Antibody repertoire diversification through VH gene replacement in mice cloned from an IgA plasma cell

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 5, 2015, Pages E450-E457

  Kumar, Rashmi ^a   Bach, Martina P ^b,c   Mainoldi, Federica ^c   Maruya, Mikako ^d   Kishigami, Satoshi ^e,g   Jumaa, Hassan ^b,c   Wakayama, Teruhiko ^e,g   Kanagawa, Osami ^f   Fagarasan, Sidonia ^d   Casola, Stefano ^a  

^a FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^b UNIVERSITY HOSPITAL ULM   (Germany)

^c MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^d Institute of Physical and Chemical Research   (Japan)

^e RIKEN Center for Biosystems Dynamics Research   (Japan)

^f Akashi City Hospital   (Japan)

^g UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Antibody repertoire; B cells; IgA; Nuclear cloning; VH replacement

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN M; PRE B CELL RECEPTOR; IMMUNOGLOBULIN VARIABLE REGION;

ALLELIC EXCLUSION; ANIMAL EXPERIMENT; ANTIBODY SPECIFICITY; ARTICLE; B LYMPHOCYTE; CELL MATURATION; CELL NUCLEUS; CELL NUCLEUS TRANSPLANTATION; CONTROLLED STUDY; GERM LINE; IMMUNOGLOBULIN VARIABLE REGION; LAMINA PROPRIA; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PLASMA CELL; PRE B LYMPHOCYTE; PRIORITY JOURNAL; SMALL INTESTINE; SOMATIC CELL NUCLEAR TRANSFER; ANIMAL; CLONING; GENETICS; IMMUNOLOGY; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ANIMALIA; MAMMALIA; MUS;

ANIMALS; BASE SEQUENCE; CLONING, ORGANISM; IMMUNOGLOBULIN A; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, NUCLEIC ACID; SIGNAL TRANSDUCTION;

EID: 84922240530     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1417988112     Document Type: Article

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