Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: Performance and mechanism

Journal of Controlled Release

Volumn 149, Issue 2, 2011, Pages 168-174

  Gao, Fang ^a,b   Zhang, Zhiwen ^a   Bu, Huihui ^a   Huang, Yan ^a   Gao, Zhiwei ^a   Shen, Jianan ^a   Zhao, Chunjie ^b   Li, Yaping ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Candesartan; Candesartan cilexetil; Nanoemulsion; Oral absorption

Indexed keywords

ANTIHYPERTENSIVE EFFECT; AQUEOUS SOLUBILITY; CANDESARTAN; CLATHRIN-MEDIATED ENDOCYTOSIS; CLINICAL APPLICATION; CONCENTRATION-TIME; ENTEROCYTES; GASTROINTESTINAL TRACT; INTESTINAL ABSORPTION; INTESTINAL TRACT; LC-MS-MS; NANOEMULSION; NEGATIVE POTENTIAL; ORAL ABSORPTION; PHYSICOCHEMICAL CHARACTERISTICS; PORTAL VEINS; PRODRUGS; RAT PLASMA; SOLVENT EVAPORATION TECHNIQUES; SYSTEMIC CIRCULATION;

BIOCHEMISTRY; EMULSIFICATION; MOLECULAR BIOLOGY;

ABSORPTION;

CANDESARTAN HEXETIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG HALF LIFE; DRUG RELEASE; DRUG TRANSPORT; ENDOCYTOSIS; INTESTINE ABSORPTION; INTESTINE CELL; MALE; MAXIMUM PLASMA CONCENTRATION; NANOEMULSION; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; BENZIMIDAZOLES; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; BIPHENYL COMPOUNDS; CACO-2 CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CARRIERS; DUODENUM; EMULSIONS; ENDOCYTOSIS; HUMANS; ILEUM; INTESTINAL ABSORPTION; JEJUNUM; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MOUTH MUCOSA; NANOSTRUCTURES; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SURFACE PROPERTIES; TANDEM MASS SPECTROMETRY; TETRAZOLES;

EID: 78651379634     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.10.013     Document Type: Article

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