Enhanced transport of nanocage stabilized pure nanodrug across intestinal epithelial barrier mimicking Listeria monocytogenes

Biomaterials

Volumn 37, Issue , 2015, Pages 320-332

  Xia, Dengning ^a   Tao, Jinsong ^a,b   He, Yuan ^a,c   Zhu, Quanlei ^a   Chen, Dan ^a   Yu, Miaorong ^a   Cui, Fude ^d   Gan, Yong ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b NANCHANG UNIVERSITY   (China)

^c CHONGQING MEDICAL UNIVERSITY   (China)

^d SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Epithelial barrier; Goblet cells; Nanocage; Nanocrystals; Wheat germ agglutinin

Indexed keywords

BIOCHEMISTRY; CELLS; CONTROLLED DRUG DELIVERY; CYTOLOGY; GRAFTING (CHEMICAL); LIGANDS; LISTERIA; NANOCRYSTALS; PATHOGENS;

COVALENT CROSSLINKING; EPITHELIAL BARRIER; GASTROINTESTINAL TRACT; GRAFTED NANOPARTICLES; LISTERIA MONOCYTOGENES; NANOCAGES; ORAL BIOAVAILABILITIES; WHEAT GERM AGGLUTININ;

TARGETED DRUG DELIVERY;

ITRACONAZOLE; NANOCAGE; NANOCRYSTAL; POLY(ACRYLIC ACID) B POLY(METHYL ACRYLATE); POLY(METHYL METHACRYLATE); UNCLASSIFIED DRUG; WHEAT GERM AGGLUTININ; NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL FUNCTIONS; CACO 2 CELL LINE; CELL MEMBRANE; CONFOCAL LASER MICROSCOPY; CROSS LINKING; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG SOLUBILITY; DRUG SYNTHESIS; DRUG UPTAKE; EX VIVO STUDY; GOBLET CELL; IN VIVO STUDY; INTESTINE EPITHELIUM CELL; LAMINA PROPRIA; LISTERIA MONOCYTOGENES; MALE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SURFACE PROPERTY; TRANSCYTOSIS; ZETA POTENTIAL; ABSORPTION; ANIMAL; CHEMISTRY; DRUG EFFECTS; ENDOCYTOSIS; EPITHELIUM CELL; FLUORESCENCE; HUMAN; INTESTINE MUCOSA; METABOLISM; PARTICLE SIZE; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; STATIC ELECTRICITY; TRANSPORT AT THE CELLULAR LEVEL; ULTRASTRUCTURE;

LISTERIA MONOCYTOGENES; RATTUS; TRITICUM AESTIVUM;

ABSORPTION, PHYSIOLOGICAL; ANIMALS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; ENDOCYTOSIS; EPITHELIAL CELLS; FLUORESCENCE; HUMANS; INTESTINAL MUCOSA; ITRACONAZOLE; LISTERIA MONOCYTOGENES; MALE; NANOPARTICLES; PARTICLE SIZE; RATS, SPRAGUE-DAWLEY; STATIC ELECTRICITY; WHEAT GERM AGGLUTININS;

EID: 84922265147     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.10.038     Document Type: Article

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