A novel polymorphism in the aldose reductase gene promoter region is strongly associated with diabetic retinopathy in adolescents with type 1 diabetes

Diabetes

Volumn 48, Issue 6, 2000, Pages 1338-1340

  Kao, Yan Lin ^a,b   Donaghue, Kim ^a,c   Chan, Albert ^a   Knight, John ^b   Silink, Martin ^a,c  

^a CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^b CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE REDUCTASE;

ADOLESCENT; ARTICLE; CONTROLLED STUDY; DIABETIC RETINOPATHY; FEMALE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION;

ADOLESCENT; ALDEHYDE REDUCTASE; CHILD; DIABETES MELLITUS, TYPE 1; DIABETIC RETINOPATHY; FEMALE; GENETIC MARKERS; GENOTYPE; HUMANS; MALE; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS);

EID: 0345161817     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.6.1338     Document Type: Article

References (14)

1. Heesom AE, Hibberd ML, Millward A, Demaine AG: Polymorphism in the 5′-end of the aldose reductase gene is strongly associated with the development of diabetic nephropathy in type 1 diabetes. Diabetes 64:287-291, 1997
2. n dinucleotide repeat polymorphic marker at the 5′ end of the aldose reductase gene is associated with early-onset diabetic retinopathy in NIDDM patients. Diabetes 44:727-732, 1995
3. Vallabh OS, Marina S, Jovanka N, Yijuan S: Z-2 microsatellite allele is linked to increased expression of the aldose reductase gene in diabetic nephropathy. J Clin Endocrinol Metab 83:2886-2891, 1998
4. Hamada Y, Kitoh R, Paskin P: Crucial role of aldose reductase activity and plasma glucose level in sorbitol accumulation in erythrocytes from diabetic patients. Diabetes 40:1233-1240, 1991
5. Kinoshita JH, Fukushi S, Kador P, Merola LO: Aldose reductase in diabetic complications of the eye. Metabolism 28 (Suppl. 1):462-469, 1979
6. Dent MT, Tebbs SE, Gonzalez AM, Ward JM, Wilson RM: Neutrophil aldose reductase activity and its association with established diabetic microvascular complications. Diabet Med 8:439-442, 1994
7. Shah VO, Dorin RI, Sun Y, Braun M, Zager PG: Aldose reductase gene expression is increased in diabetic nephropathy. J. Clin Endocrinol Metab 82: 2294-2298, 1997
8. Hamada H, Kitoh R, Paskin P: Association of erythrocyte aldose reductase activity with diabetic complications in type 1 diabetes mellitus. Diabet Med 10:33-38, 1993
9. Hamada Y, Kitoh R, Raskin P: Increased activity of erythrocyte aldose reductase in insulin-independent diabetes with severe diabetic complications. Diabet Med 8:226-231, 1991
10. Carr LM, Markham AF: Molecular genetic analysis of the human sorbitol dehydrogenase gene. Mammalian Genome 6:645-652, 1995
11. Ruepp B, Bohren KM, Gabbay KH: Characterisation of the osmotic response element of the human aldose reductase gene promoter. Proc Natl Acad Sci U S A 93:8624-8629, 1996
12. Sorbinil Retinopathy Trial Research Group: The sorbinil retinopathy trial: neuropathy results. Neurology 43:1141-1149, 1993
13. Graham A, Brown L, Hedgen PL, Gammack AJ, Markham AF: Structure of human aldose reductase gene. J Biol Chem 266:6872-6877, 1991
14. Wang K, Bohren KM, Gabbay KH: Characterisation of human aldose reductase gene promoter. J Biol Chem 268:16052-16058, 1993