AT 2 receptor non-peptide agonist C21 promotes natriuresis in obese Zucker rats

Hypertension Research

Volumn 35, Issue 6, 2012, Pages 654-660

  Ali, Quaisar ^a   Hussain, Tahir ^a  

^a AUBURN UNIVERSITY   (United States)

Author keywords

amiloride; angiotensin II type 2 receptor; bendroflumethiazide; kidney; obese Zucker rats

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; AMILORIDE; BENDROFLUMETHIAZIDE; C 21; CYCLIC GMP; EPITHELIAL SODIUM CHANNEL; SODIUM; SODIUM CHLORIDE COTRANSPORTER; UNCLASSIFIED DRUG; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN 2 RECEPTOR; IMIDAZOLE DERIVATIVE; N BUTYLOXYCARBONYL 3 (4 IMIDAZOL 1 YLMETHYLPHENYL) 5 ISOBUTYLTHIOPHENE 2 SULFONAMIDE; N-BUTYLOXYCARBONYL-3-(4-IMIDAZOL-1-YLMETHYLPHENYL)-5-ISOBUTYLTHIOPHENE-2-SULFONAMIDE; NATRIURETIC FACTOR; PYRIDINE DERIVATIVE; SULFONAMIDE; THIAZIDE DIURETIC AGENT; THIOPHENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; DIURESIS; DOSE RESPONSE; DRUG EFFECT; GLOMERULUS FILTRATION RATE; MALE; MICTURITION; NATRIURESIS; NONHUMAN; OBESITY; RAT; SODIUM TRANSPORT; SODIUM URINE LEVEL; ZUCKER RAT; ANIMAL; DISEASE MODEL; DRUG POTENTIATION; PHYSIOLOGY; URINE;

AMILORIDE; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BENDROFLUMETHIAZIDE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL SODIUM CHANNELS; IMIDAZOLES; MALE; NATRIURESIS; NATRIURETIC AGENTS; OBESITY; PYRIDINES; RATS; RATS, ZUCKER; RECEPTOR, ANGIOTENSIN, TYPE 2; SODIUM; SODIUM CHLORIDE SYMPORTER INHIBITORS; SODIUM CHLORIDE SYMPORTERS; SULFONAMIDES; THIOPHENES; URINATION;

EID: 84861847267     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1038/hr.2012.13     Document Type: Article

References (41)

1. Carey RM, Wang ZQ, Siragy HM. Role of the angiotensin type 2 receptor in the regulation of blood pressure and renal function. Hypertension 2000; 35: 155-163. (Pubitemid 30054167)
2. Gao J, Zhang H, Le KD, Chao J, Gao L. Activation of central Angiotensin type 2 receptors suppresses norepinephrine excretion and blood pressure in conscious rats. Am J Hypertens 2011; 24: 724-730.
3. Rompe F, Artuc M, Hallberg A, Alterman M, Stroder K, Thone-Reineke C, Reichenbach A, Schacherl J, Dahlof B, Bader M, Alenina N, Schwaninger M, Zuberbier T, Funke-Kaiser H, Schmidt C, Schunck WH, Unger T, Steckelings UM. Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappaB. Hypertension 2010; 55: 924-931.
4. de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 2000; 52: 415-472.
5. 2) receptor protein in rat kidney. Hypertension 1997; 30: 1238-1246.
6. Touyz RM, Schiffrin EL. Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacol Rev 2000; 52: 639-672.
7. Clauser E, Curnow KM, Davies E, Conchon S, Teutsch B, Vianello B, Monnot C, Corvol P. Angiotensin II receptors: protein and gene structures, expression and potential pathological involvements. Eur J Endocrinol 1996; 134: 403-441.
8. Pieruzzi F, Abassi ZA, Keiser HR. Expression of renin-angiotensin system components in the heart, kidneys, and lungs of rats with experimental heart failure. Circulation 1995; 92: 3105-3112.
9. Gross V, Schunck WH, Honeck H, Milia AF, Kärgel E, Walther T, Bader M, Inagami T, Schneider W, Luft FC. Inhibition of pressure natriuresis in mice lacking the AT2receptor. Kidney Int 2000; 57: 191-202. (Pubitemid 30227766)
10. Padia SH, Howell NL, Siragy HM, Carey RM. Renal angiotensin type 2 receptors mediate natriuresis via angiotensin III in the angiotensin II type 1 receptor-blocked rat. Hypertension 2006; 47: 537-544. (Pubitemid 43843872)
11. Hakam AC, Hussain T. Renal angiotensin II type-2 receptors are upregulated and mediate the candesartan-induced natriuresis/diuresis in obese Zucker rats. Hypertension 2005; 45: 270-275. (Pubitemid 40179971)
12. Siddiqui AH, Ali Q, Hussain T. Protective role of angiotensin II subtype 2 receptor in blood pressure increase in obese Zucker rats. Hypertension 2009; 53: 256-261.
13. Hakam AC, Hussain T. Angiotensin II type 2 receptor agonist directly inhibits proximal tubule sodium pump activity in obese but not in lean Zucker rats. Hypertension 2006; 47: 1117-1124. (Pubitemid 44289169)
14. Wan Y, Wallinder C, Plouffe B, Beaudry H, Mahalingam AK, Wu X, Johansson B Holm M, Botoros M, Karlen A, Pettersson A, Nyberg F, Fandriks L, Gallo-Payet N, Hallberg A, Alterman M. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem 2004; 47: 5995-6008. (Pubitemid 39507341)
15. Hiranyachattada S, Saetew S, Harris PJ. Acute effects of candesartan on rat renal haemodynamics and proximal tubular reabsorption. Clin Exp Pharmacol Physiol 2005; 32: 714-720. (Pubitemid 41613510)
16. Nordquist L, Isaksson B, Sjöquist M. The effect of amiloride during infusion of oxytocin in male sprague-dawley rats: a study of a possible intrarenal target site for oxytocin. Clin Exp Hypertens 2008; 30: 151-158. (Pubitemid 351302229)
17. Khan O, Riazi S, Hu X, Song J, Wade JB, Ecelbarger CA. Regulation of the renal thiazide-sensitive Na-Cl cotransporter, blood pressure, and natriuresis in obese Zucker rats treated with rosiglitazone. Am J Physiol Renal Physiol 2005; 289: F442-F450. (Pubitemid 41003674)
18. Chen Z, Vaughn DA, Fanestil DD. Influence of gender on renal thiazide diuretic receptor density and response. J Am Soc Nephrol 1994; 5: 1112-1119. (Pubitemid 24977089)
19. Peti-Peterdi J, Warnock DG, Bell PD. Angiotensin II directly stimulates ENaC activity in the cortical collecting duct via AT(1) receptors. J Am Soc Nephrol 2002; 13: 1131-1135. (Pubitemid 34441392)
20. Majid DS, Navar LG. Blockade of distal nephron sodium transport attenuates pressure natriuresis in dogs. Hypertension 1994; 23: 1040-1045. (Pubitemid 24180862)
21. Hall JE, Jones DW, Kuo JJ, da Silva A, Tallam LS, Liu J. Impact of the obesity epidemic on hypertension and renal disease. Curr Hypertens Rep 2003; 5: 386-392. (Pubitemid 38898962)
22. 1receptor blockade or angiotensin- converting enzyme inhibition in obese Zucker rats. Clin Exp Pharmacol Physiol 2001; 28: 433-440.
23. Alonso-Galicia M, Brands MW, Zappe DH, Hall JE. Hypertension in obese Zucker rats. Role of angiotensin II and adrenergic activity. Hypertension. 1996; 28: 1047-1054. (Pubitemid 26415823)
24. Shah S, Hussain T. Enhanced angiotensin II-induced activation of Na+, K+-ATPase in the proximal tubules of obese Zucker rats. Clin Exp Hypertens 2006; 28: 29-40. (Pubitemid 43200782)
25. 1receptor function in obese Zucker rat. Clin Exp Hypertens 2003; 25: 35-47.
26. 2 receptor stimulation inhibits early renal inflammation in renovascular hypertension. Hypertension 2011; 57: 308-313.
27. 2-receptor agonists. Curr Opin Pharmacol 2011; 11: 187-192.
28. Bosnyak S, Welungoda IK, Hallberg A, Alterman M, Widdop RE, Jones ES. Stimulation of angiotensin AT2 receptors by the non-peptide agonist, Compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats. Br J Pharmacol 2010; 159: 709-716.
29. Wan Y, Wallinder C, Plouffe B, Beaudry H, Mahalingam AK, Wu X, Johansson B, Holm M, Botoros M, Karlén A, Pettersson A, Nyberg F, Fändriks L, Gallo-Payet N, Hallberg A, Alterman M. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem 2004; 47: 5995-6008. (Pubitemid 39507341)
30. 2 receptors promote natriuresis in streptozotocin-induced diabetic rats. Am J Physiol Renal Physiol 2006; 290: F503-F508.
31. Tsutsumi Y, Matsubara H, Masaki H, Kurihara H, Murasawa S, Takai S, Miyazaki M, Nozawa Y, Ozono R, Nakagawa K, Miwa T, Kawada N, Mori Y, Shibasaki Y, Tanaka Y, Fujiyama S, Koyama Y, Fujiyama A, Takahashi H, Iwasaka T. Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation. J Clin Invest 1999; 104: 925-935. (Pubitemid 29536342)
32. Tejera N, Gomez-Garre D, Lazaro A, Gallego-Delgado J, Alonso C, Blanco J, Ortiz A, Egido J. Persistent proteinuria upregulates angiotensin II type 2 receptor and induces apoptosis in proximal tubular cells. Am J Pathol 2004; 164: 1817-1826. (Pubitemid 38529784)
33. Thomsen K, Shirley DG. The validity of lithium clearance as an index of sodium and water delivery from the proximal tubules. Nephron 1997; 77: 125-138. (Pubitemid 27440402)
34. 2 receptor subtypes in the rat kidney. Am J Physiol 1999; 277: F437-F446.
35. Thomsen K, Shirley DG. The validity of lithium clearance as an index of sodium and water delivery from the proximal tubules. Nephron 1997; 77: 125-138. (Pubitemid 27440402)
36. Koomans HA, Boer WH, Dorhout Mees EJ. Evaluation of lithium clearance as a marker of proximal tubule sodium handling. Kidney Int 1989; 36: 2-12. (Pubitemid 19276970)
37. Hashimoto S, Yamada K, Kawata T, Mochizuki T, Schnermann J, Koike T. Abnormal autoregulation and tubuloglomerular feedback in prediabetic and diabetic OLETF rats. Am J Physiol Renal Physiol 2009; 296: F598-F604.
38. Hall JE, Crook ED, Jones DW, Wofford MR, Dubbert PM. Mechanisms of obesity-associated cardiovascular and renal disease. Am J Med Sci 2002; 24: 127-113.
39. Marwaha A, LokhandwalaMF. Diminished natriuretic response to dopamine D1 receptor agonist, SKF-38393 in obese Zucker rats. Clin Exp Hypertens 2003; 25: 509-515. (Pubitemid 37443138)
40. Hussain T, Beheray SA, Lokhandwala MF. Defective dopamine receptor function in proximal tubules of obese Zucker rats. Hypertension 1999; 34: 1091-1096.
41. Zeigler DW, Patel KP. Reduced renal responses to an acute saline load in obese Zucker rats. Am J Physiol 1991; 261: R712-R718.