Spray-dried composite particles of lactose and sodium alginate for direct tabletting and controlled releasing

International Journal of Pharmaceutics

Volumn 174, Issue 1-2, 1998, Pages 91-100

  Takeuchi, Hirofumi ^a   Yasuji, Takehiko ^a   Hino, Tomoaki ^a   Yamamoto, Hiromitsu ^a   Kawashima, Yoshiaki ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Amorphous composite particle; Controlled releasing filler; Direct tabletting; Lactose; Spray drying

Indexed keywords

ALGINIC ACID; LACTOSE; PARACETAMOL;

AQUEOUS SOLUTION; ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; MATRIX TABLET; PARTICLE SIZE; PRIORITY JOURNAL; TABLET COMPRESSION; TABLET MANUFACTURE; TENSILE STRENGTH; THERMOSTABILITY;

EID: 0031766174     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(98)00248-8     Document Type: Article

References (14)

1. Buckton G., Darcy P. The use of gravimetric studies to assess the degree of crystallinity of predominantly crystalline powders. Int. J. Pharm. 123:1995;265-271.
2. Elamin A.A., Sebhatu T., Ahlneck C. The use of amorphous model substances to study mechanically activated materials in the solid state. Int. J. Pharm. 119:1995;25-36.
3. Fell J.T., Newton J.M. Determination of tablet strength by the diametral-compression tests. J. Pharm. Sci. 59:1970;688-691.
4. Garacia-Arieta A., Torrrado-Santiago D., Torrado J.J. Comparative study of aqueous and organic enteric coatings of chlorpheniramine maleate tablets. Drug Dev. Ind. Pharm. 22:1996;579-585.
5. Gunsel W.C., Lachman L. Comparative evaluation of tablet formulations prepared from conventionally-processed and spray-dried lactose. J. Pharm. Sci. 52:1963;178-182.
6. Higuchi T. Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J. Pharm. Sci. 52:1963;1145-1149.
7. Hodsdon A.C., Mitchell J.R., Davies M.C., Melia C.D. Structure and behaviour in hydrophillic matrix sustained release dosage forms: 3. The influence of pH on the sustained-release performance and internal gel structure of sodium alginate matrices. J. Control. Release. 33:1995;143-152.
8. Ishino R., Yoshino H., Hirakawa Y., Noda K. Design and preparation of pulsatile release tablet as a new oral drug delivery system. Chem. Pharm. Bull. 40:1992;3036-3041.
9. Lerk C.F. Consolidation and compaction of lactose. Drug Dev. Ind. Pharm. 19:1993;2359-2398.
10. Sebhatu T., Elamin A.A., Ahlneck C. Effect of sorption on tabletting characteristics of spray dried (15% amorphous) lactose. Pharm. Res. 11:1994;1233-1238.
11. Sebhatu T., Ahlneck C., Alderborn G. The effect of moisture content on the compression and bond-formation properties of amorphous lactose particles. Int. J. Pharm. 146:1997;101-114.
12. Tahara K., Yamamoto K., Nishihata T. Overall mechanism behind matrix sustained release (SR) tablets prepared with hydroxypropyl methylcellulose 2910. J. Control. Release. 35:1995;59-66.
13. Vromans H., Boluhuis G.K., Lerk C.F., Kussendrager K.D., Bosch H. Studies on tableting properties of lactose. VI. Consolidation on tableting properties of spray dried lactose. Acta Pharm. Suec. 23:1986;231-240.
14. Vromans H., Boluhuis G.K., Lerk C.F., Biggelaar V.D., Bosch H. Studies on tableting properties of lactose. VII. The effect of variations in primary particle size and percentage of amorphous lactose in spray dried lactose products. Int. J. Pharm. 35:1987;29-37.