An anti-inflammatory drug (mefenamic acid) incorporated in biodegradable alginate beads: Development and optimization of the process using factorial design

Pharmaceutical Development and Technology

Volumn 13, Issue 1, 2008, Pages 5-13

  Sevgi, Ferhan ^a   Kaynarsoy, Buket ^a   Ertan, Gökhan ^a  

^a EGE UNIVERSITY   (Turkey)

Author keywords

Alginate; Bead; Controlled release; Factorial design; Mefenamic acid

Indexed keywords

ALGINIC ACID; ANTIINFLAMMATORY AGENT; CALCIUM CHLORIDE; MEFENAMIC ACID;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIODEGRADABILITY; CONTROLLED DRUG RELEASE; CONTROLLED RELEASE FORMULATION; DRUG FORMULATION; DRUG RELEASE; DRUG TRANSPORT; ENCAPSULATION; FACTORIAL DESIGN; GELATION; IN VIVO STUDY; NONHUMAN; PARTICLE SIZE; POLYMERIZATION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PRODUCT RECOVERY; SCANNING ELECTRON MICROSCOPE; STOMACH IRRITATION;

ALGINATES; ALGORITHMS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; DRUG DESIGN; EXCIPIENTS; MEFENAMIC ACID; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; SOLUBILITY;

EID: 39749162721     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.1080/10837450701702339     Document Type: Article

References (37)

1. Bodmeier R, Wang J. Microencapsulation of drugs with aqueous colloidal polymer dispersions. J. Pharm. Sci. 1993;82:191-194.
2. Kim CK, Lee EJ. The controlled release of blue dextran from alginate beads. Int. J. Pharm. 1992;79:11-19.
3. Çaliş S, Arica B, Atilla P, Durku T, Çakar N, Hincal A. Effect of ibuprofen and ibuprofen incorporated biodegradable alginate beads on gastric and duodenal mucosa (a comparative histological study). In: Controlled Release Society 30th Annual Meeting Proceedings; July 19-23, 2003:495.
4. Tonnesen HH, Karlsen, J. Alginate in drug delivery systems. Drug Dev. Ind. Pharm. 2002;28:621-630.
5. Badwan AA, Abumaloohs A, Salam E, Abukalaf A, Jawan O. A sustained release drug delivery system using alginate beads. Drug Dev. Ind. Pharm. 1985;11:239-256.
6. Shu XZ, Zhu KJ. The release behavior of brilliant blue from calcium-alginate gel beads coated by chitosan: the preparation method effect. Eur. J. Pharm. Biopharm. 2002;53:93-201.
7. Gaudio PD, Colombo P, Colombo G, Russo P, Sonvico F. Mechanisms of formation and disintegration of alginate beads obtained by prilling. Int. J. Pharm. 2005;302:1-9.
8. Türkoǧlu M, Gürsoy A, Eroǧlu L, Okar I. Effect of aqueous polymer dispersions on properties of diclofenac/alginate beads and in vivo evaluations in rats. STP Pharma Sci. 1997;7:135-140.
9. Sugawara S, Imai T, Otagiri M. The controlled release of prednisolone uing alginate gel. Pharm. Res. 1994;11:272-277.
10. Pillay V, Dango CM, Govender T, Moopanar KR, Hurban SN. Ionotropic gelation:encapsulaton of indomethacin in calcium alginate gel discs. J. Microen. 1998;15:215-226.
11. Halder A, Maiti S, Sa B. Entrapment efficiency and release characteristics of polyethyleneimine-treated or -untreated calcium alginate beads loaded with propranolol-resin complex. Int. J. Pharm. 2005;302:84-94.
12. Martindale. The Extra Pharmacopoeia. 31st ed., London: The Pharmaceutical Press; 1998:58-59.
13. European Pharmacopoeia, 4th ed., Strasbourg: Council of Europea; 2002.
14. th Inter. Pharm. Technol. Symp, Antalya, Turkey; Sept. 10-13, 2006:75-76.
15. Joo Y, Kim H, Woo R, Park C. Mefenamic acid shows neuroprotective effects and improves cognitive impairment in in vitro and in vivo Alzheimer's disease models. Mol. Pharm. 2006;69:76-84.
16. Ozsoy Y, Berşigadi N. Preparation of mefenamic acid sustained release beads based on ?-carregeenana. Boll. Chim. Farmac. 2000;139:89-92.
17. Betageri GV, Kurumaddali KR, Ravis WR. Preparation and in vitro evaluation of mefenamic acid sustained release beads. Drug Dev. Ind. Pharm. 1995;21:265-275.
18. Ramadan, EM, El-Helw, A, El-Said, Y. Effect of encapsulation of mefenamic acid with cationic Eudragit E on its bioavailability and gastric ulcerogenic activity in rabbits. J. Microen. 1987;4:125-132.
19. Lalla, JK, Ahuja, PL. Drug targeting using non-magnetic and magnetic albumin-globulin mix microspheres of mefenamic acid. J. Microen. 1991;8:37-52.
20. th Inter. Pharm. Technol. Symp. Antalya, Turkey; Sept. 10-13, 2006.
21. Sevgi F, Sarpaş B, Yurdasiper A. The effect of tabletting on the release characteristics of mefenamic acid microspheres, European Conference on Drug Delivery and Pharmaceutical Technology. Sevilla-Spain; May 10-12, 2004:326.
22. Gungor S, Yildiz A, Ozsoy Y, Cevher E, Araman A. Investigations on mefenamic acid sustained release tablets with water-insoluble gel. Il Farmaco, 2003;58:397-401.
23. Ozyazici M, Sevgi F, Ertan G. Sustained-release dosage form of nicardipine hydrochloride: Application of factorial design and effect of surfactant on release kinetics. Drug Dev. Ind. Pharm. 1997;23:761-770.
24. Gohel MC, Amin AF. Formulation optimization of controlled release diclofenac sodium microspheres using factorial design. J. Control. Release. 1998;51:115-122.
25. Sevgi, F, Ozyazici, M, Güneri, T. Sustained-release dosage form of phenylpropanolamine hydrochloride (3). Application of factorial design. J. Microen. 1994;11:439-444.
26. Kulkarni, AR, Soppimath, KS, Aminabhavi, M. Controlled release of diclofenac sodium from sodium alginate beads crosslinked with glutaraldehyde. Pharm. Acta Helv. 1999;74:29-36.
27. The United States Pharmacopeia 24, United States Pharmacopeial Convention, Inc., Rockville, MD; 2000.
28. Peppas NA. Analysis of Fickian and non-Fickian drug release from polymers. Pharm. Acta Helv. 1985;60:110-111.
29. Ritger PL, Peppas, N. A simple equation for description of solute release II. Fickian and anomalous release from swellable devices. J. Control. Release 1987;5:37-42.
30. Ege MA, Karasulu HY, Karasulu E, Ertan G. A computer program designed for in vitro dissolution kinetics, in vitro-in vivo kinetic correlations and routine applications, in: 4th Central European Symposium on Pharmaceutical Technology; Scientia Pharmaceutical; September 23-25, 2001 (Suppl. 1 Band 69): S127-S128. http://pharm.ege.edu.tr/applications/
31. Østberg T, Graffner C. Calcium alginate matrices for oral multiple unit administration: III. Influence of calcium concentration, amount of drug added and alginate characteristics on drug release. Int. J. Pharm. 1994;111:271-282.
32. Bodmeier R, Oh-KH, Pramar Y. Preparation and evaluation of drug-containing chitosan beads. Drug Dev. Ind. Pharm. 1989;15:1475-1494.
33. Segi N, Yotsuyanagi T, Ikeda K. Interaction of calcium-induced alginate gel beads with propranolol. Chem. Pharm. Bull. 1989;37:3092-3095.
34. Haug A, Smidsrod O. The effect of divalent metals on the properties of alginate solutions. Acta Chem. Scand. 1965;17:341-351.
35. Takka S, Ocak OH, Acarturk F. Formulation and investigation of nicardipine HCl-alginate gel beads with factorial design-based studies. Europ. J. Pharm. Sci. 1998;6:241-246.
36. Su XY, Al-Kansas R, Po ALW. Statistical modelling of ibuprofen release from spherical lipophilic matrices. Eur. J. Pharm. Biopharm. 1994;40:73-76.
37. Karasulu, E, Karasulu, HY, Ertan, G, Kirilmaz, L, Güneri, T. Extended release lipophilic indomethacin microspheres: formulation factors and mathematical equations fitted drug release rates. Eur. J. Pharm. Sci. 2003;19:99-104.