Multiple chromatin-bound protein kinases assemble factors that regulate insulin gene transcription

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 52, 2009, Pages 22181-22186

  Lawrence, Michael C ^a   Shao, Chunli ^a   McGlynn, Kathleen ^a   Naziruddin, Bashoo ^b   Levy, Marlon F ^b   Cobb, Melanie H ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

ERK1 2; Histone acetylation; Interleukin 1

Indexed keywords

GLUCOSE; INSULIN; INTERLEUKIN 1BETA; PROTEIN KINASE; RNA POLYMERASE II; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROMOTER REGION; SENSITIZATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ACETYLATION; ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE; CHROMATIN; FASTING; GLUCOSE; HISTONES; HUMANS; HYPERGLYCEMIA; INSULIN; INSULIN-SECRETING CELLS; INTERLEUKIN-1BETA; MICE; MODELS, ANATOMIC; PROMOTER REGIONS, GENETIC; PROTEIN KINASES; PROTEIN PRECURSORS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 76049126005     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0912596106     Document Type: Article

References (54)

1. Genuth S, et al. (2003) Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 26:3160-3167.
2. Yoo SD, Cho YH, Tena G, Xiong Y, Sheen J (2008) Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling. Nature 451:789-795.
3. Rutter GA, Parton LE (2008) The β-cell in type 2 diabetes and in obesity. Front Horm Res 36:118-134.
4. Metz SA, Halter JB, Robertson RP (1979) Paradoxical inhibition of insulin secretion by glucose in human diabetes mellitus. J Clin Endocrinol Metab 48:827-835.
5. Davalli AM, et al. (1991) Abnormal sensitivity to glucose of human islets cultured in a high glucose medium: Partial reversibility after an additional culture in a normal glucose medium. J Clin Endocrinol Metab 72:202-208.
6. Eizirik DL, Korbutt GS, Hellerstrom C (1992) Prolonged exposure ofhumanpancreatic islets to high glucose concentrations in vitro impairs the β-cell function. J Clin Invest 90:1263-1268.
7. Olson LK, Redmon JB, Towle HC, Robertson RP (1993) Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein. J Clin Invest 92:514-519.
8. Philippe J, Pacheco I, Meda P (1994) Insulin gene transcription is decreased rapidly by lowering glucose concentrations in rat islet cells. Diabetes 43:523-528.
9. Janjic D, AsfariM(1992) Effects of cytokines on rat insulinoma INS-1 cells. J Endocrinol 132:67-76.
10. Cavallo MG, et al. (1992) Viral infection induces cytokine release by β islet cells. Immunology 75:664-668.
11. Maedler K, et al. (2002) Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets. J Clin Invest 110:851-860.
12. Cnop M, Welsh N, Jonas JC, Jorns A, Lenzen S, Eizirik DL (2005) Mechanisms of pancreatic {beta}-cell death in type 1 and type 2 diabetes: Many differences, few similarities. Diabetes 54(Suppl 2):S97-S107.
13. Lu M, Seufert J, Habener JF (1997) Pancreatic β-cell-specific repression of insulin gene transcription by CCAAT/enhancer-binding protein β. Inhibitory interactions with basic helix-loop-helix transcription factor E47. J Biol Chem 272:28349-28359.
14. Aramat S, Han SI, Yasuda K, Kataoka K (2005) Synergistic activation of the insulin gene promoter by the β-cell enriched transcription factors MafA, β2, and Pdx1. Biochim Biophys Acta 1730:41-46.
15. Ohneda K, Ee H, GermanM(2000) Regulation of insulin gene transcription. Semin Cell Dev Biol 11:227-233.
16. Zhao L, et al. (2005) The islet βcell-enriched MafA activator is a key regulator of insulin gene transcription. J Biol Chem 280:11887-11894.
17. Habener JF, StoffersDA(1998)Anewly discovered role of transcription factors involved in pancreas development and the pathogenesis of diabetes mellitus. Proc Assoc Am Physicians 110:12-21.
18. Vaxillaire M, Froguel P (2008) Monogenic diabetes in the young, pharmacogenetics and relevance to multifactorial forms of type 2 diabetes. Endocr Rev 29:254-264.
19. Lawrence MC, Bhatt HS, Watterson JM, Easom RA. 2001. Regulation of insulin gene transcription by a Ca(2+)-responsive pathway involving calcineurin and nuclear factor of activated T cells. Mol Endocrinol 15:1758-1767.
20. Lawrence MC, McGlynn K, Park BH, Cobb MH (2005) ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter. J Biol Chem 28026751-26759.
21. Heit JJ (2007) Calcineurin/NFAT signaling in the β-cell: From diabetes to new therapeutics. Bioessays 29:1011-1021.
22. Lawrence MC, et al. (2008) Chromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in β-cells. Proc Natl Acad Sci USA 105:13315-13320.
23. Arnette D, et al. (2003) Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic β cells. J Biol Chem 278:32517-32525.
24. Cardozo AK, et al. (2001) A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic β-cells. J Biol Chem 276:48879-48886.
25. Oetjen E, et al. (2007) Inhibition of MafA transcriptional activity and human insulin gene transcription by interleukin-1β and mitogen-activated protein kinase kinase kinase in pancreatic islet β cells. Diabetologia 50:1678-1687.
26. 2+, leading to induction of endoplasmic reticulum stress in pancreatic β-cells. Diabetes 54:452-461.
27. Rieneck K, et al. (2000) Massive parallel gene expression profiling of RINm5F pancreatic islet β-cells stimulated with interleukin-1β. APMIS 108:855-872.
28. Jonas JC, et al. (1999) Chronic hyperglycemia triggers loss of pancreatic β cell differentiation in an animal model of diabetes. J Biol Chem 274:14112-14121.
29. Seufert J, Weir GC, Habener JF (1998) Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein β and transactivator islet duodenum homeobox-1 in rat pancreatic βcells during the development of diabetes mellitus. J Clin Invest 101:2528-2539.
30. Olson LK, et al. (1995) Reduction of insulin gene transcription in HIT-T15 β cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression. Proc Natl Acad Sci USA 92:9127-9131.
31. Kaneto H, et al. (2002) Involvement of c-Jun N-terminal kinase in oxidative stressmediated suppression of insulin gene expression. J Biol Chem 277:30010-30018.
32. Harmon JS, Stein R, Robertson RP (2005) Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic β cells. J Biol Chem 280:11107-11113.
33. Poitout V, Olson LK, Robertson RP (1996) Chronic exposure of βTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator. J Clin Invest 97:1041-1046.
34. Kawamori D, et al. (2003) Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase. Diabetes 52:2896-2904.
35. Inagaki N, et al. (1992) c-Jun represses the human insulin promoter activity that depends on multiple cAMP response elements. Proc Natl Acad Sci USA 89:1045-1049.
36. Tirosh A, et al. (2005) Normal fasting plasma glucose levels and type 2 diabetes in young men. N Engl J Med 353:1454-1462.
37. Khoo S, Cobb MH (1997) Activation of MAP kinase by glucose is not required for insulin secretion. Proc Natl Acad Sci USA 94:5599-5604.
38. Ban N, et al. (2000) Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression. Diabetes 49:1142-1148.
39. Hay CW, Ferguson LA, Docherty K (2007) ATF-2 stimulates the human insulin promoter through the conserved CRE2 sequence. Biochim Biophys Acta 1769:79-91.
40. Mellor J (2006) Dynamic nucleosomes and gene transcription. Trends Genet 22:320-329.
41. Sassone-Corsi P, et al. (1999) Requirement of Rsk-2 for epidermal growth factoractivated phosphorylation of histone H3. Science 285:886-891.
42. Levenson JM, et al. (2004) Regulation of histone acetylation during memory formation in the hippocampus. J Biol Chem 279:40545-40559.
43. Soloaga A, et al. (2003) MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. EMBO J 22:2788-2797.
44. Galasinski SC, Louie DF, Gloor KK, Resing KA, Ahn NG (2002) Global regulation of post-translational modifications on core histones. J Biol Chem 277:2579-2588.
45. Chakrabarti SK, Francis J, Ziesmann SM, Garmey JC, MirmiraRG(2003) Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic β cells. J Biol Chem 278:23617-23623.
46. Mosley AL, Ozcan S (2003) Glucose regulates insulin gene transcription by hyperacetylation of histone h4. J Biol Chem 278:19660-19666.
47. Bruhat A, et al. (2000) Amino acids control mammalian gene transcription: Activating transcription factor 2 is essential for the amino acid responsiveness of the CHOP promoter. Mol Cell Biol 20:7192-7204.
48. Mosley AL, Corbett JA, Ozcan S (2004) Glucose regulation of insulin gene expression requires the recruitment of p300 by the β-cell-specific transcription factor Pdx-1. Mol Endocrinol 18:2279-2290.
49. Stanojevic V, Habener JF, Thomas MK (2004) Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300. Endocrinology 145:2918-2928.
50. Iype T, et al. (2005) Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: Application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes. J Biol Chem 280:16798-16807.
51. Qiu Y, Sharma A, Stein R (1998) p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene. Mol Cell Biol 18:2957-2964.
52. Di Poi N, Desvergne B, Michalik L, Wahli W (2005) Transcriptional repression of peroxisome proliferator-activated receptor beta/delta in murine keratinocytes by CCAAT/enhancer-binding proteins. J Biol Chem 280:38700-38710.
53. Garcia-Rodriguez C, Rao A (1998) Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP). J Exp Med 187:2031-2036.
54. Boulton TG, Cobb MH (1991) Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies. Cell Regul 2:357-371.