Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus

Nature

Volumn 503, Issue 7476, 2013, Pages 406-409

  Dougan, Stephanie K ^a   Ashour, Joseph ^a   Karssemeijer, Roos A ^a   Popp, Maximilian W ^a,b   Avalos, Ana M ^a   Barisa, Marta ^a   Altenburg, Arwen F ^a   Ingram, Jessica R ^a   Cragnolini, Juan Jose ^a   Guo, Chunguang ^c   Alt, Frederick W ^c   Jaenisch, Rudolf ^a   Ploegh, Hidde L ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; IMMUNOGLOBULIN G2B; INFLUENZA VIRUS HEMAGGLUTININ; NUCLEOPROTEIN; PROTEIN M2; SIALIC ACID DERIVATIVE;

ANTIBODY; ANTIGEN; CELL ORGANELLE; INFECTIVITY; INFLUENZA; VIRUS;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; IMMUNOPRECIPITATION; INFLUENZA; LUNG; LUNG LAVAGE; MEDIASTINUM LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SOMATIC MUTATION; SPLEEN;

ANIMALS; ANTIBODIES; ANTIBODY SPECIFICITY; B-LYMPHOCYTES; CELL DEATH; FEMALE; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; IMMUNOGLOBULIN G; LUNG; LYMPH NODES; MALE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS; NUCLEAR TRANSFER TECHNIQUES; ORTHOMYXOVIRIDAE; RECEPTORS, ANTIGEN, B-CELL; VIRUS REPLICATION;

INFLUENZA A VIRUS; MUS; ORTHOMYXOVIRIDAE;

EID: 84888044830     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12637     Document Type: Article

References (30)

1. Valkenburg, S. A. et al. Immunity to seasonal and pandemic influenza A viruses. Microbes Infect. 13, 489-501 (2011).
2. Onodera, T. et al. Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection. Proc. Natl Acad. Sci. USA 109, 2485-2490 (2012).
3. Manicassamy, B. et al. Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus. Proc. Natl Acad. Sci. USA 107, 11531-11536 (2010).
4. Popp, M. W., Karssemeijer, R. A. & Ploegh, H. L. Chemoenzymatic site-specific labeling of influenza glycoproteins as a tool to observe virus budding in real time. PLoS Pathog. 8, e1002604 (2012).
5. Popp, M. W. & Ploegh, H. L. Making and breaking peptide bonds: protein engineering using sortase. Angew. Chem. Int. Edn Engl. 50, 5024-5032 (2011).
6. Antos, J. M., Miller, G. M., Grotenbreg, G. M. & Ploegh, H. L. Lipid modification of proteins through sortase-catalyzed transpeptidation. J. Am. Chem. Soc. 130, 16338-16343 (2008).
7. Dougan, S. K. et al. IgG11 ovalbumin-specific B-cell transnuclear mice show class switch recombination in rare allelically included B cells. Proc. Natl Acad. Sci. USA 109, 13739-13744 (2012).
8. Kirak, O. et al. Transnuclear mice with predefined T cell receptor specificities against Toxoplasma gondii obtained via SCNT. Science 328, 243-248 (2010).
9. Dougan, S. K. et al. Transnuclear TRP1-specific CD8 T cells with high or low affinity TCRs show equivalent anti-tumor activity. Cancer Immunol. Res. 1, 99-111 (2013).
10. Wiley, D. C. & Skehel, J. J. The structure and function of the hemagglutinin membrane glycoprotein of influenza virus. Annu. Rev. Biochem. 56, 365-394 (1987).
11. Stray, S. J., Cummings, R. D. & Air, G. M. Influenza virus infection of desialylated cells. Glycobiology 10, 649-658 (2000).
12. Thompson, C. I., Barclay, W. S., Zambon, M. C. & Pickles, R. J. Infection of human airway epithelium by human and avian strains of influenza a virus. J. Virol. 80, 8060-8068 (2006).
13. Pedroso de Lima, M. C. et al. Target cell membrane sialic acid modulates both binding and fusion activity of influenza virus. Biochim. Biophys. Acta 1236, 323-330 (1995).
14. Huang, R. T., Lichtenberg, B. & Rick, O. Involvement of annexin V in the entry of influenza viruses and role of phospholipids in infection. FEBS Lett. 392, 59-62 (1996).
15. Chu, V. C. & Whittaker, G. R. Influenza virus entry and infection require host cell N-linked glycoprotein. Proc. Natl Acad. Sci. USA 101, 18153-18158 (2004).
16. Londrigan, S. L. et al. N-linked glycosylation facilitates sialic acid-independent attachment and entry of influenza A viruses into cells expressing DC-SIGN or L-SIGN. J. Virol. 85, 2990-3000 (2011).
17. Eierhoff, T., Hrincius, E. R., Rescher, U., Ludwig, S. & Ehrhardt, C. The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells. PLoS Pathog. 6, e1001099 (2010).
18. Harwood, N. E. & Batista, F. D. Early events in B cell activation. Annu. Rev. Immunol. 28, 185-210 (2010).
19. Witte, M. D. et al. Preparation of unnatural N-to-N and C-to-C protein fusions. Proc. Natl Acad. Sci. USA 109, 11993-11998 (2012).
20. Moltedo, B. et al. Cutting edge: stealth influenza virus replication precedes the initiation of adaptive immunity. J. Immunol. 183, 3569-3573 (2009).
21. Moltedo, B., Li, W., Yount, J. S. & Moran, T. M. Unique type I interferon responses determine the functional fate of migratory lung dendritic cells during influenza virus infection. PLoS Pathog. 7, e1002345 (2011).
22. Joo, H. M., He, Y. & Sangster, M. Y. Broad dispersion and lung localization of virus-specific memory B cells induced by influenza pneumonia. Proc. Natl Acad. Sci. USA 105, 3485-3490 (2008).
23. Jones, P. D. & Ada, G. L. Influenza-specific antibody-secreting cells and B cell memory in the murine lung after immunization with wild-type, cold-adapted variant and inactivated influenza viruses. Vaccine 5, 244-248 (1987).
24. Popp, M. W., Antos, J. M. & Ploegh, H. L. Site-specific protein labeling via sortasemediated transpeptidation. Curr. Protoc. Protein Sci. 15, Unit 15.13 (2009).
25. Boes, M. et al. T-cell engagement of dendritic cells rapidly rearrangesMHCclass II transport. Nature 418, 983-988 (2002).
26. Morgan, D. J.,McLain, L.&Dimmock,N. J.Protection of three strains ofmice against lethal influenza in vivo by defective interfering virus. VirusRes. 29,179-193(1993).
27. Kirak, O. et al. Transnuclear mice with pre-defined T cell receptor specificities against Toxoplasma gondii obtained via SCNT. J. Vis. Exp. 43, e2168 (2010).
28. Sehrawat, S. et al. CD81 T cells frommice transnuclear for a TCR that recognizes a singleH-2Kb-restricted MHV68 epitope derived from gB-ORF8 help control infection. Cell Rep. 1, 461-471 (2012).
29. Kishigami, S. et al. Production of cloned mice by somatic cell nuclear transfer. Nature Protocols 1, 125-138 (2006).
30. Simons, K., Helenius, A., Leonard, K., Sarvas, M. & Gething, M. J. Formation of protein micelles fromamphiphilicmembrane proteins. Proc. Natl Acad. Sci. USA 75, 5306-5310 (1978).