The peripheral benzodiazepine receptor modulates Ca2+ transport through the VDAC in rat heart mitochondria

Journal of Clinical and Basic Cardiology

Volumn 11, Issue 1-4, 2008, Pages 24-29

  Tamse, C T ^a   Lu, X ^a   Mortel, E G ^a   Cabrales, E ^b   Feng, W ^b   Schaefer, Saul ^a,c,d  

^a Division of Cardiovascular Medicine   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Northern California Health Care System   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Benzodiazepine receptor; Bilayer; Calcium; Mitochondria; MPT; Permeability transition; Translocator protein; VDAC; Voltage dependent anion channel

Indexed keywords

BENZODIAZEPINE RECEPTOR; CALCIUM; CYCLOSPORIN A; HEMIN; LIPID; VOLTAGE DEPENDENT ANION CHANNEL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; HEART MITOCHONDRION; LIPID BILAYER; MALE; MITOCHONDRIAL PERMEABILITY; MODULATION; NONHUMAN; PRIORITY JOURNAL; RAT; TIME;

EID: 57349162727     PISSN: 15612775     EISSN: 16809386     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Shoshan-Barmatz V, Israelson A, Brdiczka D, Sheu S. The voltage-dependent anion channel (VDAC): function in intracellular signalling, cell life and cell death. Curr Pharm Des 2006; 12: 2249-70.
2. da Silva EM, Soares AM, Moreno AJ. The use of the mitochondrial transmembrane electric potential as an effective biosensor in ecotoxicological research. Chemosphere 1998; 36: 2375-90.
3. Perez Velazquez JL, Frantseva MV, Huzar DV, Carlen PL. Mitochondrial porin required for ischemia-induced mitochondrial dysfunction and neuronal damage. Neuroscience 2000; 97: 363-9.
4. Zaid H, Abu-Hamad S, Israelson A, Nathan I, Shoshan-Barmatz V. The voltage-dependent anion channel-1 modulates apoptotic cell death. Cell Death Differ 2005; 12: 751-60.
5. Gincel D, Zaid H, Shoshan-Barmatz V. Calcium binding and translocation by the voltage-dependent anion channel: a possible regulatory mechanism in mitochondrial function. Biochem J 2001; 358: 147-55.
6. Veenman L, Papadopoulos V, Gavish M. Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response. Curr Pharm Des 2007; 13: 2385-405.
7. Wang L, Cherednichenko G, Hernandez L, Halow J, Camacho SA, Figueredo V, Schaefer S. Preconditioning limits mitochondrial Ca(2+) during ischemia in rat hearts: role of K(ATP) channels. Am J Physiol Heart Circ Physiol 2001; 280: H2321-H2328.
8. m overload in rat hearts. Am J Physiol 1996; 271: H2145-H2153.
9. Garcia-Rivas Gde J, Carvajal K, Correa F, Zazueta C. Ru360, a specific mitochondrial calcium uptake inhibitor, improves cardiac post-ischaemic functional recovery in rats in vivo. Br J Pharmacol 2006; 149: 829-37.
10. Arieli Y, Gursahani H, Eaton MM, Hernandez LA, Schaefer S. Gender modulation of Ca(2+) uptake in cardiac mitochondria. J Mol Cell Cardiol 2004; 37: 507-13.
11. Gursahani HI, Schaefer S. Acidification reduces mitochondrial calcium uptake in rat cardiac mitochondria. Am J Physiol Heart Circ Physiol 2004; 287: H2659-H2665.
12. Bradford MM. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principal of protein-dye binding. Anal Biochem 1976; 72: 248-54.
13. De Pinto V, Zara V, Benz R, Gnoni GV, Palmieri F. Characterization of pore-forming activity in liver mitochondria from Anguilla anguilla. Two porins in mitochondria? Biochim Biophys Acta 1991; 1061: 279-86.
14. Olsen I, Wiker HG. Diffusion blotting for rapid production of multiple identical imprints from sodium dodecyl sulfate polyacrylamide gel electrophoresis on a solid support. J Immunol Methods 1998; 220: 77-84.
15. Feng W, Shoshan-Barmatz V. Involvement of lysine residues in the gating of the ryanodine receptor/Ca2+-release channel of skeletal muscle sarcoplasmic reticulum. Eur J Biochem 1997; 247: 955-62.
16. Shoshan-Barmatz V, Hadad N, Feng W, Shafir I, Orr I, Varsanyi M, Heilmeyer LM. VDAC/porin is present in sarcoplasmic reticulum from skeletal muscle. FEBS Lett 1996; 386: 205-10.
17. McEnery MW, Dawson TM, Verma A, Gurley D, Colombini M, Snyder SH. Mitochondrial voltage-dependent anion channel. Immunochemical and immunohistochemical characterization in rat brain. J Biol Chem 1993; 268: 23289-96.
18. McEnery MW, Snowman AM, Trifiletti RR, Snyder SH. Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl Acad Sci USA 1992; 89: 3170-4.
19. Szabo I, Zoratti M. The mitochondrial permeability transition pore may comprise VDAC molecules. I. Binary structure and voltage dependence of the pore. FEBS Lett 1993; 330: 201-5.
20. Rostovtseva TK, Tan W, Colombini M. On the role of VDAC in apoptosis: fact and fiction. J Bioenerg Biomembr 2005; 37: 129-42.
21. Rapizzi E, Pinton P, Szabadkai G, Wieckowski MR, Vandecasteele G, Baird G, Tuft RA, Fogarty KE, Rizzuto R. Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria. J Cell Biol 2002; 159: 613-24.
22. Chelli B, Falleni A, Salvetti F, Gremigni V, Lucacchini A, Martini C. Peripheral-type benzodiazepine receptor ligands: mitochondrial permeability transition induction in rat cardiac tissue. Biochem Pharmacol 2001; 61: 695-705.
23. Hirsch T, Decaudin D, Susin SA, Marchetti P, Larochette N, Resche-Rigon M, Kroemer G. PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection. Exp Cell Res 1998; 241: 426-34.
24. Kunduzova OR, Escourrou G, De La Farge F, Salvayre R, Seguelas MH, Leducq N, Bono F, Herbert JM, Parini A. Involvement of peripheral benzodiazepine receptor in the oxidative stress, death-signaling pathways, and renal injury induced by ischemia-reperfusion. J Am Soc Nephrol 2004; 15: 2152-60.
25. Taketani S, Kohno H, Furukawa T, Tokunaga R. Involvement of peripheraltype benzodiazepine receptors in the intracellular transport of heme and porphyrins. J Biochem (Tokyo) 1995; 117: 875-80.
26. Wendler G, Lindemann P, Lacapere JJ, Papadopoulos V. Protoporphyrin IX binding and transport by recombinant mouse PBR. Biochem Biophys Res Commun 2003; 311: 847-52.
27. Papadopoulou LC, Tsiftsoglou AS. Effects of hemin on apoptosis, suppression of cytochrome c oxidase gene expression, and bone-marrow toxicity induced by doxorubicin (adriamycin). Biochem Pharmacol 1996; 52: 713-22.
28. Ichas F, Mazat JP. From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance state. Biochim Biophys Acta 1998; 1366: 33-50.
29. Azarashvili T, Grachev D, Krestinina O, Evtodienko Y, Yurkov I, Papadopoulos V, Reiser G. The peripheral-type benzodiazepine receptor is involved in control of Ca2+-induced permeability transition pore opening in rat brain mitochondria. Cell Calcium 2007; 42: 27-39.
30. Tan W, Colombini M. VDAC closure increases calcium ion flux. Biochim Biophys Acta 2007; 1768: 2510-5.
31. Sardanelli AM, Technikova-Dobrova Z, Scacco SC, Speranza F, Papa S. Characterization of proteins phosphorylated by the cAMP-dependent protein kinase of bovine heart mitochondria. FEBS Lett 1995; 377: 470-4.
32. Mannella CA. Minireview: on the structure and gating mechanism of the mitochondrial channel. VDAC. J Bioenerg Biomembr 1997; 29: 525-31.
33. Verma A, Nye JS, Snyder SH. Porphyrins are endogenous ligands for the mitochondrial (peripheral-type) benzodiazepine receptor. Proc Natl Acad Sci USA 1987; 84: 2256-60.
34. Baines CP, Kaiser RA, Sheiko T, Craigen WJ, Molkentin JD. Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nat Cell Biol 2007; 9: 550-5.