Enhanced glucose-induced intracellular signaling promotes insulin hypersecretion: Pancreatic beta-cell functional adaptations in a model of genetic obesity and prediabetes

Molecular and Cellular Endocrinology

Volumn 404, Issue , 2015, Pages 46-55

  Irles, Esperanza ^a,b   Ñeco, Patricia ^a,b   Lluesma, Mónica ^a,b   Villar Pazos, Sabrina ^a,b   Santos Silva, Junia Carolina ^a,c   Vettorazzi, Jean F ^a,c   Alonso Magdalena, Paloma ^a,b   Carneiro, Everardo M ^c   Boschero, Antonio C ^c   Nadal, Ángel ^a,b   Quesada, Ivan ^a,b  

^a MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Calcium signals; Diabetes; Electrical activity; Insulin secretion; Obesity; Pancreatic beta cell

Indexed keywords

GLUCOSE; INSULIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; CALCIUM; GLUCOSE BLOOD LEVEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CELL ACTIVITY; CELL FUNCTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRIC ACTIVITY; EXOCYTOSIS; FEMALE; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERPOLARIZATION; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; INSULIN RESISTANCE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PATCH CLAMP TECHNIQUE; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; DISEASE MODEL; GLUCOSE BLOOD LEVEL; HUMAN; METABOLISM; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; SECRETION (PROCESS);

ANIMALS; BLOOD GLUCOSE; CALCIUM; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MICE; MICE, OBESE; OBESITY; PREDIABETIC STATE;

EID: 84922256854     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2015.01.033     Document Type: Article

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