Helix 8 and the i3 loop of the muscarinic M3 receptor are crucial sites for its regulation by the Gβ5-RGS7 complex

Biochemistry

Volumn 54, Issue 4, 2015, Pages 1077-1088

  Karpinsky Semper, Darla ^a   Tayou, Junior ^a   Levay, Konstantin ^a   Schuchardt, Brett J ^a   Bhat, Vikas ^a   Volmar, Claude Henry ^a   Farooq, Amjad ^a   Slepak, Vladlen Z ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CALCIUM; CELL MEMBRANES; DICHROISM; PROTEINS;

CALCIUM SIGNALING; CELL SURFACES; COUPLED RECEPTORS; HELICAL CONFORMATION; HETERO DIMERS; INTRACELLULAR STORES; REGULATORY PROTEIN; SURFACE EXPRESSION;

CIRCULAR DICHROISM SPECTROSCOPY;

ATROPINE; CALCIUM ION; GUANINE NUCLEOTIDE BINDING PROTEIN; HETERODIMER; MUSCARINIC M3 RECEPTOR; RGS PROTEIN; CHOLINERGIC RECEPTOR STIMULATING AGENT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT;

ALPHA HELIX; ANIMAL CELL; ARTICLE; CALCIUM SIGNALING; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; GENE OVEREXPRESSION; HELIX 8; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; WESTERN BLOTTING; WILD TYPE; AGONISTS; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CHEMISTRY; CRICETULUS; DOSE RESPONSE; HAMSTER; MOLECULAR GENETICS; PHYSIOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CHOLINERGIC AGENTS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; GTP-BINDING PROTEIN BETA SUBUNITS; MOLECULAR SEQUENCE DATA; RECEPTOR, MUSCARINIC M3;

EID: 84922212133     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi500980d     Document Type: Article

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