2,5-Dimethylfuran (DMFu): An internal standard for the "Traceless" quantitation of unknown samples via 1H NMR

Journal of Combinatorial Chemistry

Volumn 2, Issue 1, 2000, Pages 39-41

  Gerritz, Samuel W ^a   Sefler, Andrea M ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0002780599     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc990041v     Document Type: Article

References (18)

1. Reviews: (a) Brown, A. R.: Hermkens, P. H. H.; Ottenheijm, H. C. J.; Rees, D. C. Synlett 1998, 817.
2. (b) Thompson, L. A.; Ellman, J. A. Chem. Rev. 1996, 96, 555.
3. (c)Hermkens, P. H. H.; Ottenheijm, H. C. J.; Rees, D. C. Tetrahedron 1997, 53, 5643.
4. Reviews: (a) Bailey, N.; Cooper, A. W. J.; Deal, M. J.; Dean, A. W.; Gore A. L.; Hawes, M. C.; Judd, D. B.; Merritt, A. T.; Storer, R.; Travers, S.; Watson, S. P. Chimia 1997, 51, 832.
5. (b) Merritt, A. T. Comb. Chem. High Throughput Screening 1998, 1, 57.
6. Czarnik, A. W. Anal. Chem. 1998, 70, 378A.
7. Kyranos, J. N.; Hogan, J. C., Jr. Anal. Chem. 1998, 70, 389A.
8. Fujinari, E. M.; Manes, J. D. J. Chromatogr., A 1994, 676, 113.
9. (b) Fitch, W. L.; Szardenings, A. K.; Fujinari, E. M. Tetrahedron Lett. 1997, 38, 1689.
10. (c) Taylor, E. W.; Qian, M. G.; Dollinger, G. D. Anal. Chem. 1998, 70, 3339.
11. Rabenstein, D. L.; Keire, D. A. Pract. Spectrosc. 1991, 11, 323-69.
12. (b) Szantay, C., Jr. Trends Anal. Chem. 1992, 11, 332.
13. Keifer, P. A. Drug Discovery Today, 1997, 2, 468.
14. (b) Keifer, P. A. Drugs Future 1998, 23, 301
15. For recent examples, see: (a) Hamper, B. C.; Kolodziej, S. A.; Scates, A. M.; Smith, R. G.; Cortez, E. J. Org. Chem. 1998, 63, 708.
16. (b) Hamper, B. C.; Snyderman, D. M.; Owen, T. J.; Scates, A. M.; Owsley, D. C.; Kesselring, A. S.; Chott, R. C. J. Comb. Chem. 1999, 1, 140.
17. Clearly, some peak overlap is inevitable, but a careful examination of "general regions of chemical shifts" (as found in Gordon, A. J.; Ford, R. A The Chemist's Companion; John Wiley and Sons: New York, 1972; pp 252-255) suggested to us that the 5.5-6.0 ppm region of the NMR spectrum offers the best compromise between signal overlap and proximity to the aromatic region of the spectrum.
18. 1 for DMFu to be 6.2 s.