메뉴 건너뛰기




Volumn 47, Issue 9, 2013, Pages 740-749

N-acetylcysteine amide, a thiol antioxidant, prevents bleomycin-induced toxicity in human alveolar basal epithelial cells (A549)

Author keywords

Bleomycin; GSH prodrug; N acetylcysteine amide; Oxidative stress; Reactive oxygen species

Indexed keywords

ANTIOXIDANT; BLEOMYCIN; GLUTATHIONE; MALONALDEHYDE; N ACETYLCYSTEINE AMIDE; REACTIVE OXYGEN METABOLITE; THIOL DERIVATIVE; UNCLASSIFIED DRUG; ACETYLCYSTEINE; N-ACETYLCYSTEINAMIDE;

EID: 84882434200     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2013.819974     Document Type: Article
Times cited : (20)

References (81)
  • 2
    • 0033980083 scopus 로고    scopus 로고
    • Bleomycin: New perspectives on the mechanism of action
    • Hecht SM. Bleomycin: new perspectives on the mechanism of action. J Nat Prod 2000; 63: 158-168.
    • (2000) J Nat Prod , vol.63 , pp. 158-168
    • Hecht, S.M.1
  • 3
    • 0025234884 scopus 로고
    • Possible mechanisms of bleomycin-induced fi brosis
    • Chandler DB. Possible mechanisms of bleomycin-induced fi brosis. Clin Chest Med 1990; 11: 21-30.
    • (1990) Clin Chest Med , vol.11 , pp. 21-30
    • Chandler, D.B.1
  • 4
    • 0030332498 scopus 로고    scopus 로고
    • C-C chemokines: Novel mediators of the profi brotic infl ammatory response to bleomycin challenge
    • Smith RE, Strieter RM, Phan SH, Kunkel SL. C-C chemokines: novel mediators of the profi brotic infl ammatory response to bleomycin challenge. Am J Respir Cell Mol Biol 1996; 15: 693-702.
    • (1996) Am J Respir Cell Mol Biol , vol.15 , pp. 693-702
    • Smith, R.E.1    Strieter, R.M.2    Phan, S.H.3    Kunkel, S.L.4
  • 5
    • 0033571117 scopus 로고    scopus 로고
    • IFN-gamma-inducible protein-10 attenuates bleomycin-induced pulmonary fi brosis via inhibition of angiogenesis
    • Keane MP, Belperio JA, Arenberg DA, Burdick MD, Xu ZJ, Xue YY, Strieter RM. IFN-gamma-inducible protein-10 attenuates bleomycin-induced pulmonary fi brosis via inhibition of angiogenesis. J Immunol 1999; 163: 5686-5692.
    • (1999) J Immunol , vol.163 , pp. 5686-5692
    • Keane, M.P.1    Belperio, J.A.2    Arenberg, D.A.3    Burdick, M.D.4    Xu, Z.J.5    Xue, Y.Y.6    Strieter, R.M.7
  • 6
    • 0026328064 scopus 로고
    • Protective eff ects of human recombinant MnSOD in adjuvant arthritis and bleomycin-induced lung fi brosis
    • Parizada B, Werber MM, Nimrod A. Protective eff ects of human recombinant MnSOD in adjuvant arthritis and bleomycin-induced lung fi brosis. Free Radic Res Commun 1991; 15: 297-301.
    • (1991) Free Radic Res Commun , vol.15 , pp. 297-301
    • Parizada, B.1    Werber, M.M.2    Nimrod, A.3
  • 8
    • 0031913152 scopus 로고    scopus 로고
    • Antioxidant activity in alveolar epithelial type 2 cells of rats during the development of bleomycin injury
    • Karam H, Hurbain-Kosmath I, Housset B. Antioxidant activity in alveolar epithelial type 2 cells of rats during the development of bleomycin injury. Cell Biol Toxicol 1998; 14: 13-22.
    • (1998) Cell Biol Toxicol , vol.14 , pp. 13-22
    • Karam, H.1    Hurbain-Kosmath, I.2    Housset, B.3
  • 9
    • 84860863023 scopus 로고    scopus 로고
    • Thiol-redox antioxidants protect against lung vascular endothelial cytoskeletal alterations caused by pulmonary fi brosis inducer, bleomycin: Comparison between classical thiol-protectant, N-acetyl-L-cysteine, and novel thiol antioxidant, N,N'-bis-2-mercaptoethyl isophthalamide
    • Patel RB, Kotha SR, Sauers LA, Malireddy S, Gurney TO, Gupta NN, et al. Thiol-redox antioxidants protect against lung vascular endothelial cytoskeletal alterations caused by pulmonary fi brosis inducer, bleomycin: comparison between classical thiol-protectant, N-acetyl-L-cysteine, and novel thiol antioxidant, N,N'-bis-2-mercaptoethyl isophthalamide. Toxicol Mech Methods 2012; 22: 383-396.
    • (2012) Toxicol Mech Methods , vol.22 , pp. 383-396
    • Patel, R.B.1    Kotha, S.R.2    Sauers, L.A.3    Malireddy, S.4    Gurney, T.O.5    Gupta, N.N.6
  • 11
    • 0026709243 scopus 로고
    • Free-radical mechanisms involved in the formation of sequence-dependent bistranded DNA lesions by the antitumor antibiotics bleomycin, neocarzinostatin, and calicheamicin
    • Dedon PC, Goldberg IH. Free-radical mechanisms involved in the formation of sequence-dependent bistranded DNA lesions by the antitumor antibiotics bleomycin, neocarzinostatin, and calicheamicin. Chem Res Toxicol 1992; 5: 311-332.
    • (1992) Chem Res Toxicol , vol.5 , pp. 311-332
    • Dedon, P.C.1    Goldberg, I.H.2
  • 12
    • 0030915094 scopus 로고    scopus 로고
    • Increased production of the potent oxidant peroxynitrite in the lungs of patients with idiopathic pulmonary fi brosis
    • Saleh D, Barnes PJ, Giaid A. Increased production of the potent oxidant peroxynitrite in the lungs of patients with idiopathic pulmonary fi brosis. Am J Respir Crit Care Med 1997; 155: 1763-1769.
    • (1997) Am J Respir Crit Care Med , vol.155 , pp. 1763-1769
    • Saleh, D.1    Barnes, P.J.2    Giaid, A.3
  • 13
    • 0024581879 scopus 로고
    • The eosinophil component of the alveolitis in idiopathic pulmonary fi brosis. Signs of eosinophil activation in the lung are related to impaired lung function
    • Hallgren R, Bjermer L, Lundgren R, Venge P. The eosinophil component of the alveolitis in idiopathic pulmonary fi brosis. Signs of eosinophil activation in the lung are related to impaired lung function. Am Rev Respir Dis 1989; 139: 373-377.
    • (1989) Am Rev Respir Dis , vol.139 , pp. 373-377
    • Hallgren, R.1    Bjermer, L.2    Lundgren, R.3    Venge, P.4
  • 14
    • 0036142953 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase, but not xanthine oxidase, is highly expressed in interstitial pneumonias and granulomatous diseases of human lung
    • Lakari E, Soini Y, Saily M, Koistinen P, Paakko P, Kinnula VL. Inducible nitric oxide synthase, but not xanthine oxidase, is highly expressed in interstitial pneumonias and granulomatous diseases of human lung. Am J Clin Pathol 2002; 117: 132-142.
    • (2002) Am J Clin Pathol , vol.117 , pp. 132-142
    • Lakari, E.1    Soini, Y.2    Saily, M.3    Koistinen, P.4    Paakko, P.5    Kinnula, V.L.6
  • 16
    • 0021359782 scopus 로고
    • Inhibition of the genotoxicity of bleomycin by superoxide dismutase
    • Cunningham ML, Ringrose PS, Lokesh BR. Inhibition of the genotoxicity of bleomycin by superoxide dismutase. Mutat Res 1984; 135: 199-202.
    • (1984) Mutat Res , vol.135 , pp. 199-202
    • Cunningham, M.L.1    Ringrose, P.S.2    Lokesh, B.R.3
  • 17
    • 0033909952 scopus 로고    scopus 로고
    • Aerosolized administration of N-acetylcysteine attenuates lung fi brosis induced by bleomycin in mice
    • Hagiwara SI, Ishii Y, Kitamura S. Aerosolized administration of N-acetylcysteine attenuates lung fi brosis induced by bleomycin in mice. Am J Respir Crit Care Med 2000; 162: 225-231.
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 225-231
    • Hagiwara, S.I.1    Ishii, Y.2    Kitamura, S.3
  • 18
    • 0034011575 scopus 로고    scopus 로고
    • Inhibitory eff ects of a lecithinized superoxide dismutase on bleomycin-induced pulmonary fi brosis in mice
    • Tamagawa K, Taooka Y, Maeda A, Hiyama K, Ishioka S, Yamakido M. Inhibitory eff ects of a lecithinized superoxide dismutase on bleomycin-induced pulmonary fi brosis in mice. Am J Respir Crit Care Med 2000; 161: 1279-1284.
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 1279-1284
    • Tamagawa, K.1    Taooka, Y.2    Maeda, A.3    Hiyama, K.4    Ishioka, S.5    Yamakido, M.6
  • 21
    • 0021943873 scopus 로고
    • Inhibition of bleomycin lung toxicity by N-acetyl cysteine in the rat
    • Berend N. Inhibition of bleomycin lung toxicity by N-acetyl cysteine in the rat. Pathology 1985; 17: 108-110.
    • (1985) Pathology , vol.17 , pp. 108-110
    • Berend, N.1
  • 22
    • 0023263336 scopus 로고
    • Interaction of N-acetylcysteine and bleomycin on hyperbaric oxygen-induced lung damage in mice
    • Jamieson DD, Kerr DR, Unsworth I. Interaction of N-acetylcysteine and bleomycin on hyperbaric oxygen-induced lung damage in mice. Lung 1987; 165: 239-247.
    • (1987) Lung , vol.165 , pp. 239-247
    • Jamieson, D.D.1    Kerr, D.R.2    Unsworth, I.3
  • 23
    • 0023513687 scopus 로고
    • Failure of systemic N-acetyl cysteine to protect the rat lung against bleomycin toxicity
    • Ward HE, Nicholson A, Berend N. Failure of systemic N-acetyl cysteine to protect the rat lung against bleomycin toxicity. Pathology 1987; 19: 358-360.
    • (1987) Pathology , vol.19 , pp. 358-360
    • Ward, H.E.1    Nicholson, A.2    Berend, N.3
  • 24
    • 0023893909 scopus 로고
    • Eff ects of repeated administration of N-acetyl-L-cysteine on sulfhydryl levels of diff erent tissues and bleomycin-induced lung fi brosis in hamsters
    • Giri SN, Hyde DM, Schiedt MJ. Eff ects of repeated administration of N-acetyl-L-cysteine on sulfhydryl levels of diff erent tissues and bleomycin-induced lung fi brosis in hamsters. J Lab Clin Med 1988; 111: 715-724.
    • (1988) J Lab Clin Med , vol.111 , pp. 715-724
    • Giri, S.N.1    Hyde, D.M.2    Schiedt, M.J.3
  • 25
    • 0025875690 scopus 로고
    • Oral N-acetylcysteine reduces bleomycin-induced collagen deposition in the lungs of mice
    • Shahzeidi S, Sarnstrand B, Jeff ery PK, McAnulty RJ, Laurent GJ. Oral N-acetylcysteine reduces bleomycin-induced collagen deposition in the lungs of mice. Eur Respir J 1991; 4: 845-852.
    • (1991) Eur Respir J , vol.4 , pp. 845-852
    • Shahzeidi, S.1    Sarnstrand, B.2    Jeffery, P.K.3    McAnulty, R.J.4    Laurent, G.J.5
  • 27
    • 0031449645 scopus 로고    scopus 로고
    • Antioxidative and clinical eff ects of high-dose N-acetylcysteine in fi brosing alveolitis. Adjunctive therapy to maintenance immunosuppression
    • Behr J, Maier K, Degenkolb B, Krombach F, Vogelmeier C. Antioxidative and clinical eff ects of high-dose N-acetylcysteine in fi brosing alveolitis. Adjunctive therapy to maintenance immunosuppression. Am J Respir Crit Care Med 1997; 156: 1897-1901.
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 1897-1901
    • Behr, J.1    Maier, K.2    Degenkolb, B.3    Krombach, F.4    Vogelmeier, C.5
  • 28
    • 0036318611 scopus 로고    scopus 로고
    • P-selectin upregulation in bleomycin induced lung injury in rats: Eff ect of N-acetyl-L-cysteine
    • Serrano-Mollar A, Closa D, Cortijo J, Morcillo EJ, Prats N, Gironella M, et al. P-selectin upregulation in bleomycin induced lung injury in rats: eff ect of N-acetyl-L-cysteine. Thorax 2002; 57: 629-634.
    • (2002) Thorax , vol.57 , pp. 629-634
    • Serrano-Mollar, A.1    Closa, D.2    Cortijo, J.3    Morcillo, E.J.4    Prats, N.5    Gironella, M.6
  • 30
    • 0036014536 scopus 로고    scopus 로고
    • Intracellular glutathione and bronchoalveolar cells in fi brosing alveolitis: Eff ects of N-acetylcysteine
    • Behr J, Degenkolb B, Krombach F, Vogelmeier C. Intracellular glutathione and bronchoalveolar cells in fi brosing alveolitis: eff ects of N-acetylcysteine. Eur Respir J 2002; 19: 906-911.
    • (2002) Eur Respir J , vol.19 , pp. 906-911
    • Behr, J.1    Degenkolb, B.2    Krombach, F.3    Vogelmeier, C.4
  • 31
    • 0029093174 scopus 로고
    • Intravenous N-acetylcysteine and lung glutathione of patients with pulmonary fi brosis and normals
    • Meyer A, Buhl R, Kampf S, Magnussen H. Intravenous N-acetylcysteine and lung glutathione of patients with pulmonary fi brosis and normals. Am J Respir Crit Care Med 1995; 152: 1055-1060.
    • (1995) Am J Respir Crit Care Med , vol.152 , pp. 1055-1060
    • Meyer, A.1    Buhl, R.2    Kampf, S.3    Magnussen, H.4
  • 32
    • 0028230612 scopus 로고
    • The eff ect of oral N-acetylcysteine on lung glutathione levels in idiopathic pulmonary fi brosis
    • Meyer A, Buhl R, Magnussen H. The eff ect of oral N-acetylcysteine on lung glutathione levels in idiopathic pulmonary fi brosis. Eur Respir J 1994; 7: 431-436.
    • (1994) Eur Respir J , vol.7 , pp. 431-436
    • Meyer, A.1    Buhl, R.2    Magnussen, H.3
  • 33
    • 0345018815 scopus 로고    scopus 로고
    • N-acetylcysteine: Pharmacological considerations and experimental and clinical applications
    • Cotgreave IA. N-acetylcysteine: pharmacological considerations and experimental and clinical applications. Adv Pharmacol 1997; 38: 205-227.
    • (1997) Adv Pharmacol , vol.38 , pp. 205-227
    • Cotgreave, I.A.1
  • 34
    • 64249169355 scopus 로고    scopus 로고
    • N-acetylcysteineamide (NACA) prevents infl ammation and oxidative stress in animals exposed to diesel engine exhaust
    • Banerjee A, Trueblood MB, Zhang X, Manda KR, Lobo P, Whitefi eld PD, et al. N-acetylcysteineamide (NACA) prevents infl ammation and oxidative stress in animals exposed to diesel engine exhaust. Toxicol Lett 2009; 187: 187-193.
    • (2009) Toxicol Lett , vol.187 , pp. 187-193
    • Banerjee, A.1    Trueblood, M.B.2    Zhang, X.3    Manda, K.R.4    Lobo, P.5    Whitefield, P.D.6
  • 35
    • 84882381141 scopus 로고    scopus 로고
    • N-Acetyl L-cysteine amide protects retinal pigment epithelium against methamphetamine-induced oxidative stress
    • Carey JW, Tobwala S, Zhang X, Banerjee A, Ercal N, Pinarci E, Karacal H. N-Acetyl L-cysteine amide protects retinal pigment epithelium against methamphetamine-induced oxidative stress. J Biophys Chem 2012; 3: 101-110.
    • (2012) J Biophys Chem , vol.3 , pp. 101-110
    • Carey, J.W.1    Tobwala, S.2    Zhang, X.3    Banerjee, A.4    Ercal, N.5    Pinarci, E.6    Karacal, H.7
  • 36
    • 79951682959 scopus 로고    scopus 로고
    • In vivo inhibition of l-buthionine-(S,R)-sulfoximine-induced cataracts by a novel antioxidant, N-acetylcysteine amide
    • Carey JW, Pinarci Y, Penugonda S, Karacal H, Ercal N. In vivo inhibition of l-buthionine-(S,R)-sulfoximine-induced cataracts by a novel antioxidant, N-acetylcysteine amide. Free Radical Bio Med 2011; 50: 722-729.
    • (2011) Free Radical Bio Med , vol.50 , pp. 722-729
    • Carey, J.W.1    Pinarci, Y.2    Penugonda, S.3    Karacal, H.4    Ercal, N.5
  • 37
    • 10344243974 scopus 로고    scopus 로고
    • N-acetylcysteine amide, a novel cell-permeating thiol, restores cellular glutathione and protects human red blood cells from oxidative stress
    • Grinberg L, Fibach E, Amer J, Atlas D. N-acetylcysteine amide, a novel cell-permeating thiol, restores cellular glutathione and protects human red blood cells from oxidative stress. Free Radical Bio Med 2005; 38: 136-145.
    • (2005) Free Radical Bio Med , vol.38 , pp. 136-145
    • Grinberg, L.1    Fibach, E.2    Amer, J.3    Atlas, D.4
  • 38
    • 79651474418 scopus 로고    scopus 로고
    • Comparative evaluation of N-acetylcysteine (NAC) and N-acetylcysteine amide (NACA) on glutamate and lead-induced toxicity in CD-1 mice
    • Penugonda S, Ercal N. Comparative evaluation of N-acetylcysteine (NAC) and N-acetylcysteine amide (NACA) on glutamate and lead-induced toxicity in CD-1 mice. Toxicol Lett 2011; 201: 1-7.
    • (2011) Toxicol Lett , vol.201 , pp. 1-7
    • Penugonda, S.1    Ercal, N.2
  • 39
    • 79959232837 scopus 로고    scopus 로고
    • N-acetylcysteine amide (NACA) prevents retinal degeneration by up-regulating reduced glutathione production and reversing lipid peroxidation
    • Schimel AM, Abraham L, Cox D, Sene A, Kraus C, Dace DS, et al. N-acetylcysteine amide (NACA) prevents retinal degeneration by up-regulating reduced glutathione production and reversing lipid peroxidation. Am J Pathol 2011; 178: 2032-2043.
    • (2011) Am J Pathol , vol.178 , pp. 2032-2043
    • Schimel, A.M.1    Abraham, L.2    Cox, D.3    Sene, A.4    Kraus, C.5    Dace, D.S.6
  • 40
    • 67349094895 scopus 로고    scopus 로고
    • N-Acetylcysteine amide protects against methamphetamine-induced oxidative stress and neurotoxicity in immortalized human brain endothelial cells
    • Zhang X, Banerjee A, Banks WA, Ercal N. N-Acetylcysteine amide protects against methamphetamine-induced oxidative stress and neurotoxicity in immortalized human brain endothelial cells. Brain Res 2009; 1275: 87-95.
    • (2009) Brain Res , vol.1275 , pp. 87-95
    • Zhang, X.1    Banerjee, A.2    Banks, W.A.3    Ercal, N.4
  • 41
    • 84866483825 scopus 로고    scopus 로고
    • N-Acetylcysteine amide protects against methamphetamine-induced tissue damage in CD-1 mice
    • Zhang X, Tobwala S, Ercal N. N-Acetylcysteine amide protects against methamphetamine-induced tissue damage in CD-1 mice. Hum Exp Toxicol 2012; 31: 931-944.
    • (2012) Hum Exp Toxicol , vol.31 , pp. 931-944
    • Zhang, X.1    Tobwala, S.2    Ercal, N.3
  • 42
    • 2642579050 scopus 로고    scopus 로고
    • A low molecular weight copper chelator crosses the blood-brain barrier and attenuates experimental autoimmune encephalomyelitis
    • Off en D, Gilgun-Sherki Y, Barhum Y, Benhar M, Grinberg L, Reich R, et al. A low molecular weight copper chelator crosses the blood-brain barrier and attenuates experimental autoimmune encephalomyelitis. J Neurochem 2004; 89: 1241-1251.
    • (2004) J Neurochem , vol.89 , pp. 1241-1251
    • Offen, D.1    Gilgun-Sherki, Y.2    Barhum, Y.3    Benhar, M.4    Grinberg, L.5    Reich, R.6
  • 43
    • 0032820452 scopus 로고    scopus 로고
    • Quantifying cellular oxidative stress by dichlorofl uorescein assay using microplate reader
    • Wang H, Joseph JA. Quantifying cellular oxidative stress by dichlorofl uorescein assay using microplate reader. Free Radic Biol Med 1999; 27: 612-616.
    • (1999) Free Radic Biol Med , vol.27 , pp. 612-616
    • Wang, H.1    Joseph, J.A.2
  • 44
    • 0029026590 scopus 로고
    • Analysis of glutathione glutathione disulfi de cysteine homocysteine and other biological thiols by high-performance liquid chromatography following derivatization by n-(1- pyrenyl)maleimide
    • Winters RA, Zukowski J, Ercal N, Matthews RH, Spitz DR. Analysis of glutathione, glutathione disulfi de, cysteine, homocysteine, and other biological thiols by high-performance liquid chromatography following derivatization by n-(1- pyrenyl)maleimide. Anal Biochem 1995; 227: 14-21.
    • (1995) Anal Biochem , vol.227 , pp. 14-21
    • Winters, R.A.1    Zukowski, J.2    Ercal, N.3    Matthews, R.H.4    Spitz, D.R.5
  • 45
    • 0027366166 scopus 로고
    • A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials
    • Draper HH, Squires EJ, Mahmoodi H, Wu J, Agarwal S, Hadley M. A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials. Free Radic Biol Med 1993; 15: 353-363.
    • (1993) Free Radic Biol Med , vol.15 , pp. 353-363
    • Draper, H.H.1    Squires, E.J.2    Mahmoodi, H.3    Wu, J.4    Agarwal, S.5    Hadley, M.6
  • 46
    • 0021318441 scopus 로고
    • Catalase in vitro
    • Aebi H. Catalase in vitro. Methods Enzymol 1984; 105: 121-126.
    • (1984) Methods Enzymol , vol.105 , pp. 121-126
    • Aebi, H.1
  • 47
    • 0014691242 scopus 로고
    • Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)
    • McCord JM, Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 1969; 244: 6049-6055.
    • (1969) J Biol Chem , vol.244 , pp. 6049-6055
    • McCord, J.M.1    Fridovich, I.2
  • 48
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 49
    • 0024615873 scopus 로고
    • Idiopathic pulmonary fi brosis: Cellular and molecular pathogenesis
    • Weissler JC. Idiopathic pulmonary fi brosis: cellular and molecular pathogenesis. Am J Med Sci 1989; 297: 91-104.
    • (1989) Am J Med Sci , vol.297 , pp. 91-104
    • Weissler, J.C.1
  • 51
    • 0027932291 scopus 로고
    • Involvement of membrane bleomycin-binding sites in bleomycin cytotoxicity
    • Pron G, Belehradek J Jr, Orlowski S, Mir LM. Involvement of membrane bleomycin-binding sites in bleomycin cytotoxicity. Biochem Pharmacol 1994; 48: 301-310.
    • (1994) Biochem Pharmacol , vol.48 , pp. 301-310
    • Pron, G.1    Belehradek Jr., J.2    Orlowski, S.3    Mir, L.M.4
  • 53
    • 0348013238 scopus 로고    scopus 로고
    • Oral N-acetylcysteine reduces bleomycininduced lung damage and mucin Muc5ac expression in rats
    • Mata M, Ruiz A, Cerda M, Martinez-Losa M, Cortijo J, Santangelo F, et al. Oral N-acetylcysteine reduces bleomycininduced lung damage and mucin Muc5ac expression in rats. Eur Respir J 2003; 22: 900-905.
    • (2003) Eur Respir J , vol.22 , pp. 900-905
    • Mata, M.1    Ruiz, A.2    Cerda, M.3    Martinez-Losa, M.4    Cortijo, J.5    Santangelo, F.6
  • 54
    • 0017038214 scopus 로고
    • Bleomycin, a review
    • Crooke ST, Bradner WT. Bleomycin, a review. J Med 1976; 7: 333-428.
    • (1976) J Med , vol.7 , pp. 333-428
    • Crooke, S.T.1    Bradner, W.T.2
  • 55
    • 0023184815 scopus 로고
    • Acute chest pain syndrome during bleomycin infusions
    • White DA, Schwartzberg LS, Kris MG, Bosl GJ. Acute chest pain syndrome during bleomycin infusions. Cancer 1987; 59: 1582-1585.
    • (1987) Cancer , vol.59 , pp. 1582-1585
    • White, D.A.1    Schwartzberg, L.S.2    Kris, M.G.3    Bosl, G.J.4
  • 58
  • 60
    • 33746342090 scopus 로고    scopus 로고
    • Acetyl-L-carnitine modulates bleomycin-induced oxidative stress and energy depletion in lung tissues
    • Sayed-Ahmed MM, Mansour HH, Gharib OA, Hafez HF. Acetyl-L-carnitine modulates bleomycin-induced oxidative stress and energy depletion in lung tissues. J Egypt Natl Canc Inst 2004; 16: 237-243.
    • (2004) J Egypt Natl Canc Inst , vol.16 , pp. 237-243
    • Sayed-Ahmed, M.M.1    Mansour, H.H.2    Gharib, O.A.3    Hafez, H.F.4
  • 61
    • 0029007943 scopus 로고
    • Glutathione metabolism
    • Meister A. Glutathione metabolism. Methods Enzymol 1995; 251: 3-7.
    • (1995) Methods Enzymol , vol.251 , pp. 3-7
    • Meister, A.1
  • 62
    • 1542376929 scopus 로고    scopus 로고
    • Glutathione metabolism and its implications for health
    • Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr 2004; 134: 489-492.
    • (2004) J Nutr , vol.134 , pp. 489-492
    • Wu, G.1    Fang, Y.Z.2    Yang, S.3    Lupton, J.R.4    Turner, N.D.5
  • 63
    • 0032752658 scopus 로고    scopus 로고
    • Potential role of cerebral glutathione in the maintenance of blood-brain barrier integrity in rat
    • Agarwal R, Shukla GS. Potential role of cerebral glutathione in the maintenance of blood-brain barrier integrity in rat. Neurochem Res 1999; 24: 1507-1514.
    • (1999) Neurochem Res , vol.24 , pp. 1507-1514
    • Agarwal, R.1    Shukla, G.S.2
  • 64
    • 0023860819 scopus 로고
    • Promotion of cystine uptake and its utilization for glutathione biosynthesis induced by cysteamine and N-acetylcysteine
    • Issels RD, Nagele A, Eckert KG, Wilmanns W. Promotion of cystine uptake and its utilization for glutathione biosynthesis induced by cysteamine and N-acetylcysteine. Biochem Pharmacol 1988; 37: 881-888.
    • (1988) Biochem Pharmacol , vol.37 , pp. 881-888
    • Issels, R.D.1    Nagele, A.2    Eckert, K.G.3    Wilmanns, W.4
  • 66
    • 80053350634 scopus 로고    scopus 로고
    • Boswellic acids extract attenuates pulmonary fi brosis induced by bleomycin and oxidative stress from gamma irradiation in rats
    • Ali EN, Mansour SZ. Boswellic acids extract attenuates pulmonary fi brosis induced by bleomycin and oxidative stress from gamma irradiation in rats. Chin Med 2011; 6: 36.
    • (2011) Chin Med , vol.6 , pp. 36
    • Ali, E.N.1    Mansour, S.Z.2
  • 67
    • 0036991290 scopus 로고    scopus 로고
    • Eff ects of ICRF-187 and L-carnitine on bleomycin-induced lung toxicity in rats
    • Shouman SA, Abdel-Hamid MA, Hassan ZA, Mansour HH. Eff ects of ICRF-187 and L-carnitine on bleomycin-induced lung toxicity in rats. Saudi Pharm J 2002; 10: 184-189.
    • (2002) Saudi Pharm J , vol.10 , pp. 184-189
    • Shouman, S.A.1    Abdel-Hamid, M.A.2    Hassan, Z.A.3    Mansour, H.H.4
  • 68
    • 0024339305 scopus 로고
    • Bleomycin and cyclophosphamide toxicity in mice with damaged lung tissue
    • Kehrer JP. Bleomycin and cyclophosphamide toxicity in mice with damaged lung tissue. Toxicol 1989; 57: 69-82.
    • (1989) Toxicol , vol.57 , pp. 69-82
    • Kehrer, J.P.1
  • 69
    • 0025697262 scopus 로고
    • Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury
    • Janero DR. Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic Biol Med 1990; 9: 515-540.
    • (1990) Free Radic Biol Med , vol.9 , pp. 515-540
    • Janero, D.R.1
  • 70
    • 0033535371 scopus 로고    scopus 로고
    • Lipid peroxidation-DNA damage by malondialdehyde
    • Marnett LJ. Lipid peroxidation-DNA damage by malondialdehyde. Mutat Res 1999; 424: 83-95.
    • (1999) Mutat Res , vol.424 , pp. 83-95
    • Marnett, L.J.1
  • 71
    • 20444377322 scopus 로고    scopus 로고
    • Attenuation of bleomycin-induced lung fi brosis by oral sulfhydryl containing antioxidants in rats: Erdosteine and N-acetylcysteine
    • Yildirim Z, Kotuk M, Iraz M, Kuku I, Ulu R, Armutcu F, Ozen S. Attenuation of bleomycin-induced lung fi brosis by oral sulfhydryl containing antioxidants in rats: erdosteine and N-acetylcysteine. Pulm Pharmacol Ther 2005; 18: 367-373.
    • (2005) Pulm Pharmacol Ther , vol.18 , pp. 367-373
    • Yildirim, Z.1    Kotuk, M.2    Iraz, M.3    Kuku, I.4    Ulu, R.5    Armutcu, F.6    Ozen, S.7
  • 72
    • 5644232445 scopus 로고    scopus 로고
    • Eff ects of aminoguanidine and antioxidant erdosteine on bleomycin-induced lung fi brosis in rats
    • Yildirim Z, Turkoz Y, Kotuk M, Armutcu F, Gurel A, Iraz M, et al. Eff ects of aminoguanidine and antioxidant erdosteine on bleomycin-induced lung fi brosis in rats. Nitric Oxide 2004; 11: 156-165.
    • (2004) Nitric Oxide , vol.11 , pp. 156-165
    • Yildirim, Z.1    Turkoz, Y.2    Kotuk, M.3    Armutcu, F.4    Gurel, A.5    Iraz, M.6
  • 74
    • 77952890083 scopus 로고    scopus 로고
    • Protective eff ect of octreotide on intra-tracheal bleomycin-induced oxidative damage in rats
    • Kara H, Karatas F, Tug T, Canatan H, Karaoglu A. Protective eff ect of octreotide on intra-tracheal bleomycin-induced oxidative damage in rats. Exp Toxicol Pathol 2010; 62: 235-241.
    • (2010) Exp Toxicol Pathol , vol.62 , pp. 235-241
    • Kara, H.1    Karatas, F.2    Tug, T.3    Canatan, H.4    Karaoglu, A.5
  • 77
    • 0021083988 scopus 로고
    • Eff ects of intratracheal administration of bleomycin on GSH-shuttle enzymes, catalase, lipid peroxidation, and collagen content in the lungs of hamsters
    • Giri SN, Chen ZL, Younker WR, Schiedt MJ. Eff ects of intratracheal administration of bleomycin on GSH-shuttle enzymes, catalase, lipid peroxidation, and collagen content in the lungs of hamsters. Toxicol Appl Pharmacol 1983; 71: 132-141.
    • (1983) Toxicol Appl Pharmacol , vol.71 , pp. 132-141
    • Giri, S.N.1    Chen, Z.L.2    Younker, W.R.3    Schiedt, M.J.4
  • 79
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006; 443: 787-795.
    • (2006) Nature , vol.443 , pp. 787-795
    • Lin, M.T.1    Beal, M.F.2
  • 80
    • 58049100967 scopus 로고    scopus 로고
    • Cisplatin combined with zidovudine enhances cytotoxicity and oxidative stress in human head and neck cancer cells via a thiol-dependent mechanism
    • Mattson DM, Ahmad IM, Dayal D, Parsons AD, Aykin-Burns N, Li L, et al. Cisplatin combined with zidovudine enhances cytotoxicity and oxidative stress in human head and neck cancer cells via a thiol-dependent mechanism. Free Radic Biol Med 2009; 46: 232-237.
    • (2009) Free Radic Biol Med , vol.46 , pp. 232-237
    • Mattson, D.M.1    Ahmad, I.M.2    Dayal, D.3    Parsons, A.D.4    Aykin-Burns, N.5    Li, L.6
  • 81
    • 0032504568 scopus 로고
    • The mitochondrial permeability transition in cell death: A common mechanism in necrosis, apoptosis and autophagy
    • Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, et al. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta 1988; 1366: 177-196.
    • (1988) Biochim Biophys Acta , vol.1366 , pp. 177-196
    • Lemasters, J.J.1    Nieminen, A.L.2    Qian, T.3    Trost, L.C.4    Elmore, S.P.5    Nishimura, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.