-
1
-
-
0041343303
-
Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease
-
An W.L., Cowburn R.F., Li L., Braak H., Alafuzoff I., Iqbal K., Iqbal I.G., Winblad B., Pei J.J. Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease. Am. J. Pathol. 2003, 163:591-607.
-
(2003)
Am. J. Pathol.
, vol.163
, pp. 591-607
-
-
An, W.L.1
Cowburn, R.F.2
Li, L.3
Braak, H.4
Alafuzoff, I.5
Iqbal, K.6
Iqbal, I.G.7
Winblad, B.8
Pei, J.J.9
-
2
-
-
0026477133
-
Lysosomal proteinases as putative diagnostic tools in human neuropathology: Alzheimer disease (AD) and schizophrenia
-
Bernstein H.G., Kirschke H., Wiederanders B., Khudoerkov R.M., Hinz W., Rinne A. Lysosomal proteinases as putative diagnostic tools in human neuropathology: Alzheimer disease (AD) and schizophrenia. Acta Histochem. Suppl. 1992, 42:19-24.
-
(1992)
Acta Histochem. Suppl.
, vol.42
, pp. 19-24
-
-
Bernstein, H.G.1
Kirschke, H.2
Wiederanders, B.3
Khudoerkov, R.M.4
Hinz, W.5
Rinne, A.6
-
3
-
-
0030833055
-
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins
-
Borchelt D.R., Ratovitski T., van Lare J., Lee M.K., Gonzales V., Jenkins N.A., Copeland N.G., Price D.L., Sisodia S.S. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 1997, 19:939-945.
-
(1997)
Neuron
, vol.19
, pp. 939-945
-
-
Borchelt, D.R.1
Ratovitski, T.2
van Lare, J.3
Lee, M.K.4
Gonzales, V.5
Jenkins, N.A.6
Copeland, N.G.7
Price, D.L.8
Sisodia, S.S.9
-
4
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio invitro and invivo
-
Borchelt D.R., Thinakaran G., Eckman C.B., Lee M.K., Davenport F., Ratovitsky T., Prada C.M., Kim G., Seekins S., Yager D., Slunt H.H., Wang R., Seeger M., Levey A.I., Gandy S.E., Copeland N.G., Jenkins N.A., Price D.L., Younkin S.G., Sisodia S.S. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio invitro and invivo. Neuron 1996, 17:1005-1013.
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
Lee, M.K.4
Davenport, F.5
Ratovitsky, T.6
Prada, C.M.7
Kim, G.8
Seekins, S.9
Yager, D.10
Slunt, H.H.11
Wang, R.12
Seeger, M.13
Levey, A.I.14
Gandy, S.E.15
Copeland, N.G.16
Jenkins, N.A.17
Price, D.L.18
Younkin, S.G.19
Sisodia, S.S.20
more..
-
5
-
-
0017184389
-
Arapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford M.M. Arapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
-
(1976)
Anal. Biochem.
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
6
-
-
77951227122
-
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments
-
Caccamo A., Majumder S., Richardson A., Strong R., Oddo S. Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. J.Biol. Chem. 2010, 285:13107-13120.
-
(2010)
J.Biol. Chem.
, vol.285
, pp. 13107-13120
-
-
Caccamo, A.1
Majumder, S.2
Richardson, A.3
Strong, R.4
Oddo, S.5
-
7
-
-
79953208952
-
Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism
-
Caccamo A., Maldonado M.A., Majumder S., Medina D.X., Holbein W., Magri A., Oddo S. Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism. J.Biol. Chem. 2011, 286:8924-8932.
-
(2011)
J.Biol. Chem.
, vol.286
, pp. 8924-8932
-
-
Caccamo, A.1
Maldonado, M.A.2
Majumder, S.3
Medina, D.X.4
Holbein, W.5
Magri, A.6
Oddo, S.7
-
8
-
-
11844253848
-
Protection from mitochondrial complex II inhibition invitro and invivo by Nrf2-mediated transcription
-
Calkins M.J., Jakel R.J., Johnson D.A., Chan K., Kan Y.W., Johnson J.A. Protection from mitochondrial complex II inhibition invitro and invivo by Nrf2-mediated transcription. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:244-249.
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 244-249
-
-
Calkins, M.J.1
Jakel, R.J.2
Johnson, D.A.3
Chan, K.4
Kan, Y.W.5
Johnson, J.A.6
-
9
-
-
0034613345
-
Maturation and pro-peptide cleavage of beta-secretase
-
Capell A., Steiner H., Willem M., Kaiser H., Meyer C., Walter J., Lammich S., Multhaup G., Haass C. Maturation and pro-peptide cleavage of beta-secretase. J.Biol. Chem. 2000, 275:30849-30854.
-
(2000)
J.Biol. Chem.
, vol.275
, pp. 30849-30854
-
-
Capell, A.1
Steiner, H.2
Willem, M.3
Kaiser, H.4
Meyer, C.5
Walter, J.6
Lammich, S.7
Multhaup, G.8
Haass, C.9
-
10
-
-
0028947294
-
Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system
-
Cataldo A.M., Barnett J.L., Berman S.A., Li J., Quarless S., Bursztajn S., Lippa C., Nixon R.A. Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system. Neuron 1995, 14:671-680.
-
(1995)
Neuron
, vol.14
, pp. 671-680
-
-
Cataldo, A.M.1
Barnett, J.L.2
Berman, S.A.3
Li, J.4
Quarless, S.5
Bursztajn, S.6
Lippa, C.7
Nixon, R.A.8
-
11
-
-
0025195944
-
Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain
-
Cataldo A.M., Nixon R.A. Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain. Proc. Natl. Acad. Sci. U.S.A. 1990, 87:3861-3865.
-
(1990)
Proc. Natl. Acad. Sci. U.S.A.
, vol.87
, pp. 3861-3865
-
-
Cataldo, A.M.1
Nixon, R.A.2
-
12
-
-
4644319713
-
Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome
-
Cataldo A.M., Petanceska S., Terio N.B., Peterhoff C.M., Durham R., Mercken M., Mehta P.D., Buxbaum J., Haroutunian V., Nixon R.A. Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome. Neurobiol. Aging 2004, 25:1263-1272.
-
(2004)
Neurobiol. Aging
, vol.25
, pp. 1263-1272
-
-
Cataldo, A.M.1
Petanceska, S.2
Terio, N.B.3
Peterhoff, C.M.4
Durham, R.5
Mercken, M.6
Mehta, P.D.7
Buxbaum, J.8
Haroutunian, V.9
Nixon, R.A.10
-
13
-
-
0025355591
-
Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin
-
Cataldo A.M., Thayer C.Y., Bird E.D., Wheelock T.R., Nixon R.A. Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin. Brain Res. 1990, 513:181-192.
-
(1990)
Brain Res.
, vol.513
, pp. 181-192
-
-
Cataldo, A.M.1
Thayer, C.Y.2
Bird, E.D.3
Wheelock, T.R.4
Nixon, R.A.5
-
14
-
-
0030451213
-
NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
-
Chan K., Lu R., Chang J.C., Kan Y.W. NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:13943-13948.
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, pp. 13943-13948
-
-
Chan, K.1
Lu, R.2
Chang, J.C.3
Kan, Y.W.4
-
15
-
-
62449132771
-
Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: critical role for the astrocyte
-
Chen P.C., Vargas M.R., Pani A.K., Smeyne R.J., Johnson D.A., Kan Y.W., Johnson J.A. Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: critical role for the astrocyte. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:2933-2938.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 2933-2938
-
-
Chen, P.C.1
Vargas, M.R.2
Pani, A.K.3
Smeyne, R.J.4
Johnson, D.A.5
Kan, Y.W.6
Johnson, J.A.7
-
16
-
-
21844468767
-
Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase
-
Chiang G.G., Abraham R.T. Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase. J.Biol. Chem. 2005, 280:25485-25490.
-
(2005)
J.Biol. Chem.
, vol.280
, pp. 25485-25490
-
-
Chiang, G.G.1
Abraham, R.T.2
-
17
-
-
0035921427
-
The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein
-
Cupers P., Bentahir M., Craessaerts K., Orlans I., Vanderstichele H., Saftig P., De Strooper B., Annaert W. The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein. J.Cell Biol. 2001, 154:731-740.
-
(2001)
J.Cell Biol.
, vol.154
, pp. 731-740
-
-
Cupers, P.1
Bentahir, M.2
Craessaerts, K.3
Orlans, I.4
Vanderstichele, H.5
Saftig, P.6
De Strooper, B.7
Annaert, W.8
-
18
-
-
0025295039
-
Cleavage of amyloid beta peptide during constitutive processing of its precursor
-
Esch F.S., Keim P.S., Beattie E.C., Blacher R.W., Culwell A.R., Oltersdorf T., McClure D., Ward P.J. Cleavage of amyloid beta peptide during constitutive processing of its precursor. Science 1990, 248:1122-1124.
-
(1990)
Science
, vol.248
, pp. 1122-1124
-
-
Esch, F.S.1
Keim, P.S.2
Beattie, E.C.3
Blacher, R.W.4
Culwell, A.R.5
Oltersdorf, T.6
McClure, D.7
Ward, P.J.8
-
19
-
-
79952139698
-
Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation
-
Fujita K., Maeda D., Xiao Q., Srinivasula S.M. Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation. Proc. Natl. Acad. Sci. U. S. A 2011, 108:1427-1432.
-
(2011)
Proc. Natl. Acad. Sci. U. S. A
, vol.108
, pp. 1427-1432
-
-
Fujita, K.1
Maeda, D.2
Xiao, Q.3
Srinivasula, S.M.4
-
20
-
-
84870549095
-
Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein aggregation throughout the CNS in the alpha-synuclein mutant (A53T) mouse model
-
Gan L., Vargas M.R., Johnson D.A., Johnson J.A. Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein aggregation throughout the CNS in the alpha-synuclein mutant (A53T) mouse model. J.Neurosci. 2012, 32:17775-17787.
-
(2012)
J.Neurosci.
, vol.32
, pp. 17775-17787
-
-
Gan, L.1
Vargas, M.R.2
Johnson, D.A.3
Johnson, J.A.4
-
21
-
-
1442264828
-
Take five-BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation
-
Haass C. Take five-BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation. EMBO J. 2004, 23:483-488.
-
(2004)
EMBO J.
, vol.23
, pp. 483-488
-
-
Haass, C.1
-
22
-
-
0026735070
-
Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments
-
Haass C., Koo E.H., Mellon A., Hung A.Y., Selkoe D.J. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature 1992, 357:500-503.
-
(1992)
Nature
, vol.357
, pp. 500-503
-
-
Haass, C.1
Koo, E.H.2
Mellon, A.3
Hung, A.Y.4
Selkoe, D.J.5
-
23
-
-
84861674567
-
Genetic ablation of Nrf2/antioxidant response pathway in Alexander disease mice reduces hippocampal gliosis but does not impact survival
-
Hagemann T.L., Jobe E.M., Messing A. Genetic ablation of Nrf2/antioxidant response pathway in Alexander disease mice reduces hippocampal gliosis but does not impact survival. PLoS One 2012, 7:e37304.
-
(2012)
PLoS One
, vol.7
, pp. e37304
-
-
Hagemann, T.L.1
Jobe, E.M.2
Messing, A.3
-
24
-
-
81855204961
-
Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation
-
Hybertson B.M., Gao B., Bose S.K., McCord J.M. Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Mol. Aspects Med. 2011, 32:234-246.
-
(2011)
Mol. Aspects Med.
, vol.32
, pp. 234-246
-
-
Hybertson, B.M.1
Gao, B.2
Bose, S.K.3
McCord, J.M.4
-
25
-
-
77955608828
-
Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1
-
Innamorato N.G., Jazwa A., Rojo A.I., Garcia C., Fernandez-Ruiz J., Grochot-Przeczek A., Stachurska A., Jozkowicz A., Dulak J., Cuadrado A. Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1. PLoS One 2010, 5:e11838.
-
(2010)
PLoS One
, vol.5
, pp. e11838
-
-
Innamorato, N.G.1
Jazwa, A.2
Rojo, A.I.3
Garcia, C.4
Fernandez-Ruiz, J.5
Grochot-Przeczek, A.6
Stachurska, A.7
Jozkowicz, A.8
Dulak, J.9
Cuadrado, A.10
-
26
-
-
0031577292
-
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
-
Itoh K., Chiba T., Takahashi S., Ishii T., Igarashi K., Katoh Y., Oyake T., Hayashi N., Satoh K., Hatayama I., Yamamoto M., Nabeshima Y. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun. 1997, 236:313-322.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.236
, pp. 313-322
-
-
Itoh, K.1
Chiba, T.2
Takahashi, S.3
Ishii, T.4
Igarashi, K.5
Katoh, Y.6
Oyake, T.7
Hayashi, N.8
Satoh, K.9
Hatayama, I.10
Yamamoto, M.11
Nabeshima, Y.12
-
27
-
-
77954599053
-
P62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
-
Jain A., Lamark T., Sjottem E., Larsen K.B., Awuh J.A., Overvatn A., McMahon M., Hayes J.D., Johansen T. p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J.Biol. Chem. 2010, 285:22576-22591.
-
(2010)
J.Biol. Chem.
, vol.285
, pp. 22576-22591
-
-
Jain, A.1
Lamark, T.2
Sjottem, E.3
Larsen, K.B.4
Awuh, J.A.5
Overvatn, A.6
McMahon, M.7
Hayes, J.D.8
Johansen, T.9
-
28
-
-
0035049961
-
Co-expression of multiple transgenes in mouse CNS: a comparison of strategies
-
Jankowsky J.L., Slunt H.H., Ratovitski T., Jenkins N.A., Copeland N.G., Borchelt D.R. Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol. Eng. 2001, 17:157-165.
-
(2001)
Biomol. Eng.
, vol.17
, pp. 157-165
-
-
Jankowsky, J.L.1
Slunt, H.H.2
Ratovitski, T.3
Jenkins, N.A.4
Copeland, N.G.5
Borchelt, D.R.6
-
29
-
-
77951557888
-
The absence of the pro-antioxidant transcription factor Nrf2 exacerbates experimental autoimmune encephalomyelitis
-
Johnson D.A., Amirahmadi S., Ward C., Fabry Z., Johnson J.A. The absence of the pro-antioxidant transcription factor Nrf2 exacerbates experimental autoimmune encephalomyelitis. Toxicol. Sci. 2010, 114:237-246.
-
(2010)
Toxicol. Sci.
, vol.114
, pp. 237-246
-
-
Johnson, D.A.1
Amirahmadi, S.2
Ward, C.3
Fabry, Z.4
Johnson, J.A.5
-
30
-
-
53749088028
-
Nuclear factor erythroid 2-related factor 2 protects against beta amyloid
-
Kanninen K., Malm T.M., Jyrkkanen H.K., Goldsteins G., Keksa-Goldsteine V., Tanila H., Yamamoto M., Yla-Herttuala S., Levonen A.L., Koistinaho J. Nuclear factor erythroid 2-related factor 2 protects against beta amyloid. Mol. Cell Neurosci. 2008, 39:302-313.
-
(2008)
Mol. Cell Neurosci.
, vol.39
, pp. 302-313
-
-
Kanninen, K.1
Malm, T.M.2
Jyrkkanen, H.K.3
Goldsteins, G.4
Keksa-Goldsteine, V.5
Tanila, H.6
Yamamoto, M.7
Yla-Herttuala, S.8
Levonen, A.L.9
Koistinaho, J.10
-
31
-
-
77649265091
-
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
-
Komatsu M., Kurokawa H., Waguri S., Taguchi K., Kobayashi A., Ichimura Y., Sou Y.S., Ueno I., Sakamoto A., Tong K.I., Kim M., Nishito Y., Iemura S., Natsume T., Ueno T., Kominami E., Motohashi H., Tanaka K., Yamamoto M. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat. Cell Biol. 2010, 12:213-223.
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 213-223
-
-
Komatsu, M.1
Kurokawa, H.2
Waguri, S.3
Taguchi, K.4
Kobayashi, A.5
Ichimura, Y.6
Sou, Y.S.7
Ueno, I.8
Sakamoto, A.9
Tong, K.I.10
Kim, M.11
Nishito, Y.12
Iemura, S.13
Natsume, T.14
Ueno, T.15
Kominami, E.16
Motohashi, H.17
Tanaka, K.18
Yamamoto, M.19
-
32
-
-
0842304134
-
Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult
-
Kraft A.D., Johnson D.A., Johnson J.A. Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult. J.Neurosci. 2004, 24:1101-1112.
-
(2004)
J.Neurosci.
, vol.24
, pp. 1101-1112
-
-
Kraft, A.D.1
Johnson, D.A.2
Johnson, J.A.3
-
33
-
-
33748080476
-
Neuronal sensitivity to kainic acid is dependent on the Nrf2-mediated actions of the antioxidant response element
-
Kraft A.D., Lee J.M., Johnson D.A., Kan Y.W., Johnson J.A. Neuronal sensitivity to kainic acid is dependent on the Nrf2-mediated actions of the antioxidant response element. J.Neurochem. 2006, 98:1852-1865.
-
(2006)
J.Neurochem.
, vol.98
, pp. 1852-1865
-
-
Kraft, A.D.1
Lee, J.M.2
Johnson, D.A.3
Kan, Y.W.4
Johnson, J.A.5
-
34
-
-
21344459656
-
MTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease
-
Lafay-Chebassier C., Paccalin M., Page G., Barc-Pain S., Perault-Pochat M.C., Gil R., Pradier L., Hugon J. mTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease. J.Neurochem. 2005, 94:215-225.
-
(2005)
J.Neurochem.
, vol.94
, pp. 215-225
-
-
Lafay-Chebassier, C.1
Paccalin, M.2
Page, G.3
Barc-Pain, S.4
Perault-Pochat, M.C.5
Gil, R.6
Pradier, L.7
Hugon, J.8
-
35
-
-
84655162704
-
Soluble Abeta oligomer production and toxicity
-
Larson M.E., Lesne S.E. Soluble Abeta oligomer production and toxicity. J.Neurochem. 2012, 120(Suppl 1):125-139.
-
(2012)
J.Neurochem.
, vol.120
, pp. 125-139
-
-
Larson, M.E.1
Lesne, S.E.2
-
36
-
-
77953366801
-
Anoncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62
-
Lau A., Wang X.J., Zhao F., Villeneuve N.F., Wu T., Jiang T., Sun Z., White E., Zhang D.D. Anoncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol. Cell Biol. 2010, 30:3275-3285.
-
(2010)
Mol. Cell Biol.
, vol.30
, pp. 3275-3285
-
-
Lau, A.1
Wang, X.J.2
Zhao, F.3
Villeneuve, N.F.4
Wu, T.5
Jiang, T.6
Sun, Z.7
White, E.8
Zhang, D.D.9
-
37
-
-
77953913051
-
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
-
Lee J.H., Yu W.H., Kumar A., Lee S., Mohan P.S., Peterhoff C.M., Wolfe D.M., Martinez-Vicente M., Massey A.C., Sovak G., Uchiyama Y., Westaway D., Cuervo A.M., Nixon R.A. Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell 2010, 141:1146-1158.
-
(2010)
Cell
, vol.141
, pp. 1146-1158
-
-
Lee, J.H.1
Yu, W.H.2
Kumar, A.3
Lee, S.4
Mohan, P.S.5
Peterhoff, C.M.6
Wolfe, D.M.7
Martinez-Vicente, M.8
Massey, A.C.9
Sovak, G.10
Uchiyama, Y.11
Westaway, D.12
Cuervo, A.M.13
Nixon, R.A.14
-
38
-
-
84877293577
-
Brain amyloid-beta oligomers in ageing and Alzheimer's disease
-
Lesne S.E., Sherman M.A., Grant M., Kuskowski M., Schneider J.A., Bennett D.A., Ashe K.H. Brain amyloid-beta oligomers in ageing and Alzheimer's disease. Brain 2013, 136:1383-1398.
-
(2013)
Brain
, vol.136
, pp. 1383-1398
-
-
Lesne, S.E.1
Sherman, M.A.2
Grant, M.3
Kuskowski, M.4
Schneider, J.A.5
Bennett, D.A.6
Ashe, K.H.7
-
39
-
-
17944382037
-
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
-
Lewis J., Dickson D.W., Lin W.L., Chisholm L., Corral A., Jones G., Yen S.H., Sahara N., Skipper L., Yager D., Eckman C., Hardy J., Hutton M., McGowan E. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 2001, 293:1487-1491.
-
(2001)
Science
, vol.293
, pp. 1487-1491
-
-
Lewis, J.1
Dickson, D.W.2
Lin, W.L.3
Chisholm, L.4
Corral, A.5
Jones, G.6
Yen, S.H.7
Sahara, N.8
Skipper, L.9
Yager, D.10
Eckman, C.11
Hardy, J.12
Hutton, M.13
McGowan, E.14
-
40
-
-
33749052075
-
Signalling and autophagy regulation in health, aging and disease
-
Meijer A.J., Codogno P. Signalling and autophagy regulation in health, aging and disease. Mol. Aspects Med. 2006, 27:411-425.
-
(2006)
Mol. Aspects Med.
, vol.27
, pp. 411-425
-
-
Meijer, A.J.1
Codogno, P.2
-
41
-
-
39849109338
-
Autophagy fights disease through cellular self-digestion
-
Mizushima N., Levine B., Cuervo A.M., Klionsky D.J. Autophagy fights disease through cellular self-digestion. Nature 2008, 451:1069-1075.
-
(2008)
Nature
, vol.451
, pp. 1069-1075
-
-
Mizushima, N.1
Levine, B.2
Cuervo, A.M.3
Klionsky, D.J.4
-
42
-
-
33747388358
-
Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease
-
Nixon R.A., Cataldo A.M. Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease. J.Alzheimers Dis. 2006, 9(3 Suppl):277-289.
-
(2006)
J.Alzheimers Dis.
, vol.9
, Issue.3 Suppl
, pp. 277-289
-
-
Nixon, R.A.1
Cataldo, A.M.2
-
43
-
-
14844303381
-
Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study
-
Nixon R.A., Wegiel J., Kumar A., Yu W.H., Peterhoff C., Cataldo A., Cuervo A.M. Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J.Neuropathol. Exp. Neurol. 2005, 64:113-122.
-
(2005)
J.Neuropathol. Exp. Neurol.
, vol.64
, pp. 113-122
-
-
Nixon, R.A.1
Wegiel, J.2
Kumar, A.3
Yu, W.H.4
Peterhoff, C.5
Cataldo, A.6
Cuervo, A.M.7
-
44
-
-
79955969705
-
Autophagy failure in Alzheimer's disease-locating the primary defect
-
Nixon R.A., Yang D.S. Autophagy failure in Alzheimer's disease-locating the primary defect. Neurobiol. Dis. 2011, 43:38-45.
-
(2011)
Neurobiol. Dis.
, vol.43
, pp. 38-45
-
-
Nixon, R.A.1
Yang, D.S.2
-
45
-
-
84863890450
-
Autophagy and neuronal cell death in neurological disorders
-
Nixon R.A., Yang D.S. Autophagy and neuronal cell death in neurological disorders. Cold Spring Harb. Perspect. Biol. 2012, 4:1-23.
-
(2012)
Cold Spring Harb. Perspect. Biol.
, vol.4
, pp. 1-23
-
-
Nixon, R.A.1
Yang, D.S.2
-
46
-
-
84869413374
-
The role of mTOR signaling in Alzheimer disease
-
Oddo S. The role of mTOR signaling in Alzheimer disease. Front. Biosci. (Schol Ed) 2012, 4:941-952.
-
(2012)
Front. Biosci. (Schol Ed)
, vol.4
, pp. 941-952
-
-
Oddo, S.1
-
47
-
-
0037698096
-
Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane
-
Pasternak S.H., Bagshaw R.D., Guiral M., Zhang S., Ackerley C.A., Pak B.J., Callahan J.W., Mahuran D.J. Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane. J.Biol. Chem. 2003, 278:26687-26694.
-
(2003)
J.Biol. Chem.
, vol.278
, pp. 26687-26694
-
-
Pasternak, S.H.1
Bagshaw, R.D.2
Guiral, M.3
Zhang, S.4
Ackerley, C.A.5
Pak, B.J.6
Callahan, J.W.7
Mahuran, D.J.8
-
48
-
-
0033036818
-
Quinone reductase (NQO1), a sensitive redox indicator, is increased in Alzheimer's disease
-
Raina A.K., Templeton D.J., Deak J.C., Perry G., Smith M.A. Quinone reductase (NQO1), a sensitive redox indicator, is increased in Alzheimer's disease. Redox Rep. 1999, 4:23-27.
-
(1999)
Redox Rep.
, vol.4
, pp. 23-27
-
-
Raina, A.K.1
Templeton, D.J.2
Deak, J.C.3
Perry, G.4
Smith, M.A.5
-
49
-
-
33846073880
-
Expression of Nrf2 in neurodegenerative diseases
-
Ramsey C.P., Glass C.A., Montgomery M.B., Lindl K.A., Ritson G.P., Chia L.A., Hamilton R.L., Chu C.T., Jordan-Sciutto K.L. Expression of Nrf2 in neurodegenerative diseases. J.Neuropathol. Exp. Neurol. 2007, 66:75-85.
-
(2007)
J.Neuropathol. Exp. Neurol.
, vol.66
, pp. 75-85
-
-
Ramsey, C.P.1
Glass, C.A.2
Montgomery, M.B.3
Lindl, K.A.4
Ritson, G.P.5
Chia, L.A.6
Hamilton, R.L.7
Chu, C.T.8
Jordan-Sciutto, K.L.9
-
50
-
-
43849096294
-
Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease
-
Resende R., Moreira P.I., Proenca T., Deshpande A., Busciglio J., Pereira C., Oliveira C.R. Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease. Free Radic. Biol. Med. 2008, 44:2051-2057.
-
(2008)
Free Radic. Biol. Med.
, vol.44
, pp. 2051-2057
-
-
Resende, R.1
Moreira, P.I.2
Proenca, T.3
Deshpande, A.4
Busciglio, J.5
Pereira, C.6
Oliveira, C.R.7
-
51
-
-
79952319993
-
Autophagy inhibition engages Nrf2-p62 Ub-associated signaling
-
Riley B.E., Kaiser S.E., Kopito R.R. Autophagy inhibition engages Nrf2-p62 Ub-associated signaling. Autophagy 2011, 7:338-340.
-
(2011)
Autophagy
, vol.7
, pp. 338-340
-
-
Riley, B.E.1
Kaiser, S.E.2
Kopito, R.R.3
-
52
-
-
78049495046
-
Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection
-
Riley B.E., Kaiser S.E., Shaler T.A., Ng A.C., Hara T., Hipp M.S., Lage K., Xavier R.J., Ryu K.Y., Taguchi K., Yamamoto M., Tanaka K., Mizushima N., Komatsu M., Kopito R.R. Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection. J.Cell Biol. 2010, 191:537-552.
-
(2010)
J.Cell Biol.
, vol.191
, pp. 537-552
-
-
Riley, B.E.1
Kaiser, S.E.2
Shaler, T.A.3
Ng, A.C.4
Hara, T.5
Hipp, M.S.6
Lage, K.7
Xavier, R.J.8
Ryu, K.Y.9
Taguchi, K.10
Yamamoto, M.11
Tanaka, K.12
Mizushima, N.13
Komatsu, M.14
Kopito, R.R.15
-
53
-
-
0036523031
-
Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells
-
Runz H., Rietdorf J., Tomic I., de Bernard M., Beyreuther K., Pepperkok R., Hartmann T. Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells. J.Neurosci. 2002, 22:1679-1689.
-
(2002)
J.Neurosci.
, vol.22
, pp. 1679-1689
-
-
Runz, H.1
Rietdorf, J.2
Tomic, I.3
de Bernard, M.4
Beyreuther, K.5
Pepperkok, R.6
Hartmann, T.7
-
54
-
-
29844450760
-
Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment
-
Schipper H.M., Bennett D.A., Liberman A., Bienias J.L., Schneider J.A., Kelly J., Arvanitakis Z. Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment. Neurobiol. Aging 2006, 27:252-261.
-
(2006)
Neurobiol. Aging
, vol.27
, pp. 252-261
-
-
Schipper, H.M.1
Bennett, D.A.2
Liberman, A.3
Bienias, J.L.4
Schneider, J.A.5
Kelly, J.6
Arvanitakis, Z.7
-
55
-
-
0037996661
-
Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress
-
Shih A.Y., Johnson D.A., Wong G., Kraft A.D., Jiang L., Erb H., Johnson J.A., Murphy T.H. Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress. J.Neurosci. 2003, 23:3394-3406.
-
(2003)
J.Neurosci.
, vol.23
, pp. 3394-3406
-
-
Shih, A.Y.1
Johnson, D.A.2
Wong, G.3
Kraft, A.D.4
Jiang, L.5
Erb, H.6
Johnson, J.A.7
Murphy, T.H.8
-
56
-
-
0025373508
-
Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing
-
Sisodia S.S., Koo E.H., Beyreuther K., Unterbeck A., Price D.L. Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science 1990, 248:492-495.
-
(1990)
Science
, vol.248
, pp. 492-495
-
-
Sisodia, S.S.1
Koo, E.H.2
Beyreuther, K.3
Unterbeck, A.4
Price, D.L.5
-
57
-
-
78751703950
-
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
-
Taguchi K., Motohashi H., Yamamoto M. Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes Cells 2011, 16:123-140.
-
(2011)
Genes Cells
, vol.16
, pp. 123-140
-
-
Taguchi, K.1
Motohashi, H.2
Yamamoto, M.3
-
58
-
-
1842732209
-
Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain
-
Takahashi R.H., Almeida C.G., Kearney P.F., Yu F., Lin M.T., Milner T.A., Gouras G.K. Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain. J.Neurosci. 2004, 24:3592-3599.
-
(2004)
J.Neurosci.
, vol.24
, pp. 3592-3599
-
-
Takahashi, R.H.1
Almeida, C.G.2
Kearney, P.F.3
Yu, F.4
Lin, M.T.5
Milner, T.A.6
Gouras, G.K.7
-
59
-
-
84871962419
-
Keap1 is localized in neuronal and glial cytoplasmic inclusions in various neurodegenerative diseases
-
Tanji K., Maruyama A., Odagiri S., Mori F., Itoh K., Kakita A., Takahashi H., Wakabayashi K. Keap1 is localized in neuronal and glial cytoplasmic inclusions in various neurodegenerative diseases. J.Neuropathol. Exp. Neurol. 2013, 72:18-28.
-
(2013)
J.Neuropathol. Exp. Neurol.
, vol.72
, pp. 18-28
-
-
Tanji, K.1
Maruyama, A.2
Odagiri, S.3
Mori, F.4
Itoh, K.5
Kakita, A.6
Takahashi, H.7
Wakabayashi, K.8
-
60
-
-
70349333698
-
The Nrf2-ARE cytoprotective pathway in astrocytes
-
Vargas M.R., Johnson J.A. The Nrf2-ARE cytoprotective pathway in astrocytes. Expert Rev. Mol. Med. 2009, 11:e17.
-
(2009)
Expert Rev. Mol. Med.
, vol.11
, pp. e17
-
-
Vargas, M.R.1
Johnson, J.A.2
-
61
-
-
58149379610
-
Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis
-
Vargas M.R., Johnson D.A., Sirkis D.W., Messing A., Johnson J.A. Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis. J.Neurosci. 2008, 28:13574-13581.
-
(2008)
J.Neurosci.
, vol.28
, pp. 13574-13581
-
-
Vargas, M.R.1
Johnson, D.A.2
Sirkis, D.W.3
Messing, A.4
Johnson, J.A.5
-
62
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R., Bennett B.D., Babu-Khan S., Kahn S., Mendiaz E.A., Denis P., Teplow D.B., Ross S., Amarante P., Loeloff R., Luo Y., Fisher S., Fuller J., Edenson S., Lile J., Jarosinski M.A., Biere A.L., Curran E., Burgess T., Louis J.C., Collins F., Treanor J., Rogers G., Citron M. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999, 286:735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
Luo, Y.11
Fisher, S.12
Fuller, J.13
Edenson, S.14
Lile, J.15
Jarosinski, M.A.16
Biere, A.L.17
Curran, E.18
Burgess, T.19
Louis, J.C.20
Collins, F.21
Treanor, J.22
Rogers, G.23
Citron, M.24
more..
-
63
-
-
33749176134
-
GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing
-
von Arnim C.A., Spoelgen R., Peltan I.D., Deng M., Courchesne S., Koker M., Matsui T., Kowa H., Lichtenthaler S.F., Irizarry M.C., Hyman B.T. GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing. J.Neurosci. 2006, 26:9913-9922.
-
(2006)
J.Neurosci.
, vol.26
, pp. 9913-9922
-
-
von Arnim, C.A.1
Spoelgen, R.2
Peltan, I.D.3
Deng, M.4
Courchesne, S.5
Koker, M.6
Matsui, T.7
Kowa, H.8
Lichtenthaler, S.F.9
Irizarry, M.C.10
Hyman, B.T.11
-
64
-
-
77956915802
-
When NRF2 talks, who's listening?
-
Wakabayashi N., Slocum S.L., Skoko J.J., Shin S., Kensler T.W. When NRF2 talks, who's listening?. Antioxid. Redox Signal 2010, 13:1649-1663.
-
(2010)
Antioxid. Redox Signal
, vol.13
, pp. 1649-1663
-
-
Wakabayashi, N.1
Slocum, S.L.2
Skoko, J.J.3
Shin, S.4
Kensler, T.W.5
-
65
-
-
0035805592
-
Phosphorylation regulates intracellular trafficking of beta-secretase
-
Walter J., Fluhrer R., Hartung B., Willem M., Kaether C., Capell A., Lammich S., Multhaup G., Haass C. Phosphorylation regulates intracellular trafficking of beta-secretase. J.Biol. Chem. 2001, 276:14634-14641.
-
(2001)
J.Biol. Chem.
, vol.276
, pp. 14634-14641
-
-
Walter, J.1
Fluhrer, R.2
Hartung, B.3
Willem, M.4
Kaether, C.5
Capell, A.6
Lammich, S.7
Multhaup, G.8
Haass, C.9
-
66
-
-
0034622230
-
NAD(P)H:quinone oxidoreductase activity is increased in hippocampal pyramidal neurons of patients with Aalzheimer's disease
-
Wang Y., Santa-Cruz K., DeCarli C., Johnson J.A. NAD(P)H:quinone oxidoreductase activity is increased in hippocampal pyramidal neurons of patients with Aalzheimer's disease. Neurobiol. Aging 2000, 21:525-531.
-
(2000)
Neurobiol. Aging
, vol.21
, pp. 525-531
-
-
Wang, Y.1
Santa-Cruz, K.2
DeCarli, C.3
Johnson, J.A.4
-
67
-
-
84879232282
-
Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification
-
Wolfe D.M., Lee J.H., Kumar A., Lee S., Orenstein S.J., Nixon R.A. Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification. Eur. J. Neurosci. 2013, 37:1949-1961.
-
(2013)
Eur. J. Neurosci.
, vol.37
, pp. 1949-1961
-
-
Wolfe, D.M.1
Lee, J.H.2
Kumar, A.3
Lee, S.4
Orenstein, S.J.5
Nixon, R.A.6
-
68
-
-
26444587508
-
Macroautophagy-a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease
-
Yu W.H., Cuervo A.M., Kumar A., Peterhoff C.M., Schmidt S.D., Lee J.H., Mohan P.S., Mercken M., Farmery M.R., Tjernberg L.O., Jiang Y., Duff K., Uchiyama Y., Naslund J., Mathews P.M., Cataldo A.M., Nixon R.A. Macroautophagy-a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J.Cell Biol. 2005, 171:87-98.
-
(2005)
J.Cell Biol.
, vol.171
, pp. 87-98
-
-
Yu, W.H.1
Cuervo, A.M.2
Kumar, A.3
Peterhoff, C.M.4
Schmidt, S.D.5
Lee, J.H.6
Mohan, P.S.7
Mercken, M.8
Farmery, M.R.9
Tjernberg, L.O.10
Jiang, Y.11
Duff, K.12
Uchiyama, Y.13
Naslund, J.14
Mathews, P.M.15
Cataldo, A.M.16
Nixon, R.A.17
-
69
-
-
4344689871
-
Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease
-
Yu W.H., Kumar A., Peterhoff C., Shapiro Kulnane L., Uchiyama Y., Lamb B.T., Cuervo A.M., Nixon R.A. Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease. Int. J. Biochem. Cell Biol. 2004, 36:2531-2540.
-
(2004)
Int. J. Biochem. Cell Biol.
, vol.36
, pp. 2531-2540
-
-
Yu, W.H.1
Kumar, A.2
Peterhoff, C.3
Shapiro Kulnane, L.4
Uchiyama, Y.5
Lamb, B.T.6
Cuervo, A.M.7
Nixon, R.A.8
|