메뉴 건너뛰기




Volumn 201, Issue 1, 2011, Pages 1-7

Comparative evaluation of N-acetylcysteine (NAC) and N-acetylcysteine amide (NACA) on glutamate and lead-induced toxicity in CD-1 mice

Author keywords

Antioxidant; Glutamate; Lead; NAC; NACA; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; GLUTAMATE AMMONIA LIGASE; GLUTAMIC ACID; GLUTAMINE; GLUTATHIONE; GLUTATHIONE DISULFIDE; LEAD; MALONALDEHYDE; N ACETYLCYSTEINE AMIDE; PHOSPHOLIPASE A2; UNCLASSIFIED DRUG;

EID: 79651474418     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.11.013     Document Type: Article
Times cited : (33)

References (38)
  • 1
    • 48849086919 scopus 로고    scopus 로고
    • Antioxidant and free radical scavenging properties of N-acetylcysteine amide (NACA) and comparison with N-acetylcysteine (NAC)
    • Ates B., Abraham L., Ercal N. Antioxidant and free radical scavenging properties of N-acetylcysteine amide (NACA) and comparison with N-acetylcysteine (NAC). Free Radic. Res. 2008, 42:372-377.
    • (2008) Free Radic. Res. , vol.42 , pp. 372-377
    • Ates, B.1    Abraham, L.2    Ercal, N.3
  • 3
    • 77951938520 scopus 로고    scopus 로고
    • HIV proteins (gp120 and Tat) and methamphetamine in oxidative stress-induced damage in the brain: potential role of the thiol antioxidant N-acetylcysteine amide
    • Banerjee A., Zhang X., Manda K.R., Banks W.A., Ercal N. HIV proteins (gp120 and Tat) and methamphetamine in oxidative stress-induced damage in the brain: potential role of the thiol antioxidant N-acetylcysteine amide. Free Radic. Biol. Med. 2010, 48:1388-1398.
    • (2010) Free Radic. Biol. Med. , vol.48 , pp. 1388-1398
    • Banerjee, A.1    Zhang, X.2    Manda, K.R.3    Banks, W.A.4    Ercal, N.5
  • 4
    • 48449096004 scopus 로고    scopus 로고
    • Mitochondria as an important target in heavy metal toxicity in rat hepatoma AS-30D cells
    • Belyaeva E.A., Dymkowska D., Wieckowski M.R., Wojtczak L. Mitochondria as an important target in heavy metal toxicity in rat hepatoma AS-30D cells. Toxicol. Appl. Pharmacol. 2008, 231:34-42.
    • (2008) Toxicol. Appl. Pharmacol. , vol.231 , pp. 34-42
    • Belyaeva, E.A.1    Dymkowska, D.2    Wieckowski, M.R.3    Wojtczak, L.4
  • 5
    • 0029012812 scopus 로고
    • Age- and peroxidative stress-related modifications of the cerebral enzymatic activities linked to mitochondria and the glutathione system
    • Benzi G., Moretti A. Age- and peroxidative stress-related modifications of the cerebral enzymatic activities linked to mitochondria and the glutathione system. Free Radic. Biol. Med. 1995, 19:77-101.
    • (1995) Free Radic. Biol. Med. , vol.19 , pp. 77-101
    • Benzi, G.1    Moretti, A.2
  • 7
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 8
    • 0033805296 scopus 로고    scopus 로고
    • Triggering and modulation of apoptosis by oxidative stress
    • Chandra J., Samali A., Orrenius S. Triggering and modulation of apoptosis by oxidative stress. Free Radic. Biol. Med. 2000, 29:323-333.
    • (2000) Free Radic. Biol. Med. , vol.29 , pp. 323-333
    • Chandra, J.1    Samali, A.2    Orrenius, S.3
  • 9
    • 0026552808 scopus 로고
    • 2+ block of NMDA-receptor channels as a mechanism of modulation
    • 2+ block of NMDA-receptor channels as a mechanism of modulation. Nature 1992, 356:521-523.
    • (1992) Nature , vol.356 , pp. 521-523
    • Chen, L.1    Huang, L.Y.2
  • 10
    • 0141848392 scopus 로고    scopus 로고
    • Tea catechins protect against lead-induced ROS formation, mitochondrial dysfunction, and calcium dysregulation in PC12 cells
    • Chen L., Yang X., Jiao H., Zhao B. Tea catechins protect against lead-induced ROS formation, mitochondrial dysfunction, and calcium dysregulation in PC12 cells. Chem. Res. Toxicol. 2003, 16:1155-1161.
    • (2003) Chem. Res. Toxicol. , vol.16 , pp. 1155-1161
    • Chen, L.1    Yang, X.2    Jiao, H.3    Zhao, B.4
  • 11
    • 0345018815 scopus 로고    scopus 로고
    • N-acetylcysteine: pharmacological considerations and experimental and clinical applications
    • Cotgreave I.A. N-acetylcysteine: pharmacological considerations and experimental and clinical applications. Adv. Pharmacol. 1997, 38:205-227.
    • (1997) Adv. Pharmacol. , vol.38 , pp. 205-227
    • Cotgreave, I.A.1
  • 12
    • 0023096396 scopus 로고
    • No penetration of orally administered N-acetylcysteine into bronchoalveolar lavage fluid
    • Cotgreave I.A., Eklund A., Larsson K., Moldeus P.W. No penetration of orally administered N-acetylcysteine into bronchoalveolar lavage fluid. Eur. J. Respir. Dis. 1987, 70:73-77.
    • (1987) Eur. J. Respir. Dis. , vol.70 , pp. 73-77
    • Cotgreave, I.A.1    Eklund, A.2    Larsson, K.3    Moldeus, P.W.4
  • 13
    • 79651472316 scopus 로고
    • The direct spectrophotometric determination of the saturation of hemoglobin in the arterial blood of man
    • Drabkin D.L., Schmidt C.F., Bruner H.D., Pennes H.H. The direct spectrophotometric determination of the saturation of hemoglobin in the arterial blood of man. Am. J. Med. Sci. 1944, 208:135.
    • (1944) Am. J. Med. Sci. , vol.208 , pp. 135
    • Drabkin, D.L.1    Schmidt, C.F.2    Bruner, H.D.3    Pennes, H.H.4
  • 14
    • 0037097270 scopus 로고    scopus 로고
    • Elevation of brain glutathione by gamma-glutamylcysteine ethyl ester protects against peroxynitrite-induced oxidative stress
    • Drake J., Kanski J., Varadarajan S., Tsoras M., Butterfield D.A. Elevation of brain glutathione by gamma-glutamylcysteine ethyl ester protects against peroxynitrite-induced oxidative stress. J. Neurosci. Res. 2002, 68:776-784.
    • (2002) J. Neurosci. Res. , vol.68 , pp. 776-784
    • Drake, J.1    Kanski, J.2    Varadarajan, S.3    Tsoras, M.4    Butterfield, D.A.5
  • 15
    • 0027366166 scopus 로고
    • A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials
    • Draper H.H., Squires E.J., Mahmoodi H., Wu J., Agarwal S., Hadley M. A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials. Free Radic. Biol. Med. 1993, 15:353-363.
    • (1993) Free Radic. Biol. Med. , vol.15 , pp. 353-363
    • Draper, H.H.1    Squires, E.J.2    Mahmoodi, H.3    Wu, J.4    Agarwal, S.5    Hadley, M.6
  • 16
    • 0035750172 scopus 로고    scopus 로고
    • Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage
    • Ercal N., Gurer-Orhan H., Aykin-Burns N. Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage. Curr. Top. Med. Chem. 2001, 1:529-539.
    • (2001) Curr. Top. Med. Chem. , vol.1 , pp. 529-539
    • Ercal, N.1    Gurer-Orhan, H.2    Aykin-Burns, N.3
  • 17
    • 0029996841 scopus 로고    scopus 로고
    • In vivo indices of oxidative stress in lead-exposed C57BL/6 mice are reduced by treatment with meso-2,3-dimercaptosuccinic acid or N-acetylcysteine
    • Ercal N., Treeratphan P., Hammond T.C., Matthews R.H., Grannemann N.H., Spitz D.R. In vivo indices of oxidative stress in lead-exposed C57BL/6 mice are reduced by treatment with meso-2,3-dimercaptosuccinic acid or N-acetylcysteine. Free Radic. Biol. Med. 1996, 21:157-161.
    • (1996) Free Radic. Biol. Med. , vol.21 , pp. 157-161
    • Ercal, N.1    Treeratphan, P.2    Hammond, T.C.3    Matthews, R.H.4    Grannemann, N.H.5    Spitz, D.R.6
  • 18
    • 10344243974 scopus 로고    scopus 로고
    • N-acetylcysteine amide, a novel cell-permeating thiol, restores cellular glutathione and protects human red blood cells from oxidative stress
    • Grinberg L., Fibach E., Amer J., Atlas D. N-acetylcysteine amide, a novel cell-permeating thiol, restores cellular glutathione and protects human red blood cells from oxidative stress. Free Radic. Biol. Med. 2005, 38:136-145.
    • (2005) Free Radic. Biol. Med. , vol.38 , pp. 136-145
    • Grinberg, L.1    Fibach, E.2    Amer, J.3    Atlas, D.4
  • 19
    • 0028799706 scopus 로고
    • Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration
    • Heales S.J., Davies S.E., Bates T.E., Clark J.B. Depletion of brain glutathione is accompanied by impaired mitochondrial function and decreased N-acetyl aspartate concentration. Neurochem. Res. 1995, 20:31-38.
    • (1995) Neurochem. Res. , vol.20 , pp. 31-38
    • Heales, S.J.1    Davies, S.E.2    Bates, T.E.3    Clark, J.B.4
  • 20
    • 0023258018 scopus 로고
    • Lead toxicity in primary cultured cerebral astrocytes and cerebellar granular neurons
    • Holtzman D., Olson J.E., DeVries C., Bensch K. Lead toxicity in primary cultured cerebral astrocytes and cerebellar granular neurons. Toxicol. Appl. Pharmacol. 1987, 89:211-225.
    • (1987) Toxicol. Appl. Pharmacol. , vol.89 , pp. 211-225
    • Holtzman, D.1    Olson, J.E.2    DeVries, C.3    Bensch, K.4
  • 21
    • 0034685682 scopus 로고    scopus 로고
    • Contribution of protein kinase C and glutamate in Pb(2+)-induced cytotoxicity
    • Jadhav A.L., Ramesh G.T., Gunasekar P.G. Contribution of protein kinase C and glutamate in Pb(2+)-induced cytotoxicity. Toxicol. Lett. 2000, 115:89-98.
    • (2000) Toxicol. Lett. , vol.115 , pp. 89-98
    • Jadhav, A.L.1    Ramesh, G.T.2    Gunasekar, P.G.3
  • 22
    • 0014300985 scopus 로고
    • Regulation of glutamine synthetase, XI. The nature and implications of a lag phase in the Escherichia coli glutamine synthetase reaction
    • Kingdon H.S., Hubbard J.S., Stadtman E.R. Regulation of glutamine synthetase, XI. The nature and implications of a lag phase in the Escherichia coli glutamine synthetase reaction. Biochemistry 1968, 7:2136-2142.
    • (1968) Biochemistry , vol.7 , pp. 2136-2142
    • Kingdon, H.S.1    Hubbard, J.S.2    Stadtman, E.R.3
  • 23
    • 0034471862 scopus 로고    scopus 로고
    • Glutamatergic components underlying lead-induced impairments in hippocampal synaptic plasticity
    • Lasley S.M., Gilbert M.E. Glutamatergic components underlying lead-induced impairments in hippocampal synaptic plasticity. Neurotoxicology 2000, 21:1057-1068.
    • (2000) Neurotoxicology , vol.21 , pp. 1057-1068
    • Lasley, S.M.1    Gilbert, M.E.2
  • 24
    • 0346008026 scopus 로고    scopus 로고
    • Glutamate increases toxicity of inorganic lead in GT1-7 neurons: partial protection induced by flunarizine
    • Loikkanen J., Naarala J., Vahakangas K.H., Savolainen K.M. Glutamate increases toxicity of inorganic lead in GT1-7 neurons: partial protection induced by flunarizine. Arch. Toxicol. 2003, 77:663-671.
    • (2003) Arch. Toxicol. , vol.77 , pp. 663-671
    • Loikkanen, J.1    Naarala, J.2    Vahakangas, K.H.3    Savolainen, K.M.4
  • 25
    • 0033396991 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases
    • Mattson M.P., Pedersen W.A., Duan W., Culmsee C., Camandola S. Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases. Ann. N Y Acad. Sci. 1999, 893:154-175.
    • (1999) Ann. N Y Acad. Sci. , vol.893 , pp. 154-175
    • Mattson, M.P.1    Pedersen, W.A.2    Duan, W.3    Culmsee, C.4    Camandola, S.5
  • 27
    • 2642579050 scopus 로고    scopus 로고
    • A low molecular weight copper chelator crosses the blood-brain barrier and attenuates experimental autoimmune encephalomyelitis
    • Offen D., Gilgun-Sherki Y., Barhum Y., Benhar M., Grinberg L., Reich R., Melamed E., Atlas D. A low molecular weight copper chelator crosses the blood-brain barrier and attenuates experimental autoimmune encephalomyelitis. J. Neurochem. 2004, 89:1241-1251.
    • (2004) J. Neurochem. , vol.89 , pp. 1241-1251
    • Offen, D.1    Gilgun-Sherki, Y.2    Barhum, Y.3    Benhar, M.4    Grinberg, L.5    Reich, R.6    Melamed, E.7    Atlas, D.8
  • 28
    • 0023731529 scopus 로고
    • Cellular glutathione levels and sensitivity to radiation and antineoplastic agents in human ovarian cancer
    • Ozols R.F., Hamilton T.C., Young R.C. Cellular glutathione levels and sensitivity to radiation and antineoplastic agents in human ovarian cancer. Prog. Clin. Biol. Res. 1988, 276:287-293.
    • (1988) Prog. Clin. Biol. Res. , vol.276 , pp. 287-293
    • Ozols, R.F.1    Hamilton, T.C.2    Young, R.C.3
  • 29
    • 27644527347 scopus 로고    scopus 로고
    • Effects of N-acetylcysteine amide (NACA), a novel thiol antioxidant against glutamate-induced cytotoxicity in neuronal cell line PC12
    • Penugonda S., Mare S., Goldstein G., Banks William A., Ercal N. Effects of N-acetylcysteine amide (NACA), a novel thiol antioxidant against glutamate-induced cytotoxicity in neuronal cell line PC12. Brain Res. 2005, 1056:132-138.
    • (2005) Brain Res. , vol.1056 , pp. 132-138
    • Penugonda, S.1    Mare, S.2    Goldstein, G.3    Banks William, A.4    Ercal, N.5
  • 30
    • 33749079851 scopus 로고    scopus 로고
    • Potentiation of lead-induced cell death in PC12 cells by glutamate: protection by N-acetylcysteine amide (NACA), a novel thiol antioxidant
    • Penugonda S., Mare S., Lutz P., Banks W.A., Ercal N. Potentiation of lead-induced cell death in PC12 cells by glutamate: protection by N-acetylcysteine amide (NACA), a novel thiol antioxidant. Toxicol. Appl. Pharmacol. 2006, 216:197-205.
    • (2006) Toxicol. Appl. Pharmacol. , vol.216 , pp. 197-205
    • Penugonda, S.1    Mare, S.2    Lutz, P.3    Banks, W.A.4    Ercal, N.5
  • 32
  • 33
    • 22144436290 scopus 로고    scopus 로고
    • Changes in expression of neuronal and glial glutamate transporters in lead-exposed adult rat brain
    • Struzynska L., Chalimoniuk M., Sulkowski G. Changes in expression of neuronal and glial glutamate transporters in lead-exposed adult rat brain. Neurochem. Int. 2005, 47:326-333.
    • (2005) Neurochem. Int. , vol.47 , pp. 326-333
    • Struzynska, L.1    Chalimoniuk, M.2    Sulkowski, G.3
  • 34
    • 0028036950 scopus 로고
    • The effect of lead on dopamine, GABA and histidine spontaneous and KCl-dependent releases from rat brain synaptosomes
    • Struzynska L., Rafalowska U. The effect of lead on dopamine, GABA and histidine spontaneous and KCl-dependent releases from rat brain synaptosomes. Acta Neurobiol. Exp. (Wars) 1994, 54:201-207.
    • (1994) Acta Neurobiol. Exp. (Wars) , vol.54 , pp. 201-207
    • Struzynska, L.1    Rafalowska, U.2
  • 35
    • 0035853604 scopus 로고    scopus 로고
    • Simultaneous determination of several amino acids, including homocysteine, cysteine and glutamic acid, in human plasma by isocratic reversed-phase high-performance liquid chromatography with fluorimetric detection
    • Tcherkas Y.V., Denisenko A.D. Simultaneous determination of several amino acids, including homocysteine, cysteine and glutamic acid, in human plasma by isocratic reversed-phase high-performance liquid chromatography with fluorimetric detection. J. Chromatogr. A 2001, 913:309-313.
    • (2001) J. Chromatogr. A , vol.913 , pp. 309-313
    • Tcherkas, Y.V.1    Denisenko, A.D.2
  • 36
    • 27544506060 scopus 로고    scopus 로고
    • Lead neurotoxicity: from exposure to molecular effects
    • Toscano C.D., Guilarte T.R. Lead neurotoxicity: from exposure to molecular effects. Brain Res. Brain Res. Rev. 2005, 49:529-554.
    • (2005) Brain Res. Brain Res. Rev. , vol.49 , pp. 529-554
    • Toscano, C.D.1    Guilarte, T.R.2
  • 37
    • 0029026590 scopus 로고
    • Analysis of glutathione, glutathione disulfide, cysteine, homocysteine, and other biological thiols by high-performance liquid chromatography following derivatization by n-(1-pyrenyl)maleimide
    • Winters R.A., Zukowski J., Ercal N., Matthews R.H., Spitz D.R. Analysis of glutathione, glutathione disulfide, cysteine, homocysteine, and other biological thiols by high-performance liquid chromatography following derivatization by n-(1-pyrenyl)maleimide. Anal. Biochem. 1995, 227:14-21.
    • (1995) Anal. Biochem. , vol.227 , pp. 14-21
    • Winters, R.A.1    Zukowski, J.2    Ercal, N.3    Matthews, R.H.4    Spitz, D.R.5
  • 38
    • 43049129180 scopus 로고    scopus 로고
    • Effects of N-acetylcysteine amide (NACA), a thiol antioxidant on radiation-induced cytotoxicity in Chinese hamster ovary cells
    • Wu W., Abraham L., Ogony J., Matthews R., Goldstein G., Ercal N. Effects of N-acetylcysteine amide (NACA), a thiol antioxidant on radiation-induced cytotoxicity in Chinese hamster ovary cells. Life Sci. 2008, 82:1122-1130.
    • (2008) Life Sci. , vol.82 , pp. 1122-1130
    • Wu, W.1    Abraham, L.2    Ogony, J.3    Matthews, R.4    Goldstein, G.5    Ercal, N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.