18F-GE-180: a novel TSPO radiotracer compared to 11C-R-PK11195 in a preclinical model of stroke

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 42, Issue 3, 2015, Pages 503-511

  Boutin, Hervé ^a   Murray, Katie ^a   Pradillo, Jesus ^a,b   Maroy, Renaud ^c   Smigova, Alison ^a   Gerhard, Alexander ^a   Jones, Paul A ^d   Trigg, William ^d  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c DIF   (France)

^d GE HEALTHCARE   (United Kingdom)

Author keywords

Brain ischaemia; GE 180; Positron emission tomography; R PK11195; Translocator protein

Indexed keywords

(N,N DIETHYL 9,2 FLUOROETHYL) 5 METHOXY 2,3,4,9 TETRAHYDRO 1H CARBAZOLE 4 CARBOXAMIDE FLUORODEOXYGLUCOSE F18; CARRIER PROTEIN; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE C 11; RADIOISOTOPE; UNCLASSIFIED DRUG; (R)-(11C)1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-3-ISOQUINOLINECARBOXAMIDE; 4 AMINOBUTYRIC ACID A RECEPTOR; AMIDE; BZRP PROTEIN, RAT; CARBAZOLE DERIVATIVE; GE-180; ISOQUINOLINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BRAIN DAMAGE; CELL ACTIVATION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DRUG UPTAKE; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; RAT; SIGNAL NOISE RATIO; ANIMAL; BRAIN; CEREBRAL ARTERY DISEASE; COMPARATIVE STUDY; DIAGNOSTIC USE; DRUG SCREENING; METABOLISM; POSITRON EMISSION TOMOGRAPHY; SCINTISCANNING; TISSUE DISTRIBUTION; WISTAR RAT;

AMIDES; ANIMALS; BRAIN; CARBAZOLES; CARRIER PROTEINS; DRUG EVALUATION, PRECLINICAL; INFARCTION, MIDDLE CEREBRAL ARTERY; ISOQUINOLINES; MALE; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; RECEPTORS, GABA-A; TISSUE DISTRIBUTION;

EID: 84922576884     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-014-2939-8     Document Type: Article

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