Titanium dioxide nanoparticle-induced oxidative stress triggers DNA damage and hepatic injury in mice

Nanomedicine

Volumn 9, Issue 9, 2014, Pages 1423-1434

  Shukla, Ritesh K ^a   Kumar, Ashutosh ^b   Vallabani, Naga Veera Srikanth ^b   Pandey, Alok K ^a   Dhawan, Alok ^a,b  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^b AHMEDABAD UNIVERSITY   (India)

Author keywords

apoptosis; DNA damage; fpg Comet assay; histopathological changes; liver; mouse; oxidative stress; titanium dioxide nanoparticles

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CASPASE 3; CASPASE 9; GLUTATHIONE; HEAT SHOCK PROTEIN; MALONALDEHYDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; TITANIUM DIOXIDE NANOPARTICLE; TUMOR SUPPRESSOR PROTEIN; METAL NANOPARTICLE; TITANIUM; TITANIUM DIOXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; ENDOTHELIUM CELL; ENZYME BLOOD LEVEL; GENOTOXICITY; HISTOPATHOLOGY; HYDRODYNAMICS; IMMUNOBLOTTING; LIVER CELL; LIVER INJURY; LIVER TOXICITY; MALE; MICRONUCLEUS; MONONUCLEAR CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PARTICLE SIZE; PROTEIN EXPRESSION; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL; ANIMAL; DRUG EFFECTS; HUMAN; INJURIES; LIVER; METABOLISM; MICRONUCLEUS TEST; NANOMEDICINE; ORAL DRUG ADMINISTRATION; ULTRASTRUCTURE;

ADMINISTRATION, ORAL; ANIMALS; DNA DAMAGE; HEAT-SHOCK PROTEINS; HEPATOCYTES; HUMANS; LIVER; MALE; METAL NANOPARTICLES; MICE; MICRONUCLEUS TESTS; NANOMEDICINE; OXIDATIVE STRESS; TITANIUM;

EID: 84907027854     PISSN: 17435889     EISSN: 17486963     Source Type: Journal    
DOI: 10.2217/nnm.13.100     Document Type: Article

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