Angiotensin II, independent of plasma renin activity, contributes to the hypertension of autonomic failure

Hypertension

Volumn 61, Issue 3, 2013, Pages 701-706

  Arnold, Amy C ^a   Okamoto, Luis E ^a   Gamboa, Alfredo ^a   Shibao, Cyndya ^a   Raj, Satish R ^a   Robertson, David ^a   Biaggioni, Italo ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

angiotensin; autonomic nervous system; hypertension; natriuresis; renin

Indexed keywords

ALDOSTERONE; ANGIOTENSIN II; CAPTOPRIL; LOSARTAN; PLACEBO;

ADULT; AGED; ALDOSTERONE BLOOD LEVEL; AREA UNDER THE CURVE; BEDTIME DOSAGE; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HYPERTENSION; MALE; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; PURE AUTONOMIC FAILURE; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; SODIUM URINE LEVEL; STATISTICAL SIGNIFICANCE; SUPINE POSITION; SYSTOLIC BLOOD PRESSURE;

AGED; ALDOSTERONE; ANGIOTENSIN II; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANTIHYPERTENSIVE AGENTS; CAPTOPRIL; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPERTENSION; LOSARTAN; MALE; MIDDLE AGED; ORTHOSTATIC INTOLERANCE; PURE AUTONOMIC FAILURE; RENIN; SODIUM;

EID: 84874386315     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.00377     Document Type: Conference Paper

References (31)

1. Kaufmann H. Consensus statement on the definition of orthostatic hypotension, pure autonomic failure and multiple system atrophy. Clin Auton Res. 1996;6:125-126.
2. Biaggioni I, Robertson RM. Hypertension in orthostatic hypotension and autonomic dysfunction. Cardiol Clin. 2002;20:291-301, vii.
3. Vagaonescu TD, Saadia D, Tuhrim S, Phillips RA, Kaufmann H. Hypertensive cardiovascular damage in patients with primary autonomic failure. Lancet. 2000;355:725-726.
4. Garland EM, Gamboa A, Okamoto L, Raj SR, Black BK, Davis TL, Biaggioni I, Robertson D. Renal impairment of pure autonomic failure. Hypertension. 2009;54:1057-1061.
5. Ferrario CM. Role of angiotensin II in cardiovascular disease therapeutic implications of more than a century of research. J Renin Angiotensin Aldosterone Syst. 2006;7:3-14.
6. Catanzaro DF, Frishman WH. Angiotensin receptor blockers for management of hypertension. South Med J. 2010;103:669-673.
7. Biaggioni I, Garcia F, Inagami T, Haile V. Hyporeninemic normoaldosteronism in severe autonomic failure. J Clin Endocrinol Metab. 1993;76:580-586.
8. Baser SM, Brown RT, Curras MT, Baucom CE, Hooper DR, Polinsky RJ. β-receptor sensitivity in autonomic failure. Neurology. 1991;41:1107-1112.
9. Low PA. Testing the autonomic nervous system. Semin Neurol. 2003; 23:407-421.
10. Goldstein DS, Eisenhofer G, Stull R, Folio CJ, Keiser HR, Kopin IJ. Plasma dihydroxyphenylglycol and the intraneuronal disposition of norepinephrine in humans. J Clin Invest. 1988;81:213-220.
11. Ferrario CM, Jessup J, Chappell MC, Averill DB, Brosnihan KB, Tallant EA, Diz DI, Gallagher PE. Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2. Circulation. 2005;111:2605-2610.
12. Swales JD, Thurston H. Plasma renin and angiotensin II measurement in hypertensive and normal subjects: correlation of basal and stimulated states. J Clin Endocrinol Metab. 1977;45:159-163.
13. Campbell DJ, Krum H, Esler MD. Losartan increases bradykinin levels in hypertensive humans. Circulation. 2005;111:315-320.
14. Genest J, Cantin M, Garcia R, Thibault G, Gutkowska J, Schiffrin E, Kuchel O, Hamet P. Extrarenal angiotensin-forming enzymes. Clin Exp Hypertens A. 1983;5:1065-1080.
15. Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, Sraer JD. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest. 2002;109:1417-1427.
16. Nagata S, Kato J, Sasaki K, Minamino N, Eto T, Kitamura K. Isolation and identification of proangiotensin-12, a possible component of the reninangiotensin system. Biochem Biophys Res Commun. 2006;350:1026-1031.
17. Bader M. Tissue renin-angiotensin-aldosterone systems: Targets for pharmacological therapy. Annu Rev Pharmacol Toxicol. 2010;50:439-465.
18. McIntyre M, Caffe SE, Michalak RA, Reid JL. Losartan, an orally active angiotensin (AT1) receptor antagonist: a review of its efficacy and safety in essential hypertension. Pharmacol Ther. 1997;74:181-194.
19. Burnier M, Waeber B, Brunner HR. Clinical pharmacology of the angiotensin II receptor antagonist losartan potassium in healthy subjects. J Hypertens Suppl. 1995;13:S23-S28.
20. Goldberg MR, Bradstreet TE, McWilliams EJ, Tanaka WK, Lipert S, Bjornsson TD, Waldman SA, Osborne B, Pivadori L, Lewis G. Biochemical effects of losartan, a nonpeptide angiotensin II receptor antagonist, on the renin-angiotensin-aldosterone system in hypertensive patients. Hypertension. 1995;25:37-46.
21. Kooner JS, Raimbach S, Bannister R, Peart S, Mathias CJ. Angiotensin converting enzyme inhibition lowers blood pressure in patients with primary autonomic failure independently of plasma renin levels and sympathetic nervous activity. J Hypertens Suppl. 1989;7:S42-S43.
22. Hodsman GP, Isles CG, Murray GD, Usherwood TP, Webb DJ, Robertson JI. Factors related to first dose hypotensive effect of captopril: prediction and treatment. BMJ. (Clin Res Ed). 1983;286:832-834.
23. Jansen PA, De Vries OO, De Rooy SE, Raymakers JA. Blood pressure reduction after the first dose of captopril and perindopril. J Am Geriatr Soc. 2001;49:1574-1575.
24. Shibao C, Gamboa A, Abraham R, Raj SR, Diedrich A, Black B, Robertson D, Biaggioni I. Clonidine for the treatment of supine hypertension and pressure natriuresis in autonomic failure. Hypertension. 2006;47:522-526.
25. Gamboa A, Shibao C, Diedrich A, Paranjape SY, Farley G, Christman B, Raj SR, Robertson D, Biaggioni I. Excessive nitric oxide function and blood pressure regulation in patients with autonomic failure. Hypertension. 2008;51:1531-1536.
26. Ten Harkel AD, Van Lieshout JJ, Wieling W. Treatment of orthostatic hypotension with sleeping in the head-up tilt position, alone and in combination with fludrocortisone. J Intern Med. 1992;232:139-145.
27. Jordan J, Shannon JR, Pohar B, Paranjape SY, Robertson D, Robertson RM, Biaggioni I. Contrasting effects of vasodilators on blood pressure and sodium balance in the hypertension of autonomic failure. J Am Soc Nephrol. 1999;10:35-42.
28. Fauvel JP, Velon S, Berra N, Pozet N, Madonna O, Zech P, Laville M. Effects of losartan on renal function in patients with essential hypertension. J Cardiovasc Pharmacol. 1996;28:259-263.
29. Semple PF, Boyd AS, Dawes PM, Morton JJ. Angiotensin II and its heptapeptide (2-8), hexapeptide (3-8), and pentapeptide (4-8) metabolites in arterial and venous blood of man. Circ Res. 1976;39:671-678.
30. Shannon JR, Jordan J, Diedrich A, Pohar B, Black BK, Robertson D, Biaggioni I. Sympathetically mediated hypertension in autonomic failure. Circulation. 2000;101:2710-2715.
31. Kronenberg MW, Forman MB, Onrot J, Robertson D. Enhanced left ventricular contractility in autonomic failure: assessment using pressurevolume relations. J Am Coll Cardiol. 1990;15:1334-1342.