Conformational dynamics of helix 8 in the GPCR rhodopsin controls arrestin activation in the desensitization process

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 46, 2011, Pages 18690-18695

  Kirchberg, Kristina ^a,b   Kim, Tai Yang ^a   Mol̈ler, Martina ^a   Skegro, Darko ^b   Raju, Gayathri Dasara ^b   Granzin, Joachim ^b   Bul̈dt, Georg ^b,c   Schlesinger, Ramona ^a,b   Alexiev, Ulrike ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b FORSCHUNGSZENTRUM JÜLICH   (Germany)

^c MOSCOW INSTITUTE OF PHYSICS AND TECHNOLOGY   (Russian Federation)

Author keywords

Binding kinetics; Membrane receptor; Protein conformational change

Indexed keywords

G PROTEIN COUPLED RECEPTOR; HELIX 7 PROTEIN; HELIX 8 PROTEIN; PROTEIN; RETINA S ANTIGEN; RHODOPSIN; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOPLASM; DEPOLARIZATION; DESENSITIZATION; FLUORESCENCE ANALYSIS; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE;

ANIMALS; ANISOTROPY; ARRESTIN; CATTLE; CRYSTALLOGRAPHY, X-RAY; KINETICS; MICROSCOPY, FLUORESCENCE; MOLECULAR CONFORMATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; RETINA; RHODOPSIN; SIGNAL TRANSDUCTION; SPECTROPHOTOMETRY;

EID: 81755187017     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1015461108     Document Type: Article

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