1,2-Benzothiazine 1,1-dioxide carboxylate derivatives as novel potent inhibitors of aldose reductase

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 23, 2011, Pages 7262-7269

  Chen, Xin ^a   Zhang, Shuzhen ^a   Yang, Yanchun ^a   Hussain, Saghir ^a   He, Minlan ^a   Gui, Dequan ^a   Ma, Bing ^a   Jing, Chaojun ^a   Qiao, Zhixin ^b   Zhu, Changjin ^a   Yu, Qun ^b  

^a BEIJING INSTITUTE OF TECHNOLOGY   (China)

^b BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

1,2 Benzothiazine 1,1 dioxide; Aldose reductase; Inhibitor

Indexed keywords

1,2 BENZOTHIAZINE 1,1 DIOXIDE ACETIC ACID DERIVATIVE; 1,2 BENZOTHIAZINE 1,1 DIOXIDE CARBOXYLATE DERIVATIVE; 2 (2,4,5 TRIFLUOROBENZYL) 2H 1,2 BENZOTHIAZIN 4(3H) ONE 1,1 DIOXIDE; 2 (3 NITROBENZYL) 2H 1,2 BENZOTHIAZIN 4(3H) ONE 1,1 DIOXIDE; 2 (4 BROMO 2 FLUOROBENZYL) 2H 1,2 BENZOTHIAZIN 4(3H) ONE 1,1 DIOXIDE; 2 [2 (2 FLUOROBENZYL) 1,1 DIOXIDO 2H 1,2 BENZOTHIAZIN 4(3H) YLIDENE]ACETIC ACID METHYL ESTER; 2 [2 (2 FLUOROBENZYL) 1,1 DIOXIDO 3,4 DIHYDRO 2H 1,2 BENZOTHIAZIN YL]ACETIC ACID METHYL ESTER; 2 [2 (2,4,5 TRIFLUOROBENZYL) 1,1 DIOXIDO 2H 1,2 BENZOTHIAZIN 4(3H) YLIDENE]ACETIC ACID; 2 [2 (2,4,5 TRIFLUOROBENZYL) 1,1 DIOXIDO 2H 1,2 BENZOTHIAZIN 4(3H) YLIDENE]ACETIC ACID METHYL ESTER; 2 [2 (2,4,5 TRIFLUOROBENZYL) 1,1 DIOXIDO 3,4 DIHYDRO 2H 1,2 BENZOTHIAZIN YL]ACETIC ACID METHYL ESTER; 2 [2 (3 NITROBENZYL) 1,1 DIOXIDO 2H 1,2 BENZOTHIAZIN 4(3H) YLIDENE]ACETIC ACID METHYL ESTER; 2 [2 (4 BROMO 2 FLUOROBENZYL) 1,1 DIOXIDO 2H 1,2 BENZOTHIAZIN 4(3H) YLIDENE]ACETIC ACID METHYL ESTER; 2 [2 (4 BROMO 2 FLUOROBENZYL)1,1 DIOXIDO 2H 1,2 BENZOTHIAZIN 4(3H) YLIDENE]ACETIC ACID; 2 [2 [3,5 BIS( TRIFLUOROMETHYL)BENZYL] 1,1 DIOXIDO 2H 1,2 BENZOTHIAZIN 4(3H) YLIDENE]ACETIC ACID METHYL ESTER; 2 [2 [3,5 BIS(TRIFLUOROMETHYL)BENZYL] 1,1 DIOXIDO 3,4 DIHYDRO 2H 1,2 BENZOTHIAZIN YL]ACETIC ACID METHYL ESTER; 2 [2 [4 (TRIFLUOROMETHYL)BENZYL] 1,1 DIOXIDO 2H 1,2 BENZOTHIAZIN 4(3H) YLIDENE]ACETIC ACID METHYL ESTER; 2 [2 [4 (TRIFLUOROMETHYL)BENZYL] 1,1 DIOXIDO 3,4 DIHYDRO 2H 1,2 BENZOTHIAZIN YL]ACETIC ACID METHYL ESTER; 2 [3,5 BIS(TRIFLUOROMETHYL)BENZYL] 2H 1,2 BENZOTHIAZIN 4(3H) ONE 1,1 DIOXIDE; 2[4 (TRIFLUOROMETHYL)BENZYL] 2H 1,2 BENZOTHIAZIN 4(3H) ONE 1,1 DIOXIDE; 2H 1,2 BENZOTHIAZIN 4(3H) ONE 1,1 DIOXIDE; ALDOSE REDUCTASE INHIBITOR; EPALRESTAT; FIDARESTAT; LIDORESTAT; METHYL 4 HYDROXY 2H 1,2 BENZOTHIAZINE 3 CARBOXYLATE 1,1 DIOXIDE; METHYL [1,1 DIOXIDO 3 OXO 1,2 BENZISOTHIAZOL 2(3H) YL]ACETATE; RANIRESTAT; SORBINIL; TOLRESTAT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; MOLECULAR MODEL; STEREOISOMERISM;

ALDEHYDE REDUCTASE; ANIMALS; CARBOXYLIC ACIDS; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZINES;

EID: 80655136956     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.07.051     Document Type: Article

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