-
1
-
-
0023062991
-
G proteins: Transducers of receptor-generated signals
-
Gilman, A. G. G proteins: transducers of receptor-generated signals. Annu. Rev. Biochem. 56, 615-649 (1987).
-
(1987)
Annu. Rev. Biochem.
, vol.56
, pp. 615-649
-
-
Gilman, A.G.1
-
2
-
-
0019137579
-
A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled β-adrenergic receptor
-
De Lean, A., Stadel, J. M. & Lefkowitz, R. J. A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. J. Biol. Chem. 255, 7108-7117 (1980). (Pubitemid 11232874)
-
(1980)
Journal of Biological Chemistry
, vol.255
, Issue.15
, pp. 7108-7117
-
-
De Lean, A.1
Stadel, J.M.2
Lefkowitz, R.J.3
-
3
-
-
33750702165
-
Structural basis of function in heterotrimeric G proteins
-
DOI 10.1017/S0033583506004306, PII S0033583506004306
-
Oldham, W. M. & Hamm, H. E. Structural basis of function in heterotrimeric G proteins. Q. Rev. Biophys. 39, 117-166 (2006). (Pubitemid 44706968)
-
(2006)
Quarterly Reviews of Biophysics
, vol.39
, Issue.2
, pp. 117-166
-
-
Oldham, W.M.1
Hamm, H.E.2
-
4
-
-
0030935667
-
Structural basis of receptor/G protein coupling selectivity studied with muscarinic receptors as model systems
-
DOI 10.1016/S0024-3205(97)00041-6, PII S0024320597000416
-
Wess, J. et al. Structural basis of receptor/G protein coupling selectivity studied with muscarinic receptors as model systems. Life Sci. 60, 1007-1014 (1997). (Pubitemid 27165569)
-
(1997)
Life Sciences
, vol.60
, Issue.13-14
, pp. 1007-1014
-
-
Wess, J.1
Liu, J.2
Blin, N.3
Yun, J.4
Lerche, C.5
Kostenis, E.6
-
5
-
-
80051658642
-
Crystal structure of the β2 adrenergic receptor-Gs protein complex
-
advance online publication, 19 July
-
Rasmussen, S. G. F. et al. Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature advance online publication,
-
(2011)
Nature
-
-
Rasmussen, S.G.F.1
-
6
-
-
0027936892
-
Membrane organization in G-protein mechanisms
-
Neubig, R. R. Membrane organization in G-protein mechanisms. FASEB J. 8, 939-946 (1994). (Pubitemid 24286857)
-
(1994)
FASEB Journal
, vol.8
, Issue.12
, pp. 939-946
-
-
Neubig, R.R.1
-
8
-
-
0038445997
-
Protein complexes involved in heptahelical receptor-mediated signal transduction
-
DOI 10.1080/10606820308243
-
Rebois, R. V. & Hebert, T. E. Protein complexes involved in heptahelical receptor-mediated signal transduction. Receptors Channels 9, 169-194 (2003). (Pubitemid 36874791)
-
(2003)
Receptors and Channels
, vol.9
, Issue.3
, pp. 169-194
-
-
Rebois, R.V.1
Hebert, T.E.2
-
9
-
-
18744376919
-
Real-time monitoring of receptor and G-protein interactions in living cells
-
DOI 10.1038/nmeth743
-
Galés, C. et al. Real-time monitoring of receptor and G-protein interactions in living cells. Nat. Methods 2, 177-184 (2005). (Pubitemid 41122124)
-
(2005)
Nature Methods
, vol.2
, Issue.3
, pp. 177-184
-
-
Gales, C.1
Rebois, R.V.2
Hogue, M.3
Trieu, P.4
Breit, A.5
Hebert, T.E.6
Bouvier, M.7
-
10
-
-
33748355624
-
Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes
-
DOI 10.1038/nsmb1134, PII NSMB1134
-
Galés, C. et al. Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes. Nat. Struct. Mol. Biol. 13, 778-786 (2006). (Pubitemid 44338771)
-
(2006)
Nature Structural and Molecular Biology
, vol.13
, Issue.9
, pp. 778-786
-
-
Gales, C.1
Van Durm, J.J.J.2
Schaak, S.3
Pontier, S.4
Percherancier, Y.5
Audet, M.6
Paris, H.7
Bouvier, M.8
-
11
-
-
29444446964
-
Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells
-
DOI 10.1073/pnas.0504778102
-
Nobles, M., Benians, A. & Tinker, A. Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells. Proc. Natl. Acad. Sci. USA 102, 18706-18711 (2005). (Pubitemid 43011290)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.51
, pp. 18706-18711
-
-
Nobles, M.1
Benians, A.2
Tinker, A.3
-
12
-
-
0018125541
-
Mode of coupling between the beta-adrenergic receptor and adenylate cyclase in turkey erythrocytes
-
Tolkovsky, A. M. & Levitzki, A. Mode of coupling between the beta-adrenergic receptor and adenylate cyclase in turkey erythrocytes. Biochemistry 17, 3795 (1978).
-
(1978)
Biochemistry
, vol.17
, pp. 3795
-
-
Tolkovsky, A.M.1
Levitzki, A.2
-
13
-
-
77952679732
-
Third-party bioluminescence resonance energy transfer indicates constitutive association of membrane proteins: Application to class A G-protein-coupled receptors and G-proteins
-
Kuravi, S., Lan, T. H., Barik, A. & Lambert, N. A. Third-party bioluminescence resonance energy transfer indicates constitutive association of membrane proteins: application to class A G-protein-coupled receptors and G-proteins. Biophys. J. 98, 2391-2399 (2010).
-
(2010)
Biophys. J.
, vol.98
, pp. 2391-2399
-
-
Kuravi, S.1
Lan, T.H.2
Barik, A.3
Lambert, N.A.4
-
14
-
-
33845313646
-
PI (3, 4, 5) P3 and PI (4, 5) P2 lipids target proteins with polybasic clusters to the plasma membrane
-
Heo, W. D. et al. PI (3, 4, 5) P3 and PI (4, 5) P2 lipids target proteins with polybasic clusters to the plasma membrane. Science 314, 1458-1461 (2006).
-
(2006)
Science
, vol.314
, pp. 1458-1461
-
-
Heo, W.D.1
-
15
-
-
38149094836
-
Membrane phosphatidylserine regulates surface charge and protein localization
-
Yeung, T. et al. Membrane phosphatidylserine regulates surface charge and protein localization. Science 319, 210-213 (2008).
-
(2008)
Science
, vol.319
, pp. 210-213
-
-
Yeung, T.1
-
16
-
-
33646534202
-
Co-ordinated covalent modification of G-protein coupled receptors
-
Torrecilla, I. & Tobin, A. B. Co-ordinated covalent modification of G-protein coupled receptors. Curr. Pharm. Des. 12, 1797-1808 (2006).
-
(2006)
Curr. Pharm. Des.
, vol.12
, pp. 1797-1808
-
-
Torrecilla, I.1
Tobin, A.B.2
-
17
-
-
34548433883
-
Kinetic Analysis of G Protein-Coupled Receptor Signaling Using Fluorescence Resonance Energy Transfer in Living Cells
-
DOI 10.1016/S0065-3233(07)74005-6, PII S0065323307740056, Mechanisms and Pathways of Heterotrimeric G Protein Signaling
-
Lohse, M. J., Hoffmann, C., Nikolaev, V. O., Vilardaga, J. P. & Bunemann, M. Kinetic analysis of G protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells. Adv. Protein Chem. 74, 167-188 (2007). (Pubitemid 47369750)
-
(2007)
Advances in Protein Chemistry
, vol.74
, pp. 167-188
-
-
Lohse, M.J.1
Hoffmann, C.2
Nikolaev, V.O.3
Vilardaga, J.4
Bunemann, M.5
-
18
-
-
70350362562
-
A G protein-coupled receptor at work: The rhodopsin model
-
Hofmann, K. P. et al. A G protein-coupled receptor at work: the rhodopsin model. Trends Biochem. Sci. 34, 540-552 (2009).
-
(2009)
Trends Biochem. Sci.
, vol.34
, pp. 540-552
-
-
Hofmann, K.P.1
-
19
-
-
44949236117
-
High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation
-
DOI 10.1073/pnas.0802515105
-
Altenbach, C., Kusnetzow, A. K., Ernst, O. P., Hofmann, K. P. & Hubbell, W. L. High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation. Proc. Natl. Acad. Sci. USA 105, 7439-7444 (2008). (Pubitemid 351830036)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.21
, pp. 7439-7444
-
-
Altenbach, C.1
Kusnetzow, A.K.2
Ernst, O.P.3
Hofmann, K.P.4
Hubbell, W.L.5
-
20
-
-
52949102889
-
Crystal structure of opsin in its G-protein-interacting conformation
-
Scheerer, P. et al. Crystal structure of opsin in its G-protein-interacting conformation. Nature 455, 497-502 (2008).
-
(2008)
Nature
, vol.455
, pp. 497-502
-
-
Scheerer, P.1
-
21
-
-
77951877209
-
Tracking G-protein-coupled receptor activation using genetically encoded infrared probes
-
Ye, S. et al. Tracking G-protein-coupled receptor activation using genetically encoded infrared probes. Nature 464, 1386-1389 (2010).
-
(2010)
Nature
, vol.464
, pp. 1386-1389
-
-
Ye, S.1
-
22
-
-
67249125561
-
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
-
Yao, X. J. et al. The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex. Proc. Natl. Acad. Sci. USA 106, 9501-9506 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 9501-9506
-
-
Yao, X.J.1
-
23
-
-
28644443374
-
Dynamics of receptor/G protein coupling in living cells
-
DOI 10.1038/sj.emboj.7600870
-
Hein, P., Frank, M., Hoffmann, C., Lohse, M. J. & Bunemann, M. Dynamics of receptor/G protein coupling in living cells. EMBO J. 24, 4106-4114 (2005). (Pubitemid 41752879)
-
(2005)
EMBO Journal
, vol.24
, Issue.23
, pp. 4106-4114
-
-
Hein, P.1
Frank, M.2
Hoffmann, C.3
Lohse, M.J.4
Bunemann, M.5
-
24
-
-
48749105304
-
Abundance and stability of complexes containing inactive G protein-coupled receptors and G proteins
-
Qin, K., Sethi, P. R. & Lambert, N. A. Abundance and stability of complexes containing inactive G protein-coupled receptors and G proteins. FASEB J. 22, 2920-2927 (2008).
-
(2008)
FASEB J.
, vol.22
, pp. 2920-2927
-
-
Qin, K.1
Sethi, P.R.2
Lambert, N.A.3
-
25
-
-
77953810501
-
Structural basis of G protein-coupled receptor-G protein interactions
-
Hu, J. et al. Structural basis of G protein-coupled receptor-G protein interactions. Nat. Chem. Biol. 6, 541-548 (2010).
-
(2010)
Nat. Chem. Biol.
, vol.6
, pp. 541-548
-
-
Hu, J.1
-
26
-
-
0034695482
-
Mutation of the fourth cytoplasmic loop of rhodopsin affects binding of transducin and peptides derived from the carboxyl-terminal sequences of transducin α and γ subunits
-
DOI 10.1074/jbc.275.3.1937
-
Ernst, O. P. et al. Mutation of the fourth cytoplasmic loop of rhodopsin affects binding of transducin and peptides derived from the carboxyl-terminal sequences of transducin alpha and gamma subunits. J. Biol. Chem. 275, 1937-1943 (2000). (Pubitemid 30060819)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.3
, pp. 1937-1943
-
-
Ernst, O.P.1
Meyer, C.K.2
Marin, E.P.3
Henklein, P.4
Fu, W.-Y.5
Sakmar, T.P.6
Hofmann, K.P.7
-
27
-
-
0034695476
-
The amino terminus of the fourth cytoplasmic loop of rhodopsin modulates rhodopsin-transducin interaction
-
DOI 10.1074/jbc.275.3.1930
-
Marin, E. P. et al. The amino terminus of the fourth cytoplasmic loop of rhodopsin modulates rhodopsin-transducin interaction. J. Biol. Chem. 275, 1930-1936 (2000). (Pubitemid 30060818)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.3
, pp. 1930-1936
-
-
Marin, E.P.1
Krishna, A.G.2
Zvyaga, T.A.3
Isele, J.4
Siebert, F.5
Sakmar, T.P.6
-
28
-
-
26944450513
-
An electrostatic steering mechanism of Cdc42 recognition by Wiskott-Aldrich syndrome proteins
-
DOI 10.1016/j.molcel.2005.08.036, PII S1097276505016023
-
Hemsath, L., Dvorsky, R., Fiegen, D., Carlier, M. F. & Ahmadian, M. R. An electrostatic steering mechanism of Cdc42 recognition by Wiskott-Aldrich syndrome proteins. Mol. Cell 20, 313-324 (2005). (Pubitemid 41484175)
-
(2005)
Molecular Cell
, vol.20
, Issue.2
, pp. 313-324
-
-
Hemsath, L.1
Dvorsky, R.2
Fiegen, D.3
Carlier, M.-F.4
Ahmadian, M.R.5
-
29
-
-
34548487749
-
16α palmitoylation, plasma membrane localization, and signaling function
-
DOI 10.1074/jbc.M610297200
-
Pedone, K. H. & Hepler, J. R. The importance of N-terminal polycysteine and polybasic sequences for G14alpha and G16alpha palmitoylation, plasma membrane localization, and signaling function. J. Biol. Chem. 282, 25199-25212 (2007). (Pubitemid 47372833)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.35
, pp. 25199-25212
-
-
Pedone, K.H.1
Hepler, J.R.2
-
30
-
-
28444477387
-
Plasma membrane phosphoinositide organization by protein electrostatics
-
DOI 10.1038/nature04398
-
McLaughlin, S. & Murray, D. Plasma membrane phosphoinositide organization by protein electrostatics. Nature 438, 605-611 (2005). (Pubitemid 41740564)
-
(2005)
Nature
, vol.438
, Issue.7068
, pp. 605-611
-
-
McLaughlin, S.1
Murray, D.2
-
31
-
-
49549123353
-
N-terminal polybasic motifs are required for plasma membrane localization of Galpha (s) and Galpha (q)
-
Crouthamel, M., Thiyagarajan, M. M., Evanko, D. S. & Wedegaertner, P. B. N-terminal polybasic motifs are required for plasma membrane localization of Galpha (s) and Galpha (q). Cell. Signal. 20, 1900-1910 (2008).
-
(2008)
Cell. Signal.
, vol.20
, pp. 1900-1910
-
-
Crouthamel, M.1
Thiyagarajan, M.M.2
Evanko, D.S.3
Wedegaertner, P.B.4
-
32
-
-
0033943654
-
Stoichiometry and compartmentation in G protein-coupled receptor signaling: Implications for therapeutic interventions involving G(s)
-
Ostrom, R. S., Post, S. R. & Insel, P. A. Stoichiometry and compartmentation in G protein-coupled receptor signaling: implications for therapeutic interventions involving G (s). J. Pharmacol. Exp. Ther. 294, 407-412 (2000). (Pubitemid 30490809)
-
(2000)
Journal of Pharmacology and Experimental Therapeutics
, vol.294
, Issue.2
, pp. 407-412
-
-
Ostrom, R.S.1
Post, S.R.2
Insel, P.A.3
-
33
-
-
0026803223
-
G protein-coupled mechanisms and nervous signaling
-
Hille, B. G protein-coupled mechanisms and nervous signaling. Neuron 9, 187-195 (1992).
-
(1992)
Neuron
, vol.9
, pp. 187-195
-
-
Hille, B.1
-
35
-
-
75749117137
-
Kinetics of M1 muscarinic receptor and G protein signaling to phospholipase C in living cells
-
Falkenburger, B. H., Jensen, J. B. & Hille, B. Kinetics of M1 muscarinic receptor and G protein signaling to phospholipase C in living cells. J. Gen. Physiol. 135, 81-97 (2010).
-
(2010)
J. Gen. Physiol.
, vol.135
, pp. 81-97
-
-
Falkenburger, B.H.1
Jensen, J.B.2
Hille, B.3
-
36
-
-
0035830890
-
Visualization of a functional Galpha q-green fluorescent protein fusion in living cells. Association with the plasma membrane is disrupted by mutational activation and by elimination of palmitoylation sites, but not be activation mediated by receptors or AlF4
-
Hughes, T. E., Zhang, H., Logothetis, D. E. & Berlot, C. H. Visualization of a functional Galpha q-green fluorescent protein fusion in living cells. Association with the plasma membrane is disrupted by mutational activation and by elimination of palmitoylation sites, but not be activation mediated by receptors or AlF4. J. Biol. Chem. 276, 4227-4235 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 4227-4235
-
-
Hughes, T.E.1
Zhang, H.2
Logothetis, D.E.3
Berlot, C.H.4
-
37
-
-
3142766112
-
Visualization of G protein βγ dimers using bimolecular fluorescence complementation demonstrates roles for both β and γ in subcellular targeting
-
DOI 10.1074/jbc.M401432200
-
Hynes, T. R. et al. Visualization of G protein betagamma dimers using bimolecular fluorescence complementation demonstrates roles for both beta and gamma in subcellular targeting. J. Biol. Chem. 279, 30279-30286 (2004). (Pubitemid 38937955)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.29
, pp. 30279-30286
-
-
Hynes, T.R.1
Tang, L.2
Mervine, S.M.3
Sabo, J.L.4
Yost, E.A.5
Devreotes, P.N.6
Berlot, C.H.7
-
38
-
-
33644971702
-
Differences in eNOS activity because of subcellular localization are dictated by phosphorylation state rather than the local calcium environment
-
Church, J. E. & Fulton, D. Differences in eNOS activity because of subcellular localization are dictated by phosphorylation state rather than the local calcium environment. J. Biol. Chem. 281, 1477-1488 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 1477-1488
-
-
Church, J.E.1
Fulton, D.2
|