Experimental design for the formulation and optimization of novel cross-linked oilispheres developed for in vitro site-specific release of Mentha piperita oil

AAPS PharmSciTech

Volumn 5, Issue 1, 2004, Pages

  Sibanda, Wilbert ^a   Pillay, Viness ^b   Danckwerts, Michael ^a   Viljoen, Alvaro M ^a   van Vuuren, Sandy ^a   Khan, Riaz A ^b  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b FLORIDA A AND M UNIVERSITY   (United States)

Author keywords

Artificial neural networks; Constrained optimization; Crosslinked oilisphere delivery system; Lag time with zero order kinetics; Mentha piperita oil; Plackett Burman design

Indexed keywords

ALGINIC ACID; ALUMINUM CHLORIDE; ALUMINUM SULFATE; CALCIUM CHLORIDE; PECTIN; PEPPERMINT OIL; POLYMER; DRUG CARRIER; MICROSPHERE; OIL;

ACCURACY; ANALYTIC METHOD; ARTICLE; ARTIFICIAL NEURAL NETWORK; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION COEFFICIENT; CROSS LINKING; DIFFUSION COEFFICIENT; DRUG DETERMINATION; DRUG FORMULATION; DRUG RELEASE; ENCAPSULATION; EXPERIMENTAL DESIGN; GRAVIMETRY; IN VITRO STUDY; IRRITABLE COLON; MENTHA PIPERITA; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PROCESS OPTIMIZATION; REACTION TIME; SENSITIVITY ANALYSIS; STATISTICAL SIGNIFICANCE; CHEMISTRY; DRUG DELIVERY SYSTEM;

CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; MENTHA PIPERITA; MICROSPHERES; OILS;

EID: 23144461645     PISSN: 15309932     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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