Vaccine-like controlled-release delivery of an immunomodulating peptide to treat experimental autoimmune encephalomyelitis

Molecular Pharmaceutics

Volumn 9, Issue 4, 2012, Pages 979-985

  Büyüktimkin, Barlas ^a   Wang, Qun ^b   Kiptoo, Paul ^a   Stewart, John M ^a   Berkland, Cory ^a,b   Siahaan, Teruna J ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b University of Kansas   (United States)

Author keywords

alginate; autoimmune disease; bifunctional peptide inhibitor; chitosan; colloidal gel; experimental autoimmune encephalomyelitis; immune tolerance; PLGA

Indexed keywords

ACETIC ACID DERIVATIVE; ALGINIC ACID; AMINE; BIFUNCTIONAL PEPTIDE INHIBITOR; CHITOSAN; GAMMA INTERFERON; IMMUNOMODULATING AGENT; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NANOCARRIER; POLYGLACTIN; PROTEIN INHIBITOR; PROTEOLIPID PROTEIN; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIFFUSION; DISEASE COURSE; DISEASE SEVERITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG RELEASE; FEMALE; IMMUNE RESPONSE; IN VITRO STUDY; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN BINDING; SPLEEN CELL; TH17 CELL; TREATMENT RESPONSE;

ANIMALS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; IMMUNOLOGIC FACTORS; LACTIC ACID; MICE; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; PEPTIDES; POLYGLYCOLIC ACID;

EID: 84859348936     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200614q     Document Type: Article

References (29)

1. Lassmann, H. Classification of demyelinating diseases at the interface between etiology and pathogenesis Curr. Opin. Neurol. 2001, 14 (3) 253-8 (Pubitemid 32510587)
2. Wu, G. F.; Alvarez, E. The immunopathophysiology of multiple sclerosis Neurol. Clin. 2011, 29 (2) 257-78
3. Markowitz, C. E. The current landscape and unmet needs in multiple sclerosis Am. J. Managed Care 2010, 16 (8 Suppl.) S211-8
4. Manikwar, P.; Kiptoo, P.; Badawi, A. H.; Buyuktimkin, B.; Siahaan, T. J. Antigen-specific blocking of CD4-specific immunological synapse formation using BPI and current therapies for autoimmune diseases Med. Res. Rev. 2011, 10.1002/med.20243
5. Lee, K. H.; Holdorf, A. D.; Dustin, M. L.; Chan, A. C.; Allen, P. M.; Shaw, A. S. T cell receptor signaling precedes immunological synapse formation Science 2002, 295 (5559) 1539-42 (Pubitemid 34174012)
6. Murray, J. S.; Oney, S.; Page, J. E.; Kratochvil-Stava, A.; Hu, Y.; Makagiansar, I. T.; Brown, J. C.; Kobayashi, N.; Siahaan, T. J. Suppression of type 1 diabetes in NOD mice by bifunctional peptide inhibitor: modulation of the immunological synapse formation Chem. Biol. Drug Des. 2007, 70 (3) 227-36 (Pubitemid 47305400)
7. Heron, L.; Selnikova, O.; Moiseieva, A.; Van Damme, P.; van der Wielen, M.; Levie, K.; Hoet, B.; Stoffel, M. Immunogenicity, reactogenicity and safety of two-dose versus three-dose (standard care) hepatitis B immunisation of healthy adolescents aged 11-15 years: a randomised controlled trial Vaccine 2007, 25 (15) 2817-22 (Pubitemid 46412571)
8. Peek, L. J.; Middaugh, C. R.; Berkland, C. Nanotechnology in vaccine delivery Adv. Drug Delivery Rev. 2008, 60 (8) 915-28
9. Mata, E.; Igartua, M.; Patarroyo, M. E.; Pedraz, J. L.; Hernandez, R. M. Enhancing immunogenicity to PLGA microparticulate systems by incorporation of alginate and RGD-modified alginate Eur. J. Pharm. Sci. 2011, 44 (1-2) 32-40
10. Zhu, B.; Qie, Y.; Wang, J.; Zhang, Y.; Wang, Q.; Xu, Y.; Wang, H. Chitosan microspheres enhance the immunogenicity of an Ag85B-based fusion protein containing multiple T-cell epitopes of Mycobacterium tuberculosis Eur. J. Pharm. Biopharm. 2007, 66 (3) 318-26 (Pubitemid 46756229)
11. Nishimura, K.; Nishimura, S.; Nishi, N.; Numata, F.; Tone, Y.; Tokura, S.; Azuma, I. Adjuvant activity of chitin derivatives in mice and guinea-pigs Vaccine 1985, 3 (5) 379-84 (Pubitemid 16201992)
12. Otterlei, M.; Ostgaard, K.; Skjak-Braek, G.; Smidsrod, O.; Soon-Shiong, P.; Espevik, T. Induction of cytokine production from human monocytes stimulated with alginate J. Immunother. (1991) 1991, 10 (4) 286-91
13. Brodbeck, K. J.; Pushpala, S.; McHugh, A. J. Sustained release of human growth hormone from PLGA solution depots Pharm. Res. 1999, 16 (12) 1825-9 (Pubitemid 30040697)
14. Jiang, W.; Gupta, R. K.; Deshpande, M. C.; Schwendeman, S. P. Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens Adv. Drug Delivery Rev. 2005, 57 (3) 391-410 (Pubitemid 39550967)
15. Borges, O.; Borchard, G.; Verhoef, J. C.; de Sousa, A.; Junginger, H. E. Preparation of coated nanoparticles for a new mucosal vaccine delivery system Int. J. Pharm. 2005, 299 (1-2) 155-66 (Pubitemid 40962417)
16. Shive, M. S.; Anderson, J. M. Biodegradation and biocompatibility of PLA and PLGA microspheres Adv. Drug Delivery Rev. 1997, 28 (1) 5-24 (Pubitemid 27497671)
17. Kobayashi, N.; Kiptoo, P.; Kobayashi, H.; Ridwan, R.; Brocke, S.; Siahaan, T. J. Prophylactic and therapeutic suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor Clin. Immunol. 2008, 129 (1) 69-79
18. Kobayashi, N.; Kobayashi, H.; Gu, L.; Malefyt, T.; Siahaan, T. J. Antigen-specific suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor J. Pharmacol. Exp. Ther. 2007, 322 (2) 879-86 (Pubitemid 47105795)
19. Ridwan, R.; Kiptoo, P.; Kobayashi, N.; Weir, S.; Hughes, M.; Williams, T.; Soegianto, R.; Siahaan, T. J. Antigen-specific suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor: structure optimization and pharmacokinetics J. Pharmacol. Exp. Ther. 2010, 332 (3) 1136-45
20. Zhao, H.; Kiptoo, P.; Williams, T. D.; Siahaan, T. J.; Topp, E. M. Immune response to controlled release of immunomodulating peptides in a murine experimental autoimmune encephalomyelitis (EAE) model J. Controlled Release 2010, 141 (2) 145-52
21. Wang, Q.; Wang, J.; Lu, Q.; Detamore, M. S.; Berkland, C. Injectable PLGA based colloidal gels for zero-order dexamethasone release in cranial defects Biomaterials 2010, 31 (18) 4980-6
22. Wang, Q.; Jamal, S.; Detamore, M. S.; Berkland, C. PLGA-chitosan/PLGA- alginate nanoparticle blends as biodegradable colloidal gels for seeding human umbilical cord mesenchymal stem cells J. Biomed. Mater. Res., Part A 2011, 96 (3) 520-7
23. Zheng, X.; Huang, Y.; Zheng, C.; Dong, S.; Liang, W. Alginate-chitosan- PLGA composite microspheres enabling single-shot hepatitis B vaccination AAPS J. 2010, 12 (4) 519-24
24. Wang, Y.; Irvine, D. J. Engineering chemoattractant gradients using chemokine-releasing polysaccharide microspheres Biomaterials 2011, 32 (21) 4903-13
25. Fox, E. J. Alemtuzumab in the treatment of relapsing-remitting multiple sclerosis Expert Rev. Neurother. 2010, 10 (12) 1789-97
26. Vanderlugt, C. L.; Neville, K. L.; Nikcevich, K. M.; Eagar, T. N.; Bluestone, J. A.; Miller, S. D. Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing experimental autoimmune encephalomyelitis J. Immunol. 2000, 164 (2) 670-8 (Pubitemid 30043687)
27. Strzepa, A.; Szczepanik, M. IL-17-expressing cells as a potential therapeutic target for treatment of immunological disorders Pharmacol. Rep. 2011, 63 (1) 30-44
28. Abbott, N. J.; Ronnback, L.; Hansson, E. Astrocyte-endothelial interactions at the blood-brain barrier Nat. Rev. Neurosci. 2006, 7 (1) 41-53 (Pubitemid 41828930)
29. Harrington, L. E.; Hatton, R. D.; Mangan, P. R.; Turner, H.; Murphy, T. L.; Murphy, K. M.; Weaver, C. T. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages Nat. Immunol. 2005, 6 (11) 1123-32 (Pubitemid 41541790)