Expression of endoplasmic reticulum aminopeptidases in EBV-B cell lines from healthy donors and in leukemia/lymphoma, carcinoma, and melanoma cell lines

Journal of Immunology

Volumn 176, Issue 8, 2006, Pages 4869-4879

  Fruci, Doriana ^a   Ferracuti, Silvia ^a   Limongi, Maria Zaira ^a   Cunsolo, Veronica ^a   Giorda, Ezio ^a,b   Fraioli, Rocco ^b   Sibilio, Leonardo ^b   Carroll, Oliver ^c   Hattori, Akira ^d   Van Endert, Peter M ^c   Giacomini, Patrizio ^b  

^a BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^c INSERM   (France)

^d INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPEPTIDASE; ERAP1 PROTEIN; ERAP2 PROTEIN; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 1 H CHAIN; PEPTIDE; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING 1; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CANCER CELL CULTURE; CARCINOMA CELL; CARCINOMA CELL LINE; CELL LINE; CELL STRAIN; CELL STRAIN EBV B; DONOR; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOSURVEILLANCE; LEUKEMIA CELL LINE; LYMPHOMA CELL LINE; MELANOMA CELL; MELANOMA CELL LINE; MICROSOME; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; QUANTITATIVE ANALYSIS; TUMOR ESCAPE;

EID: 33645754224     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.8.4869     Document Type: Article

References (34)

1. Taylor, A. 1993. Aminopeptidases: structure and function. FASEB J. 7: 290-298.
2. Rock, K. L., and A. L. Goldberg. 1999. Degradation of cell proteins and the generation of MHC class I-presented peptides. Annu. Rev. Immunol 17: 739-779.
3. Reits, E., J. Neijssen, C. Herberts, W. Benckhuijsen, L. Janssen, J. W. Drijfhout, and J. Neefjes. 2004. A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation. Immunity 20: 495-506.
4. York, I. A., A. X. Mo, K. Lemerise, W. Zeng, Y. Shen, C. R. Abraham, T. Saric, A. L. Goldberg, and K. L. Rock. 2003. The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation. Immunity 18: 429-440.
5. Reits, E., A. Griekspoor, J. Neijssen, T. Groothuis, K. Jalink, P. van Veelen, H. Janssen, J. Calafat, J. W. Drijfhout, and J. Neefjes. 2003. Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I. Immunity 18: 97-108.
6. Fruci, D., G. Niedermann, R. H. Butler, and P. M. van Endert. 2001. Efficient MHC class I-independent amino-terminal trimming of epitope precursor peptides in the endoplasmic reticulum. Immunity 15: 467-476.
7. Serwold, T., S. Gaw, and N. Shastri. 2001. ER aminopeptidases generate a unique pool of peptides for MHC class I molecules. Nat. Immunol. 2: 644-651.
8. Serwold, T., F. Gonzalez, J. Kim, R. Jacob, and N. Shastri. 2002. ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum. Nature 419: 480-483.
9. Saric, T., S. C. Chang, A. Hattori, I. A. York, S. Markant, K. L. Rock, M. Tsujimoto, and A. L. Goldberg. 2002. An IFN-γ-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides. Nat. Immunol. 3: 1169-1176.
10. Hattori, A., H. Matsumoto, S. Mizutani, and M. Tsujimoto. 1999. Molecular cloning of adipocyte-derived leucine aminopeptidase highly related to placental leucine aminopeptidase/oxytocinase. J. Biochem. 125: 931-938.
11. Schomburg, L., H. Kollmus, S. Friedrichsen, and K. Bauer. 2000. Molecular characterization of a puromycin-insensitive leucyl-specific aminopeptidase, PILS-AP. Eur. J. Biochem. 267: 3198-3207.
12. Cui, X., F. Hawaii, S. Alsaaty, M. Lawrence, C. A. Combs, W. Geng, F. N. Rouhani, D. Miskinis, and S. J. Levine. 2002. Identification of ARTS-1 as a novel TNFR1-binding protein that promotes TNFR1 ectodomain shedding. J. Clin. Invest. 110: 515-526.
13. Tanioka, T., A. Hattori, S. Masuda, Y. Nomura, H. Nakayama, S. Mizutani, and M. Tsujimoto. 2003. Human leukocyte-derived arginine aminopeptidase: the third member of the oxytocinase subfamily of aminopeptidases. J. Biol. Chem. 278: 32275-32283.
14. Saveanu, L., Carroll, O., Lindo, V., Del Val, M., Lopez, D., Lepelletier, Y., Greer, F., Schomburg, L., Fruci, D., Niedermann, G., and van Enden, P. 2005. Human aminopeptidases ERAP1 and ERAP2 associate for concerted peptide trimming in the endoplasmic reticulum. Nat. Immunol. 6: 689-697.
15. Momburg, F., J. Roelse, G. J. Hammerling, and J. J. Neefjes. 1994. Peptide size selection by the major histocompatibility complex-encoded peptide transporter. J. Exp. Med. 179: 1613-1623.
16. York, I. A., S. C. Chang, T. Saric, J. A. Keys, J. M. Favreau, A. L. Goldberg, and K. L. Rock. 2002. The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues. Nat. Immunol. 3: 1177-1184.
17. Marincola, F. M., E. M. Jaffee, D. J. Hicklin, and S. Ferrone. 2000. Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance. Adv. Immunol. 74: 181-273.
18. Hattori, A., K. Kitatani, H. Matsumoto, S. Miyazawa, T. Rogi, N. Tsuruoka, S. Mizutani, Y. Natori, and M. Tsujimoto. 2000. Characterization of recombinant human adipocyte-derived leucine aminopeptidase expressed in Chinese hamster ovary cells. J. Biochem. 128: 755-762.
19. Stam, N. J., H. Spits, and H. L. Ploegh. 1986. Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of certain HLA-C locus products. J. Immunol. 137: 2299-2306.
20. Sernee, M. F., H. L. Ploegh, and D. J. Schust. 1998. Why certain antibodies cross-react with HLA-A and HLA-G: epitope mapping of two common MHC class I reagents. Mol. Immunol. 35: 177-188.
21. Barnstable, C. J., W. F. Bodmer, G. Brown, G. Galfre, C. Milstein, A. F. Williams, and A. Ziegler. 1978. Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis. Cell 14: 9-20.
22. Kovats, S., E. K. Main, C. Librach, M. Stubblebine, S. J. Fisher, and R. DeMars. 1990. A class I antigen, HLA-G, expressed in human trophoblasts. Science 248: 220-223.
23. Giorda, E., L. Sibilio, A. Martayan, S. Moretti, I. Venturo, M. Mottolese, G. B. Ferrara, S. Cappellacci, L. Eibenschutz, C. Catricala, P. Grammatico, and P. Giacomini. 2003. The antigen processing machinery of class I human leukocyte antigens: linked patterns of gene expression in neoplastic cells. Cancer Res. 63: 4119-4127.
24. Salter, R. D., and P. Cresswell. 1986. Impaired assembly and transport of HLA-A and -B antigens in a mutant TxB cell hybrid. EMBO J. 5: 943-949.
25. Shimizu, Y., D. E. Geraghty, B. H. Koller, H. T. Orr, and R. DeMars. 1988. Transfer and expression of three cloned human non-HLA-A,B,C class I major histocompatibility complex genes in mutant lymphoblastoid cells. Proc. Natl. Acad. Sci. USA 85: 227-231.
26. Grandea, A. G. III, M. J. Androlewicz, R. S. Athwal, D. E. Geraghty, and T. Spies. 1995. Dependence of peptide binding by MHC class I molecules on their interaction with TAP. Science 270: 105-108.
27. Browning, M. J., J. A. Madrigal, P. Krausa, H. Kowalski, C. E. Allsopp, A. M. Little, S. Turner, E. J. Adams, K. L. Amett, W. F. Bodmer, et al. 1995. The HLA-A,B,C genotype of the class I negative cell line Daudi reveals novel HLA-A and -B alleles. Tissue Antigens 45: 177-187.
28. Guillaudeux, T., A. M. Rodriguez, M. Girr, V. Mallet, S. A. Ellis, I. L. Sargent, R. Fauchet, E. Alsat, and P. Le Bouteiller. 1995. Methylation status and transcriptional expression of the MHC class I loci in human trophoblast cells from term placenta. J. Immunol. 154: 3283-3299.
29. Santamaria, P., A. L. Lindstrom, M. T. Boyce-Jacino, S. H. Myster, J. J. Barbosa, A. J. Faras, and S. S. Rich. 1993. HLA class I sequence-based typing. Hum. Immunol. 37: 39-50.
30. Delfino, L., G. Ciccarelli, D. Bini, A. Morabito, S. Pozzi, A. Martayan, E. Giorda, A. Setini, R. Fraioli, P. Giacomini, and G. B. Ferrara. 1999. HLA-A, -B, -C genotyping and expression in human nonlymphoid tumor cell lines. J. Immunother. 22: 7-15.
31. Pollack, M. S., S. D. Heagney, P. O. Livingston, and J. Fogh. 1981. HLA-A, B, C and DR alloantigen expression on forty-six cultured human tumor cell lines. J. Natl. Cancer Inst. 66: 1003-1012.
32. 2-microglobulin. Hum. Immunol. 53: 23-33.
33. Hammer, G. E., F. Gonzalez, M. Champsaur, D. Cado, and N. Shastri. 2006. The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules. Nat. Immunol. 7: 103-112.
34. Chang, S. C., F. Momburg, N. Bhutani, and A. L. Goldberg. 2005. The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism. Proc. Natl. Acad. Sci. USA 102: 17107-17112.