biener, Gabriel ^a   Yang, Jay ^b   Oliver, Julie A ^a   Ruoho, Arnold ^b   Raicu, Valericə ^a  

^a UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Chaperone; Fret spectrometry; Ligand effect; Sigma 1 receptor (s1r); Stoichiometry.

Indexed keywords

HALOPERIDOL; MONOMER; OLIGOMER; PENTAZOCINE; SIGMA 1 OPIATE RECEPTOR; HYBRID PROTEIN; LIGAND; NARCOTIC ANALGESIC AGENT; NARCOTIC ANTAGONIST; PHOTOPROTEIN; PROTEIN AGGREGATE; SIGMA OPIATE RECEPTOR; SIGMA-1 RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; COS 7 CELL LINE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HETEROLOGOUS EXPRESSION; IN VIVO STUDY; MAMMAL CELL; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; AGONISTS; AMINO ACID SUBSTITUTION; ANIMAL; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; DIMERIZATION; DRUG EFFECTS; ENDOPLASMIC RETICULUM; GENETICS; HUMAN; METABOLISM; POINT MUTATION; PROTEIN STABILITY;

MAMMALIA;

AMINO ACID SUBSTITUTION; ANALGESICS, OPIOID; ANIMALS; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; COS CELLS; DIMERIZATION; ENDOPLASMIC RETICULUM; HALOPERIDOL; HUMANS; LIGANDS; LUMINESCENT PROTEINS; MODELS, MOLECULAR; NARCOTIC ANTAGONISTS; PENTAZOCINE; POINT MUTATION; PROTEIN AGGREGATES; PROTEIN STABILITY; RECEPTORS, SIGMA; RECOMBINANT FUSION PROTEINS;

EID: 84923171576     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20141321     Document Type: Article

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