Effects of water-soluble tacrolimus-PEG conjugate on insulindependent diabetes mellitus and systemic lupus erythematosus

Archives of Pharmacal Research

Volumn 34, Issue 8, 2011, Pages 1301-1310

  Choi, Du Bok ^a   Kim, Bok Hee ^b   Lee, Myung Koo ^a   Cho, Hoon ^b  

^a Chungbuk National University   (South Korea)

^b Chosun University   (South Korea)

Author keywords

Insulin dependent diabetes mellitus; Soluble tacrolimus PEG conjugates; Systemic lupus erythematosus; Tacrolimus

Indexed keywords

3 HYDROXYBUTYRIC ACID; ALBUMIN; CHOLESTEROL; GLUCOSE; IMMUNOSUPPRESSIVE AGENT; KI 102; TACROLIMUS; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ALBUMIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG CONCENTRATION; DRUG CONJUGATION; DRUG DOSE INCREASE; DRUG EFFECT; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; DRUG STORAGE; DRUG STRUCTURE; FEMALE; GLUCOSE BLOOD LEVEL; IMMUNOSUPPRESSIVE TREATMENT; INSULIN DEPENDENT DIABETES MELLITUS; LIPID BLOOD LEVEL; MOUSE; NONHUMAN; PH; PHARMACOKINETICS; RAT; SURVIVAL; SYSTEMIC LUPUS ERYTHEMATOSUS; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL;

ADMINISTRATION, ORAL; ALBUMINS; ANIMALS; ANTIBODIES, ANTINUCLEAR; BLOOD GLUCOSE; CAPSULES; CHOLESTEROL; DIABETES MELLITUS, TYPE 1; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; DRUG STABILITY; FEMALE; FREEZE DRYING; HYDROGEN-ION CONCENTRATION; IMMUNOSUPPRESSIVE AGENTS; INSULIN; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; POLYETHYLENE GLYCOLS; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; TACROLIMUS; TRIGLYCERIDES;

EID: 80855128249     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-011-0810-z     Document Type: Article

References (17)

1. Besarab, A., Jarrell, B. E., Hirsch, S., Carabasi, R. A., Cressman, M. D., and Green, P., Use of the isolated perfused kidney model to assess the acute pharmacologic effects of cyclosporine and its vehicle, cremophor EL. Transplantation, 44, 195-201 (1987). (Pubitemid 17148072)
2. Choi, D. and Cho, H., Effect of tacrolimus derivatives on immunosuppression. Arch. Pharm. Res., 32, 549-557 (2009).
3. Chung, Y. and Cho, H., Preparation of highly water soluble tacrolimus derivatives: poly(ethylene glycol) esters as potential prodrugs. Arch. Pharm. Res., 27, 878-883 (2004). (Pubitemid 43073711)
4. Fung, J. J., Tacrolimus and transplantation: a decade in review. Transplantation, 77, S41-S43 (2004). (Pubitemid 38668458)
5. Hane, K., Fujioka, M., Namiki, Y., Kitagawa, T., Kihara, N., Shimatani, K., and Yasuda, T., Physico-chemical properties of FK-506. Iyakuhin Kenkyu, 23, 33-43 (1992).
6. Harris, J. M. and Chess, R. B., Effect of pegylation on pharmaceuticals. Nat. Rev. Drug Discov., 2, 214-221 (2003). (Pubitemid 37361666)
7. Kim, H. S. and Park, Y. I., Isolation and identification of a novel microorganism producing the immunosuppressant tacrolimus. J. Biosci. Bioeng., 105, 418-421 (2008). (Pubitemid 351680742)
8. Koo, J. Y., Fleischer, A. B. Jr., Abramovits, W., Pariser, D. M., McCall, C. O., Horn, T. D., Gottlieb, A. B., Jaracz, E., and Rico, M. J., Tacrolimus ointment is safe and effective in the treatment of atopic dermatitis: results in 8000 patients. J. Am. Acad. Dermatol., 53, S195-S205 (2005). (Pubitemid 40966766)
9. Kremer, J. M., Habros, J. S., Kolba, K. S., Kaine, J. L., Borton, M. A., Mengle-Gaw, L. J., Schwartz, B. D., Wisemandle, W., and Mekki, Q. A., Tacrolimus in rheumatoid arthritis patients receiving concomitant methotrexate: a six-month, open-label study. Arthritis Rheum., 48, 2763-2768 (2003). (Pubitemid 37280603)
10. Mathew, A. E., Mejillano, M. R., Nath, J. P., Himes, R. H., and Stella, V. J., Synthesis and evaluation of some watersoluble prodrugs and derivatives of taxol with antitumor activity. J. Med. Chem., 35, 145-151 (1992).
11. Mattila, P. S., Ullman, K. S., Fiering, S., Emmel, E. A., McCutcheon, M., Crabtree, G. R., and Herzenberg, L. A., The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes. EMBO J., 9, 4425-4433 (1990). (Pubitemid 120026000)
12. Noguchi, Y., Wu, J., Duncan, R., Strohalm, J., Ulbrich, K., Akaike, T., and Maeda, H., Early phase tumor accumulation of macromolecules: a great difference in clearance rate between tumor and normal tissues. Jpn. J. Cancer Res., 89, 307-314 (1998). (Pubitemid 28197296)
13. Peters, D. H., Fitton, A., Plosker, G. L., and Faulds, D., Tacrolimus. A review of its pharmacology, and therapeutic potential in hepatic and renal transplantation. Drugs, 46, 746-794 (1993). (Pubitemid 23331067)
14. Shafiee, A., Motamedi, H., and Chen, T., Enzymology of FK-506 biosynthesis. Purification and characterization of 31-O-desmethylFK-506 O: methyltransferase from Streptomyces sp. MA6858. Eur. J. Biochem., 225, 755-764 (1994). (Pubitemid 24325594)
15. Snyder, S. H. and Sabatini, D. M., Immunophilins and the nervous system. Nat. Med., 1, 32-37 (1995).
16. Tanaka, H., Kuroda, A., Marusawa, H., Hatanaka, H., Kino, T., Koto, T., Hashmoto, M., and Taga, T., Structure of FK-506: a novel immunosuppressant isolated from Streptomyces. J. Am. Chem. Soc., 109, 5031-5033 (1987). (Pubitemid 17112542)
17. Yocum, D. E., Furst, D. E., Kaine, J. L., Baldassare, A. R., Stevenson, J. T., Borton, M. A., Mengle-Gaw, L. J., Schwartz, B. D., Wisemandle, W., and Mekki, Q. A., Efficacy and safety of tacrolimus in patients with rheumatoid arthritis: a double-blind trial. Arthritis Rheum., 48, 3328-3337 (2003). (Pubitemid 37531899)