Intra-spike crosslinking overcomes antibody evasion by HIV-1

Cell

Volumn 160, Issue 3, 2015, Pages 433-446

  Galimidi, Rachel P ^a   Klein, Joshua S ^a   Politzer, Maria S ^a   Bai, Shiyu ^a   Seaman, Michael S ^b   Nussenzweig, Michel C ^c,d   West, Anthony P ^a   Bjorkman, Pamela J ^a,d  

^a California Institute of Technology   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; EPITOPE; IMMUNOGLOBULIN G; NEUTRALIZING ANTIBODY; CROSS LINKING REAGENT; GLYCOPROTEIN GP 120; GP120 PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT;

ANTIBODY ENGINEERING; ANTIGEN BINDING; ARTICLE; BINDING SITE; COMPARATIVE STUDY; CONCENTRATION PROCESS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CROSS LINKING; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNE EVASION; IMMUNE SYSTEM; INTER SPIKE CROSSLINKING; NONHUMAN; PRIORITY JOURNAL; VIRION; VIRUS ATTACHMENT; VIRUS MUTATION; VIRUS NEUTRALIZATION; VIRUS RESISTANCE; VIRUS SPIKE; CHEMISTRY; IMMUNOLOGY; METABOLISM; PROTEIN ENGINEERING; X RAY CRYSTALLOGRAPHY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTIBODIES, NEUTRALIZING; CROSS-LINKING REAGENTS; CRYSTALLOGRAPHY, X-RAY; EPITOPES; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV-1; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; PROTEIN ENGINEERING;

EID: 84922224963     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2015.01.016     Document Type: Article

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