Alginate drug delivery systems: Application in context of pharmaceutical and biomedical research

Drug Development and Industrial Pharmacy

Volumn 40, Issue 12, 2014, Pages 1576-1584

  Jain, Dharmendra ^a   Bar Shalom, Daniel ^b  

^a DR H S GOUR UNIVERSITY   (India)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Beads; Floating systems; Membranes; Microspheres; Nanoparticles; Sodium alginate

Indexed keywords

ALGINIC ACID; MICROSPHERE; NANOBEAD; NANOFILM; NANOSPHERE; DRUG CARRIER; GLUCURONIC ACID; HEXURONIC ACID;

ADHESION; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; DRUG INDUSTRY; DRUG PELLET; GEL; HYDROGEL; MATERIAL COATING; MATRIX TABLET; MEDICAL RESEARCH; MEMBRANE; ANIMAL; CHEMISTRY; HUMAN; MEDICINAL CHEMISTRY; PROCEDURES; TRENDS;

ALGINATES; ANIMALS; BIOMEDICAL RESEARCH; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GLUCURONIC ACID; HEXURONIC ACIDS; HUMANS; MICROSPHERES;

EID: 84922233225     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2014.917657     Document Type: Article

References (81)

1. Tønnesen HH, Jan Karlsen J. Alginate in drug delivery systems. Drug Dev Ind Pharm 2002;28:621-30.
2. Liew CV, Chan LW, Ching AL, Heng PWS. Evaluation of sodium alginate as drug release modifier in matrix tablets. Int J Pharm 2006; 309:25-37.
3. Tugcu-Demiröz F, Acartürk F, Takka S, Konųs-Boyunaga Ö. Evaluation of alginate based mesalazine tablets for intestinal drug delivery. Eur J Pharm Biopharm 2007;67:491-7.
4. Chan LW, Ching AL, Liew CV, Heng PWS. Mechanistic study on hydration and drug release behavior of sodium alginate compacts. Drug Dev Ind Pharm 2007;33:667-76.
5. Yang J-S, Xie Y-J, He W. Research progress on chemical modification of alginate: a review. Carbohyd Polym 2011;84: 33-9.
6. Reis CP, Neufeld RJ, Vilela S, et al. Review and current status of emulsion/dispersion technology using an internal gelation process for the design of alginate particles. J Microencapsul 2006;23: 245-57.
7. Wandrey C, Espinosa D, Rehor A, Hunkeler D. Influence of alginate characteristics on the properties of multi-component microcapsules. J Microencapsul 2003;20:597-611.
8. Draget KI, Skjak-Braek G, Smidsrød O. Alginate based new materials. Int J Biol Macromol 1997;21:47-55.
9. Harden CJ, Richardson JC, Dettmar PW, et al. An ionic-gelling alginate drink attenuates postprandial glycaemia in males. J Functional Foods 2012;4:122-8.
10. Pongjanyakul T, Priprem A, Puttipipatkhachorn S. Investigation of novel alginate magnesium aluminum silicate microcomposite films for modified-release tablets. J Control Release 2005;107: 343-56.
11. Sun J, Tan H. Alginate-based biomaterials for regenerative medicine applications. Materials 2013;6:1285-309.
12. Darrabie MD, Kendall WF, Opara EC. Effect of alginate composition and gelling cation on micro-bead swelling. J Microencapsul 2006;23:29-37.
13. Josef E, Zilberman M, Bianco-Peled H. Composite alginate hydrogels: an innovative approach for the controlled release of hydrophobic drugs. Acta Biomater 2010;6:4642-9.
14. Wang W, Wang A. Synthesis and swelling properties of pH-sensitive semi-IPN superabsorbent hydrogels based on sodium alginate-gpoly( sodium acrylate) and polyvinylpyrrolidone. Carbohyd Polym 2010;80:1028-36.
15. Cohen S, Lobel E, Trevgoda A, Peled Y. A novel in situ-forming ophthalmic drug delivery system from alginates undergoing gelation in the eye. J Control Release 1997;44:201-8.
16. Srivastava R, Mcshane MJ. Application of self-Assembled ultra-Thin film coatings to stabilize macromolecule encapsulation in alginate microspheres. J Microencapsul 2005;22:397-411.
17. Jeon O, Bouhadir KH, Mansour JM, Alsberg E. Photocrosslinked alginate hydrogels with tunable biodegradation rates and mechanical properties. Biomaterials 2009;30:2724-34.
18. Leung A, Lawrie G, Nielsen LK, Trau M. Synthesis and characterization of alginate/poly-L-ornithine/alginate microcapsules for local immunosuppression. J Microencapsul 2008;25:387-98.
19. Sibanda W, Pillay V, Danckwerts MP, et al. Experimental design for the formulation and optimization of novel cross-linked oilispheres developed for in vitro site-specific release of Mentha piperita oil. AAPS Pharm Sci Tech 2004;5:1-14.
20. Pongjanyakul T, Puttipipatkhachorn S. Modulating drug release and matrix erosion of alginate matrix capsules by microenvironmental interaction with calcium ion. Eur J Pharm Biopharm 2007;67: 187-95.
21. Ostberg T, Graffner C. Calcium alginate matrices for oral multiple unit administration: III. Influence of calcium concentration, amount of drug added and alginate characteristics on drug release. Int J Pharm 1994;111:271-82.
22. Al-Musa S, Fara DA, Badwan AA. Evaluation of parameters involved in preparation and release of drug loaded in crosslinked matrices of alginate. J Control Release 1999;57:223-32.
23. Hodsdon AC, Mitchell JR, Davies MC, Melia CD. Structure and behaviour in hydrophilic matrix sustained release dosage forms: 3. The influence of pH on the sustained-release performance and internal gel structure of sodium alginate matrices. J Control Release 1995;33:143-52.
24. Toti US, Aminabhavi TM. Different viscosity grade sodium alginate and modified sodium alginate membranes in pervaporation separation of water+acetic acid and water+isopropanol mixtures. J Membrane Sci 2004;228:199-208.
25. Pongjanyakul T, Puttipipatkhachorn S. Alginate-magnesium aluminum silicate films: Effect of plasticizers on film properties, drug permeation and drug release from coated tablets. Int J Pharm 2007; 333:34-44.
26. Bastos Dda S, Araujo KG, Leão MH. Ascorbic acid retaining using a new calcium alginate-Capsul based edible film. J Microencapsul 2009;26:97-103.
27. Mandal S, Basu SK, Sa B. Ca2+ ion cross-linked interpenetrating network matrix tablets of polyacrylamide-grafted-sodium alginate and sodium alginate for sustained release of diltiazem hydrochloride. Carbohyd Polym 2010;82:867-73.
28. Giunchedi P, Gavini E, Moretti MDL, Pirisino G. Evaluation of alginate compressed matrices as prolonged drug delivery systems. AAPS Pharm Sci Tech 2000;1:31-6.
29. Holte O, Onsøyen E, Myrvold R, Karlsen J. Sustained release of water-soluble drug from directly compressed alginate tablets. Eur J Pharm Sci 2003;20:403-7.
30. Sirkia T, Salonen H, Veski P, et al. Biopharmaceutical evaluation of new prolonged-release press-coated ibuprofen tablets containing sodium alginate to adjust drug release. Int J Pharm 1994;107: 179-87.
31. Klayraung S, Viernstein H, Okonogia S. Development of tablets containing probiotics: effects of formulation and processing parameters on bacterial viability. Int J Pharm 2009;370:54-60.
32. Sriamornsak P, Thirawong N, Korkerd K. Swelling, erosion and release behavior of alginate-based matrix tablets. Eur J Pharm Biopharm 2007;66:435-50.
33. Takeuchi H, Yasuji T, Hino T, et al. Spray-dried composite particles of lactose and sodium alginate for direct tabletting and controlled releasing. Int J Pharm 1998;174:91-100.
34. Rahman Z, Kohli K, Khar RK, et al. Characterization of 5-fluorouracil microspheres for colonic delivery. AAPS Pharm Sci Tech 2006;7:E1-9.
35. Tu J, Bolla S, Barr J, et al. Alginate microparticles prepared by spray-coagulation method: preparation, drug loading and release characterization. Int J Pharm 2005;303:171-81.
36. Coppi G, Iannuccelli V, Bernabei MT, Cameroni R. Alginate microparticles for enzyme peroral administration. Int J Pharm 2002; 242:263-6.
37. Jaya S, Durance TD, Wang R. Effect of alginate-pectin composition on drug release characteristics of microcapsules. J Microencapsul 2009;26:143-53.
38. Ribeiro CC, Barrias CC, Barbosa MA. Calcium phosphate-Alginate microspheres as enzyme delivery matrices. Biomaterials 2004;25: 4363-73.
39. IŞiklan N,-Inal M, KurŞun F, Ercan G. pH responsive itaconic acid grafted alginate microspheres for the controlled release of nifedipine. Carbohyd Polym 2011;84:933-43.
40. Gursoy A, Kalkan F, Okars I. Preparation and tabletting of dipyridamole alginate-Eudragit microspheres. J Microencapsul 1998;15:621-8.
41. Oddo L, Masci G, Meo CD, et al. Novel thermosensitive calcium alginate microspheres: physico-chemical characterization and delivery properties. Acta Biomater 2010;6:3657-64.
42. Xu P, Guo F, Huang J, et al. Alginate-based ferrofluid and magnetic microsphere thereof. Int J Biol Macromol 2010;47:654-60.
43. Alipour S, Montaseri H, Tafaghodi M. Preparation and characterization of biodegradable paclitaxel loaded alginate microparticles for pulmonary delivery. Colloids Surf B Biointerfaces 2010;81: 521-9.
44. Jayant RD, McShane MJ, Srivastava R. Polyelectrolyte-coated alginate microspheres as drug delivery carriers for dexamethasone release. Drug Deliv 2009;16:331-40.
45. Pongjanyakul T, Puttipipatkhachorn S. Sodium alginate-magnesium aluminum silicate composite gels: characterization of flow behavior, microviscosity, and drug diffusivity. AAPS Pharm Sci Tech 2007;8: E1-8.
46. Smidsrød O, Skjak-Braek G. Alginate as immobilization matrix for cells. Trends Biotechnol 1990;8:71-8.
47. Kim C-K, Lee E-J. The controlled release of blue dextran from alginate beads. Int J Pharm 1992;79:11-19.
48. Han MR, Kwon MC, Lee HY, et al. pH-dependent release property of alginate beads containing calcium carbonate particles. J Microencapsul 2007;24:787-96.
49. Bajpai SK, Saxena SK, Sharma S. Swelling behavior of barium ionscrosslinked bipolymeric sodium alginate-carboxymethyl guar gum blend beads. Reactive Functional Polym 2006;66:659-66.
50. Halder A, Maiti S, Sa B. Entrapment efficiency and release characteristics of polyethyleneimine-Treated or-untreated calcium alginate beads loaded with propranolol-resin complex. Int J Pharm 2005;302:84-94.
51. Sriamornsak P, Nunthanid J, Luangtana-Anan M, et al. Alginatebased pellets prepared by extrusion/spheronization: effect of the amount and type of sodium alginate and calcium salts. Eur J Pharm Biopharm 2008;69:274-84.
52. Bodmeier R, Paeratakul O. A novel multiple-unit sustained release indomethacin-hydroxypropyl methylcellulose delivery system prepared by ionotropic gelation of sodium alginate at elevated temperatures. Carbohyd Polym 1991;16:399-408.
53. El-Sherbiny IM, Abdel-Mogib M, Dawidar A-AM, et al. Biodegradable pH-responsive alginate-poly (lactic-co-glycolic acid) nano/micro hydrogel matrices for oral delivery of silymarin. Carbohyd Polym 2011;83:1345-54.
54. Singh B, Sharma V, Chauhan D. Gastroretentive floating sterculia-Alginate beads for use in antiulcer drug delivery. Chem Eng Res Design 2010;88:997-1012.
55. Hua S, Ma H, Li X, et al. pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-Thawing cycles for controlled release of diclofenac sodium. Int J Biol Macromol 2010;46:517-23.
56. Setty CM, Sahoo SS, Sa B. Alginate-coated alginate-polyethyleneimine beads for prolonged release of furosemide in simulated intestinal fluid. Drug Dev Ind Pharm 2005;31:435-46.
57. Takka S, Ocak ÖH, Acartürk F. Formulation and investigation of nicardipine HCl-Alginate gel beads with factorial design-based studies. Eur J Pharm Sci 1998;6:241-6.
58. Pongjanyakul T, Rongthong T. Enhanced entrapment efficiency and modulated drug release of alginate beads loaded with drug-clay intercalated complexes as microreservoirs. Carbohydrate Polym 2010;81:409-19.
59. Ostberg T, Vesterhus L, Graffner C. Calcium alginate matrices for oral multiple unit administration: II. Effect of process and formulation factors on matrix properties. Int J Pharm 1993;97: 183-93.
60. Sankalia MG, Mashru RC, Sankalia JM, Sutariya VB. Papain entrapment in alginate beads for stability improvement and sitespecific delivery: physicochemical characterization and factorial optimization using neural network modeling. AAPS Pharm Sci Tech 2005;6:E209-22.
61. Sevgi F, Kaynarsoy B, Ertan G. An anti-inflammatory drug (mefenamic acid) incorporated in biodegradable alginate beads: development and optimization of the process using factorial design. Pharm Dev Technol 2008;13:5-13.
62. Lai F, Loy G, Manconi M, et al. Artemisia arborescens L essential oil loaded beads: preparation and characterization. AAPS Pharm Sci Tech 2007;8:E1-7.
63. Kulkarni AR, Soppimath KS, Aminabhavi TM. Controlled release of diclofenac sodium from sodium alginate beads crosslinked with glutaraldehyde. Pharmaceutica Acta Helvetiae 1999;74:29-36.
64. Klokk TI, Melvik JE. Controlling the size of alginate gel beads by use of a high electrostatic potential. J Microencapsul 2002;19: 415-24.
65. Zhang J, Wang Q, Wang A. In situ generation of sodium alginate/ hydroxyapatite nanocomposite beads as drug-controlled release matrices. Acta Biomaterialia 2010;6:445-54.
66. Martinsen A, Skjak-Braek G, Smidsrød O. Alginate as immobilization material: I. Correlation between chemical and physical properties of alginate gel beads. Biotechnol Bioeng 1989; 33:79-89.
67. Davies NM, Farr SJ, Kellaway IW, et al. A comparison of the gastric retention of alginate containing tablet formulations with and without the inclusion of excipient calcium ions. Int J Pharm 1994;105: 97-101.
68. Choi BY, Park HJ, Hwang SJ, Park JB. Preparation of alginate beads for floating drug delivery system: effects of CO2 gas-forming agents. Int J Pharm 2002;239:81-91.
69. Pillay V, Fassihi R. In vitro release modulation from crosslinked pellets for site-specific drug delivery to the gastrointestinal tract I. Comparison of pH-responsive drug release and associated kinetics. J Control Release 1999;59:229-42.
70. Chan LW, Liu X, Heng PW. Liquid phase coating to produce controlled-release alginate microspheres. J Microencapsul 2005;22: 891-900.
71. Chan LW, Lee HY, Heng PWS. Mechanisms of external and internal gelation and their impact on the functions of alginate as a coat and delivery system. Carbohyd Polym 2006;63:176-87.
72. Wang Q, Hu X, Du Y, Kennedy JF. Alginate/starch blend fibers and their properties for drug controlled release. Carbohyd Polym 2010; 82:842-7.
73. Jain S, Mondal K, Gupta MN. Applications of alginate in bioseparation of proteins. Artif Cells Blood Substit Biotechnol 2006;34:127-44.
74. Srinivasulu B, Adinarayana K, Ellaiah P. Investigations on neomycin production with immobilized cells of Streptomyces marinensis Nuv-5 in calcium alginate matrix. AAPS Pharm Sci Tech 2003;4:1-6.
75. Paxman JR, Richardson JC, Dettmar PW, Corfe BM. Daily ingestion of alginate reduces energy intake in free-living subjects. Appetite 2008;51:713-19.
76. Hampson FC, Farndale A, Strugala V, et al. Alginate rafts and their characterization. Int J Pharm 2005;294:137-47.
77. Dettmar PW, Hampson FC, Jain A, et al. Administration of an alginate based gastric reflux suppressant on the bioavailability of omeprazole. Indian J Med Res 2006;123:517-24.
78. Dettmar PW, Hampson FC, Taubel J, et al. The suppression of gastro-oesophageal reflux by alginates. Int J Clin Pract 2007;61: 1654-62.
79. Strugala V, Avis J, Jolliffe IG, et al. The role of an alginate suspension on pepsin and bile acids-key aggressors in the gastric refluxate. Does this have implications for the treatment of gastrooesophageal reflux disease. J Pharm Pharmacol 2009;61:1021-8.
80. McGlashan JA, Johnstone LM, Sykes J, et al. The value of a liquid alginate suspension (Gaviscon Advance) in the management of laryngopharyngeal reflux. Eur Arch Otorhinolaryngol 2009;266: 243-51.
81. Nordgard CT, Draget KI. Oligosaccharides as modulators of rheology in complex mucous systems. Biomacromolecules 2011; 12:3084-90.