Demonstration of a direct interaction between σ-1 receptors and acid-sensing Ion channels

Biophysical Journal

Volumn 98, Issue 7, 2010, Pages 1182-1191

  Carnally, Stewart M ^a   Johannessen, Molly ^b   Henderson, Robert M ^b   Jackson, Meyer B ^a   Michael Edwardson, J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID SENSING ION CHANNEL; ASIC1 PROTEIN, HUMAN; HALOPERIDOL; HISTIDINE; ION; LIGAND; NERVE PROTEIN; SIGMA OPIATE RECEPTOR; SIGMA-1 RECEPTOR; SODIUM CHANNEL;

ATOMIC FORCE MICROSCOPY; BIOLOGICAL MODEL; CELL LINE; CHEMISTRY; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; HUMAN; METABOLISM; PROCEDURES;

ACID SENSING ION CHANNELS; CELL LINE; HALOPERIDOL; HISTIDINE; HUMANS; IONS; LIGANDS; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; NERVE TISSUE PROTEINS; RECEPTORS, SIGMA; SODIUM CHANNELS; TRANSFECTION;

EID: 77950648247     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2009.12.4293     Document Type: Article

References (36)

1. Martin, W. R., C. G. Eades.....P. E. Gilbert. 1976. The effects of morphine- and nalorphine-like drugs in. the nondependent and morphine-dependent chronic spinal dog. J. Pharmacol. Exp. Ther. 197:517-532.
2. 2+: clinical and therapeutic relevance. Biol. Cell. 97:873-883.
3. 3. Hanner, M., F. F. Moebius,...,H. Glossmann. 1996. Purification, molecular cloning, and expression of the mammalian σ1-binding site. Proc. Natl. Acad. Sci. USA. 93:8072-8077. (Pubitemid 26277167)
4. 4. Aydar, E., C. P. Palmer,...,M. B. Jackson. 2002. The σ receptor as a ligand-regulated auxiliary potassium channel subunit. Neuron. 34:399-410. (Pubitemid 34465498)
5. 2+ signaling and cell, survival. Cell. 131:596-610.
6. 6. Kennedy, C., and G. Henderson. 1990. Inhibition of potassium currents by the a receptor ligand (+)-3-(3-hydroxyphenyl)-N-(l-propyl)p.iperidine in sympathetic neurons of the mouse isolated hypogastric ganglion. Neuroscience. 35:725-733. (Pubitemid 20198404)
7. 7. Wilke, R. A., R. P. Mehta,...,M. B. Jackson. 1999. σ Receptor photolabeling and σ receptor-mediated modulation of potassium channels in tumor cells. J. Biol. Chem. 274:18387-18392. (Pubitemid 129519239)
8. 8. Zhang, H., and J. Cuevas. 2005. σ Receptor activation blocks potassium channels and depresses neuroexcitability in rat intracardiac neurons. J. Pharmacol. Exp. Ther. 313:1387-1396. (Pubitemid 40727046)
9. Johannessen, M., S. Ramachandran, ..., M. B. Jackson. 2009. Voltage-gated sodium channel modulation by σ-receptors in cardiac myocytes and heterologous systems. Am. J. Physiol. Cell Physiol. 296:C1049-C1057.
10. 10. Zhang, H., and J. Cuevas. 2002. σ Receptors inhibit high-voltageactivated calcium channels in rat sympathetic and parasympathetic neurons. J. Neurophysiol. 87:2867-2879. (Pubitemid 34670667)
11. Lysko, P. G., R. C. Gagnon, ..., G. Feuerstein. 1992. Neuroprotective effects of SKF 10,047 in cultured rat cerebellar neurons and in gerbil global brain ischemia. Stroke. 23:4.14-419.
12. 12. Ishiguro, H., T. Ohtsuki,...,T. Arinami. 1998. Association between polymorphisms in the type 1 σ receptor gene and schizophrenia. Neurosci. Lett. 257:45-48. (Pubitemid 28546901)
13. Fontanilla, D., M. Johannessen,...,A. E. Ruoho. 2009. The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous σ-1 receptor regulator. Science. 323:934-937.
14. 14. Seth, P., M. E. Ganapathy,...,V. Ganapathy. 2001. Expression pattern of the type 1 σ receptor in the brain and identity of critical anionic amino acid residues in the ligand-binding domain of the receptor. Biochim. Biophys. Acta. 1540:59-67. (Pubitemid 32710049)
15. 15. Pal, A., A. R. Hajipour,..., A. E. Ruoho. 2007. Identification of regions of the σ-1 receptor ligand binding site using a novel photoprobe. Mol. Pharmacol. 72:921-933. (Pubitemid 47481415)
16. Pal, A., U. B. Chu,...,A. E. Ruoho. 2008. Juxtaposition of the steroid binding domain-like I and II regions constitutes a ligand binding site in the σ-1 receptor. J. Biol. Chem. 283:19646-19656.
17. Palmer, C. P., R. Manen,...,E. Aydar. 2007. σ-1. Receptors bind cholesterol and remodel lipid rafts in breast cancer cell lines. Cancer Res. 67:11166-11175.
18. + channels in rat neurohypophysial terminals requires neither G-protein nor ATP. J. Physiol. 526:527-539.
19. 2+ influx in rat cortical neurons. J. Pharmacol. Exp. Ther. 327:491-502.
20. Wemmie, J. A., M. P. Price, and M. J. Welsh. 2006. Acid-sensing ion. channels: advances, questions and therapeutic opportunities. Trends Neurosci. 29:578-586.
21. 21. Jasti, J., H. Furukawa, ..., E. Gouaux. 2007. Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH. Nature. 449:316-323. (Pubitemid 47443482)
22. Carnally, S. M., H. S. Dev,...,J. M. Edwardson. 2008. Direct visualization of the trimeric structure of the ASICIa channel, using AFM imaging. Biochem. Biophys. Res. Commun. 372:752-755.
23. +-gated channels in mouse sensory neurons. Proc. Natl, Acad. Sci, USA. 99:2338-2343.
24. 24. Yermolaieva, O., A. S. Leonard,...,M. J. Welsh. 2004. Extracellular acidosis increases neuronal cell calcium by activating acid-sensing ion channel la. Proc. Natl. Acad. Sci. USA. 101:6752-6757. (Pubitemid 38586046)
25. Barrera, N. P., S. J. Ormond,...,J. M. Edwardson. 2005. AFM imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize. J. Biol. Chem. 280:10759-10765.
26. 3 receptors. Proc. Natl. Acad. Sci. USA. 102:12595-12600.
27. A receptor. Mol. Pharmacol. 73:960-967.
28. Barrera, N. P., Y. Shaifta,...,J. M. Edwardson. 2007. AFM imaging reveals the tetrameric structure of the TRPCl channel. Biochem. Biophys. Res. Commun, 358:1086-1090.
29. 29. Barrera, N. P., H. Ge,...,J. M. Edwardson. 2008. Automated analysis of the architecture of receptors, imaged by atomic force microscopy. Micron. 39:101-110. (Pubitemid 351273607)
30. 30. Meltzer, R. H., N. Kapoor,..., D. J. Benos. 2007. Heteromeric assembly of acid-sensitive ion channel and epithelial sodium channel subunits. J. Biol. Chem. 282:25548-25559. (Pubitemid 47372793)
31. Neaves, K. J., L. P. Cooper,..., R. M. Henderson. 2009. Atomic force microscopy of the EcoKI type I DNA restriction enzyme bound to DNA shows enzyme dimerization and DNA looping. Nucleic Acids Res. 37:2053-2063.
32. + channels to distinct lipid raft populations. Targeting of Kv1.5 to caveolae. J. Biol. Chem. 276:8409-8414.
33. 33. Wong, W., and L. C. Schlichter. 2004. Differential recruitment of Kv 1.4 and Kv4.2 to lipid rafts by PSD-95. J. Biol. Chem. 279:444-452. (Pubitemid 38044845)
34. 34. Schuck, S., M. Honsho,...,K. Simons. 2003. Resistance of cell membranes to different detergents. Proc. Natl. Acad. Sci. USA. 100:5795-5800. (Pubitemid 36576887)
35. Schneider, S. W., J. Lärmer,...,H. Oberleithner. 1998. Molecular weights of individual proteins correlate with molecular volumes measured by atomic force microscopy. Pflugers Arch. 435:362-367.
36. Hayashi, T., and T.-P. Su. 2003. σ-1 Receptors (σ(1) binding sites) form raft-like microdomains and target lipid droplets on the endoplasmic reticulum.: roles in endoplasmic reticulum lipid compartmentalization and export. J. Pharmacol, Exp. Ther. 306:718-725.