메뉴 건너뛰기




Volumn 12, Issue 2, 2015, Pages 504-513

Mechanism of enhanced oral absorption of Morin by phospholipid complex based self-nanoemulsifying drug delivery system

Author keywords

Caco 2 cells; intestinal absorption; mechanism; morin; phospholipid complex; self nanoemulsifying

Indexed keywords

CLATHRIN; CREMOPHOR; MORIN; PHOSPHOLIPID; DRUG CARRIER; EMULSION; FLAVONOID;

EID: 84922109387     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp5005806     Document Type: Article
Times cited : (61)

References (41)
  • 1
    • 33751014029 scopus 로고    scopus 로고
    • Formulation of poorly water-soluble drugs for oral administration: Physicochemical and physiological issues and the lipid formulation classification system
    • Pouton, C. W. Formulation of poorly water-soluble drugs for oral administration: Physicochemical and physiological issues and the lipid formulation classification system Eur. J. Pharm. Sci. 2006, 29 (3-4) 278-287
    • (2006) Eur. J. Pharm. Sci. , vol.29 , Issue.34 , pp. 278-287
    • Pouton, C.W.1
  • 2
    • 0030590446 scopus 로고    scopus 로고
    • Polymeric micelles as new drug carriers
    • Kwon, G. S.; Okano, T. Polymeric micelles as new drug carriers Adv. Drug Delivery Rev. 1996, 21 (2) 107-116
    • (1996) Adv. Drug Delivery Rev. , vol.21 , Issue.2 , pp. 107-116
    • Kwon, G.S.1    Okano, T.2
  • 4
    • 0035946615 scopus 로고    scopus 로고
    • Solid lipid nanoparticles: Production, characterization and applications
    • Mehnert, W.; Mäder, K. Solid lipid nanoparticles: production, characterization and applications Adv. Drug Delivery Rev. 2001, 47 (2) 165-196
    • (2001) Adv. Drug Delivery Rev. , vol.47 , Issue.2 , pp. 165-196
    • Mehnert, W.1    Mäder, K.2
  • 5
    • 78651379634 scopus 로고    scopus 로고
    • Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: Performance and mechanism
    • Gao, F.; Zhang, Z.; Bu, H.; Huang, Y.; Gao, Z.; Shen, J.; Zhao, C.; Li, Y. Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: Performance and mechanism J. Controlled Release 2011, 149 (2) 168-174
    • (2011) J. Controlled Release , vol.149 , Issue.2 , pp. 168-174
    • Gao, F.1    Zhang, Z.2    Bu, H.3    Huang, Y.4    Gao, Z.5    Shen, J.6    Zhao, C.7    Li, Y.8
  • 6
    • 79955629340 scopus 로고    scopus 로고
    • Nano-emulsions and micro-emulsions: Clarifications of the critical differences
    • Anton, N.; Vandamme, T. F. Nano-emulsions and micro-emulsions: clarifications of the critical differences Pharm. Sci. 2011, 28 (5) 978-985
    • (2011) Pharm. Sci. , vol.28 , Issue.5 , pp. 978-985
    • Anton, N.1    Vandamme, T.F.2
  • 7
    • 78650539714 scopus 로고    scopus 로고
    • Self-nanoemulsifying drug delivery systems: Formulation insights, applications and advances
    • Date, A. A.; Desai, N.; Dixit, R.; Nagarsenker, M. Self-nanoemulsifying drug delivery systems: formulation insights, applications and advances Nanomedicine 2010, 5 (10) 1595-1616
    • (2010) Nanomedicine , vol.5 , Issue.10 , pp. 1595-1616
    • Date, A.A.1    Desai, N.2    Dixit, R.3    Nagarsenker, M.4
  • 8
    • 69749105594 scopus 로고    scopus 로고
    • Self-nanoemulsifying drug delivery systems of tamoxifen citrate: Design and optimization
    • Elnaggar, Y. S.; El-Massik, M. A.; Abdallah, O. Y. Self-nanoemulsifying drug delivery systems of tamoxifen citrate: Design and optimization Int. J. Pharm. 2009, 380 (1) 133-141
    • (2009) Int. J. Pharm. , vol.380 , Issue.1 , pp. 133-141
    • Elnaggar, Y.S.1    El-Massik, M.A.2    Abdallah, O.Y.3
  • 9
    • 43049125803 scopus 로고    scopus 로고
    • Scavenging and antioxidant properties of compound derived from chlorogenic acid in South-China honeysuckle
    • Xiang, Z.; Ning, Z. X. Scavenging and antioxidant properties of compound derived from chlorogenic acid in South-China honeysuckle Food Sci. Technol. Int. 2008, 41 (7) 1189-1203
    • (2008) Food Sci. Technol. Int. , vol.41 , Issue.7 , pp. 1189-1203
    • Xiang, Z.1    Ning, Z.X.2
  • 10
    • 33846234714 scopus 로고    scopus 로고
    • Curcumin-phospholipid complex: Preparation, therapeutic evaluation and pharmacokinetic study in rats
    • Maiti, K.; Mukherjee, K.; Gantait, A.; Saha, B. P.; Mukherjee, P. K. Curcumin-phospholipid complex: Preparation, therapeutic evaluation and pharmacokinetic study in rats Int. J. Pharm. 2007, 330 (1-2) 155-163
    • (2007) Int. J. Pharm. , vol.330 , Issue.12 , pp. 155-163
    • Maiti, K.1    Mukherjee, K.2    Gantait, A.3    Saha, B.P.4    Mukherjee, P.K.5
  • 11
    • 83355162688 scopus 로고    scopus 로고
    • A rapid-acting, long-acting insulin formulation based on a phospholipid complex loaded PHBHHx nanoparticles
    • Peng, Q.; Zhang, Z.-R.; Gong, T.; Chen, G.-Q.; Sun, X. A rapid-acting, long-acting insulin formulation based on a phospholipid complex loaded PHBHHx nanoparticles Biomaterials 2012, 33 (5) 1583-1588
    • (2012) Biomaterials , vol.33 , Issue.5 , pp. 1583-1588
    • Peng, Q.1    Zhang, Z.-R.2    Gong, T.3    Chen, G.-Q.4    Sun, X.5
  • 12
    • 84878192040 scopus 로고    scopus 로고
    • Nanoemulsion loaded with lycobetaine-oleic acid ionic complex: Physicochemical characteristics, in vitro, in vivo evaluation, and antitumor activity
    • Zhao, H.; Lu, H.; Gong, T.; Zhang, Z. R. Nanoemulsion loaded with lycobetaine-oleic acid ionic complex: physicochemical characteristics, in vitro, in vivo evaluation, and antitumor activity Int. J. Nanomed. 2013, 8, 1959-1973
    • (2013) Int. J. Nanomed. , vol.8 , pp. 1959-1973
    • Zhao, H.1    Lu, H.2    Gong, T.3    Zhang, Z.R.4
  • 13
    • 33747884001 scopus 로고    scopus 로고
    • Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: Preparation, in vitro characterization and in vivo evaluation
    • Cui, F.; Shi, K.; Zhang, L.; Tao, A.; Kawashima, Y. Biodegradable nanoparticles loaded with insulin-phospholipid complex for oral delivery: Preparation, in vitro characterization and in vivo evaluation J. Controlled Release 2006, 114 (2) 242-250
    • (2006) J. Controlled Release , vol.114 , Issue.2 , pp. 242-250
    • Cui, F.1    Shi, K.2    Zhang, L.3    Tao, A.4    Kawashima, Y.5
  • 15
    • 74149090979 scopus 로고    scopus 로고
    • Preparation and evaluation of self-nanoemulsified drug delivery systems (SNEDDSs) of matrine based on drug-phospholipid complex technique
    • Ruan, J.; Liu, J.; Zhu, D.; Gong, T.; Yang, F.; Hao, X.; Zhang, Z. Preparation and evaluation of self-nanoemulsified drug delivery systems (SNEDDSs) of matrine based on drug-phospholipid complex technique Int. J. Pharm. 2010, 386 (1) 282-290
    • (2010) Int. J. Pharm. , vol.386 , Issue.1 , pp. 282-290
    • Ruan, J.1    Liu, J.2    Zhu, D.3    Gong, T.4    Yang, F.5    Hao, X.6    Zhang, Z.7
  • 16
    • 29344472864 scopus 로고    scopus 로고
    • The dual actions of morin (3,5,7,2′,4′-pentahydroxyflavone) as a hypouricemic agent: Uricosuric effect and xanthine oxidase inhibitory activity
    • Yu, Z.; Fong, W. P.; Cheng, C. H. The dual actions of morin (3,5,7,2′,4′-pentahydroxyflavone) as a hypouricemic agent: uricosuric effect and xanthine oxidase inhibitory activity J. Pharm. Exp. Ther. 2006, 316 (1) 169-175
    • (2006) J. Pharm. Exp. Ther. , vol.316 , Issue.1 , pp. 169-175
    • Yu, Z.1    Fong, W.P.2    Cheng, C.H.3
  • 17
    • 84864781347 scopus 로고    scopus 로고
    • Preparation, characterization, and in vivo evaluation of a self-nanoemulsifying drug delivery system (SNEDDS) loaded with morin-phospholipid complex
    • Zhang, J. J.; Peng, Q.; Shi, S. J.; Zhang, Q.; Sun, X.; Gong, T.; Zhang, Z. R. Preparation, characterization, and in vivo evaluation of a self-nanoemulsifying drug delivery system (SNEDDS) loaded with morin-phospholipid complex Int. J. Nanomed. 2011, 6, 3405-3414
    • (2011) Int. J. Nanomed. , vol.6 , pp. 3405-3414
    • Zhang, J.J.1    Peng, Q.2    Shi, S.J.3    Zhang, Q.4    Sun, X.5    Gong, T.6    Zhang, Z.R.7
  • 18
    • 1842535358 scopus 로고    scopus 로고
    • Quercetin-4′ glucoside is more potent than quercetin-3-glucoside in protection of rat intestinal mucosa homogenates against iron ion-induced lipid peroxidation
    • Murota, K.; Mitsukuni, Y.; Ichikawa, N.; Tsushida, T.; Miyamoto, S.; Terao, J. Quercetin-4′ glucoside is more potent than quercetin-3-glucoside in protection of rat intestinal mucosa homogenates against iron ion-induced lipid peroxidation J. Agric. Food Chem. 2004, 52 (7) 1907-1912
    • (2004) J. Agric. Food Chem. , vol.52 , Issue.7 , pp. 1907-1912
    • Murota, K.1    Mitsukuni, Y.2    Ichikawa, N.3    Tsushida, T.4    Miyamoto, S.5    Terao, J.6
  • 19
    • 77950572322 scopus 로고    scopus 로고
    • Mechanisms of Phospholipid Complex Loaded Nanoparticles Enhancing the Oral Bioavailability
    • Peng, Q.; Zhang, Z. R.; Sun, X.; Zuo, J.; Zhao, D.; Gong, T. Mechanisms of Phospholipid Complex Loaded Nanoparticles Enhancing the Oral Bioavailability Mol. Pharmaceutics 2010, 7 (2) 565-575
    • (2010) Mol. Pharmaceutics , vol.7 , Issue.2 , pp. 565-575
    • Peng, Q.1    Zhang, Z.R.2    Sun, X.3    Zuo, J.4    Zhao, D.5    Gong, T.6
  • 20
    • 58549089321 scopus 로고    scopus 로고
    • Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles
    • Li, H.; Zhao, X.; Ma, Y.; Zhai, G.; Li, L.; Lou, H. Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles J. Controlled Release 2009, 133 (3) 238-244
    • (2009) J. Controlled Release , vol.133 , Issue.3 , pp. 238-244
    • Li, H.1    Zhao, X.2    Ma, Y.3    Zhai, G.4    Li, L.5    Lou, H.6
  • 21
    • 84872099658 scopus 로고    scopus 로고
    • A self-assembled nanocarrier loading teniposide improves the oral delivery and drug concentration in tumor
    • Zhang, Z.; Ma, L.; Jiang, S.; Liu, Z.; Huang, J.; Chen, L.; Yu, H.; Li, Y. A self-assembled nanocarrier loading teniposide improves the oral delivery and drug concentration in tumor J. Controlled Release 2013, 166 (1) 30-37
    • (2013) J. Controlled Release , vol.166 , Issue.1 , pp. 30-37
    • Zhang, Z.1    Ma, L.2    Jiang, S.3    Liu, Z.4    Huang, J.5    Chen, L.6    Yu, H.7    Li, Y.8
  • 22
    • 84883635817 scopus 로고    scopus 로고
    • Enhanced intestinal absorption of etoposide by self-microemulsifying drug delivery systems: Roles of P-glycoprotein and cytochrome P450 3A inhibition
    • Zhao, G.; Huang, J.; Xue, K.; Si, L.; Li, G. Enhanced intestinal absorption of etoposide by self-microemulsifying drug delivery systems: Roles of P-glycoprotein and cytochrome P450 3A inhibition Eur. J. Pharm. Sci. 2013, 50 (3-4) 429-439
    • (2013) Eur. J. Pharm. Sci. , vol.50 , Issue.34 , pp. 429-439
    • Zhao, G.1    Huang, J.2    Xue, K.3    Si, L.4    Li, G.5
  • 23
    • 84872812121 scopus 로고    scopus 로고
    • Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier
    • Beloqui, A.; Solins, M. n.; Gascn, A. R.; del Pozo-Rodrguez, A.; des Rieux, A.; Prat, V. Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier J. Contolled Release 2013, 166 (2) 115-123
    • (2013) J. Contolled Release , vol.166 , Issue.2 , pp. 115-123
    • Beloqui, A.1    Solins, N.M.2    Gascn, A.R.3    Del Pozo-Rodrguez, A.4    Des Rieux, A.5    Prat, V.6
  • 24
    • 34547114456 scopus 로고    scopus 로고
    • Pathways of clathrin-independent endocytosis
    • Mayor, S.; Pagano, R. E. Pathways of clathrin-independent endocytosis Nat. Rev. Mol. Cell Biol. 2007, 8 (8) 603-612
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , Issue.8 , pp. 603-612
    • Mayor, S.1    Pagano, R.E.2
  • 26
    • 0036017680 scopus 로고    scopus 로고
    • Clathrin-dependent or not: Is it still the question?
    • Ludger Johannes, C. L. Clathrin-dependent or not: Is it still the question? Blackwell Munksgaard 2002, 3, 443-451
    • (2002) Blackwell Munksgaard , vol.3 , pp. 443-451
    • Ludger Johannes, C.L.1
  • 27
    • 20444447208 scopus 로고    scopus 로고
    • Liquid chromatography-tandem mass spectroscopy assay for quercetin and conjugated quercetin metabolites in human plasma and urine
    • Wang, L.; Morris, M. E. Liquid chromatography-tandem mass spectroscopy assay for quercetin and conjugated quercetin metabolites in human plasma and urine J. Chromatogr. B: Biomed. Sci. Appl. 2005, 821 (2) 194-201
    • (2005) J. Chromatogr. B: Biomed. Sci. Appl. , vol.821 , Issue.2 , pp. 194-201
    • Wang, L.1    Morris, M.E.2
  • 28
    • 67349163568 scopus 로고    scopus 로고
    • Effects of polyoxyethylene (40) stearate on the activity of P-glycoprotein and cytochrome P450
    • Zhu, S.; Huang, R.; Hong, M.; Jiang, Y.; Hu, Z.; Liu, C.; Pei, Y. Effects of polyoxyethylene (40) stearate on the activity of P-glycoprotein and cytochrome P450 Eur. J. Pharm. Sci. 2009, 37 (5) 573-580
    • (2009) Eur. J. Pharm. Sci. , vol.37 , Issue.5 , pp. 573-580
    • Zhu, S.1    Huang, R.2    Hong, M.3    Jiang, Y.4    Hu, Z.5    Liu, C.6    Pei, Y.7
  • 29
    • 0141751843 scopus 로고    scopus 로고
    • Metabolism of tea flavonoids in the gastrointestinal tract
    • Spencer, J. P. E. Metabolism of tea flavonoids in the gastrointestinal tract J. Nutr. 2003, 133 (10) 3255s-3261s
    • (2003) J. Nutr. , vol.133 , Issue.10 , pp. 3255s-3261s
    • Spencer, J.P.E.1
  • 30
    • 79955522520 scopus 로고    scopus 로고
    • The mechanism of enhancement on oral absorption of paclitaxel by N-octyl-O-sulfate chitosan micelles
    • Mo, R.; Jin, X.; Li, N.; Ju, C.; Sun, M.; Zhang, C.; Ping, Q. The mechanism of enhancement on oral absorption of paclitaxel by N-octyl-O-sulfate chitosan micelles Biomaterials 2011, 32 (20) 4609-4620
    • (2011) Biomaterials , vol.32 , Issue.20 , pp. 4609-4620
    • Mo, R.1    Jin, X.2    Li, N.3    Ju, C.4    Sun, M.5    Zhang, C.6    Ping, Q.7
  • 31
    • 80155125186 scopus 로고    scopus 로고
    • A self-assembled nanodelivery system enhances the oral bioavailability of daidzein: In vitro characteristics and in vivo performance
    • Zhang, Z.; Huang, Y.; Gao, F.; Gao, Z.; Bu, H.; Gu, W.; Li, Y. A self-assembled nanodelivery system enhances the oral bioavailability of daidzein: in vitro characteristics and in vivo performance Nanomedicine 2011, 6 (8) 1365-1379
    • (2011) Nanomedicine , vol.6 , Issue.8 , pp. 1365-1379
    • Zhang, Z.1    Huang, Y.2    Gao, F.3    Gao, Z.4    Bu, H.5    Gu, W.6    Li, Y.7
  • 32
    • 79956350930 scopus 로고    scopus 로고
    • Intestinal absorption and intestinal lymphatic transport of sirolimus from self-microemulsifying drug delivery systems assessed using the single-pass intestinal perfusion (SPIP) technique and a chylomicron flow blocking approach: Linear correlation with oral bioavailabilities in rats
    • Sun, M.; Zhai, X.; Xue, K.; Hu, L.; Yang, X.; Li, G.; Si, L. Intestinal absorption and intestinal lymphatic transport of sirolimus from self-microemulsifying drug delivery systems assessed using the single-pass intestinal perfusion (SPIP) technique and a chylomicron flow blocking approach: Linear correlation with oral bioavailabilities in rats Eur. J. Pharm. Sci. 2011, 43 (3) 132-140
    • (2011) Eur. J. Pharm. Sci. , vol.43 , Issue.3 , pp. 132-140
    • Sun, M.1    Zhai, X.2    Xue, K.3    Hu, L.4    Yang, X.5    Li, G.6    Si, L.7
  • 33
    • 39149108776 scopus 로고    scopus 로고
    • Lipid-based delivery systems and intestinal lymphatic drug transport: A mechanistic update
    • Trevaskis, N. L.; Charman, W. N.; Porter, C. J. H. Lipid-based delivery systems and intestinal lymphatic drug transport: A mechanistic update Adv. Drug Delivery Rev. 2008, 60 (6) 702-716
    • (2008) Adv. Drug Delivery Rev. , vol.60 , Issue.6 , pp. 702-716
    • Trevaskis, N.L.1    Charman, W.N.2    Porter, C.J.H.3
  • 34
    • 0023974813 scopus 로고
    • Role of M Cells and Macrophages in the Entrance of Mycobacterium paratuberculosis into Domes of Ileal Peyers Patches in Calves
    • Momotani, E.; Whipple, D. L.; Thiermann, A. B.; Cheville, N. F. Role of M Cells and Macrophages in the Entrance of Mycobacterium paratuberculosis into Domes of Ileal Peyers Patches in Calves Vet. Pathol. 1988, 25 (2) 131-137
    • (1988) Vet. Pathol. , vol.25 , Issue.2 , pp. 131-137
    • Momotani, E.1    Whipple, D.L.2    Thiermann, A.B.3    Cheville, N.F.4
  • 35
    • 84859719708 scopus 로고    scopus 로고
    • Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers
    • Ensign, L. M.; Cone, R.; Hanes, J. Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers Adv. Drug Delivery Rev. 2012, 64 (6) 557-570
    • (2012) Adv. Drug Delivery Rev. , vol.64 , Issue.6 , pp. 557-570
    • Ensign, L.M.1    Cone, R.2    Hanes, J.3
  • 36
    • 33646547331 scopus 로고    scopus 로고
    • Microemulsions: A potential drug delivery system
    • Ghosh, P.; Murthy, R. Microemulsions: a potential drug delivery system Curr. Drug Delivery 2006, 3 (2) 167-180
    • (2006) Curr. Drug Delivery , vol.3 , Issue.2 , pp. 167-180
    • Ghosh, P.1    Murthy, R.2
  • 37
    • 0023145301 scopus 로고
    • Quantitative contributions of cholesterol and the individual classes of phospholipids and their degree of fatty acyl (un) saturation to membrane fluidity measured by fluorescence polarization
    • Van Blitterswijk, W. J.; Van der Meer, B. W.; Hilkmann, H. Quantitative contributions of cholesterol and the individual classes of phospholipids and their degree of fatty acyl (un) saturation to membrane fluidity measured by fluorescence polarization Biochemistry 1987, 26 (6) 1746-1756
    • (1987) Biochemistry , vol.26 , Issue.6 , pp. 1746-1756
    • Van Blitterswijk, W.J.1    Van Der Meer, B.W.2    Hilkmann, H.3
  • 38
    • 2142711101 scopus 로고    scopus 로고
    • Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport
    • Zhang, S.; Yang, X.; Morris, M. E. Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport Mol. Pharmaceutics 2004, 65 (5) 1208-1216
    • (2004) Mol. Pharmaceutics , vol.65 , Issue.5 , pp. 1208-1216
    • Zhang, S.1    Yang, X.2    Morris, M.E.3
  • 39
    • 77957253754 scopus 로고    scopus 로고
    • Enhanced oral absorption of saquinavir with methyl-beta-cyclodextrin-preparation and in vitro and in vivo evaluation
    • Pathak, S. M.; Musmade, P.; Dengle, S.; Karthik, A.; Bhat, K.; Udupa, N. Enhanced oral absorption of saquinavir with methyl-beta-cyclodextrin-preparation and in vitro and in vivo evaluation Eur. J. Pharm. Sci. 2010, 41 (3) 440-451
    • (2010) Eur. J. Pharm. Sci. , vol.41 , Issue.3 , pp. 440-451
    • Pathak, S.M.1    Musmade, P.2    Dengle, S.3    Karthik, A.4    Bhat, K.5    Udupa, N.6
  • 40
    • 0030949124 scopus 로고    scopus 로고
    • Functional rafts in cell membranes
    • Kai Simons, E. I. Functional rafts in cell membranes Nature 1997, 387 (5) 569-572
    • (1997) Nature , vol.387 , Issue.5 , pp. 569-572
    • Kai Simons, E.I.1
  • 41
    • 0034595877 scopus 로고    scopus 로고
    • Essential role for cholesterol in entry of mycobacteria into macrophages
    • Gatfield, J.; Pieters, J. Essential role for cholesterol in entry of mycobacteria into macrophages Science 2000, 288 (5471) 1647-1650
    • (2000) Science , vol.288 , Issue.5471 , pp. 1647-1650
    • Gatfield, J.1    Pieters, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.