메뉴 건너뛰기




Volumn 163, Issue , 2015, Pages 241-250

Total aralosides of aralia elata (Miq) seem (TASAES) ameliorate nonalcoholic steatohepatitis by modulating IRE1α-mediated JNK and NF-κB pathways in ApoE-/- mice

Author keywords

Hepatocyte apoptosis; Inflammatory cytokines; JNK; NASH; NF B; TASAES

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIINFLAMMATORY AGENT; APOLIPOPROTEIN E; ARALIA ELATA EXTRACT; ARALOSIDE DERIVATIVE; ASPARTATE AMINOTRANSFERASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 6; LIPID; LIVER PROTECTIVE AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PLANT EXTRACT; PROBUCOL; PROTEIN IRE1; PROTEIN IRE1ALPHA; SAPONIN DERIVATIVE; TRANSCRIPTION FACTOR RELA; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ERN1 PROTEIN, MOUSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; OLEANOLIC ACID; PROTEIN SERINE THREONINE KINASE; RIBONUCLEASE; SAPONIN;

EID: 84923112046     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2015.01.017     Document Type: Article
Times cited : (55)

References (54)
  • 3
    • 84885321773 scopus 로고    scopus 로고
    • Cyclooxygenase-2 promotes hepatocellular apoptosis by interacting with TNF-alpha and IL-6 in the pathogenesis of nonalcoholic steatohepatitis in rats
    • Q. Cheng, N. Li, M. Chen, J. Zheng, Z. Qian, X. Wang, C. Huang, S. Xu, and G. Shi Cyclooxygenase-2 promotes hepatocellular apoptosis by interacting with TNF-alpha and IL-6 in the pathogenesis of nonalcoholic steatohepatitis in rats Digestive Diseases and Sciences 58 2013 2895 2902
    • (2013) Digestive Diseases and Sciences , vol.58 , pp. 2895-2902
    • Cheng, Q.1    Li, N.2    Chen, M.3    Zheng, J.4    Qian, Z.5    Wang, X.6    Huang, C.7    Xu, S.8    Shi, G.9
  • 4
    • 4344628553 scopus 로고    scopus 로고
    • Insulin resistance and the pathogenesis of nonalcoholic fatty liver disease
    • (ix)
    • J. Choudhury, and A.J. Sanyal Insulin resistance and the pathogenesis of nonalcoholic fatty liver disease Clinics in Liver Disease 8 2004 575 594 (ix)
    • (2004) Clinics in Liver Disease , vol.8 , pp. 575-594
    • Choudhury, J.1    Sanyal, A.J.2
  • 6
    • 0037910211 scopus 로고    scopus 로고
    • The future of GI and liver research: Editorial perspectives. III. JNK/AP-1 regulation of hepatocyte death
    • M.J. Czaja The future of GI and liver research: editorial perspectives. III. JNK/AP-1 regulation of hepatocyte death American Journal of Physiology. Gastrointestinal and Liver Physiology 284 2003 G875 G879
    • (2003) American Journal of Physiology. Gastrointestinal and Liver Physiology , vol.284 , pp. G875-G879
    • Czaja, M.J.1
  • 7
    • 0036780582 scopus 로고    scopus 로고
    • Pathogenesis of steatohepatitis. Best practice & research
    • C.P. Day Pathogenesis of steatohepatitis. Best practice & research Clinical Gastroenterology 16 2002 663 678
    • (2002) Clinical Gastroenterology , vol.16 , pp. 663-678
    • Day, C.P.1
  • 8
    • 30044431801 scopus 로고    scopus 로고
    • From fat to inflammation
    • C.P. Day From fat to inflammation Gastroenterology 130 2006 207 210
    • (2006) Gastroenterology , vol.130 , pp. 207-210
    • Day, C.P.1
  • 9
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two "hits"?
    • C.P. Day, and O.F. James Steatohepatitis: a tale of two "hits"? Gastroenterology 114 1998 842 845
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 10
    • 79251524594 scopus 로고    scopus 로고
    • Systematic review: The diagnosis and staging of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
    • J.K. Dowman, J.W. Tomlinson, and P.N. Newsome Systematic review: the diagnosis and staging of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis Alimentary Pharmacology & Therapeutics 33 2011 525 540
    • (2011) Alimentary Pharmacology & Therapeutics , vol.33 , pp. 525-540
    • Dowman, J.K.1    Tomlinson, J.W.2    Newsome, P.N.3
  • 13
    • 80053369081 scopus 로고    scopus 로고
    • Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response
    • B.M. Gardner, and P. Walter Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response Science 333 2011 1891 1894
    • (2011) Science , vol.333 , pp. 1891-1894
    • Gardner, B.M.1    Walter, P.2
  • 15
    • 33645815074 scopus 로고    scopus 로고
    • Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression
    • P. Hu, Z. Han, A.D. Couvillon, R.J. Kaufman, and J.H. Exton Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression Molecular and Cellular Biology 26 2006 3071 3084
    • (2006) Molecular and Cellular Biology , vol.26 , pp. 3071-3084
    • Hu, P.1    Han, Z.2    Couvillon, A.D.3    Kaufman, R.J.4    Exton, J.H.5
  • 17
    • 0029905776 scopus 로고    scopus 로고
    • Two new saponins, congmuyenosides A and B, from the leaves of Aralia elata collected in Heilongjiang, China
    • H.X. Kuang, H. Sun, N. Zhang, Y. Okada, and T. Okuyama Two new saponins, congmuyenosides A and B, from the leaves of Aralia elata collected in Heilongjiang, China Chemical & Pharmaceutical Bulletin 44 1996 2183 2185
    • (1996) Chemical & Pharmaceutical Bulletin , vol.44 , pp. 2183-2185
    • Kuang, H.X.1    Sun, H.2    Zhang, N.3    Okada, Y.4    Okuyama, T.5
  • 18
    • 84856139907 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha agonist, Wy 14,643, improves metabolic indices, steatosis and ballooning in diabetic mice with non-alcoholic steatohepatitis
    • C.Z. Larter, M.M. Yeh, D.M. Van Rooyen, J. Brooling, K. Ghatora, and G.C. Farrell Peroxisome proliferator-activated receptor-alpha agonist, Wy 14,643, improves metabolic indices, steatosis and ballooning in diabetic mice with non-alcoholic steatohepatitis Journal of Gastroenterology and Hepatology 27 2012 341 350
    • (2012) Journal of Gastroenterology and Hepatology , vol.27 , pp. 341-350
    • Larter, C.Z.1    Yeh, M.M.2    Van Rooyen, D.M.3    Brooling, J.4    Ghatora, K.5    Farrell, G.C.6
  • 19
    • 68149161143 scopus 로고    scopus 로고
    • Isolation and tandem mass fragmentations of an anti-inflammatory compound from Aralia elata
    • J.H. Lee, Y.M. Ha, C.S. Jeong, Y.S. Kim, and Y. Park Isolation and tandem mass fragmentations of an anti-inflammatory compound from Aralia elata Archives of Pharmacal Research 32 2009 831 840
    • (2009) Archives of Pharmacal Research , vol.32 , pp. 831-840
    • Lee, J.H.1    Ha, Y.M.2    Jeong, C.S.3    Kim, Y.S.4    Park, Y.5
  • 20
    • 84905000446 scopus 로고    scopus 로고
    • Pharmacological research progress of Aralia elata
    • M. Li, and W.X. Lu Pharmacological research progress of Aralia elata Medical Recapitulate 20 2009 3157 3160
    • (2009) Medical Recapitulate , vol.20 , pp. 3157-3160
    • Li, M.1    Lu, W.X.2
  • 21
    • 51349135630 scopus 로고    scopus 로고
    • Inflammatory stress exacerbates lipid accumulation in hepatic cells and fatty livers of apolipoprotein e knockout mice
    • K.L. Ma, X.Z. Ruan, S.H. Powis, Y. Chen, J.F. Moorhead, and Z. Varghese Inflammatory stress exacerbates lipid accumulation in hepatic cells and fatty livers of apolipoprotein E knockout mice Hepatology 48 2008 770 781
    • (2008) Hepatology , vol.48 , pp. 770-781
    • Ma, K.L.1    Ruan, X.Z.2    Powis, S.H.3    Chen, Y.4    Moorhead, J.F.5    Varghese, Z.6
  • 22
    • 79952708723 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in liver disease
    • H. Malhi, and R.J. Kaufman Endoplasmic reticulum stress in liver disease Journal of Hepatology 54 2011 795 809
    • (2011) Journal of Hepatology , vol.54 , pp. 795-809
    • Malhi, H.1    Kaufman, R.J.2
  • 28
    • 84864269699 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in nonalcoholic fatty liver disease
    • M.J. Pagliassotti Endoplasmic reticulum stress in nonalcoholic fatty liver disease Annual Review of Nutrition 32 2012 17 33
    • (2012) Annual Review of Nutrition , vol.32 , pp. 17-33
    • Pagliassotti, M.J.1
  • 29
    • 79958211266 scopus 로고    scopus 로고
    • Rutin attenuates metabolic changes, nonalcoholic steatohepatitis, and cardiovascular remodeling in high-carbohydrate, high-fat diet-fed rats
    • S.K. Panchal, H. Poudyal, T.V. Arumugam, and L. Brown Rutin attenuates metabolic changes, nonalcoholic steatohepatitis, and cardiovascular remodeling in high-carbohydrate, high-fat diet-fed rats The Journal of Nutrition 141 2011 1062 1069
    • (2011) The Journal of Nutrition , vol.141 , pp. 1062-1069
    • Panchal, S.K.1    Poudyal, H.2    Arumugam, T.V.3    Brown, L.4
  • 30
    • 84862956270 scopus 로고    scopus 로고
    • Green tea extract suppresses NFkappaB activation and inflammatory responses in diet-induced obese rats with nonalcoholic steatohepatitis
    • H.J. Park, J.Y. Lee, M.Y. Chung, Y.K. Park, A.M. Bower, S.I. Koo, C. Giardina, and R.S. Bruno Green tea extract suppresses NFkappaB activation and inflammatory responses in diet-induced obese rats with nonalcoholic steatohepatitis The Journal of Nutrition 142 2012 57 63
    • (2012) The Journal of Nutrition , vol.142 , pp. 57-63
    • Park, H.J.1    Lee, J.Y.2    Chung, M.Y.3    Park, Y.K.4    Bower, A.M.5    Koo, S.I.6    Giardina, C.7    Bruno, R.S.8
  • 31
    • 34248681601 scopus 로고    scopus 로고
    • CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis
    • S.M. Rahman, J.M. Schroeder-Gloeckler, R.C. Janssen, H. Jiang, I. Qadri, K.N. Maclean, and J.E. Friedman CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis Hepatology 45 2007 1108 1117
    • (2007) Hepatology , vol.45 , pp. 1108-1117
    • Rahman, S.M.1    Schroeder-Gloeckler, J.M.2    Janssen, R.C.3    Jiang, H.4    Qadri, I.5    Maclean, K.N.6    Friedman, J.E.7
  • 32
    • 84923093436 scopus 로고    scopus 로고
    • Chemical synthesis and antitumor activities of a nature triterpenoid saponin
    • L. Ren, B.T. Lu, Y. Liu, and M.S. Cheng Chemical synthesis and antitumor activities of a nature triterpenoid saponin Chinese Journal of Medicinal Chemistry 21 2011 280 285
    • (2011) Chinese Journal of Medicinal Chemistry , vol.21 , pp. 280-285
    • Ren, L.1    Lu, B.T.2    Liu, Y.3    Cheng, M.S.4
  • 33
    • 0027363714 scopus 로고
    • Comparison of cytoprotective effects of saponins isolated from leaves of Aralia elata Seem. (Araliaceae) with synthesized bisdesmosides of oleanoic acid and hederagenin on carbon tetrachloride-induced hepatic injury
    • S. Saito, J. Ebashi, S. Sumita, T. Furumoto, Y. Nagamura, K. Nishida, and I. Isiguro Comparison of cytoprotective effects of saponins isolated from leaves of Aralia elata Seem. (Araliaceae) with synthesized bisdesmosides of oleanoic acid and hederagenin on carbon tetrachloride-induced hepatic injury Chemical & Pharmaceutical Bulletin 41 1993 1395 1401
    • (1993) Chemical & Pharmaceutical Bulletin , vol.41 , pp. 1395-1401
    • Saito, S.1    Ebashi, J.2    Sumita, S.3    Furumoto, T.4    Nagamura, Y.5    Nishida, K.6    Isiguro, I.7
  • 35
    • 84887620237 scopus 로고    scopus 로고
    • ER stress-induced cell death mechanisms
    • R. Sano, and J.C. Reed ER stress-induced cell death mechanisms Biochimica et Biophysica Acta 1833 2013 3460 3470
    • (2013) Biochimica et Biophysica Acta , vol.1833 , pp. 3460-3470
    • Sano, R.1    Reed, J.C.2
  • 39
    • 33845482278 scopus 로고    scopus 로고
    • Protective effects of aralosides on cultured myocardial cells subjected to anoxia/reoxygenation injury
    • G.B. Sun, H.B. Xu, F.C. Wen, W. Zhang, T. Ding, and X.B. Sun Protective effects of aralosides on cultured myocardial cells subjected to anoxia/reoxygenation injury Chinese Pharmacological Bulletin 22 9 2006 1092 1095
    • (2006) Chinese Pharmacological Bulletin , vol.22 , Issue.9 , pp. 1092-1095
    • Sun, G.B.1    Xu, H.B.2    Wen, F.C.3    Zhang, W.4    Ding, T.5    Sun, X.B.6
  • 44
    • 70349972775 scopus 로고    scopus 로고
    • Apoptosis and cytokines in non-alcoholic steatohepatitis
    • W.K. Syn, S.S. Choi, and A.M. Diehl Apoptosis and cytokines in non-alcoholic steatohepatitis Clinics in Liver Disease 13 2009 565 580
    • (2009) Clinics in Liver Disease , vol.13 , pp. 565-580
    • Syn, W.K.1    Choi, S.S.2    Diehl, A.M.3
  • 45
    • 14244253957 scopus 로고    scopus 로고
    • Feeding apolipoprotein E-knockout mice with cholesterol and fat enriched diets may be a model of non-alcoholic steatohepatitis
    • M. Tous, N. Ferre, J. Camps, F. Riu, and J. Joven Feeding apolipoprotein E-knockout mice with cholesterol and fat enriched diets may be a model of non-alcoholic steatohepatitis Molecular and Cellular Biochemistry 268 2005 53 58
    • (2005) Molecular and Cellular Biochemistry , vol.268 , pp. 53-58
    • Tous, M.1    Ferre, N.2    Camps, J.3    Riu, F.4    Joven, J.5
  • 46
    • 84892826675 scopus 로고    scopus 로고
    • Empirical study on anti-acute hepatic injury of Aralia Elate Seem Leaf Total Saponin
    • L.Y. Wang, H.B. Xiao, and MH. Wang Empirical study on anti-acute hepatic injury of Aralia Elate Seem Leaf Total Saponin Information on Traditional Chinese Medicine 26 2 2009 29 30
    • (2009) Information on Traditional Chinese Medicine , vol.26 , Issue.2 , pp. 29-30
    • Wang, L.Y.1    Xiao, H.B.2    Wang, M.H.3
  • 47
    • 84905028836 scopus 로고    scopus 로고
    • Effect of the total saponins of Aralia elata Seem on cardiac contractile function and intracellular calcium cycling regulation
    • M. Wang, X.D. Xu, H.B. Xu, F.C. Wen, X.P. Zhang, H. Sun, F. Yao, G.B. Sun, and X.B. Sun Effect of the total saponins of Aralia elata Seem on cardiac contractile function and intracellular calcium cycling regulation Journal of Ethnopharmacology 41 14 2014 00393 00396
    • (2014) Journal of Ethnopharmacology , vol.41 , Issue.14 , pp. 00393-00396
    • Wang, M.1    Xu, X.D.2    Xu, H.B.3    Wen, F.C.4    Zhang, X.P.5    Sun, H.6    Yao, F.7    Sun, G.B.8    Sun, X.B.9
  • 48
    • 25144466481 scopus 로고    scopus 로고
    • Enhancing hepatic glycolysis reduces obesity: Differential effects on lipogenesis depend on site of glycolytic modulation
    • C. Wu, J.E. Kang, L.J. Peng, H. Li, S.A. Khan, C.J. Hillard, D.A. Okar, and A.J. Lange Enhancing hepatic glycolysis reduces obesity: differential effects on lipogenesis depend on site of glycolytic modulation Cell Metabolism 2 2005 131 140
    • (2005) Cell Metabolism , vol.2 , pp. 131-140
    • Wu, C.1    Kang, J.E.2    Peng, L.J.3    Li, H.4    Khan, S.A.5    Hillard, C.J.6    Okar, D.A.7    Lange, A.J.8
  • 49
    • 70249103802 scopus 로고    scopus 로고
    • Protective effect of total aralosides of Aralia elata (Miq) Seem (TASAES) against diabetic cardiomyopathy in rats during the early stage, and possible mechanisms
    • S. Xi, G. Zhou, X. Zhang, W. Zhang, L. Cai, and C. Zhao Protective effect of total aralosides of Aralia elata (Miq) Seem (TASAES) against diabetic cardiomyopathy in rats during the early stage, and possible mechanisms Experimental & Molecular Medicine 41 2009 538 547
    • (2009) Experimental & Molecular Medicine , vol.41 , pp. 538-547
    • Xi, S.1    Zhou, G.2    Zhang, X.3    Zhang, W.4    Cai, L.5    Zhao, C.6
  • 50
    • 77954596880 scopus 로고    scopus 로고
    • Transient expression of interferon-inducible p204 in the early stage is required for adipogenesis in 3T3-L1 cells
    • J. Xiao, B. Sun, and G.P. Cai Transient expression of interferon-inducible p204 in the early stage is required for adipogenesis in 3T3-L1 cells Endocrinology 151 2010 3141 3153
    • (2010) Endocrinology , vol.151 , pp. 3141-3153
    • Xiao, J.1    Sun, B.2    Cai, G.P.3
  • 51
    • 0028361861 scopus 로고
    • Elatoside E, a new hypoglycemic principle from the root cortex of Aralia elata Seem.: Structure-related hypoglycemic activity of oleanolic acid glycosides
    • M. Yoshikawa, H. Matsuda, E. Harada, T. Murakami, N. Wariishi, J. Yamahara, and N. Murakami Elatoside E, a new hypoglycemic principle from the root cortex of Aralia elata Seem.: structure-related hypoglycemic activity of oleanolic acid glycosides Chemical & Pharmaceutical Bulletin 42 1994 1354 1356
    • (1994) Chemical & Pharmaceutical Bulletin , vol.42 , pp. 1354-1356
    • Yoshikawa, M.1    Matsuda, H.2    Harada, E.3    Murakami, T.4    Wariishi, N.5    Yamahara, J.6    Murakami, N.7
  • 52
    • 0028823972 scopus 로고
    • Medicinal foodstuffs. I. Hypoglycemic constituents from a garnish foodstuff "taranome," the young shoot of Aralia elata SEEM.: Elatosides G, H, I, J, and K
    • M Yoshikawa, S Yoshizumi, T Ueno, H Matsuda, T Murakami, J Yamahara, and N. Murakami Medicinal foodstuffs. I. Hypoglycemic constituents from a garnish foodstuff "taranome," the young shoot of Aralia elata SEEM.: elatosides G, H, I, J, and K Chemical and Pharmaceutical Bulletin(Tokyo) 43 1995 1878 1882
    • (1995) Chemical and Pharmaceutical Bulletin(Tokyo) , vol.43 , pp. 1878-1882
    • Yoshikawa, M.1    Yoshizumi, S.2    Ueno, T.3    Matsuda, H.4    Murakami, T.5    Yamahara, J.6    Murakami, N.7
  • 54
    • 33746299139 scopus 로고    scopus 로고
    • High-fat emulsion-induced rat model of nonalcoholic steatohepatitis
    • Y. Zou, J. Li, C. Lu, J. Wang, J. Ge, Y. Huang, L. Zhang, and Y. Wang High-fat emulsion-induced rat model of nonalcoholic steatohepatitis Life Sciences 79 2006 1100 1107
    • (2006) Life Sciences , vol.79 , pp. 1100-1107
    • Zou, Y.1    Li, J.2    Lu, C.3    Wang, J.4    Ge, J.5    Huang, Y.6    Zhang, L.7    Wang, Y.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.