Preparation of alginate beads for floating drug delivery system: Effects of CO2 gas-forming agents

International Journal of Pharmaceutics

Volumn 239, Issue 1-2, 2002, Pages 81-91

  Choi, B Y ^a   Park, H J ^a   Hwang, S J ^b   Park, J B ^c  

^a Korea University   (South Korea)

^b Chungnam National University   (South Korea)

^c Sama Pharm Co Ltd   (South Korea)

Author keywords

Alginate bead; CaCO3; Floating bead; Floating drug dosage system (FDDS); Gas forming agent; NaHCO3

Indexed keywords

ACETIC ACID; ALGINIC ACID; BICARBONATE; CALCIUM CARBONATE; CALCIUM CHLORIDE; CARBON DIOXIDE; RIBOFLAVIN;

ARTICLE; DRUG DELIVERY SYSTEM; GAS; GEL; MOLECULAR SIZE; POROSITY; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE;

ALGINATES; CALCIUM CARBONATE; CARBON DIOXIDE; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; EXCIPIENTS; HYDROGEN-ION CONCENTRATION; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; POROSITY; RIBOFLAVIN; SODIUM BICARBONATE; SURFACE PROPERTIES; TENSILE STRENGTH;

EID: 0037018959     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(02)00054-6     Document Type: Article

References (32)

1. Evaluation of oral mucoadhesive microspheres in man on the basis of the pharmacokinetics of furosemide and riboflavin, compounds with limited gastrointestinal absorption sites
2. A sustained release drug delivery system using calcium alginate beads
3. Optimisation of floating matrix tablets and evaluation of their gastric residence time
4. Effect of matrix composition and process conditions on casein-gelatin beads floating properties
5. Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering: Part 1. Structure, gelation rate and mechanical properties
6. Synthesis of fast-swelling, superporous sucrose hydrogels
7. Bioadhesive microspheres: III. An in vivo transit and bioavailability study of drug-loaded alginate and poly(fumaric-co-sebacic anhydride) microspheres
8. A floating controlled-release drug delivery system: In vitro-in vivo evaluation
9. Development of a novel controlled-release system for gastric retention
10. Preparation and evaluation of ketoprofen floating oral delivery system
11. Biological interactions between polysaccharides and divalent cations: The egg-box model
12. Retention of insulin in alginate gel beads
13. Air compartment mutiple-unit system for prolonged gastric residence. Part 1. Formulation study
14. A new multiple-unit oral floating damage system. I: Preparation and in vitro evaluation of floating and sustained-release characteristics
15. The effects of alginate molecular structure and formulation variables on the physical characteristics of alginate raft systems
16. Sustained release liquid preparation using sodium alginate for eradication of Helicobacter pyroli
17. Hollow microspheres for use as a floating controlled drug delivery system in the stomach
18. Evaluation of peroral silicone dosage forms in hymans by gamma-scintigraphy
19. Alginate-raft formulations in the treatment of heartburn and acid reflux
20. Use of floating alginate gel beads for stomach-specific drug delivery
21. Controlled release of clot-dissolving tissue-type plasminogen activator from a poly(L-glutamic acid) semi-interpenetrating polymer network hydrogel
22. Evaluation and comparison of dissolution data derived from different modified release dosage forms; And alternative method
23. A physico-chemical approach to production of alginate beads by emulsification-internal ionotropic gelation
24. Drug absorption sites in the gastrointestinal tract and dosage forms for site-specific delivery
25. Comparative pharmacokinetic study of a floating multiple-unit capsule, a high density multiple-unit capsule and an immediate-release tablet containing 25 mg atenolol
26. Floating drug delivery systems: An approach to oral controlled drug delivery via gastric retention
27. The effect of divalent metals on the properties of alginate solutions. I. Calcium ions
28. Encapsulation of probiotic bacteria with alginate-starch and evaluation of survival in simulated gastrointestinal conditions and in yoghurt
29. Oral sustained-release drug delivery systems using polycarbonate microspheres capable of floating on the gastric fluid
30. Factors controlling the buoyancy and gastric retention capabilities of floating matrix capsules: New data for reconsidering the controversy
31. Amoxycillin release from a floating dosage form based on alginates
32. Production and characterisation of enteric beads