메뉴 건너뛰기




Volumn 81, Issue , 2015, Pages 107-113

Insights into alternative splicing of sarcomeric genes in the heart

Author keywords

Alternative splicing; RBM20; RBM24; Sarcomere; Titin

Indexed keywords

ALPHA TROPOMYOSIN; ANTISENSE OLIGONUCLEOTIDE; CONNECTIN; CONTRACTILE PROTEIN; CYPHER PROTEIN; MYOMESIN; RNA BINDING MOTIF PROTEIN 20; RNA BINDING MOTIF PROTEIN 24; RNA BINDING PROTEIN; TROPOMYOSIN; TROPONIN T; UNCLASSIFIED DRUG; LDB3 PROTEIN, MOUSE; LIM PROTEIN; PROTEIN KINASE; RBM20 PROTEIN, MOUSE; RBM24 PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TITIN PROTEIN, MOUSE;

EID: 84923001691     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2015.02.008     Document Type: Review
Times cited : (51)

References (81)
  • 1
    • 56549101959 scopus 로고    scopus 로고
    • Alternative isoform regulation in human tissue transcriptomes
    • Wang E.T., Sandberg R., Luo S., Khrebtukova I., Zhang L., Mayr C., et al. Alternative isoform regulation in human tissue transcriptomes. Nature 2008, 456:470-476.
    • (2008) Nature , vol.456 , pp. 470-476
    • Wang, E.T.1    Sandberg, R.2    Luo, S.3    Khrebtukova, I.4    Zhang, L.5    Mayr, C.6
  • 2
    • 84865812140 scopus 로고    scopus 로고
    • Genomics. ENCODE project writes eulogy for junk DNA
    • Pennisi E. Genomics. ENCODE project writes eulogy for junk DNA. Science 2012, 337:1159-1161.
    • (2012) Science , vol.337 , pp. 1159-1161
    • Pennisi, E.1
  • 3
    • 0037023384 scopus 로고    scopus 로고
    • A draft sequence of the rice genome (Oryza sativa L. ssp. indica)
    • Yu J., Hu S., Wang J., Wong G.K., Li S., Liu B., et al. A draft sequence of the rice genome (Oryza sativa L. ssp. indica). Science 2002, 296:79-92.
    • (2002) Science , vol.296 , pp. 79-92
    • Yu, J.1    Hu, S.2    Wang, J.3    Wong, G.K.4    Li, S.5    Liu, B.6
  • 4
    • 70350569286 scopus 로고    scopus 로고
    • Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches
    • Chen M., Manley J.L. Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches. Nat Rev Mol Cell Biol 2009, 10:741-754.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 741-754
    • Chen, M.1    Manley, J.L.2
  • 7
    • 84860667942 scopus 로고    scopus 로고
    • RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing
    • Guo W., Schafer S., Greaser M.L., Radke M.H., Liss M., Govindarajan T., et al. RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing. Nat Med 2012, 18:766-773.
    • (2012) Nat Med , vol.18 , pp. 766-773
    • Guo, W.1    Schafer, S.2    Greaser, M.L.3    Radke, M.H.4    Liss, M.5    Govindarajan, T.6
  • 8
    • 58149492467 scopus 로고    scopus 로고
    • A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart
    • Kalsotra A., Xiao X., Ward A.J., Castle J.C., Johnson J.M., Burge C.B., et al. A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Proc Natl Acad Sci U S A 2008, 105:20333-20338.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 20333-20338
    • Kalsotra, A.1    Xiao, X.2    Ward, A.J.3    Castle, J.C.4    Johnson, J.M.5    Burge, C.B.6
  • 9
    • 19944427655 scopus 로고    scopus 로고
    • ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle
    • Xu X., Yang D., Ding J.H., Wang W., Chu P.H., Dalton N.D., et al. ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell 2005, 120:59-72.
    • (2005) Cell , vol.120 , pp. 59-72
    • Xu, X.1    Yang, D.2    Ding, J.H.3    Wang, W.4    Chu, P.H.5    Dalton, N.D.6
  • 10
    • 1242281665 scopus 로고    scopus 로고
    • Developmental control of titin isoform expression and passive stiffness in fetal and neonatal myocardium
    • Lahmers S., Wu Y., Call D.R., Labeit S., Granzier H. Developmental control of titin isoform expression and passive stiffness in fetal and neonatal myocardium. Circ Res 2004, 94:505-513.
    • (2004) Circ Res , vol.94 , pp. 505-513
    • Lahmers, S.1    Wu, Y.2    Call, D.R.3    Labeit, S.4    Granzier, H.5
  • 11
    • 1842830381 scopus 로고    scopus 로고
    • Developmentally regulated switching of titin size alters myofibrillar stiffness in the perinatal heart
    • Opitz C.A., Leake M.C., Makarenko I., Benes V., Linke W.A. Developmentally regulated switching of titin size alters myofibrillar stiffness in the perinatal heart. Circ Res 2004, 94:967-975.
    • (2004) Circ Res , vol.94 , pp. 967-975
    • Opitz, C.A.1    Leake, M.C.2    Makarenko, I.3    Benes, V.4    Linke, W.A.5
  • 13
    • 84880955708 scopus 로고    scopus 로고
    • Sequencing of mRNA identifies re-expression of fetal splice variants in cardiac hypertrophy
    • Ames E.G., Lawson M.J., Mackey A.J., Holmes J.W. Sequencing of mRNA identifies re-expression of fetal splice variants in cardiac hypertrophy. J Mol Cell Cardiol 2013, 62:99-107.
    • (2013) J Mol Cell Cardiol , vol.62 , pp. 99-107
    • Ames, E.G.1    Lawson, M.J.2    Mackey, A.J.3    Holmes, J.W.4
  • 14
    • 84907976655 scopus 로고    scopus 로고
    • RBM24 is a major regulator of muscle-specific alternative splicing
    • Yang J., Hung L.-H., Licht T., Kostin S., Looso M., Khrameeva E., et al. RBM24 is a major regulator of muscle-specific alternative splicing. Dev Cell 2014, 31:87-99.
    • (2014) Dev Cell , vol.31 , pp. 87-99
    • Yang, J.1    Hung, L.-H.2    Licht, T.3    Kostin, S.4    Looso, M.5    Khrameeva, E.6
  • 15
    • 18544406997 scopus 로고    scopus 로고
    • Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity
    • Freiburg A., Trombitas K., Hell W., Cazorla O., Fougerousse F., Centner T., et al. Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity. Circ Res 2000, 86:1114-1121.
    • (2000) Circ Res , vol.86 , pp. 1114-1121
    • Freiburg, A.1    Trombitas, K.2    Hell, W.3    Cazorla, O.4    Fougerousse, F.5    Centner, T.6
  • 16
    • 0035941407 scopus 로고    scopus 로고
    • The complete gene sequence of titin, expression of an unusual 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system
    • Bang M.L., Centner T., Fornoff F., Geach A.J., Gotthardt M., McNabb M., et al. The complete gene sequence of titin, expression of an unusual 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system. Circ Res 2001, 89:1065-1072.
    • (2001) Circ Res , vol.89 , pp. 1065-1072
    • Bang, M.L.1    Centner, T.2    Fornoff, F.3    Geach, A.J.4    Gotthardt, M.5    McNabb, M.6
  • 17
    • 0028824480 scopus 로고
    • Titins: giant proteins in charge of muscle ultrastructure and elasticity
    • Labeit S., Kolmerer B. Titins: giant proteins in charge of muscle ultrastructure and elasticity. Science 1995, 270:293-296.
    • (1995) Science , vol.270 , pp. 293-296
    • Labeit, S.1    Kolmerer, B.2
  • 18
    • 0028957373 scopus 로고
    • Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments
    • Granzier H.L., Irving T.C. Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments. Biophys J 1995, 68:1027-1044.
    • (1995) Biophys J , vol.68 , pp. 1027-1044
    • Granzier, H.L.1    Irving, T.C.2
  • 19
    • 0029823455 scopus 로고    scopus 로고
    • Titin develops restoring force in rat cardiac myocytes
    • Helmes M., Trombitas K., Granzier H. Titin develops restoring force in rat cardiac myocytes. Circ Res 1996, 79:619-626.
    • (1996) Circ Res , vol.79 , pp. 619-626
    • Helmes, M.1    Trombitas, K.2    Granzier, H.3
  • 21
    • 0034786066 scopus 로고    scopus 로고
    • Cardiac titin isoforms are coexpressed in the half-sarcomere and extend independently
    • Trombitas K., Wu Y., Labeit D., Labeit S., Granzier H. Cardiac titin isoforms are coexpressed in the half-sarcomere and extend independently. Am J Physiol Heart Circ Physiol 2001, 281:H1793-H1799.
    • (2001) Am J Physiol Heart Circ Physiol , vol.281 , pp. H1793-H1799
    • Trombitas, K.1    Wu, Y.2    Labeit, D.3    Labeit, S.4    Granzier, H.5
  • 22
    • 0344896768 scopus 로고    scopus 로고
    • Titin isoform variance and length dependence of activation in skinned bovine cardiac muscle
    • Fukuda N., Wu Y., Farman G., Irving T.C., Granzier H. Titin isoform variance and length dependence of activation in skinned bovine cardiac muscle. J Physiol 2003, 553:147-154.
    • (2003) J Physiol , vol.553 , pp. 147-154
    • Fukuda, N.1    Wu, Y.2    Farman, G.3    Irving, T.C.4    Granzier, H.5
  • 24
    • 4944235675 scopus 로고    scopus 로고
    • Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts
    • Makarenko I., Opitz C.A., Leake M.C., Neagoe C., Kulke M., Gwathmey J.K., et al. Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts. Circ Res 2004, 95:708-716.
    • (2004) Circ Res , vol.95 , pp. 708-716
    • Makarenko, I.1    Opitz, C.A.2    Leake, M.C.3    Neagoe, C.4    Kulke, M.5    Gwathmey, J.K.6
  • 25
    • 3142672018 scopus 로고    scopus 로고
    • Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy
    • Nagueh S.F., Shah G., Wu Y., Torre-Amione G., King N.M., Lahmers S., et al. Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy. Circulation 2004, 110:155-162.
    • (2004) Circulation , vol.110 , pp. 155-162
    • Nagueh, S.F.1    Shah, G.2    Wu, Y.3    Torre-Amione, G.4    King, N.M.5    Lahmers, S.6
  • 26
    • 84901480223 scopus 로고    scopus 로고
    • Experimentally increasing titin compliance in a novel mouse model attenuates the frank-starling mechanism but has a beneficial effect on diastole
    • Methawasin M., Hutchinson K.R., Lee E.J., Smith J.E., Saripalli C., Hidalgo C.G., et al. Experimentally increasing titin compliance in a novel mouse model attenuates the frank-starling mechanism but has a beneficial effect on diastole. Circulation 2014, 129:1924-1936.
    • (2014) Circulation , vol.129 , pp. 1924-1936
    • Methawasin, M.1    Hutchinson, K.R.2    Lee, E.J.3    Smith, J.E.4    Saripalli, C.5    Hidalgo, C.G.6
  • 27
    • 84876353525 scopus 로고    scopus 로고
    • Rbm20 regulates titin alternative splicing as a splicing repressor
    • Li S., Guo W., Dewey C.N., Greaser M.L. Rbm20 regulates titin alternative splicing as a splicing repressor. Nucleic Acids Res 2013, 41:2659-2672.
    • (2013) Nucleic Acids Res , vol.41 , pp. 2659-2672
    • Li, S.1    Guo, W.2    Dewey, C.N.3    Greaser, M.L.4
  • 28
    • 84905460023 scopus 로고    scopus 로고
    • RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing
    • Maatz H., Jens M., Liss M., Schafer S., Heinig M., Kirchner M., et al. RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing. J Clin Invest 2014, 124:3419-3430.
    • (2014) J Clin Invest , vol.124 , pp. 3419-3430
    • Maatz, H.1    Jens, M.2    Liss, M.3    Schafer, S.4    Heinig, M.5    Kirchner, M.6
  • 29
    • 84862777447 scopus 로고    scopus 로고
    • Genetic variation in the alternative splicing regulator RBM20 is associated with dilated cardiomyopathy
    • Refaat M.M., Lubitz S.A., Makino S., Islam Z., Frangiskakis J.M., Mehdi H., et al. Genetic variation in the alternative splicing regulator RBM20 is associated with dilated cardiomyopathy. Heart Rhythm 2012, 9:390-396.
    • (2012) Heart Rhythm , vol.9 , pp. 390-396
    • Refaat, M.M.1    Lubitz, S.A.2    Makino, S.3    Islam, Z.4    Frangiskakis, J.M.5    Mehdi, H.6
  • 31
    • 84874476580 scopus 로고    scopus 로고
    • Titin is a major human disease gene
    • LeWinter M.M., Granzier H.L. Titin is a major human disease gene. Circulation 2013, 127:938-944.
    • (2013) Circulation , vol.127 , pp. 938-944
    • LeWinter, M.M.1    Granzier, H.L.2
  • 32
    • 45349086526 scopus 로고    scopus 로고
    • Physiological functions of the giant elastic protein titin in mammalian striated muscle
    • Fukuda N., Granzier H.L., Ishiwata S., Kurihara S. Physiological functions of the giant elastic protein titin in mammalian striated muscle. J Physiol Sci 2008, 58:151-159.
    • (2008) J Physiol Sci , vol.58 , pp. 151-159
    • Fukuda, N.1    Granzier, H.L.2    Ishiwata, S.3    Kurihara, S.4
  • 33
    • 84895561196 scopus 로고    scopus 로고
    • CaMKIIdelta subtypes: localization and function
    • Gray C.B., Heller Brown J. CaMKIIdelta subtypes: localization and function. Front Pharmacol 2014, 5:15.
    • (2014) Front Pharmacol , vol.5 , pp. 15
    • Gray, C.B.1    Heller, B.J.2
  • 34
    • 0033781028 scopus 로고    scopus 로고
    • Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels
    • Dzhura I., Wu Y., Colbran R.J., Balser J.R., Anderson M.E. Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels. Nat Cell Biol 2000, 2:173-177.
    • (2000) Nat Cell Biol , vol.2 , pp. 173-177
    • Dzhura, I.1    Wu, Y.2    Colbran, R.J.3    Balser, J.R.4    Anderson, M.E.5
  • 35
    • 0037059791 scopus 로고    scopus 로고
    • 2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity
    • 2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity. J Biol Chem 2002, 277:1261-1267.
    • (2002) J Biol Chem , vol.277 , pp. 1261-1267
    • Zhang, T.1    Johnson, E.N.2    Gu, Y.3    Morissette, M.R.4    Sah, V.P.5    Gigena, M.S.6
  • 36
    • 0038643573 scopus 로고    scopus 로고
    • The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure
    • Zhang T., Maier L.S., Dalton N.D., Miyamoto S., Ross J., Bers D.M., et al. The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res 2003, 92:912-919.
    • (2003) Circ Res , vol.92 , pp. 912-919
    • Zhang, T.1    Maier, L.S.2    Dalton, N.D.3    Miyamoto, S.4    Ross, J.5    Bers, D.M.6
  • 38
    • 84856087553 scopus 로고    scopus 로고
    • Location matters: clarifying the concept of nuclear and cytosolic CaMKII subtypes
    • Mishra S., Gray C.B., Miyamoto S., Bers D.M., Brown J.H. Location matters: clarifying the concept of nuclear and cytosolic CaMKII subtypes. Circ Res 2011, 109:1354-1362.
    • (2011) Circ Res , vol.109 , pp. 1354-1362
    • Mishra, S.1    Gray, C.B.2    Miyamoto, S.3    Bers, D.M.4    Brown, J.H.5
  • 39
    • 24344470264 scopus 로고    scopus 로고
    • The M-band: an elastic web that crosslinks thick filaments in the center of the sarcomere
    • Agarkova I., Perriard J.C. The M-band: an elastic web that crosslinks thick filaments in the center of the sarcomere. Trends Cell Biol 2005, 15:477-485.
    • (2005) Trends Cell Biol , vol.15 , pp. 477-485
    • Agarkova, I.1    Perriard, J.C.2
  • 40
    • 0031034775 scopus 로고    scopus 로고
    • Molecular structure of the sarcomeric M band: mapping of titin and myosin binding domains in myomesin and the identification of a potential regulatory phosphorylation site in myomesin
    • Obermann W.M., Gautel M., Weber K., Furst D.O. Molecular structure of the sarcomeric M band: mapping of titin and myosin binding domains in myomesin and the identification of a potential regulatory phosphorylation site in myomesin. EMBO J 1997, 16:211-220.
    • (1997) EMBO J , vol.16 , pp. 211-220
    • Obermann, W.M.1    Gautel, M.2    Weber, K.3    Furst, D.O.4
  • 41
    • 0034616196 scopus 로고    scopus 로고
    • A novel marker for vertebrate embryonic heart, the EH-myomesin isoform
    • Agarkova I. A novel marker for vertebrate embryonic heart, the EH-myomesin isoform. J Biol Chem 2000, 275:10256-10264.
    • (2000) J Biol Chem , vol.275 , pp. 10256-10264
    • Agarkova, I.1
  • 44
    • 0038069065 scopus 로고    scopus 로고
    • Developmental changes in contractility and sarcomeric proteins from the early embryonic to the adult stage in the mouse heart
    • Siedner S., Kruger M., Schroeter M., Metzler D., Roell W., Fleischmann B.K., et al. Developmental changes in contractility and sarcomeric proteins from the early embryonic to the adult stage in the mouse heart. J Phys 2003, 548:493-505.
    • (2003) J Phys , vol.548 , pp. 493-505
    • Siedner, S.1    Kruger, M.2    Schroeter, M.3    Metzler, D.4    Roell, W.5    Fleischmann, B.K.6
  • 47
    • 0034059761 scopus 로고    scopus 로고
    • Regulation of contraction in striated muscle
    • Gordon A.M., Homsher E., Regnier M. Regulation of contraction in striated muscle. Physiol Rev 2000, 80:853-924.
    • (2000) Physiol Rev , vol.80 , pp. 853-924
    • Gordon, A.M.1    Homsher, E.2    Regnier, M.3
  • 48
    • 0025934457 scopus 로고
    • Troponin T isoform expression in humans. A comparison among normal and failing adult heart, fetal heart, and adult and fetal skeletal muscle
    • Anderson P.A., Malouf N.N., Oakeley A.E., Pagani E.D., Allen P.D. Troponin T isoform expression in humans. A comparison among normal and failing adult heart, fetal heart, and adult and fetal skeletal muscle. Circ Res 1991, 69:1226-1233.
    • (1991) Circ Res , vol.69 , pp. 1226-1233
    • Anderson, P.A.1    Malouf, N.N.2    Oakeley, A.E.3    Pagani, E.D.4    Allen, P.D.5
  • 49
    • 0028792519 scopus 로고
    • Molecular cloning of human cardiac troponin T isoforms: expression in developing and failing heart
    • Townsend P.J., Barton P.J., Yacoub M.H., Farza H. Molecular cloning of human cardiac troponin T isoforms: expression in developing and failing heart. J Mol Cell Cardiol 1995, 27:2223-2236.
    • (1995) J Mol Cell Cardiol , vol.27 , pp. 2223-2236
    • Townsend, P.J.1    Barton, P.J.2    Yacoub, M.H.3    Farza, H.4
  • 50
    • 0037144508 scopus 로고    scopus 로고
    • Cardiac troponin T isoforms affect the Ca2+ sensitivity and inhibition of force development. Insights into the role of troponin T isoforms in the heart
    • Gomes A.V., Guzman G., Zhao J., Potter J.D. Cardiac troponin T isoforms affect the Ca2+ sensitivity and inhibition of force development. Insights into the role of troponin T isoforms in the heart. J Biol Chem 2002, 277:35341-35349.
    • (2002) J Biol Chem , vol.277 , pp. 35341-35349
    • Gomes, A.V.1    Guzman, G.2    Zhao, J.3    Potter, J.D.4
  • 51
    • 0028943382 scopus 로고
    • Molecular basis of human cardiac troponin T isoforms expressed in the developing, adult, and failing heart
    • Anderson P.A., Greig A., Mark T.M., Malouf N.N., Oakeley A.E., Ungerleider R.M., et al. Molecular basis of human cardiac troponin T isoforms expressed in the developing, adult, and failing heart. Circ Res 1995, 76:681-686.
    • (1995) Circ Res , vol.76 , pp. 681-686
    • Anderson, P.A.1    Greig, A.2    Mark, T.M.3    Malouf, N.N.4    Oakeley, A.E.5    Ungerleider, R.M.6
  • 52
    • 77951622995 scopus 로고    scopus 로고
    • 2+-sensitivity and arrhythmia susceptibility
    • 2+-sensitivity and arrhythmia susceptibility. J Mol Cell Cardiol 2010, 48:824-833.
    • (2010) J Mol Cell Cardiol , vol.48 , pp. 824-833
    • Huke, S.1    Knollmann, B.C.2
  • 53
    • 20444443019 scopus 로고    scopus 로고
    • Dynamic balance between activation and repression regulates pre-mRNA alternative splicing during heart development
    • Ladd A.N., Stenberg M.G., Swanson M.S., Cooper T.A. Dynamic balance between activation and repression regulates pre-mRNA alternative splicing during heart development. Dev Dyn 2005, 233:783-793.
    • (2005) Dev Dyn , vol.233 , pp. 783-793
    • Ladd, A.N.1    Stenberg, M.G.2    Swanson, M.S.3    Cooper, T.A.4
  • 54
    • 0036203307 scopus 로고    scopus 로고
    • Dynamic antagonism between ETR-3 and PTB regulates cell type-specific alternative splicing
    • Charlet B.N., Logan P., Singh G., Cooper T.A. Dynamic antagonism between ETR-3 and PTB regulates cell type-specific alternative splicing. Mol Cell 2002, 9:649-658.
    • (2002) Mol Cell , vol.9 , pp. 649-658
    • Charlet, B.N.1    Logan, P.2    Singh, G.3    Cooper, T.A.4
  • 56
    • 77953762074 scopus 로고    scopus 로고
    • Coexistence of cardiac troponin T variants reduces heart efficiency
    • Feng H.Z., Jin J.P. Coexistence of cardiac troponin T variants reduces heart efficiency. Am J Physiol Heart Circ Physiol 2010, 299:H97-H105.
    • (2010) Am J Physiol Heart Circ Physiol , vol.299 , pp. H97-H105
    • Feng, H.Z.1    Jin, J.P.2
  • 57
    • 78651248717 scopus 로고    scopus 로고
    • Troponin T isoforms and posttranscriptional modifications: evolution, regulation and function
    • Wei B., Jin J.P. Troponin T isoforms and posttranscriptional modifications: evolution, regulation and function. Arch Biochem Biophys 2011, 505:144-154.
    • (2011) Arch Biochem Biophys , vol.505 , pp. 144-154
    • Wei, B.1    Jin, J.P.2
  • 58
    • 3142772675 scopus 로고    scopus 로고
    • Expression of a novel cardiac-specific tropomyosin isoform in humans
    • Denz C.R., Narshi A., Zajdel R.W., Dube D.K. Expression of a novel cardiac-specific tropomyosin isoform in humans. Biochem Biophys Res Commun 2004, 320:1291-1297.
    • (2004) Biochem Biophys Res Commun , vol.320 , pp. 1291-1297
    • Denz, C.R.1    Narshi, A.2    Zajdel, R.W.3    Dube, D.K.4
  • 59
    • 76649084202 scopus 로고    scopus 로고
    • Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform
    • Rajan S., Jagatheesan G., Karam C.N., Alves M.L., Bodi I., Schwartz A., et al. Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform. Circulation 2010, 121:410-418.
    • (2010) Circulation , vol.121 , pp. 410-418
    • Rajan, S.1    Jagatheesan, G.2    Karam, C.N.3    Alves, M.L.4    Bodi, I.5    Schwartz, A.6
  • 60
    • 0037470052 scopus 로고    scopus 로고
    • Characterization and in vivo functional analysis of splice variants of cypher
    • Huang C., Zhou Q., Liang P., Hollander M.S., Sheikh F., Li X., et al. Characterization and in vivo functional analysis of splice variants of cypher. J Biol Chem 2003, 278:7360-7365.
    • (2003) J Biol Chem , vol.278 , pp. 7360-7365
    • Huang, C.1    Zhou, Q.2    Liang, P.3    Hollander, M.S.4    Sheikh, F.5    Li, X.6
  • 61
    • 84924110084 scopus 로고    scopus 로고
    • Ablation of cypher, a PDZ-LIM domain Z-line protein, causes a severe form of congenital myopathy
    • Zhou Q., Chu P.H., Huang C., Cheng C.F., Martone M.E., Knoll G., et al. Ablation of cypher, a PDZ-LIM domain Z-line protein, causes a severe form of congenital myopathy. J Cell Biol 2001, 155:605-612.
    • (2001) J Cell Biol , vol.155 , pp. 605-612
    • Zhou, Q.1    Chu, P.H.2    Huang, C.3    Cheng, C.F.4    Martone, M.E.5    Knoll, G.6
  • 62
    • 79954480914 scopus 로고    scopus 로고
    • Selective deletion of long but not short cypher isoforms leads to late-onset dilated cardiomyopathy
    • Cheng H., Zheng M., Peter A.K., Kimura K., Li X., Ouyang K., et al. Selective deletion of long but not short cypher isoforms leads to late-onset dilated cardiomyopathy. Hum Mol Genet 2011, 20:1751-1762.
    • (2011) Hum Mol Genet , vol.20 , pp. 1751-1762
    • Cheng, H.1    Zheng, M.2    Peter, A.K.3    Kimura, K.4    Li, X.5    Ouyang, K.6
  • 63
    • 58949087565 scopus 로고    scopus 로고
    • Cardiac-specific ablation of cypher leads to a severe form of dilated cardiomyopathy with premature death
    • Zheng M., Cheng H., Li X., Zhang J., Cui L., Ouyang K., et al. Cardiac-specific ablation of cypher leads to a severe form of dilated cardiomyopathy with premature death. Hum Mol Genet 2009, 18:701-713.
    • (2009) Hum Mol Genet , vol.18 , pp. 701-713
    • Zheng, M.1    Cheng, H.2    Li, X.3    Zhang, J.4    Cui, L.5    Ouyang, K.6
  • 64
    • 0033538565 scopus 로고    scopus 로고
    • Cypher, a striated muscle-restricted PDZ and LIM domain-containing protein, binds to alpha-actinin-2 and protein kinase C
    • Zhou Q., Ruiz-Lozano P., Martone M.E., Chen J. Cypher, a striated muscle-restricted PDZ and LIM domain-containing protein, binds to alpha-actinin-2 and protein kinase C. J Biol Chem 1999, 274:19807-19813.
    • (1999) J Biol Chem , vol.274 , pp. 19807-19813
    • Zhou, Q.1    Ruiz-Lozano, P.2    Martone, M.E.3    Chen, J.4
  • 65
    • 67649410687 scopus 로고    scopus 로고
    • Impaired binding of ZASP/cypher with phosphoglucomutase 1 is associated with dilated cardiomyopathy
    • Arimura T., Inagaki N., Hayashi T., Shichi D., Sato A., Hinohara K., et al. Impaired binding of ZASP/cypher with phosphoglucomutase 1 is associated with dilated cardiomyopathy. Cardiovasc Res 2009, 83:80-88.
    • (2009) Cardiovasc Res , vol.83 , pp. 80-88
    • Arimura, T.1    Inagaki, N.2    Hayashi, T.3    Shichi, D.4    Sato, A.5    Hinohara, K.6
  • 66
    • 84861398174 scopus 로고    scopus 로고
    • RNA-binding protein RBM24 is required for sarcomere assembly and heart contractility
    • Poon K.L., Tan K.T., Wei Y.Y., Ng C.P., Colman A., Korzh V., et al. RNA-binding protein RBM24 is required for sarcomere assembly and heart contractility. Cardiovasc Res 2012, 94:418-427.
    • (2012) Cardiovasc Res , vol.94 , pp. 418-427
    • Poon, K.L.1    Tan, K.T.2    Wei, Y.Y.3    Ng, C.P.4    Colman, A.5    Korzh, V.6
  • 67
    • 78650526355 scopus 로고    scopus 로고
    • SkNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration
    • Park C.Y., Pierce S.A., von Drehle M., Ivey K.N., Morgan J.A., Blau H.M., et al. skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration. Proc Natl Acad Sci U S A 2010, 107:20750-20755.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 20750-20755
    • Park, C.Y.1    Pierce, S.A.2    von Drehle, M.3    Ivey, K.N.4    Morgan, J.A.5    Blau, H.M.6
  • 69
    • 79961032285 scopus 로고    scopus 로고
    • Desmoplakin and talin2 are novel mRNA targets of fragile X-related protein-1 in cardiac muscle
    • Whitman S.A., Cover C., Yu L., Nelson D.L., Zarnescu D.C., Gregorio C.C. Desmoplakin and talin2 are novel mRNA targets of fragile X-related protein-1 in cardiac muscle. Circ Res 2011, 109:262-271.
    • (2011) Circ Res , vol.109 , pp. 262-271
    • Whitman, S.A.1    Cover, C.2    Yu, L.3    Nelson, D.L.4    Zarnescu, D.C.5    Gregorio, C.C.6
  • 73
    • 84893698618 scopus 로고    scopus 로고
    • Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability
    • Jiang Y., Zhang M., Qian Y., Xu E., Zhang J., Chen X. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. J Biol Chem 2014, 289:3164-3175.
    • (2014) J Biol Chem , vol.289 , pp. 3164-3175
    • Jiang, Y.1    Zhang, M.2    Qian, Y.3    Xu, E.4    Zhang, J.5    Chen, X.6
  • 74
    • 84855916545 scopus 로고    scopus 로고
    • Protein-RNA interactions: new genomic technologies and perspectives
    • Konig J., Zarnack K., Luscombe N.M., Ule J. Protein-RNA interactions: new genomic technologies and perspectives. Nat Rev Gen 2011, 13:77-83.
    • (2011) Nat Rev Gen , vol.13 , pp. 77-83
    • Konig, J.1    Zarnack, K.2    Luscombe, N.M.3    Ule, J.4
  • 75
    • 84861969926 scopus 로고    scopus 로고
    • Insights into RNA biology from an atlas of mammalian mRNA-binding proteins
    • Castello A., Fischer B., Eichelbaum K., Horos R., Beckmann B.M., Strein C., et al. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 2012, 149:1393-1406.
    • (2012) Cell , vol.149 , pp. 1393-1406
    • Castello, A.1    Fischer, B.2    Eichelbaum, K.3    Horos, R.4    Beckmann, B.M.5    Strein, C.6
  • 77
    • 17644373758 scopus 로고    scopus 로고
    • Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome
    • Scaffidi P., Misteli T. Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Nat Med 2005, 11:440-445.
    • (2005) Nat Med , vol.11 , pp. 440-445
    • Scaffidi, P.1    Misteli, T.2
  • 78
    • 80053902729 scopus 로고    scopus 로고
    • Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model
    • Hua Y., Sahashi K., Rigo F., Hung G., Horev G., Bennett C.F., et al. Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model. Nature 2011, 478:123-126.
    • (2011) Nature , vol.478 , pp. 123-126
    • Hua, Y.1    Sahashi, K.2    Rigo, F.3    Hung, G.4    Horev, G.5    Bennett, C.F.6
  • 80
    • 79959527987 scopus 로고    scopus 로고
    • Calcineurin splicing variant calcineurin Abeta1 improves cardiac function after myocardial infarction without inducing hypertrophy
    • Felkin L.E., Narita T., Germack R., Shintani Y., Takahashi K., Sarathchandra P., et al. Calcineurin splicing variant calcineurin Abeta1 improves cardiac function after myocardial infarction without inducing hypertrophy. Circulation 2011, 123:2838-2847.
    • (2011) Circulation , vol.123 , pp. 2838-2847
    • Felkin, L.E.1    Narita, T.2    Germack, R.3    Shintani, Y.4    Takahashi, K.5    Sarathchandra, P.6
  • 81
    • 79959733942 scopus 로고    scopus 로고
    • IGF-1Ea induces vessel formation after injury and mediates bone marrow and heart cross-talk through the expression of specific cytokines
    • Santini M.P., Lexow J., Borsellino G., Slonimski E., Zarrinpashneh E., Poggioli T., et al. IGF-1Ea induces vessel formation after injury and mediates bone marrow and heart cross-talk through the expression of specific cytokines. Biochem Biophys Res Commun 2011, 410:201-207.
    • (2011) Biochem Biophys Res Commun , vol.410 , pp. 201-207
    • Santini, M.P.1    Lexow, J.2    Borsellino, G.3    Slonimski, E.4    Zarrinpashneh, E.5    Poggioli, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.