Endoplasmic reticulum stress and oxidative stress are involved in ZnO nanoparticle-induced hepatotoxicity

Toxicology Letters

Volumn 234, Issue 1, 2015, Pages 40-49

  Yang, Xia ^a   Shao, Huali ^a   Liu, Weirong ^a   Gu, Weizhong ^a   Shu, Xiaoli ^a   Mo, Yiqun ^b   Chen, Xuejun ^a   Zhang, Qunwei ^b   Jiang, Mizu ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

Apoptosis; Endoplasmic reticulum stress; Liver injury; Nano ZnO; Oxidative stress

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPASE 12; CASPASE 9; GLUTATHIONE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; MESSENGER RNA; PROTEIN BAX; PROTEIN KINASE; RNA DEPENDENT PROTEIN KINASE ER KINASE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ZINC OXIDE NANOPARTICLE; DNA BINDING PROTEIN; GLUCOSE REGULATED PROTEIN 94; HEAT SHOCK PROTEIN; MEMBRANE PROTEIN; MOLECULAR CHAPERONE GRP78; NANOPARTICLE; PERK KINASE; PROTEIN DISULFIDE ISOMERASE; PROTEIN KINASE R; REGULATORY FACTOR X TRANSCRIPTION FACTORS; RNA; TRANSCRIPTION FACTOR; ZINC OXIDE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL FUNCTION; CENTRAL VEIN; CONTROLLED STUDY; DEGRANULATION; DRUG MEGADOSE; ELECTRON MICROSCOPE; ENDOPLASMIC RETICULUM STRESS; ENZYME PHOSPHORYLATION; GENE EXPRESSION; LIVER CELL; LIVER INJURY; LIVER NECROSIS; LIVER TOXICITY; LOW DRUG DOSE; MALE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; UPREGULATION; VEIN DILATATION; ANIMAL; BLOOD; C57BL MOUSE; CHEMISTRY; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; GENETICS; METABOLISM; RANDOMIZATION; REAL TIME POLYMERASE CHAIN REACTION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

EUKARYOTA; MUS;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BLOTTING, WESTERN; DNA-BINDING PROTEINS; DRUG-INDUCED LIVER INJURY; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; GLUTATHIONE; HEAT-SHOCK PROTEINS; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; PROTEIN DISULFIDE-ISOMERASES; RANDOM ALLOCATION; REAL-TIME POLYMERASE CHAIN REACTION; RNA; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS; ZINC OXIDE;

EID: 84923065632     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2015.02.004     Document Type: Article

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