Oxidative stress induces gastric submucosal arteriolar dysfunction in the elderly

World Journal of Gastroenterology

Volumn 19, Issue 48, 2013, Pages 9439-9446

  Liu, Lei ^a   Liu, Yan ^a   Cui, Jie ^a   Liu, Hong ^a   Liu, Yan Bing ^a   Qiao, Wei Li ^a   Sun, Hong ^a   Yan, Chang Dong ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Aging; Gastric blood flow; Human; Oxidative stress; Vascular dysfunction

Indexed keywords

CHOLESTEROL; COLLAGEN FIBER; GLUCOSE; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; MALONALDEHYDE; MANGANESE SUPEROXIDE DISMUTASE; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; XANTHINE OXIDASE;

ADULT; AGED; AGING; ANTIOXIDANT ACTIVITY; ARTICLE; CLINICAL ARTICLE; DIASTOLIC BLOOD PRESSURE; DIGESTIVE SYSTEM DISEASE; GASTRIC SUBMUCOSAL ARTERIOLAR DYSFUNCTION; HISTOLOGY; HUMAN; HUMAN TISSUE; MALE; MIDDLE AGED; OXIDATIVE STRESS; PROTEIN EXPRESSION; SYSTOLIC BLOOD PRESSURE; VASODILATATION; VERY ELDERLY; WESTERN BLOTTING; YOUNG ADULT;

AGING; GASTRIC BLOOD FLOW; HUMAN; OXIDATIVE STRESS; VASCULAR DYSFUNCTION;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; ARTERIOLES; GASTRIC MUCOSA; GLUTATHIONE PEROXIDASE; HUMANS; HYDROGEN PEROXIDE; MALE; MALONDIALDEHYDE; MIDDLE AGED; OXIDATIVE STRESS; SUPEROXIDE DISMUTASE; VASODILATION; VASODILATOR AGENTS; XANTHINE OXIDASE;

EID: 84891448681     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v19.i48.9439     Document Type: Article

References (38)

1. Grassi M, Petraccia L, Mennuni G, Fontana M, Scarno A, Sabetta S, Fraioli A. Changes, functional disorders, and diseases in the gastrointestinal tract of elderly. Nutr Hosp 2011; 26: 659-668 [PMID: 22470008 DOI: 10.1590/S0212-16112011000400001]
2. Feldman M, Cryer B, McArthur KE, Huet BA, Lee E. Effects of aging and gastritis on gastric acid and pepsin secretion in humans: a prospective study. Gastroenterology 1996; 110: 1043-1052 [PMID: 8612992 DOI: 10.1053/gast.1996.v110. pm8612992]
3. van Asselt DZ, van den Broek WJ, Lamers CB, Corstens FH, Hoefnagels WH. Free and protein-bound cobalamin absorption in healthy middle-aged and older subjects. J Am Geriatr Soc 1996; 44: 949-953 [PMID: 8708306]
4. Somerville K, Faulkner G, Langman M. Non-steroidal anti-inflammatory drugs and bleeding peptic ulcer. Lancet 1986; 1: 462-464 [PMID: 2869207 DOI: 10.1016/S0140-6736(86)92927-2]
5. Petersson J, Phillipson M, Jansson EA, Patzak A, Lundberg JO, Holm L. Dietary nitrate increases gastric mucosal blood flow and mucosal defense. Am J Physiol Gastrointest Liver Physiol 2007; 292: G718-G724 [PMID: 17082222 DOI: 10.1152/ ajpgi.00435.2006]
6. Abdel-Salam OM, Czimmer J, Debreceni A, Szolcsányi J, Mózsik G. Gastric mucosal integrity: gastric mucosal blood flow and microcirculation. An overview. J Physiol Paris 2001; 95: 105-127 [PMID: 11595425 DOI: 10.1016/ S0928-4257(01)00015-8]
7. Cheung LY, Chang N. The role of gastric mucosal blood flow and H+ back-diffusion in the pathogenesis of acute gastric erosions. J Surg Res 1977; 22: 357-361 [PMID: 191698 DOI:10.1016/0022-4804(77)90157-3]
8. Guth PH. Current concepts in gastric microcirculatory pathophysiology. Yale J Biol Med 1992; 65: 677-688 [PMID: 1341071]
9. Kawano S, Tsuji S. Role of mucosal blood flow: a conceptional review in gastric mucosal injury and protection. J Gastroenterol Hepatol 2000; 15 Suppl: D1-D6 [PMID: 10759213 DOI: 10.1046/j.1440-1746.2000.02142.x]
10. Leung FW, Itoh M, Hirabayashi K, Guth PH. Role of blood flow in gastric and duodenal mucosal injury in the rat. Gastroenterology 1985; 88: 281-289 [PMID: 3964777 DOI: 10.1016/ S0016-5085(85)80181-5]
11. Sato N, Kawano S, Tsuji S, Ogihara T, Yamada S. Gastric blood flow in ulcer diseases. Scand J Gastroenterol Suppl 1995; 208: 14-20 [PMID: 7777796 DOI: 10.3109/00365529509107756]
12. Stein HJ, Bauerfeind P, Hinder RA, Koerfer J, Blum AL. Luminal acid reduces gastric mucosal blood flow in the ischemic stomach. J Surg Res 1989; 46: 616-619 [PMID: 2733421 DOI: 10.1016/0022-4804(89)90031-0]
13. Whittle BJ, Kauffman GL, Moncada S. Vasoconstriction with thromboxane A2 induces ulceration of the gastric mucosa. Nature 1981; 292: 472-474 [PMID: 7195986 DOI:10.1038/292472a0]
14. Cosentino F, Francia P, Camici GG, Pelicci PG, Lüscher TF, Volpe M. Final common molecular pathways of aging and cardiovascular disease: role of the p66Shc protein. Arterioscler Thromb Vasc Biol 2008; 28: 622-628 [PMID: 18162611 DOI: 10.1161/ATVBAHA.107.156059]
15. Rodriguez R, Redman R. Balancing the generation and elimination of reactive oxygen species. Proc Natl Acad Sci USA 2005; 102: 3175-3176 [PMID: 15728396 DOI: 10.1073/ pnas.0500367102]
16. Aslan M, Ozben T. Reactive oxygen and nitrogen species in Alzheimer's disease. Curr Alzheimer Res 2004; 1: 111-119 [PMID: 15975075 DOI: 10.2174/1567205043332162]
17. Thomas MP, Chartrand K, Reynolds A, Vitvitsky V, Banerjee R, Gendelman HE. Ion channel blockade attenuates aggregated alpha synuclein induction of microglial reactive oxygen species: relevance for the pathogenesis of Parkinson' s disease. J Neurochem 2007; 100: 503-519 [PMID: 17241161 DOI: 10.1111/j.1471-4159.2006.04315.x]
18. Moreau KL, Gavin KM, Plum AE, Seals DR. Ascorbic acid selectively improves large elastic artery compliance in postmenopausal women. Hypertension 2005; 45: 1107-1112 [PMID: 15867135 DOI: 10.1161/01.HYP.0000165678.63373.8c]
19. Yan C, Huang A, Wu Z, Kaminski PM, Wolin MS, Hintze TH, Kaley G, Sun D. Increased superoxide leads to decreased flow-induced dilation in resistance arteries of Mn-SOD-deficient mice. Am J Physiol Heart Circ Physiol 2005; 288: H2225-H2231 [PMID: 15637112 DOI: 10.1152/ajpheart.01036.2004]
20. Voelker R. IOM: focus on care for aging population. JAMA 2008; 299: 2611-2613 [PMID: 18544715 DOI: 10.1001/ jama.299.22.2611]
21. Marín J. Age-related changes in vascular responses: a review. Mech Ageing Dev 1995; 79: 71-114 [PMID: 7616768 DOI:10.1016/0047-6374(94)01551-V]
22. Yang JL, Weissman L, Bohr VA, Mattson MP. Mitochondrial DNA damage and repair in neurodegenerative disorders. DNA Repair (Amst) 2008; 7: 1110-1120 [PMID: 18463003 DOI:10.1016/j.dnarep.2008.03.012]
23. Slemmer JE, Shacka JJ, Sweeney MI, Weber JT. Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging. Curr Med Chem 2008; 15: 404-414 [PMID: 18288995 DOI: 10.2174/092986708783497337]
24. Brandes RP, Fleming I, Busse R. Endothelial aging. Cardiovasc Res 2005; 66: 286-294 [PMID: 15820197 DOI: 10.1016/ j.cardiores.2004.12.027]
25. Rajapakse AG, Yepuri G, Carvas JM, Stein S, Matter CM, Scerri I, Ruffieux J, Montani JP, Ming XF, Yang Z. Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition by resveratrol. PLoS One 2011; 6: e19237 [PMID: 21544240 DOI: 10.1371/journal.pone.0019237]
26. Romano AD, Serviddio G, de Matthaeis A, Bellanti F, Vendemiale G. Oxidative stress and aging. J Nephrol 2010; 23 Suppl 15: S29-S36 [PMID: 20872368]
27. Oeseburg H, Iusuf D, van der Harst P, van Gilst WH, Henning RH, Roks AJ. Bradykinin protects against oxidative stress-induced endothelial cell senescence. Hypertension 2009; 53: 417-422 [PMID: 19075096 DOI: 10.1161/HYPERTENSIONAHA.108.123729]
28. Alvarez de Sotomayor M, Mingorance C, Andriantsitohaina R. Fenofibrate improves age-related endothelial dysfunction in rat resistance arteries. Atherosclerosis 2007; 193: 112-120 [PMID: 16979646 DOI: 10.1016/j.atherosclerosis.2006.08.041]
29. Trott DW, Gunduz F, Laughlin MH, Woodman CR. Exercise training reverses age-related decrements in endotheliumdependent dilation in skeletal muscle feed arteries. J Appl Physiol (1985) 2009; 106: 1925-1934 [PMID: 19299569 DOI:10.1152/japplphysiol.91232.2008]
30. Kamada T, Kawano S, Sato N, Fukuda M, Fusamoto H, Abe H. Gastric mucosal blood distribution and its changes in the healing process of gastric ulcer. Gastroenterology 1983; 84: 1541-1546 [PMID: 6840484]
31. Liu L, Cui J, Song CJ, Bian JS, Sparatore A, Soldato PD, Wang XY, Yan CD. H(2)S-releasing aspirin protects against aspirin-induced gastric injury via reducing oxidative stress. PLoS One 2012; 7: e46301 [PMID: 23029468 DOI: 10.1371/ journal.pone.0046301]
32. Schafer FQ, Buettner GR. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/ glutathione couple. Free Radic Biol Med 2001; 30: 1191-1212 [PMID: 11368918 DOI: 10.1016/S0891-5849(01)00480-4]
33. Metwally NS, Ali SA, Mohamed AM, Khaled HM, Ahmed SA. Levels of certain tumor markers as differential factors between bilharzial and non-biharzial bladder cancer among Egyptian patients. Cancer Cell Int 2011; 11: 8 [PMID: 21473769 DOI: 10.1186/1475-2867-11-8]
34. Nishino T, Okamoto K, Eger BT, Pai EF, Nishino T. Mammalian xanthine oxidoreductase-mechanism of transition from xanthine dehydrogenase to xanthine oxidase. FEBS J 2008; 275: 3278-3289 [PMID: 18513323 DOI: 10.1111/j.1742-4658.2008.06489. x]
35. Vacek TP, Gillespie W, Tyagi N, Vacek JC, Tyagi SC. Hydrogen sulfide protects against vascular remodeling from endothelial damage. Amino Acids 2010; 39: 1161-1169 [PMID: 20352463 DOI: 10.1007/s00726-010-0550-2]
36. Nishiyama SK, Wray DW, Richardson RS. Aging affects vascular structure and function in a limb-specific manner. J Appl Physiol (1985) 2008; 105: 1661-1670 [PMID: 18719234 DOI: 10.1152/japplphysiol.90612.2008]
37. Ozbay B, Dülger H. Lipid peroxidation and antioxidant enzymes in Turkish population: relation to age, gender, exercise, and smoking. Tohoku J Exp Med 2002; 197: 119-124 [PMID: 12233785 DOI: 10.1620/tjem.197.119]
38. Rattan SI. Theories of biological aging: genes, proteins, and free radicals. Free Radic Res 2006; 40: 1230-1238 [PMID: 17090411 DOI: 10.1080/10715760600911303]