Disulfide cyclized tripeptide analogues of angiotensin IV as potent and selective inhibitors of insulin-regulated aminopeptidase (IRAP)

Journal of Medicinal Chemistry

Volumn 53, Issue 22, 2010, Pages 8059-8071

  Andersson, Hanna ^a   Demaegdt, Heidi ^b   Vauquelin, Georges ^b   Lindeberg, Gunnar ^a   Karlén, Anders ^a   Hallberg, Mathias ^a   Erdélyi, Máté ^c   Hallberg, Anders ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPEPTIDASE; ANGIOTENSIN II [3-8]; DISULFIDE; INSULIN REGULATED AMINOPEPTIDASE; INSULIN REGULATED AMINOPEPTIDASE INHIBITOR; PEPTIDE HYDROLASE INHIBITOR; PHENYLACETIC ACID; TRIPEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL LINE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; MONTE CARLO METHOD; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANGIOTENSIN II; ANIMALS; CELL LINE; CRICETINAE; CRICETULUS; CYSTINYL AMINOPEPTIDASE; DISULFIDES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MONTE CARLO METHOD; OLIGOPEPTIDES; PEPTIDES, CYCLIC; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78649500321     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100793t     Document Type: Article

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