Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25

Genome Biology

Volumn 2, Issue 10, 2001, Pages

  Valero, Rebeca ^a   Bayés, Mònica ^b   Francisca Sanchez Font M ^a   González Angulo, Olga ^a   Gonzàlez Duarte, Roser ^a   Marfany, Gemma ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSITAT POMPEU FABRA   (Spain)

Author keywords

Cysteine Domain; Deubiquitinating Enzyme; Down Syndrome; Fetal Brain; Human Fetal Brain cDNA Library

Indexed keywords

ISOPROTEIN; MESSENGER RNA; PROTEINASE; UBIQUITIN; UBIQUITIN SPECIFIC PROTEASE; UBIQUITIN-SPECIFIC PROTEASE; USP25 PROTEIN, HUMAN; USP28 PROTEIN, HUMAN;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ARTICLE; DOWN SYNDROME; GENETICS; HUMAN; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; RNA SPLICING; SEQUENCE HOMOLOGY; TISSUE DISTRIBUTION;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; BASE SEQUENCE; CLONING, MOLECULAR; DOWN SYNDROME; ENDOPEPTIDASES; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN ISOFORMS; RNA SPLICE SITES; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; TISSUE DISTRIBUTION; UBIQUITIN;

EID: 0035231979     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/gb-2001-2-10-research0043     Document Type: Article

References (27)

1. Hershko A, Ciechanover A: The ubiquitin system for protein degradation. Annu Rev Biochem. 1992, 61: 761-807. 10.1146/annurev.bi.61.070192.003553. DOI: 10.1146/annurev.bi.61.070192.003553
2. Hochstrasser M: Ubiquitin-dependent protein degradation. Annu Rev Genet. 1996, 30: 405-439. 10.1146/annurev.genet.30.1.405. DOI: 10.1146/annurev.genet.30.1.405
3. D'Andrea A, Pellman D: Deubiquitinating enzymes: A new class of biological regulators. Crit Rev Biochem Mol Biol. 1998, 33: 337-352. DOI: 10.1080/10409239891204251
4. Hochstrasser M: Ubiquitin, proteasomes, and the regulation of intracellular protein degradation. Curr Opin Cell Biol. 1995, 7: 215-223. 10.1016/0955-0674(95)80031-X. DOI: 10.1016/0955-0674(95)80031-X
5. Chung CH, Baek SH: Deubiquitinating enzymes: their diversity and emerging roles. Biochem Biophys Res Commun. 1999, 266: 633-640. 10.1006/bbrc.1999.1880. DOI: 10.1006/bbrc.1999.1880
6. Leroy E, Boyer R, Auburger G, Leube B, Ulm G, Mezey E, Harta G, Brownstein MJ, Jonnalagada S, Chernova T, et al: The ubiquitin pathway in Parkinson's disease. Nature. 1998, 395: 451-452. 10.1038/26652. DOI: 10.1038/26652
7. Baker RT, Tobias JW, Varshavsky A: Ubiquitin-specific proteases of Saccharomyces cerevisiae. Cloning of UBP2 and UBP3, and functional analysis of the UBP family. J Biol Chem. 1992, 267: 23364-23375.
8. Wilkinson KD: Regulation of ubiquitin-dependent processes by deubiquitinating enzymes. FASEB J. 1997, 11: 1245-1256.
9. Baker RT, Wang XW, Woollatt E, White JA, Sutherland GR: Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin specific protease related to UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases. Genomics. 1999, 59: 264-274. 10.1006/geno.1999.5879. DOI: 10.1006/geno.1999.5879
10. Papa FR, Hochstrasser M: The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene. Nature. 1993, 366: 313-319. 10.1038/366313a0. DOI: 10.1038/366313a0
11. Zhu Y, Lambert K, Corless C, Copeland NG, Gilbert DJ, Jenkins NA, D'Andrea A: DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes. J Biol Chem. 1997, 272: 51-57. 10.1074/jbc.272.1.51. DOI: 10.1074/jbc.272.1.51
12. Baek SH, Park KC, Lee JI, Kim KI, Yoo YJ, Tanaka K, Baker RT, Chung CH: A novel family of ubiquitin-specific proteases in chick skeletal muscle with distinct N- and C- terminal extensions. Biochem J. 1998, 334: 677-684. DOI: 10.1042/bj3340677
13. Frederick A, Rolfe M, Chiu MI: The human UNP locus at 3p21.31 encodes two tissue-selective, cytoplasmic isoforms with deubiquitinating activity that have reduced expression in small cell lung carcinoma cell lines. Oncogene. 1998, 16: 153-165. 10.1038/sj/onc/1201537. DOI: 10.1038/sj.onc.1201537
14. Valero R, Marfany G, Gonzalez-Angulo O, Gonzalez-Gonzalez G, Puelles L, Gonzalez-Duarte R: USP25, a novel gene encoding a deubiquitinating enzyme is located in the gene-poor region 21q11.2. Genomics. 1999, 62: 395-405. 10.1006/geno.1999.6025. DOI: 10.1006/geno.1999.6025
15. Jones MH, Furlong RA, Burkin H, Chalmers IJ, Brown GM, Khwaja O, Affara N: The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2 A. Hum Mol Genet. 1996, 5: 1695-1701. 10.1093/hmg/5.11.1695. DOI: 10.1093/hmg/5.11.1695
16. Lennon G, Auffray C, Polymeropoulos M, Soares MB: The IMAGE consortium: an integrated molecular analysis of genomes and their expression. Genomics. 1996, 33: 151-152. 10.1006/geno.1996.0177. DOI: 10.1006/geno.1996.0177
17. Sloper MK, Eyre HJ, Wang XW, Sutherland GR, Baker RT: Characterization and chromosomal localization of USP3, a novel human ubiquitin-specific protease. J Biol Chem. 1999, 274: 26878-26884. 10.1074/jbc.274.38.26878. DOI: 10.1074/jbc.274.38.26878
18. Falquet L, Paquet N, Frutiger S, Hughes GJ, Hoang-Van K, Jaton JC: A human de-ubiquitinating enzyme with both isopeptidase and peptidase activities in vitro. FEBS Lett. 1995, 359: 73-77. 10.1016/0014-5793(94)01451-6. DOI: 10.1016/0014-5793(94)01451-6
19. Wilkinson KD: Roles of ubiquitinylation in proteolysis and cellular regulation. Annu Rev Nutr. 1995, 15: 161-189. 10.1146/annurev.nu.15.070195.001113. DOI: 10.1146/annurev.nu.15.070195.001113
20. Chen X, Overstreet E, Wood SA, Fischer JA: On the conservation of function of the Drosophila Fat facets deubiquitinating enzyme and Fam, its mouse homolog. Dev Genes Evol. 2000, 210: 603-610. 10.1007/s004270000109. DOI: 10.1007/s004270000109
21. Weissman AM: Themes and variations on ubiquitylation. Nature Rev Mol Cell Biol. 2001, 2: 169-178. 10.1038/35056563. DOI: 10.1038/35056563
22. Liu LQ, Ilaria R, Kingsley PD, Iwama A, van Etten RA, Palis J, Zhang DE: A novel ubiquitin-specific protease, UBP43, cloned from leukemia fusion protein AML1-ETO-expressing mice, functions in hematopoietic cell differentiation. Mol Cell Biol. 1999, 19: 3029-3038. DOI: 10.1128/MCB.19.4.3029
23. Sun C, Skaletsky H, Birren B, Devon K, Tang Z, Silber S, Oates R, Page DC: An azoospermic man with a de novo point mutation in the Y-chromosomal gene USP9Y. Nat Genet. 1999, 23: 429-432. 10.1038/70539. DOI: 10.1038/70539
24. Schwer H, Liu LQ, Zhou LM, Little MT, Pan Z, Hetherington CJ, Zhang DE: Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (USP18). Genomics. 2000, 65: 44-52. 10.1006/geno.2000.6148. DOI: 10.1006/geno.2000.6148
25. Monney L, Otter I, Olivier R, Ozer HL, Haas AL, Omura S, Borner C: Defects in the ubiquitin pathway induce caspase-independent apoptosis blocked by Bcl-2. J Biol Chem. 1998, 273: 6121-6131. 10.1074/jbc.273.11.6121. DOI: 10.1074/jbc.273.11.6121
26. NCBI BLAST server. [http://www.ncbi.nlm.nih.gov/BLAST/]
27. Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman D: Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 1997, 25: 3389-3402. 10.1093/nar/25.17.3389. DOI: 10.1093/nar/25.17.3389