Design and synthesis of potent and multifunctional aldose reductase inhibitors based on quinoxalinones

Journal of Medicinal Chemistry

Volumn 58, Issue 3, 2015, Pages 1254-1267

  Qin, Xiangyu ^a   Hao, Xin ^a   Han, Hui ^a   Zhu, Shaojuan ^a   Yang, Yanchun ^a   Wu, Bobin ^a   Hussain, Saghir ^a   Parveen, Shagufta ^a   Jing, Chaojun ^a   Ma, Bing ^a   Zhu, Changjin ^a  

^a BEIJING INSTITUTE OF TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 [3 (2,4 DIHYDROXYPHENYL) 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; 2 [3 (2,4 DIHYDROXYPHENYL) 7 FLUORO 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; 2 [3 (3 INDOLYL) 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; 2 [3 (3 METHOXY 4 HYDROXYSTYRYL) 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; 2 [3 (4 FLUOROPHENYL) 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; 2 [3 (4 HYDROXYPHENETHYL) 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; 2 [3 (4 HYDROXYPHENYL) 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; 2 [3 (4 HYDROXYSTYRYL) 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; 2 [3 (4 METHOXYSTYRYL) 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; 2 [3 PHENYL 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; 2 [3,7 BIS(4 FLUOROPHENYL) 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; 2 [6 BROMO 3 (2,4 DIHYDROXYPHENYL) 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; 2 [6 CHLORO 3 (2,4 DIHYDROXYPHENYL) 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; 2 [6 FLUORO 3 (2,4 DIHYDROXYPHENYL) 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; 2 [7 (4 FLUOROBENZYL) 3 (2,4 DIHYDROXYPHENYL) 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; 2 [7 BROMO 3 (2,4 DIHYDROXYPHENYL) 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; 2 [7 BROMO 3 (3 INDOLYL) 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; 2 [7 CHLORO 3 (2 BENZOTHIOPHENE) 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; 2 [7 CHLORO 3 (2,4 DIHYDROXYPHENYL) 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; 2 [7 CHLORO 3 (4 FLUOROPHENYL) 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; 2 [7 FLUORO 3 (2,4 DIHYDROXYPHENYL) 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; 2 [7 FLUORO 3 (4 FLUOROPHENYL) 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; 2 [7 FLUORO 3 (4 HYDROXYPHENETHYL) 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; 2 [7 FLUORO 3 (4 HYDROXYSTYRYL) 2 OXOQUINOXALIN 1(2H) YL]ACETIC ACID; ALDOSE REDUCTASE INHIBITOR; ANTIOXIDANT; EPALRESTAT; QUINOXALINE DERIVATIVE; TROLOX C; UNCLASSIFIED DRUG; UNINDEXED DRUG; ALDEHYDE REDUCTASE; ENZYME INHIBITOR;

ANTIOXIDANT ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONCENTRATION (PARAMETERS); DPPH RADICAL SCAVENGING ASSAY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROGEN BOND; IC50; LIPID PEROXIDATION; MOLECULAR DOCKING; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HUMAN; METABOLISM; SYNTHESIS;

ALDEHYDE REDUCTASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; LIPID PEROXIDATION; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; QUINOXALINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84922784873     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501484b     Document Type: Article

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