Predicting drug-resistant mutations of HIV protease

Angewandte Chemie - International Edition

Volumn 47, Issue 4, 2008, Pages 697-700

  Ishikita, Hiroshi ^a   Warshel, Arieh ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Drug design; Drug resistance; HIV protease; Ligand binding; Transition states

Indexed keywords

CATALYST ACTIVITY; DRUG THERAPY; ENZYME INHIBITION; LIGANDS; PROTEINS;

DRUG DESIGN; DRUG RESISTANCE; HUMAN IMMUNODEFICIENCY VIRUS (HIV); LIGAND BINDING; TRANSITION STATES;

VIRUSES;

4,7 DIBENZYL 2,3,4,5,6,7 HEXAHYDRO 5,6 DIHYDROXY 1,3 BIS[4 (HYDROXYMETHYL)BENZYL] 2H 1,3 DIAZEPIN 2 ONE; DRUG DERIVATIVE; PROTEINASE; PROTEINASE INHIBITOR; UREA;

ANTIVIRAL RESISTANCE; ARTICLE; BINDING SITE; CATALYSIS; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; DRUG EFFECT; ELECTRICITY; GENETICS; MUTATION; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS;

BINDING SITES; CATALYSIS; COMPUTER SIMULATION; DRUG RESISTANCE, VIRAL; ELECTROSTATICS; HIV PROTEASE; HIV PROTEASE INHIBITORS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; MUTATION; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; UREA;

EID: 38349001243     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200704178     Document Type: Article

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