Poly(L-lactic acid)/hydroxyapatite nanocylinders as nanofibrous structure for bone tissue engineering scaffolds

Journal of Biomedical Nanotechnology

Volumn 9, Issue 3, 2013, Pages 424-429

  Lee, Jung Bok ^a   Park, Ha Na ^a   Ko, Wan Kyu ^a   Bae, Min Soo ^a   Heo, Dong Nyoung ^a   Yang, Dae Hyeok ^a   Kwon, Il Keun ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Bone Tissue Engineering; Hydroxyapatite (HAp); Microcylinder; Poly(L lactic acid) (PLLA); Simvastatin

Indexed keywords

BONE TISSUE ENGINEERING; HYDROXYAPATITE (HAP); MICRO CYLINDERS; POLY L LACTIC ACID; SIMVASTATIN;

AMINATION; ASPECT RATIO; BONE; CELL PROLIFERATION; CELLS; HYDROXYAPATITE; LACTIC ACID; LOADING; TISSUE;

SCAFFOLDS (BIOLOGY);

HYDROXYAPATITE; POLYLACTIC ACID; SIMVASTATIN; TISSUE SCAFFOLD;

AMINOLYSIS; ARTICLE; BONE DEVELOPMENT; BONE TISSUE; CELL ADHESION; CELL COUNT; CELL DIFFERENTIATION; CELL NUCLEUS; CELL PROLIFERATION; CELL VIABILITY; CYTOTOXICITY; DRUG RELEASE; FIBROBLAST; GEL PERMEATION CHROMATOGRAPHY; IN VITRO STUDY; INFRARED SPECTROSCOPY; MOLECULAR WEIGHT; OSTEOBLAST; PHYSICAL CHEMISTRY; POLYMERIZATION; REGENERATIVE MEDICINE; SCANNING ELECTRON MICROSCOPY; THERMOGRAVIMETRY; TISSUE ENGINEERING; ULTRASOUND; YOUNG MODULUS;

AMINES; ANIMALS; BONE AND BONES; CELL MOVEMENT; CELL SURVIVAL; DURAPATITE; LACTIC ACID; MICE; NANOFIBERS; NANOPARTICLES; NIH 3T3 CELLS; POLYMERS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84876591209     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2013.1514     Document Type: Article

References (15)

1. J. Lee, G. Tae, Y. H. Kim, IS. Park, S. H. Kim, and S. H. Kim, The effect of gelatin incorporation into electrospun poly(L-lactideco- epsilon-caprolactone) fibers on mechanical properties and cytocompatibility. Biomaterials 29, 1872 (2008).
2. M. F. Leong, K. S. Chian, P. S. Mhaisalkar, W. F. Ong, and B. D. Ratner, Effect of electrospun poly(D,L-lactide) fibrous scaffold with nanoporous surface on attachment of porcine esophageal epithelial cells and protein adsorptipn. J. Biomed. Mater. Res. 89, 1040 (2009).
3. I. K. Kwon and T. Matsuda, Co-electrospun nanofiber fabrics of poly(L-lactide-co-epsilon-caprolactone) with type I collagen or heparin. Biomacromolecules 6, 2096 (2005).
4. I. K. Kwon, S. Kidoaki, and T. Matsuda, Electrospun nano- to microfiber fabrics made of biodegradable copolyesters: Structural characteristics, mechanical properties and cell adhesion potential. Biomaterials 26, 3929 (2005).
5. A. Thorvaldsson, H. Stenhamre, P. Gatenholm, and P. Walkenstrom, Electrospinning of highly porous scaffolds for cartilage regeneration. Biomacromolecules 9, 1044 (2008).
6. S. M. Park, Y. S. Huh, K. Szeto, D. J. Joe, J. Kameoka, G. W. Coates, J. B. Edel, D. Erickson, and H. G. Craighead, Rapid prototyping of nanofluidic systems using size-reduced electrospun nanofibers for biomolecular analysis. Small 6, 2420 (2010).
7. S. Y. Chew, R. Mi, A. Hoke, and K. W. Leong, The effect of the alignment of electrospun fibrous scaffolds on schwann cell maturation. Biomaterials 29, 653 (2008).
8. H. S. Yoo, T. G. Kim, and T. G. Park, Surface-functionalized electrospun nanofibers for tissue engineering and drug delivery. Adv. Drug Deliver. Rev. 61, 1033 (2009).
9. V. Leung and F. Ko, Biomedical applications of nanofibers. Polym. Adv. Technol. 22, 350 (2011).
10. T. J. Sill, and H. A. Von Recum, Electrospinning: Applications in drug delivery and tissue engineering. Biomaterials 29, 1989 (2008).
11. J. B. Lee, S. E. Kim, D. N. Heo, and I. K. Kwon, In vitro characterization of nanofibrous plga/gelatin/hydroxyapatite composite for bone tissue engineering. Macromol. Res. 18, 1195 (2010).
12. L.Chen, Q. Yu, Y. Wang, and H. Li, BisGMA/TEGDMA dental composite containing high aspect-ratio hydroxyapatite nanofibers. Dental Materials 27, 1187 (2011).
13. K. Wei, Y. Li, K. O. Kim, Y. Nakagawa, B. S. Kim, K. Abe, G. Q. Chen, and I. S. Kim, Fabrication of nano-hydroxyapatite on electrospun silk fibroin nanofiber and their effects in osteoblastic behavior. J. Biomed. Mater. Res. A 97, 272 (2011).
14. T. I. Croll, A. J. O'Connor, G. W. Stevens, and J. J. Cooper- White, Controllable surface modification of poly(lactic-co-glycolic acid) (PLGA) by hydrolysis or aminolysis I: Physical, chemical, and theoretical aspects. Biomacromolecules 5, 463 (2004).
15. N. Grabow, M. Schlun, K. Sterngerg, N. Hakansson, S. Kramer, and P. Schmitz K, Mechanical properties of laser cut poly(L-lactide) micro-specimens: Implications for stent design, manufacture, and sterilization. J. Biomech. 127, 25 (2005).