Complex effect of hydroxyapatite nanoparticles on the differentiation and functional activity of human pre-osteoclastic cells

Journal of Biomedical Nanotechnology

Volumn 10, Issue 12, 2014, Pages 3590-3600

  Costa Rodrigues, João ^a,e   Silva, Ana ^a   Santos, Catarina ^b,c   Almeida, Maria Margarida ^d   Costa, Maria Elisabete ^d   Fernandes, Maria Helena ^a,e  

^a Universidade do Porto   (Portugal)

^b INSTITUTO POLITÉCNICO DE SETÚBAL   (Portugal)

^c INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^d UNIVERSITY OF AVEIRO   (Portugal)

^e UNIVERSITY OF PORTO   (Portugal)

Author keywords

Bone resorption; Cell differentiation.; Hydroxyapatite nanoparticles; Osteoclastogenesis; Peripheral blood mononuclear cells

Indexed keywords

BLOOD; BONE; CYTOLOGY; GENE EXPRESSION; HYDROXYAPATITE; MEDICAL APPLICATIONS; NANOPARTICLES; PRECIPITATION (CHEMICAL);

BONE RESORPTION; CELL DIFFERENTIATION; HYDROXYAPATITE NANOPARTICLES; OSTEOCLASTOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELLS;

CELLS;

HYDROXYAPATITE; NANOPARTICLE;

ADULT; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; HUMAN; MALE; OSTEOBLAST; OSTEOCLAST; PHYSIOLOGY; ULTRASTRUCTURE;

ADULT; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DURAPATITE; HUMANS; MALE; NANOPARTICLES; OSTEOBLASTS; OSTEOCLASTS;

EID: 84922466484     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2014.1873     Document Type: Article

References (51)

1. M. J. Olsztaa, X. Chenga, S. S. Jeea, R. Kumara, Y. Kima, M. J. Kaufmane, E. P. Douglasa, and L. B. Gower, Bone structure and formation: A new perspective. Mat. Sci. Eng. R. Rep. 58, 77 (2007).
2. K. Fox, P. A. Tran, and N. Tran, Recent advances in research applications of nanophase hydroxyapatite. Chemphyschem. 13, 2495 (2012).
3. H. Zhou and J. Lee, Nanoscale hydroxyapatite particles for bone tissue engineering. Acta Biomater. 7, 2769 (2011).
4. S. V. Dorozhkin, Nanosized and nanocrystalline calcium orthophosphates. Acta Biomater. 6, 715 (2010).
5. J. L. Xu, K. A. Khor, J. J. Sui, J. H. Zhang, and W. N. Chen, Protein expression profiles in osteoblasts in response to differentially shaped hydroxyapatite nanoparticles. Biomaterials 30, 5385 (2009).
6. A. Verma and F. Stellacci, Effect of surface properties on nanoparticle-cell interactions. Small 6, 12 (2010).
7. C. Santos, P. S. Gomes, J. A. Duarte, R. P. Franke, M. M. Almeida, M. E. Costa, and M. H. Fernandes, Relevance of the sterilization-induced effects on the properties of different hydroxyapatite nanoparticles and assessment of the osteoblastic cell response. J. R. Soc. Interface 9, 3397 (2012).
8. S. Pezzatini, R. Solito, L. Morbidelli, S. Lamponi, E. Boanini, A. Bigi, and M. Ziche, The effect of hydroxyapatite nanocrystals on microvascular endothelial cell viability and functions. J. Biomed. Mat. Res. 76, 656 (2006).
9. S. Pezzatini, L. Morbidelli, R. Solito, E. Paccagnini, E. Boanini, A. Bigi, and M. Ziche, Nanostructured HA crystals up-regulate FGF-2 expression and activity in microvascular endothelium promoting angiogenesis. Bone 41, 523 (2007).
10. W. Sun, C. Chu, J. Wang, and H. Zhao, Comparison of periodontal ligament cells responses to dense and nanophase hydroxyapatite. J. Mater. Sci. 18, 677 (2007).
11. Y. Cai, Y. Liu, W. Yan, Q. Hu, J. Tao, M. Zhang, Z. Shic, and R. Tang, Role of hydroxyapatite size in bone cell proliferation. J. Mater. Chem. 17, 3780 (2007).
12. I. W. Bauer, S. P. Li, Y. C. Han, L. Yuan, and M. Z. Yin, Internalization of hydroxyapatite nanoparticles in liver cancer cells. J. Mater. Sci. 19, 1091 (2008).
13. Z. Shi, X. Huang, Y. Cai, R. Tang, and D. Yang, Size effect of hydroxyapatite nanoparticles on proliferation and apoptosis of osteoblast-like cells. Acta biomater. 5, 338 (2009).
14. M. Motskin, D. M. Wright, K. Muller, N. Kyle, T. G. Gard, A. E. Porter, and J. N. Skepper, Hydroxyapatite nano and microparticles: Correlation of particle properties with cytotoxicity and biostability. Biomaterials 30, 3307 (2009).
15. Y. Liu, G. Wang, Y. Cai, H. Ji, G. Zhou, X. Zhao, R. Tang, and M. Zhang, In vitro effects of nanophase hydroxyapatite particles on proliferation and osteogenic differentiation of bone marrow-derived mesenchymal stem cells. J. Biomed. Mater. Res. 90, 1083 (2009).
16. R. Tang and Y. Cai, Calcium phosphate nanoparticles in biomineralization and biomaterials. J. Mater. Chem. 18, 3775 (2008).
17. L. A. Hails, J. C. Babister, S. Inglis, S. A. Davis, R. O. Oreffo, and S. Mann, Inhibition of hydroxyapatite nanoparticle-induced osteogenic activity in skeletal cells by adsorption of serum proteins. Small 6, 1986 (2010).
18. R. Gonzalez-McQuire, D. W. Green, K. A. Partridge, R. O. Oreffo, S. Mann, and S. Davis, Coating of human mesenchymal cells in 3D culture with bioinorganic nanoparticles promotes osteoblastic differentiation and gene transfection. Adv. Mater. 19, 2236 (2007).
19. H. K. Datta, W. F. Ng, J. A. Walker, S. P. Tuck, and S. S. Varanasi, The cell biology of bone metabolism. J. Clin. Pathol. 61, 577 (2008).
20. A. Tautzenberger, A. Kovtun, and A. Ignatius, Nanoparticles and their potential for application in bone. Int. J. Nanomedicine 7, 4545 (2012).
21. J. Costa-Rodrigues, A. Fernandes, and M. H. Fernandes, Spontaneous and induced osteoclastogenic behaviour of human peripheral blood mononuclear cells and their CD14(+) and CD14(-) cell fractions. Cell Proliferat. 44, 410 (2011).
22. H. K. Vaananen and T. Laitala-Leinonen, Osteoclast lineage and function. Arc. Biochem. Biophys. 473, 132 (2008).
23. J. Costa-Rodrigues, E. G. Martins, and M. H. Fernandes, Induced osteoclastogenesis by fluoroquinolones in unstimulated and stimulated human osteoclast precursor cells. Bone 51, 17 (2012).
24. Q. Zhao, J. Shao, W. Chen, and Y. P. Li, Osteoclast differentiation and gene regulation. Front. Biosci. 12, 2519 (2007).
25. S. L. Teitelbaum and F. P. Ross, Genetic regulation of osteoclast development and function. Nat. Rev. 4, 638 (2003).
26. K. R. Remya, J. Joseph, S. Mani, A. John, H. K. Varma, and P. Ramesh, Nanohydroxyapatite incorporated electrospun Polycaprolactone/Polycaprolactone-Polyethyleneglycol-Polycaprolactone blend scaffold for bone tissue engineering applications. J. Biomed. Nanotechnol. 9, 1483 (2013).
27. K. T. Shalumon, S. Sowmya, D. Sathish, K. P. Chennazhi, S. V. Nair, and R. Jayakumar, Effect of incorporation of nanoscale bioactive glass and hydroxyapatite in PCL/Chitosan nanofibers for bone and periodontal tissue engineering. J. Biomed. Nanotechnol. 9, 430 (2013).
28. B. Buyuktimkin, Q. Wang, P. Kiptoo, J. M. Stewart, C. Berkland, and T. J. Siahaan, Vaccine-like controlled-release delivery of an immunomodulating peptide to treat experimental autoimmune encephalomyelitis. Mol. Pharm. 9, 979 (2012).
29. P. Datta, P. Ghosh, K. Ghosh, P. Maity, S. K. Samanta, S. K. Ghosh, P. K. Das Mohapatra, J. Chatterjee, and S. Dhara, In vitro ALP and osteocalcin gene expression analysis and in vivo biocompatibility of N -methylene phosphonic chitosan nanofibers for bone regeneration. J. Biomed. Nanotechnol. 9, 870 (2013).
30. A. Aravamudhan, D. M. Ramos, J. Nip, M. D. Harmon, R. James, M. Deng, C. T. Laurencin, X. Yu, and S. G. Kumbar, Cellulose and collagen derived micro-nano structured scaffolds for bone tissue engineering. J. Biomed. Nanotechnol. 9, 719 (2013).
31. Q. Wang, S. Jamal, M. S. Detamore, and C. Berkland, PLGAchitosan/PLGA-alginate nanoparticles blends as biodegradable colloidal gels for seeding human umbilical cord mesenchymal stem cells. J. Biomed. Mater. Res. Part A 96A, 520 (2011).
32. J. B. Lee, H. N. Park, W. Ko, M. S. Bae, D. N. Heo, D. H. Yang, and I. K. Kwon, Poly(L-lactic acid)/hydroxyapatite nanocylinders as nanofibrous structure for bone tissue engineering scaffolds. J. Biomed. Nanotechnol. 9, 424 (2013).
33. S. Jin, S. Kim, J. Oh, S. Lee, E. Jang, Z. Piao, S. Lim, M. Jeong, J. Kim, J. You, S. Park, Y. Cho, S. Yang, and S. Yu, A comparative study of bone formation following grafting with different ratios of particle dentin and tricalcium phosphate combinations. J. Biomed. Nanotechnol. 9, 475 (2013).
34. Q. Wang, J. Wang, Q. Lu, M. S. Detamore, and C. Berkland, Injectable PLGA based colloidal gels for zero-order dexamethasone release in cranial defects. Biomaterials 31, 4980 (2010).
35. K. Jeong, S. Kim, J. Oh, S. Lee, Y. Cho, S. Yang, S. Park, J. You, S. Lim, M. Jeong, J. Kim, and S. Lee, Effect of platelet-rich plasma and platelet-rich fibrin on peri-implant bone defects in dogs. J. Biomed. Nanotechnol. 9, 535 (2013).
36. H. Sahana, D. K. Khajuria, R. Razdan, D. R. Mahapatra, M. R. Bhat, S. Suresh, R. R. Rao, and L. Mariappan, Improvement in bone properties by using risedronate adsorbed hydroxyapatite novel nanoparticle based formulation in a rat model of osteoporosis. J. Biomed. Nanotechnol. 9, 193 (2013).
37. J. Venkatesan and S. K. Kim, Stimulation of minerals by carbon nanotube grafted glucosamine in mouse mesenchymal stem cells for bone tissue engineering. J. Biomed. Nanotechnol. 8, 676 (2012).
38. K. C. Kavya, R. Dixit, R. Jayakumar, S. V. Nair, and K. P. Chennazhi, Synthesis and characterization of chitosan/chondroitin sulfate/nano-SiO2 composite scaffold for bone tissue engineering. J. Biomed. Nanotechnol. 8, 149 (2012).
39. C. E. Albers, W. Hofstetter, K. A. Siebenrock, R. Landmann, and F. M. Klenke, In vitro cytotoxicity of silver nanoparticles on osteoblasts and osteoclasts at antibacterial concentrations. Nanotoxicology 7, 30 (2013).
40. G. R. Beck, S. W. Ha Jr., C. E. Camalier, M. Yamaguchi, Y. Li, J. K. Lee, and M. N. Weitzmann, Bioactive silica-based nanoparticles stimulate bone-forming osteoblasts, suppress bone-resorbing osteoclasts, and enhance bone mineral density in vivo. Nanomedicine 8, 793 (2012).
41. B. Sommer, R. Felix, C. Sprecher, M. Leunig, R. Ganz, and W. Hofstetter, Wear particles and surface topographies are modulators of osteoclastogenesis in vitro. J. Biomed. Mater. Res. 72, 67 (2005).
42. F. Fanord, K. Fairbairn, H. Kim, A. Garces, V. Bhethanabotla, and V. K. Gupta, Bisphosphonate-modified gold nanoparticles: A useful vehicle to study the treatment of osteonecrosis of the femoral head. Nanotechnology 22, 035102 (2011).
43. A. Tautzenberger, L. Kreja, A. Zeller, S. Lorenz, H. Schrezenmeier, V. Mailander, K. Landfester, and A. Ignatius, Direct and indirect effects of functionalised fluorescence-labelled nanoparticles on human osteoclast formation and activity. Biomaterials 32, 1706 (2011).
44. H. Nabeshi, T. Yoshikawa, T. Akase, T. Yoshida, S. Tochigi, T. Hirai, M. Uji, K. Ichihashi, T. Yamashita, K. Higashisaka, Y. Morishita, K. Nagano, Y. Abe, H. Kamada, S. Tsunoda, N. Itoh, Y. Yoshioka, and Y. Tsutsumi, Effect of amorphous silica nanoparticles on in vitro RANKL-induced osteoclast differentiation in murine macrophages. Nanoscale Res. Lett. 6, 464 (2011).
45. O. J. Sul, J. C. Kim, T. W. Kyung, H. J. Kim, Y. Y. Kim, S. H. Kim, J. S. Kim, and H. S. Choi, Gold nanoparticles inhibited the receptor activator of nuclear factor-kappab ligand (RANKL)-induced osteoclast formation by acting as an antioxidant. Biosci. Biotechnol. Biochem. 74, 2209 (2010).
46. M. Nomura, Y. Yoshimura, T. Kikuiri, T. Hasegawa, Y. Taniguchi, Y. Deyama, K. Koshiro, H. Sano, K. Suzuki, and N. Inoue, Platinum nanoparticles suppress osteoclastogenesis through scavenging
47. N. Pal, B. Quah, P. N. Smith, L. L. Gladkis, H. Timmers, and R. W. Li, Nano-osteoimmunology as an important consideration in the design of future implants. Acta Biomater. 7, 2926 (2011).
48. V. Shalhoub, G. Elliott, L. Chiu, R. Manoukian, M. Kelley, N. Hawkins, E. Davy, G. Shimamoto, J. Beck, S. A. Kaufman, G. Van, S. Scully, M. Qi, M. Grisanti, C. Dunstan, W. J. Boyle, and D. L. Lacey, Characterization of osteoclast precursors in human blood. Brit. J. Haematol. 111, 501 (2000).
49. A. Grandjean-Laquerriere, P. Laquerriere, M. Guenounou, D. Laurent-Maquin, and T. M. Phillips, Importance of the surface area ratio on cytokines production by human monocytes in vitro induced by various hydroxyapatite particles. Biomaterials 26, 2361 (2005).
50. T. Lange, A. F. Schilling, F. Peters, F. Haag, M. M. Morlock, J. M. Rueger, and M. Amling, Proinflammatory and osteoclastogenic effects of beta-tricalciumphosphate and hydroxyapatite particles on human mononuclear cells in vitro. Biomaterials 30, 5312 (2009).
51. X. Zhao, S. Ng, B. C. Heng, J. Guo, L. Ma, T. T. Tan, K. W. Ng, and S. C. Loo, Cytotoxicity of hydroxyapatite nanoparticles is shape and cell dependent. Arch. Toxicol. 87, 1037 (2013).