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Volumn 306, Issue 1, 2014, Pages

Effect of peripherally administered leptin antagonist on whole body metabolism and bone microarchitecture and biomechanical properties in the mouse

Author keywords

Insulin resistance; Leptin signaling; Microcomputed tomography; Obesity

Indexed keywords

ALIZARIN; CALCEIN; CHOLESTEROL; GLUCOSE; INSULIN; PEPTIDE HORMONE ANTAGONIST; SUPERACTIVE MOUSE LEPTIN ANTAGONIST; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84891507109     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00155.2013     Document Type: Article
Times cited : (23)

References (91)
  • 1
    • 84870881313 scopus 로고    scopus 로고
    • Methioninerestricted C57BL/6J mice are resistant to diet-induced obesity and insulin resistance but have low bone density
    • Ables GP, Perrone CE, Orentreich D, Orentreich N. Methioninerestricted C57BL/6J mice are resistant to diet-induced obesity and insulin resistance but have low bone density. PLoS One 7: e51357, 2012.
    • (2012) PLoS One , vol.7
    • Ables, G.P.1    Perrone, C.E.2    Orentreich, D.3    Orentreich, N.4
  • 4
    • 0033773314 scopus 로고    scopus 로고
    • A neuro (endo)crine regulation of bone remodeling
    • Amling M, Takeda S, Karsenty G. A neuro (endo)crine regulation of bone remodeling. Bioessays 22: 970-975, 2000.
    • (2000) Bioessays , vol.22 , pp. 970-975
    • Amling, M.1    Takeda, S.2    Karsenty, G.3
  • 5
    • 70149087706 scopus 로고    scopus 로고
    • Circulating adiponectin represents a biomarker of the association between adiposity and bone mineral density
    • Aǧbaht K, Gürlek A, Karakaya J, Bayraktar M. Circulating adiponectin represents a biomarker of the association between adiposity and bone mineral density. Endocrine 35: 371-379, 2009.
    • (2009) Endocrine , vol.35 , pp. 371-379
    • Aǧbaht, K.1    Gürlek, A.2    Karakaya, J.3    Bayraktar, M.4
  • 7
    • 79960629585 scopus 로고    scopus 로고
    • Central (ICV) leptin injection increases bone formation, bone mineral density, muscle mass, serum IGF-1, and the expression of osteogenic genes in leptin-deficient ob/ob mice
    • Bartell SM, Rayalam S, Ambati S, Gaddam DR, Hartzell DL, Hamrick M, She JX, Della-Fera MA, Baile CA. Central (ICV) leptin injection increases bone formation, bone mineral density, muscle mass, serum IGF-1, and the expression of osteogenic genes in leptin-deficient ob/ob mice. J Bone Miner Res 26: 1710-1720, 2011.
    • (2011) J Bone Miner Res , vol.26 , pp. 1710-1720
    • Bartell, S.M.1    Rayalam, S.2    Ambati, S.3    Gaddam, D.R.4    Hartzell, D.L.5    Hamrick, M.6    She, J.X.7    Della-Fera, M.A.8    Baile, C.A.9
  • 8
    • 77956408745 scopus 로고    scopus 로고
    • Apolipoprotein E-dependent inverse regulation of vertebral bone and adipose tissue mass in C57Bl/6 mice: Modulation by dietinduced obesity
    • Bartelt A, Beil FT, Schinke T, Roeser K, Ruether W, Heeren J, Niemeier A. Apolipoprotein E-dependent inverse regulation of vertebral bone and adipose tissue mass in C57Bl/6 mice: modulation by dietinduced obesity. Bone 47: 736-745, 2010.
    • (2010) Bone , vol.47 , pp. 736-745
    • Bartelt, A.1    Beil, F.T.2    Schinke, T.3    Roeser, K.4    Ruether, W.5    Heeren, J.6    Niemeier, A.7
  • 9
    • 0141839103 scopus 로고    scopus 로고
    • Novel concepts in insulin regulation of hepatic gluconeogenesis
    • Barthel A, Schmoll D. Novel concepts in insulin regulation of hepatic gluconeogenesis. Am J Physiol Endocrinol Metab 285: E685-E692, 2003.
    • (2003) Am J Physiol Endocrinol Metab , vol.285
    • Barthel, A.1    Schmoll, D.2
  • 11
    • 79958772684 scopus 로고    scopus 로고
    • Effects of obesity on bone metabolism
    • Cao JJ. Effects of obesity on bone metabolism. J Orthop Surg Res 6: 30, 2011.
    • (2011) J Orthop Surg Res , vol.6 , pp. 30
    • Cao, J.J.1
  • 12
    • 67349252445 scopus 로고    scopus 로고
    • High-fat diet decreases cancellous bone mass but has no effect on cortical bone mass in the tibia in mice
    • Cao JJ, Gregoire BR, Gao H. High-fat diet decreases cancellous bone mass but has no effect on cortical bone mass in the tibia in mice. Bone 44: 1097-1104, 2009.
    • (2009) Bone , vol.44 , pp. 1097-1104
    • Cao, J.J.1    Gregoire, B.R.2    Gao, H.3
  • 13
    • 77950650638 scopus 로고    scopus 로고
    • Diet-induced obesity alters bone remodeling leading to decreased femoral trabecular bone mass in mice
    • Cao JJ, Sun L, Gao H. Diet-induced obesity alters bone remodeling leading to decreased femoral trabecular bone mass in mice. Ann NY Acad Sci 1192: 292-297, 2010.
    • (2010) Ann NY Acad Sci , vol.1192 , pp. 292-297
    • Cao, J.J.1    Sun, L.2    Gao, H.3
  • 15
    • 77952957668 scopus 로고    scopus 로고
    • Effect of adiponectin on ATDC5 proliferation, differentiation and signaling pathways
    • Challa TD, Rais Y, Ornan EM. Effect of adiponectin on ATDC5 proliferation, differentiation and signaling pathways. Mol Cell Endocrinol 323: 282-291, 2010.
    • (2010) Mol Cell Endocrinol , vol.323 , pp. 282-291
    • Challa, T.D.1    Rais, Y.2    Ornan, E.M.3
  • 16
    • 84878801108 scopus 로고    scopus 로고
    • A superactive leptin antagonist alters metabolism and locomotion in highleptin mice
    • Chapnik N, Solomon G, Genzer Y, Miskin R, Gertler A, Froy O. A superactive leptin antagonist alters metabolism and locomotion in highleptin mice. J Endocrinol 217: 283-290, 2013.
    • (2013) J Endocrinol , vol.217 , pp. 283-290
    • Chapnik, N.1    Solomon, G.2    Genzer, Y.3    Miskin, R.4    Gertler, A.5    Froy, O.6
  • 17
    • 84869088811 scopus 로고    scopus 로고
    • Indole-3-carbinol prevents diet-induced obesity through modulation of multiple genes related to adipogenesis, thermogenesis or inflammation in the visceral adipose tissue of mice
    • Choi Y, Kim Y, Park S, Lee KW, Park T. Indole-3-carbinol prevents diet-induced obesity through modulation of multiple genes related to adipogenesis, thermogenesis or inflammation in the visceral adipose tissue of mice. J Nutr Biochem 23: 1732-1739, 2012.
    • (2012) J Nutr Biochem , vol.23 , pp. 1732-1739
    • Choi, Y.1    Kim, Y.2    Park, S.3    Lee, K.W.4    Park, T.5
  • 18
    • 34548675597 scopus 로고    scopus 로고
    • Modulation of liver X receptor signaling as novel therapy for prostate cancer
    • Chuu CP, Kokontis JM, Hiipakka RA, Liao S. Modulation of liver X receptor signaling as novel therapy for prostate cancer. J Biomed Sci 14: 543-553, 2007.
    • (2007) J Biomed Sci , vol.14 , pp. 543-553
    • Chuu, C.P.1    Kokontis, J.M.2    Hiipakka, R.A.3    Liao, S.4
  • 19
    • 4143119937 scopus 로고    scopus 로고
    • Leptin treatment markedly increased plasma adiponectin but barely decreased plasma resistin of ob/ob mice
    • Delporte ML, El Mkadem SA, Quisquater M, Brichard SM. Leptin treatment markedly increased plasma adiponectin but barely decreased plasma resistin of ob/ob mice. Am J Physiol Endocrinol Metab 287: E446-E453, 2004.
    • (2004) Am J Physiol Endocrinol Metab , vol.287
    • Delporte, M.L.1    El Mkadem, S.A.2    Quisquater, M.3    Brichard, S.M.4
  • 20
    • 84865422329 scopus 로고    scopus 로고
    • TNF-alpha represses beta-Klotho expression and impairs FGF21 action in adipose cells: Involvement of JNK1 in the FGF21 pathway
    • Diaz-Delfin J, Hondares E, Iglesias R, Giralt M, Caelles C, Villarroya F. TNF-alpha represses beta-Klotho expression and impairs FGF21 action in adipose cells: involvement of JNK1 in the FGF21 pathway. Endocrinology 153: 4238-4245, 2012.
    • (2012) Endocrinology , vol.153 , pp. 4238-4245
    • Diaz-Delfin, J.1    Hondares, E.2    Iglesias, R.3    Giralt, M.4    Caelles, C.5    Villarroya, F.6
  • 22
    • 0025143220 scopus 로고
    • Exercise induces recruitment of the "insulinresponsive glucose transporter". Evidence for distinct intracellular insulinand exercise-recruitable transporter pools in skeletal muscle
    • Douen AG, Ramlal T, Rastogi S, Bilan PJ, Cartee GD, Vranic M, Holloszy JO, Klip A. Exercise induces recruitment of the "insulinresponsive glucose transporter". Evidence for distinct intracellular insulinand exercise-recruitable transporter pools in skeletal muscle. J Biol Chem 265: 13427-13430, 1990.
    • (1990) J Biol Chem , vol.265 , pp. 13427-13430
    • Douen, A.G.1    Ramlal, T.2    Rastogi, S.3    Bilan, P.J.4    Cartee, G.D.5    Vranic, M.6    Holloszy, J.O.7    Klip, A.8
  • 29
    • 0027940556 scopus 로고
    • Vanadate normalizes hyperglycemia and phosphoenolpyruvate carboxykinase mRNA levels in ob/ob mice
    • Ferber S, Meyerovitch J, Kriauciunas KM, Kahn CR. Vanadate normalizes hyperglycemia and phosphoenolpyruvate carboxykinase mRNA levels in ob/ob mice. Metabolism 43: 1346-1354, 1994.
    • (1994) Metabolism , vol.43 , pp. 1346-1354
    • Ferber, S.1    Meyerovitch, J.2    Kriauciunas, K.M.3    Kahn, C.R.4
  • 30
    • 77957302090 scopus 로고    scopus 로고
    • Hepatic steatosis: A role for de novo lipogenesis and the transcription factor SREBP-1c
    • Ferré P, Foufelle F. Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c. Diabetes Obes Metab 12, Suppl 2: 83-92, 2010.
    • (2010) Diabetes Obes Metab , vol.12 , Issue.SUPPL. 2 , pp. 83-92
    • Ferré, P.1    Foufelle, F.2
  • 31
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 395: 763-770, 1998.
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 32
    • 30044434035 scopus 로고    scopus 로고
    • Intracellular signalling pathways activated by leptin
    • Fruhbeck G. Intracellular signalling pathways activated by leptin. Biochem J 393: 7-20, 2006.
    • (2006) Biochem J , vol.393 , pp. 7-20
    • Fruhbeck, G.1
  • 33
    • 84862732706 scopus 로고    scopus 로고
    • Serum leptin levels negatively correlate with trabecular bone mineral density in high-fat diet-induced obesity mice
    • Fujita Y, Watanabe K, Maki K. Serum leptin levels negatively correlate with trabecular bone mineral density in high-fat diet-induced obesity mice. J Musculoskelet Neuronal Interact 12: 84-94, 2012.
    • (2012) J Musculoskelet Neuronal Interact , vol.12 , pp. 84-94
    • Fujita, Y.1    Watanabe, K.2    Maki, K.3
  • 34
    • 19044381754 scopus 로고    scopus 로고
    • Leptin treatment induces loss of bone marrow adipocytes and increases bone formation in leptin-deficient ob/ob mice
    • Hamrick MW, Della-Fera MA, Choi YH, Pennington C, Hartzell D, Baile CA. Leptin treatment induces loss of bone marrow adipocytes and increases bone formation in leptin-deficient ob/ob mice. J Bone Miner Res 20: 994-1001, 2005.
    • (2005) J Bone Miner Res , vol.20 , pp. 994-1001
    • Hamrick, M.W.1    Della-Fera, M.A.2    Choi, Y.H.3    Pennington, C.4    Hartzell, D.5    Baile, C.A.6
  • 35
    • 1542316258 scopus 로고    scopus 로고
    • Leptin deficiency produces contrasting phenotypes in bones of the limb and spine
    • Hamrick MW, Pennington C, Newton D, Xie D, Isales C. Leptin deficiency produces contrasting phenotypes in bones of the limb and spine. Bone 34: 376-383, 2004.
    • (2004) Bone , vol.34 , pp. 376-383
    • Hamrick, M.W.1    Pennington, C.2    Newton, D.3    Xie, D.4    Isales, C.5
  • 36
    • 45749111786 scopus 로고    scopus 로고
    • Differences in trabecular bone of leptin-deficient ob/ob mice in response to biomechanical loading
    • Heep H, Wedemeyer C, Wegner A, Hofmeister S, von Knoch M. Differences in trabecular bone of leptin-deficient ob/ob mice in response to biomechanical loading. Int J Biol Sci 4: 169-175, 2008.
    • (2008) Int J Biol Sci , vol.4 , pp. 169-175
    • Heep, H.1    Wedemeyer, C.2    Wegner, A.3    Hofmeister, S.4    von Knoch, M.5
  • 41
    • 29244456731 scopus 로고    scopus 로고
    • Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: Molecular characterization in liver and muscle
    • Kaidanovich-Beilin O, Eldar-Finkelman H. Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: molecular characterization in liver and muscle. J Pharmacol Exp Ther 316: 17-24, 2006.
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 17-24
    • Kaidanovich-Beilin, O.1    Eldar-Finkelman, H.2
  • 44
    • 50349088864 scopus 로고    scopus 로고
    • Transcriptional regulation of the insulin-responsive glucose transporter GLUT4 gene: From physiology to pathology
    • Karnieli E, Armoni M. Transcriptional regulation of the insulin-responsive glucose transporter GLUT4 gene: from physiology to pathology. Am J Physiol Endocrinol Metab 295: E38-E45, 2008.
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Karnieli, E.1    Armoni, M.2
  • 45
    • 0035787134 scopus 로고    scopus 로고
    • Leptin controls bone formation through a hypothalamic relay
    • Karsenty G. Leptin controls bone formation through a hypothalamic relay. Recent Prog Horm Res 56: 401-415, 2001.
    • (2001) Recent Prog Horm Res , vol.56 , pp. 401-415
    • Karsenty, G.1
  • 46
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time Quantitative PCR and the 2(-Delta Delta C(T) Method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time Quantitative PCR and the 2(-Delta Delta C(T) Method. Methods 25: 402-408, 2001.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 47
    • 0032738604 scopus 로고    scopus 로고
    • Role of CD14 in cellular recognition of bacterial lipopolysaccharides
    • Kitchens RL. Role of CD14 in cellular recognition of bacterial lipopolysaccharides. Chem Immunol 74: 61-82, 2000.
    • (2000) Chem Immunol , vol.74 , pp. 61-82
    • Kitchens, R.L.1
  • 48
    • 14244265834 scopus 로고    scopus 로고
    • Minireview: Transcriptional regulation in development of bone
    • Kobayashi T, Kronenberg H. Minireview: transcriptional regulation in development of bone. Endocrinology 146: 1012-1017, 2005.
    • (2005) Endocrinology , vol.146 , pp. 1012-1017
    • Kobayashi, T.1    Kronenberg, H.2
  • 49
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • Kronenberg HM. Developmental regulation of the growth plate. Nature 423: 332-336, 2003.
    • (2003) Nature , vol.423 , pp. 332-336
    • Kronenberg, H.M.1
  • 51
    • 65449125891 scopus 로고    scopus 로고
    • Green tea (-)-epigallocatechin-3-gallate reduces body weight with regulation of multiple genes expression in adipose tissue of diet-induced obese mice
    • Lee MS, Kim CT, Kim Y. Green tea (-)-epigallocatechin-3-gallate reduces body weight with regulation of multiple genes expression in adipose tissue of diet-induced obese mice. Ann Nutr Metab 54: 151-157, 2009.
    • (2009) Ann Nutr Metab , vol.54 , pp. 151-157
    • Lee, M.S.1    Kim, C.T.2    Kim, Y.3
  • 53
    • 84869192260 scopus 로고    scopus 로고
    • Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice
    • Li H, Xu M, Lee J, He C, Xie Z. Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice. Am J Physiol Endocrinol Metab 303: E1234-E1244, 2012.
    • (2012) Am J Physiol Endocrinol Metab , vol.303
    • Li, H.1    Xu, M.2    Lee, J.3    He, C.4    Xie, Z.5
  • 54
    • 0034107525 scopus 로고    scopus 로고
    • Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice
    • Lin S, Thomas TC, Storlien LH, Huang XF. Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice. Int J Obes Relat Metab Disord 24: 639-646, 2000.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , pp. 639-646
    • Lin, S.1    Thomas, T.C.2    Storlien, L.H.3    Huang, X.F.4
  • 55
    • 27344431720 scopus 로고    scopus 로고
    • NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates
    • Luquet S, Perez FA, Hnasko TS, Palmiter RD. NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310: 683-685, 2005.
    • (2005) Science , vol.310 , pp. 683-685
    • Luquet, S.1    Perez, F.A.2    Hnasko, T.S.3    Palmiter, R.D.4
  • 57
    • 73649136846 scopus 로고    scopus 로고
    • Anti-obesity and anti-diabetic effects of fucoxanthin on dietinduced obesity conditions in a murine model
    • Maeda H, Hosokawa M, Sashima T, Murakami-Funayama K, Miyashita K. Anti-obesity and anti-diabetic effects of fucoxanthin on dietinduced obesity conditions in a murine model. Mol Med Rep 2: 897-902, 2009.
    • (2009) Mol Med Rep , vol.2 , pp. 897-902
    • Maeda, H.1    Hosokawa, M.2    Sashima, T.3    Murakami-Funayama, K.4    Miyashita, K.5
  • 58
    • 0035999436 scopus 로고    scopus 로고
    • Leptin acts as a growth factor on the chondrocytes of skeletal growth centers
    • Maor G, Rochwerger M, Segev Y, Phillip M. Leptin acts as a growth factor on the chondrocytes of skeletal growth centers. J Bone Miner Res 17: 1034-1043, 2002.
    • (2002) J Bone Miner Res , vol.17 , pp. 1034-1043
    • Maor, G.1    Rochwerger, M.2    Segev, Y.3    Phillip, M.4
  • 59
    • 0033981302 scopus 로고    scopus 로고
    • The transmembrane mutation G380R in fibroblast growth factor receptor 3 uncouples ligand-mediated receptor activation from down-regulation
    • Monsonego-Ornan E, Adar R, Feferman T, Segev O, Yayon A. The transmembrane mutation G380R in fibroblast growth factor receptor 3 uncouples ligand-mediated receptor activation from down-regulation. Mol Cell Biol 20: 516-522, 2000.
    • (2000) Mol Cell Biol , vol.20 , pp. 516-522
    • Monsonego-Ornan, E.1    Adar, R.2    Feferman, T.3    Segev, O.4    Yayon, A.5
  • 60
    • 43549114292 scopus 로고    scopus 로고
    • Mechanisms of leptin action and leptin resistance
    • Myers MG, Cowley MA, Munzberg H. Mechanisms of leptin action and leptin resistance. Annu Rev Physiol 70: 537-556, 2008.
    • (2008) Annu Rev Physiol , vol.70 , pp. 537-556
    • Myers, M.G.1    Cowley, M.A.2    Munzberg, H.3
  • 61
    • 0032019875 scopus 로고    scopus 로고
    • Effects of growth hormone and insulin-like growth factors on human osteoblasts
    • Ohlsson C, Vidal O. Effects of growth hormone and insulin-like growth factors on human osteoblasts. Eur J Clin Invest 28: 184-186, 1998.
    • (1998) Eur J Clin Invest , vol.28 , pp. 184-186
    • Ohlsson, C.1    Vidal, O.2
  • 63
    • 24944580849 scopus 로고    scopus 로고
    • Polychrome labeling of bone with seven different fluorochromes: Enhancing fluorochrome discrimination by spectral image analysis
    • Pautke C, Vogt S, Tischer T, Wexel G, Deppe H, Milz S, Schieker M, Kolk A. Polychrome labeling of bone with seven different fluorochromes: enhancing fluorochrome discrimination by spectral image analysis. Bone 37: 441-445, 2005.
    • (2005) Bone , vol.37 , pp. 441-445
    • Pautke, C.1    Vogt, S.2    Tischer, T.3    Wexel, G.4    Deppe, H.5    Milz, S.6    Schieker, M.7    Kolk, A.8
  • 64
    • 0013199471 scopus 로고    scopus 로고
    • Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha
    • Peet DJ, Turley SD, Ma W, Janowski BA, Lobaccaro JM, Hammer RE, Mangelsdorf DJ. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell 93: 693-704, 1998.
    • (1998) Cell , vol.93 , pp. 693-704
    • Peet, D.J.1    Turley, S.D.2    Ma, W.3    Janowski, B.A.4    Lobaccaro, J.M.5    Hammer, R.E.6    Mangelsdorf, D.J.7
  • 69
    • 0036861322 scopus 로고    scopus 로고
    • Relationships among body mass, its components, and bone
    • Reid IR. Relationships among body mass, its components, and bone. Bone 31: 547-555, 2002.
    • (2002) Bone , vol.31 , pp. 547-555
    • Reid, I.R.1
  • 70
    • 0028566222 scopus 로고
    • Volumetric bone density of the lumbar spine is related to fat mass but not lean mass in normal postmenopausal women
    • Reid IR, Evans MC, Ames RW. Volumetric bone density of the lumbar spine is related to fat mass but not lean mass in normal postmenopausal women. Osteoporos Int 4: 362-367, 1994.
    • (1994) Osteoporos Int , vol.4 , pp. 362-367
    • Reid, I.R.1    Evans, M.C.2    Ames, R.W.3
  • 72
    • 84864501914 scopus 로고    scopus 로고
    • Identification of RIFL, a novel adipocyteenriched insulin target gene with a role in lipid metabolism
    • Ren G, Kim JY, Smas CM. Identification of RIFL, a novel adipocyteenriched insulin target gene with a role in lipid metabolism. Am J Physiol Endocrinol Metab 303: E334-E351, 2012.
    • (2012) Am J Physiol Endocrinol Metab , vol.303
    • Ren, G.1    Kim, J.Y.2    Smas, C.M.3
  • 73
    • 0030882551 scopus 로고    scopus 로고
    • Improvement of glucose homeostasis and hepatic insulin resistance in ob/ob mice given oral molybdate
    • Reul BA, Becker DJ, Ongemba LN, Bailey CJ, Henquin JC, Brichard SM. Improvement of glucose homeostasis and hepatic insulin resistance in ob/ob mice given oral molybdate. J Endocrinol 155: 55-64, 1997.
    • (1997) J Endocrinol , vol.155 , pp. 55-64
    • Reul, B.A.1    Becker, D.J.2    Ongemba, L.N.3    Bailey, C.J.4    Henquin, J.C.5    Brichard, S.M.6
  • 74
    • 0030739357 scopus 로고    scopus 로고
    • Influence of body mass index on the age-related slope of total and regional bone mineral content
    • Revilla M, Villa LF, Sanchez-Atrio A, Hernandez ER, Rico H. Influence of body mass index on the age-related slope of total and regional bone mineral content. Calcif Tissue Int 61: 134-138, 1997.
    • (1997) Calcif Tissue Int , vol.61 , pp. 134-138
    • Revilla, M.1    Villa, L.F.2    Sanchez-Atrio, A.3    Hernandez, E.R.4    Rico, H.5
  • 75
    • 0028719098 scopus 로고
    • The effect of obesity on postmenopausal bone loss and the risk of osteoporosis
    • Ribot C, Tremollieres F, Pouilles JM. The effect of obesity on postmenopausal bone loss and the risk of osteoporosis. Adv Nutr Res 9: 257-271, 1994.
    • (1994) Adv Nutr Res , vol.9 , pp. 257-271
    • Ribot, C.1    Tremollieres, F.2    Pouilles, J.M.3
  • 76
    • 0036300023 scopus 로고    scopus 로고
    • Isomer-dependent metabolic effects of conjugated linoleic acid: Insights from molecular markers sterol regulatory element-binding protein-1c and LXRalpha
    • Roche HM, Noone E, Sewter C, Mc Bennett S, Savage D, Gibney MJ, O'Rahilly S, Vidal-Puig AJ. Isomer-dependent metabolic effects of conjugated linoleic acid: insights from molecular markers sterol regulatory element-binding protein-1c and LXRalpha. Diabetes 51: 2037-2044, 2002.
    • (2002) Diabetes , vol.51 , pp. 2037-2044
    • Roche, H.M.1    Noone, E.2    Sewter, C.3    Mc Bennett, S.4    Savage, D.5    Gibney, M.J.6    O'Rahilly, S.7    Vidal-Puig, A.J.8
  • 77
    • 21644472266 scopus 로고    scopus 로고
    • Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll-like receptor 4 (TLR4) or TLR2 mRNA expression
    • Romics L Jr, Mandrekar P, Kodys K, Velayudham A, Drechsler Y, Dolganiuc A, Szabo G. Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll-like receptor 4 (TLR4) or TLR2 mRNA expression. Alcohol Clin Exp Res 29: 1018-1026, 2005.
    • (2005) Alcohol Clin Exp Res , vol.29 , pp. 1018-1026
    • Romics Jr., L.1    Mandrekar, P.2    Kodys, K.3    Velayudham, A.4    Drechsler, Y.5    Dolganiuc, A.6    Szabo, G.7
  • 78
    • 33646107384 scopus 로고    scopus 로고
    • Large-scale preparation of biologically active mouse and rat leptins and their L39A/ D40A/F41A muteins which act as potent antagonists
    • Salomon G, Niv-Spector L, Gussakovsky EE, Gertler A. Large-scale preparation of biologically active mouse and rat leptins and their L39A/ D40A/F41A muteins which act as potent antagonists. Protein Expr Purif 47: 128-136, 2006.
    • (2006) Protein Expr Purif , vol.47 , pp. 128-136
    • Salomon, G.1    Niv-Spector, L.2    Gussakovsky, E.E.3    Gertler, A.4
  • 81
    • 84860320670 scopus 로고    scopus 로고
    • Interleukin-1 promotes proliferation and inhibits differentiation of chondrocytes through a mechanism involving down-regulation of FGFR-3 and p21
    • Simsa-Maziel S, Monsonego-Ornan E. Interleukin-1 promotes proliferation and inhibits differentiation of chondrocytes through a mechanism involving down-regulation of FGFR-3 and p21. Endocrinology 153: 2296-2310, 2012.
    • (2012) Endocrinology , vol.153 , pp. 2296-2310
    • Simsa-Maziel, S.1    Monsonego-Ornan, E.2
  • 86
    • 2342518168 scopus 로고    scopus 로고
    • The complex effects of leptin on bone metabolism through multiple pathways
    • Thomas T. The complex effects of leptin on bone metabolism through multiple pathways. Curr Opin Pharmacol 4: 295-300, 2004.
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 295-300
    • Thomas, T.1
  • 87
    • 0027175806 scopus 로고
    • Basic biomechanical measurements of bone: A tutorial
    • Turner CH, Burr DB. Basic biomechanical measurements of bone: a tutorial. Bone 14: 595-608, 1993.
    • (1993) Bone , vol.14 , pp. 595-608
    • Turner, C.H.1    Burr, D.B.2
  • 88
    • 33644932810 scopus 로고    scopus 로고
    • Prohibitin attenuates insulin-stimulated glucose and fatty acid oxidation in adipose tissue by inhibition of pyruvate carboxylase
    • Vessal M, Mishra S, Moulik S, Murphy LJ. Prohibitin attenuates insulin-stimulated glucose and fatty acid oxidation in adipose tissue by inhibition of pyruvate carboxylase. FEBS J 273: 568-576, 2006.
    • (2006) FEBS J , vol.273 , pp. 568-576
    • Vessal, M.1    Mishra, S.2    Moulik, S.3    Murphy, L.J.4
  • 89
    • 28244436513 scopus 로고    scopus 로고
    • FGF upregulates osteopontin in epiphyseal growth plate chondrocytes: Implications for endochondral ossification
    • Weizmann S, Tong A, Reich A, Genina O, Yayon A, Monsonego-Ornan E. FGF upregulates osteopontin in epiphyseal growth plate chondrocytes: implications for endochondral ossification. Matrix Biol 24: 520-529, 2005.
    • (2005) Matrix Biol , vol.24 , pp. 520-529
    • Weizmann, S.1    Tong, A.2    Reich, A.3    Genina, O.4    Yayon, A.5    Monsonego-Ornan, E.6


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