Angiotensin type 2 receptors: Blood pressure regulation and end organ damage

Current Opinion in Pharmacology

Volumn 21, Issue , 2015, Pages 115-121

  Sumners, Colin ^a   De Kloet, Annette D ^a   Krause, Eric G ^b   Unger, Thomas ^c   Steckelings, Ulrike Muscha ^d  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA HEALTH   (United States)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; LOSARTAN; OLMESARTAN;

ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE REGULATION; BRAIN ELECTROPHYSIOLOGY; CENTRAL NERVOUS SYSTEM; HYPERTENSION; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; MEDULLA OBLONGATA; NERVE STIMULATION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEX DIFFERENCE; SOLITARY TRACT NUCLEUS; SYSTOLIC BLOOD PRESSURE; AGONISTS; ANIMAL; BLOOD PRESSURE; BRAIN; KIDNEY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; BLOOD PRESSURE; BRAIN; HYPERTENSION; KIDNEY; RECEPTOR, ANGIOTENSIN, TYPE 2;

EID: 84922560906     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2015.01.004     Document Type: Review

References (51)

1. R.A.S. Santos, A.J. Ferreira, T. Verano-Braga, and M. Bader Angiotensin-converting enzyme 2, angiotensin-(1-7) and Mas: new players of the renin-angiotensin system J Endocrinol 216 2013 R1 '7
2. R.Q. Lautner, D.C. Villela, R.A. Fraga-Silva, N. Silva, T. Verano-Braga, F. Costa-Fraga, J. Jankowski, V. Jankowski, F. Sousa, and A. Alzamora Discovery and characterization of alamandine: a novel component of the renin-angiotensin system Circ Res 112 2013 1104 1111
3. E.S. Jones, A. Vinh, C.A. McCarthy, T.A. Gaspari, and R.E. Widdop AT2 receptors: functional relevance in cardiovascular disease Pharmacol Ther 120 2008 292 316
4. U.M. Steckelings, E. Kaschina, and T. Unger The AT2 receptor - a matter of love and hate Peptides 26 2005 1401 1409
5. Y. Wan, C. Wallinder, B. Plouffe, H. Beaudry, A.K. Mahalingam, X. Wu, B. Johansson, M. Holm, M. Botoros, and A. Karlén Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist J Med Chem 47 2004 5995 6008
6. L.A. Danyel, P. Schmerler, L. Paulis, T. Unger, and U.M. Steckelings Impact of AT2-receptor stimulation on vascular biology, kidney function, and blood pressure Integr Blood Press Control 6 2013 153 161
7. S. AbdAlla, H. Lother, A.M. Abdel-tawab, and U. Quitterer The angiotensin II AT2 receptor is an AT1 receptor antagonist J Biol Chem 276 2001 39721 39726
8. H. Akazawa, M. Yano, C. Yabumoto, Y. Kudo-Sakamoto, and I. Komuro Angiotensin II type 1 and type 2 receptor-induced cell signaling Curr Pharm Des 19 2013 2988 2995
9. L.M. Hilliard, E.S. Jones, U.M. Steckelings, T. Unger, R.E. Widdop, and K.M. Denton Sex-specific influence of angiotensin type 2 receptor stimulation on renal function: a novel therapeutic target for hypertension Hypertension 59 2012 409 414
10. Q. Ali, and T. Hussain AT2 receptor non-peptide agonist C21 promotes natriuresis in obese Zucker rats Hypertens Res Off J Jpn Soc Hypertens 35 2012 654 660
11. 2 receptor activation induces natriuresis and lowers blood pressure Circ Res 115 2014 388 399
12. L.M. Hilliard, C.L.E. Chow, K.M. Mirabito, U.M. Steckelings, T. Unger, R.E. Widdop, and K.M. Denton Angiotensin type 2 receptor stimulation increases renal function in female, but not male, spontaneously hypertensive rats Hypertension 64 2014 378 383
13. S. Brouwers, I. Smolders, A. Massie, and A.G. Dupont Angiotensin II type 2 receptor-mediated and nitric oxide-dependent renal vasodilator response to compound 21 unmasked by angiotensin-converting enzyme inhibition in spontaneously hypertensive rats in vivo Hypertension 62 2013 920 926
14. P. Gelosa, A. Pignieri, L. Fändriks, M. de Gasparo, A. Hallberg, C. Banfi, L. Castiglioni, L. Turolo, U. Guerrini, and E. Tremoli Stimulation of AT2 receptor exerts beneficial effects in stroke-prone rats: focus on renal damage J Hypertens 27 2009 2444 2451
15. A. Rehman, A. Leibowitz, N. Yamamoto, Y. Rautureau, P. Paradis, and E.L. Schiffrin Angiotensin type 2 receptor agonist compound 21 reduces vascular injury and myocardial fibrosis in stroke-prone spontaneously hypertensive rats Hypertension 59 2012 291 299
16. S. Bosnyak, I.K. Welungoda, A. Hallberg, M. Alterman, R.E. Widdop, and E.S. Jones Stimulation of angiotensin AT2 receptors by the non-peptide agonist, Compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats Br J Pharmacol 159 2010 709 716
17. L. Paulis, S.T.R. Becker, K. Lucht, K. Schwengel, S. Slavic, E. Kaschina, C. Thöne-Reineke, B. Dahlöf, J. Baulmann, and T. Unger Direct angiotensin II type 2 receptor stimulation in Nω-nitro-l-arginine-methyl ester-induced hypertension: the effect on pulse wave velocity and aortic remodeling Hypertension 59 2012 485 492
18. 2 receptor stimulation inhibits early renal inflammation in renovascular hypertension Hypertension 57 2011 308 313
19. E. Kaschina, A. Grzesiak, J. Li, A. Foryst-Ludwig, M. Timm, F. Rompe, M. Sommerfeld, U.R. Kemnitz, C. Curato, and P. Namsolleck Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction? Circulation 118 2008 2523 2532
20. U.M. Steckelings, F. Rompe, E. Kaschina, P. Namsolleck, A. Grzesiak, H. Funke-Kaiser, M. Bader, and T. Unger The past, present and future of angiotensin II type 2 receptor stimulation J Renin-Angiotensin-Aldosterone Syst JRAAS 11 2010 67 73
21. M.N. Barber, D.B. Sampey, and R.E. Widdop AT(2) receptor stimulation enhances antihypertensive effect of AT(1) receptor antagonist in hypertensive rats Hypertension 34 1999 1112 1116
22. R.M. Carey, N.L. Howell, X.H. Jin, and H.M. Siragy Angiotensin type 2 receptor-mediated hypotension in angiotensin type-1 receptor-blocked rats Hypertension 38 2001 1272 1277
23. E.S. Jones, M.P. Del Borgo, J.F. Kirsch, D. Clayton, S. Bosnyak, I. Welungoda, N. Hausler, S. Unabia, P. Perlmutter, and W.G. Thomas A single beta-amino acid substitution to angiotensin II confers AT2 receptor selectivity and vascular function Hypertension 57 2011 570 576
24. R.M. Carey The intrarenal renin-angiotensin and dopaminergic systems: control of renal sodium excretion and blood pressure Hypertension 61 2013 673 680
25. K.M. Mirabito, L.M. Hilliard, M.M. Kett, R.D. Brown, S.C. Booth, R.E. Widdop, K.M. Moritz, R.G. Evans, and K.M. Denton Sex- and age-related differences in the chronic pressure-natriuresis relationship: role of the angiotensin type 2 receptor Am J Physiol Renal Physiol 307 2014 F901 F907
26. Q. Ali, Y. Wu, and T. Hussain Chronic AT2 receptor activation increases renal ACE2 activity, attenuates AT1 receptor function and blood pressure in obese Zucker rats Kidney Int 84 2013 931 939
27. A.C. Arnold, L.E. Okamoto, A. Gamboa, C. Shibao, S.R. Raj, D. Robertson, and I. Biaggioni Angiotensin II independent of plasma renin activity, contributes to the hypertension of autonomic failure Hypertension 61 2013 701 706
28. C. Capone, G. Faraco, J.R. Peterson, C. Coleman, J. Anrather, T.A. Milner, V.M. Pickel, R.L. Davisson, and C. Iadecola Central cardiovascular circuits contribute to the neurovascular dysfunction in angiotensin II hypertension J Neurosci Off J Soc Neurosci 32 2012 4878 4886
29. E.L. O'Callaghan, Y.-T. Choong, N. Jancovski, and A.M. Allen Central angiotensinergic mechanisms associated with hypertension Auton Neurosci Basic Clin 175 2013 85 92
30. Z. Lenkei, M. Palkovits, P. Corvol, and C. Llorens-Cortès Expression of angiotensin type-1 (AT1) and type-2 (AT2) receptor mRNAs in the adult rat brain: a functional neuroanatomical review Front Neuroendocrinol 18 1997 383 439
31. M.A. Millan, D.M. Jacobowitz, G. Aguilera, and K.J. Catt Differential distribution of AT1 and AT2 angiotensin II receptor subtypes in the rat brain during development Proc Natl Acad Sci U S A 88 1991 11440 11444
32. T. Ichiki, P.A. Labosky, C. Shiota, S. Okuyama, Y. Imagawa, A. Fogo, F. Niimura, I. Ichikawa, B.L. Hogan, and T. Inagami Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor Nature 377 1995 748 750
33. V. Gross, A.F. Milia, R. Plehm, T. Inagami, and F.C. Luft Long-term blood pressure telemetry in AT2 receptor-disrupted mice J Hypertens 18 2000 955 961
34. T. Matsuura, H. Kumagai, H. Onimaru, A. Kawai, K. Iigaya, T. Onami, K. Sakata, N. Oshima, T. Sugaya, and T. Saruta Electrophysiological properties of rostral ventrolateral medulla neurons in angiotensin II 1a receptor knockout mice Hypertension 46 2005 349 354
35. L. Gao, W. Wang, W. Wang, H. Li, C. Sumners, and I.H. Zucker Effects of angiotensin type 2 receptor overexpression in the rostral ventrolateral medulla on blood pressure and urine excretion in normal rats Hypertension 51 2008 521 527
36. G.T. Blanch, A.H. Freiria-Oliveira, G.F.F. Speretta, E.J. Carrera, H. Li, R.C. Speth, E. Colombari, C. Sumners, and D.S.A. Colombari Increased expression of angiotensin II type 2 receptors in the solitary-vagal complex blunts renovascular hypertension Hypertension 64 2014 777 783
37. J. Gao, H. Zhang, K.D. Le, J. Chao, and L. Gao Activation of central angiotensin type 2 receptors suppresses norepinephrine excretion and blood pressure in conscious rats Am J Hypertens 24 2011 724 730
38. L. Gao, and I.H. Zucker AT2 receptor signaling and sympathetic regulation Curr Opin Pharmacol 11 2011 124 130
39. J. Gao, I.H. Zucker, and L. Gao Activation of central angiotensin type 2 receptors by compound 21 improves arterial baroreflex sensitivity in rats with heart failure Am J Hypertens 27 2014 1248 1256
40. A. De Kloet, L. Wang, J.A. Ludin, J.A. Smith, D.J. Pioquinto, H. Hiller, U.M. Steckelings, D.A. Scheuer, C. Sumners, and E.G. Krause Reporter mouse strain provides a novel look at angiotensin type-2 receptor distribution in the central nervous system Brain Struct Funct 2014 [Epub ahead of print]
41. A.F. Sved, and J.C. Sved Endogenous GABA acts on GABAB receptors in nucleus tractus solitarius to increase blood pressure Brain Res 526 1990 235 240
42. K. Takenaka, S. Sasaki, K. Nakamura, A. Uchida, H. Fujita, H. Itoh, T. Nakata, K. Takeda, and M. Nakagawa Hypothalamic and medullary GABAA and GABAB-ergic systems differently regulate sympathetic and cardiovascular systems Clin Exp Pharmacol Physiol Suppl 22 1995 S48 S50
43. K. Tsukamoto, and A.F. Sved Enhanced gamma-aminobutyric acid-mediated responses in nucleus tractus solitarius of hypertensive rats Hypertension 22 1993 819 825
44. V.R. Durgam, M. Vitela, and S.W. Mifflin Enhanced gamma-aminobutyric acid-B receptor agonist responses and mRNA within the nucleus of the solitary tract in hypertension Hypertension 33 1999 530 536
45. M. Vitela, and S.W. Mifflin gamma-Aminobutyric acid(B) receptor-mediated responses in the nucleus tractus solitarius are altered in acute and chronic hypertension Hypertension 37 2001 619 622
46. A. Alhusban, A.Y. Fouda, Bindu Pillai, T. Ishrat, S. Soliman, and S.C. Fagan Compound 21 is pro-angiogenic in the brain and results in sustained recovery after ischemic stroke J Hypertens 2014 10.1097/HJH.0000000000000364
47. J.P. Joseph, A.P. Mecca, R.W. Regenhardt, D.M. Bennion, V. Rodríguez, F. Desland, N.A. Patel, D.J. Pioquinto, T. Unger, and M.J. Katovich The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke Neuropharmacology 81 2014 134 141
48. C.A. McCarthy, A. Vinh, B.R.S. Broughton, C.G. Sobey, J.K. Callaway, and R.E. Widdop Angiotensin II type 2 receptor stimulation initiated after stroke causes neuroprotection in conscious rats Hypertension 60 2012 1531 1537
49. C.A. McCarthy, A. Vinh, J.K. Callaway, and R.E. Widdop Angiotensin AT2 receptor stimulation causes neuroprotection in a conscious rat model of stroke Stroke J Cereb Circ 40 2009 1482 1489
50. C.A. McCarthy, A. Vinh, A.A. Miller, A. Hallberg, M. Alterman, J.K. Callaway, and R.E. Widdop Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats PLoS One 9 2014 e95762
51. L.-J. Min, M. Mogi, K. Tsukuda, F. Jing, K. Ohshima, H. Nakaoka, H. Kan-No, X.-L. Wang, T. Chisaka, and H.-Y. Bai Direct stimulation of angiotensin II type 2 receptor initiated after stroke ameliorates ischemic brain damage Am J Hypertens 27 2014 1036 1044